Browse > Article
http://dx.doi.org/10.5487/TR.2007.23.2.165

Antigastritic Effect of Carbenoxolone Disodium from Glycyrrhizae Radix  

Cho, So-Yean (Division of Herbal medicine Evaluation, Korea Food & Drug Administration)
Lee, Seung-Ho (College of Pharmacy, Yeungnam University)
Choi, Ji-Young (College of Pharmacy, Yeungnam University)
Myoung, Shin-Eun (Natural Products Research Institute, Seoul National University)
Kang, Sam-Sik (Natural Products Research Institute, Seoul National University)
Jeong, Jeong-Suk (College of Pharmacy, Duksung Women's University)
Jeong, Choon-Sik (College of Pharmacy, Duksung Women's University)
Publication Information
Toxicological Research / v.23, no.2, 2007 , pp. 165-172 More about this Journal
Abstract
Glycyrrhizae Radix, the dried roots of Glycyrrhiza glabra or Glycyrrhiza uralensis Fischer(Legumino-sae), has been used as a medicine for treatment of imflammation, arthritis, respiratory ailment, skin diseases and liver problems. The purpose of this study was to examine the effect of 70% ethanol extract, 18-${\beta}$-glycyrrhetinic acid, glycyrol and carbenoxolone disodium from Glycyrrhizae Radix on gastritis and gastric cancer. Using these materials, we tested antibacterial activity against Helicobacter pylori, antigastritic activity for HCI-ethanol-induced gastric lesion and the pylorus ligated gastric secretion with rats, and cell viability in gastric cancer cell. 18-${\beta}$-glycyrrhetinic acid and carbenoxolone disodium decreased the volume of gastric secretion and acid output in pylorus ligated rats. Also, carbenoxolone disodium had a strong effect of antibacterial activity on H. pylori. In addition 18-${\beta}$-glycyrrhetinic acid and glycyrol reduced cell viability in human gastric cancer cells(AGS and SNU638 cell) in dose-dependent manner. The reduction of total acid output and gastric secretion as well as the anti-bacterial activity against H. pylori might account for the antigastritic effects of carbenoxolone disodium.
Keywords
18-${\beta}$-Glycyrrhetinic acid; Carbenoxolone disodium; Glycyrrhizae radix; Antigastritic; Gastric cancer cell; Helicobacter pylori;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 조훈, 원성란, 양은영, 김종수, 유일수, 류도곤, 이정호, 강길웅, 백 승화 (1999). 감초추출물의 항균효과(I). 약학회지, 43, 419- 422
2 Ahn, K.S., Noh, E.J., Zhao, H.L., Jung, S.H., Kang, S.S. and Kim, Y.S. (2005). Inhibition of inducible nitric oxide synthase and cyclooxygenase II by platycodon grandiflirum saponins via suppression of NF-$\kappa$B activation in RAW 264.7 cells. Life Sci., 76, 2315-2328   DOI   ScienceOn
3 Kim, H.A,, You, H.K., Shin, H.S., Kim. Y.C,, Kang, T.H., Yu, H.H. and You, Y.O. (2003). Effects of aqueous extract of Glycyrrhiza glabra on the expression of cell cycle regulatory proteins in human oral mucosal fibroblasts. Am. J. Chin. Med., 31, 563-572   DOI   ScienceOn
4 Kim, J.M., Shin, J.E., Han, M.J., Baek, N.I. and Kim, D.H. (2003). Inhibitory Effect of Ginseng Polyacetylenes on Infection and Vacuolation of Helicobacter pylori. Nat. Prod. Sci., 9, 158-160
5 Tanaka, Y., Kikuzaki, H., Fukuda, S. and Nakatani, N. (2001). Antibacterial compounds of licorice against upper airway respiratory tract pathogens. J. Nutr. Sci. Vitaminol., 47, 270-273   DOI
6 한국약학대학협의회약전분과회편저 (2003). 대한약전 제8개정 해 설서. 문성사, 서울, pp. 264-265
7 Kim, Y.C., Kim, H.S., Wataya, Y., Sohn, D.H., Kang, T.H., Kim, M.S., Kim, Y.M., Lee, G.M., Chang, J.D. and Park, H. (2004). Antimalarial activity of lavandulyl flavanones isolated from the roots of Glycyrrhiza glabra. Biol. Pharm. Bull., 27, 748-750   DOI   ScienceOn
8 Jung, H.J., Kang, S.S., Woo, J.J. and Choi, J.S. (2005). A new lavandulylated flavonoid with free radical and ONOOscavenging activities from Glycyrrhiza glabra. Arch. Pharm. Res., 28, 1333-1336   과학기술학회마을   DOI   ScienceOn
9 Farina, C., Pinza, M. and Pifferi, G. (1998). Synthesis and anti-ulcer activity of new derivatives of glycyrrhetic, oleanolic and ursolic acids. Il Farmaco., 53, 22-32   DOI   ScienceOn
10 Ariypshi, I., Toshiharu, A., Sugimura, F., Abe M., Matsuo, Y. and Honda, T. (1986). Recurrence during maintenence therapy with histamine H2 receptors antagonist in case of gastric ulcers. Nikon University Journal of Medicine, 28, 69-74
11 Shay, H., Komarov, S.A., Fels, S.S., Meranze, D., Gruenstein, M. and Siplet, H. (1945). A simple method for the uniform production of gastric ulceration in the rat. Gastroenterol., 4, 43-61
12 한대석 저 (1995). 生藥學. 동명사, 서울 pp. 191-194
13 Gareri, P., Condorelli, D., Belluardo, N., Citraro, R., Barresi, V., Trovato-Salinato, A., Mudò, G., Ibbadu, G.F., Russo, E. and De Sarro, G. (2005). Antiabsence effects of carbenoxolone in two genetic animal models of absence epilepsy (WAG/Rij rats and lh/lh mice). Neuropharmacology, 49, 551-563   DOI   ScienceOn
14 Kenji, N., Midori, H., Shigeo. M., Yasuhiro, Y., Hideki, M. and Teruhiko, T. (1999). Preventive effects of glycyrrhizae radix extract on Estrogen-related endometrial carcinogenesis in mice. Jpn. J. Cancer Res., 90, 726-732   DOI
15 Son, J.K., Park, J.S., Kim, J.A., Kim, Y., Chung, S.R. and Lee, S.H. (2003). Prenylated flavonoids from the roots of Glycyrrhiza glabra with tyrosinase inhibitory activity. Planta Med., 69, 559-561   DOI   ScienceOn
16 Franco, L., Manara, P., Erbetti, I. and Velo, G.P. (1993). Antiulcer actinicty of carbenoxolone and ISF 3401 on PGE2 release in rat gastric mucosa. Pharmacol. Res., 27, 141- 150   DOI   ScienceOn
17 Ito, M., Shii, D., Segami, T., Kojima, R. and Suzuki, Y. (1992). Preventive actions of Z-103 through increase in the activities of oxygen-derived free radical scavenging enzymes in the gastric mucosa on ethanol-induced gastric mucosal damage in rats. Jpn. J. Pharmacol., 59, 267-274   DOI
18 Zakirov, U.B. and Abdullaev, A. (1996). The hypolipidemic and antiatherosclerotic properties of the ammonium salt of glycyrrhetinic acid and of 18-dehydroglycyrrhetic acid. Eksp. Klin. Farmakol., 59, 53-55
19 Mizui, T. and Dodeuchi, M. (1983). Effect of polyamines on acidified ethanol induced gastric lesion in rats. Jpn. J. Pharmacol., 33, 939-945   DOI
20 Andrea, T.B., Shinya, S., Gary, L.H., Martha, R., Harkey, C.L., Keen, J. S., Katsutoshi, T. and Eric, G. (2000). Shosaikoto and other Kampo (Japanese herbal) medicines: a review of their immunomodulatory activities, J. Ethnopharmacol., 73, 1-2, 1-13   DOI   ScienceOn
21 Uchiyama, M., Suzuki, Y. and Fukuzawa, K. (1968). : Biochemical studies of physiological function of tocopherolactone. Yakugaku Zasshi., 88, 678-683   DOI
22 육창수, 김성만, 정진모, 정명숙, 김정화, 김승배 (1995) : 한약의 약리성분, 임상응용. 계측문화사, 서울, pp. 414-416