• Proceedings of the Korean Information Science Society Conference
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• 2004.10a
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• pp.31-33
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• 2004

HLA (High Level Architecture) 는 모델링과 시뮬레이션 분야에서 상호 이질적인 서비스에 따른 어플리케이션의 상호운용성(interoperability)과 재사용성(reusability)을 증진시키기 위해 필요한 infrastructure를 개발하기 위한 청사진이다. RTI(RunTime Infrastructure)는 HLA 의 소프트웨어적 도구로써 IibTRI, FedExec, RTIExec의 세 가지 컴포넌트로 구성되어 있다. RTI는 분산환경에서 동적으로 다수대다수간의 통신을 제공하는 미들웨어 (middleware)이다. 대규모의 분산 시뮬레이션의 실행은 지리적으로 퍼져있는 많은 양의 컴퓨팅 자원을 필요로 할 수 있는데 이러한 환경이 가지는 보안과 동적 자원 할당이라는 문제점을 Globus Toolkit3(GT3)안의 Open Grid Service Arcitecture(OGSA)를 사용해서 해결할 수 있는 RTI-G를 개발해 왔고 이를 service-oriented RTI-G라 부른다. 이 논문에서는 service-oriented RTI on Grid 의 구조와 앞에 제시된 문제점들의 해결방안을 제시하고 실험한다.

• Proceedings of the Korea Multimedia Society Conference
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• 2004.05a
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• pp.814-817
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• 2004

그리드는 컴퓨터류만 연결된 기존의 인터넷에 모든 종류의 비컴퓨터류의 기계장치들을 인터넷상에 연결시켜 컴퓨터와 더불어 활용하는 기술을 지칭한다. 즉, 지역적으로 분산되어 있는 컴퓨팅 파워를 공유하여 마치 한 대의 고성능 컴퓨터처럼 사용할 수 있게 해 주는 것을 말한다. 이러한 그리드환경에서 client가 요구하는 작업을 명시하는 표준 RSL(Resource Specification Language)을 이용해 GRAM (Globus Resource Allocation and Management)에 작업을 제출한다. 하지만 기존의 GRAM에서는 특별한 수행 환경을 요구하는 작업을 수행시키는 방법을 알지 못한다. 이에 본 논문에서는 브로커와 상호작용가능한 실행환경정보(Excution Environment Information)를 제안함으로써, GRAM의 특수 수행 환경을 지원 할 수 있게 하였다.

• Proceedings of the Korean Information Science Society Conference
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• 2002.10c
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• pp.331-333
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• 2002

그리드는 지리적으로 분산되어 있는 이기종의 유휴 자원들을 서로 연결하여 하나의 가상 컴퓨터처럼 동작하는 환경이다. 특히, 그리드 어카운팅은 각 자원 제공의 기준을 적용할 수 있기 때문에 그리드 시스템 구축에 필수적인 요소이다. 본 논문에서는 기존의 그리드 어카운팅 시스템들에서 발생할 수 있는 부하 집중, ID중복 등의 문제점들을 해결하기 위해 슈퍼컴퓨터 환경에서의 새로운 정책기반 그리드 어카운팅 시스템을 설계하였다. 제안한 시스템은 Globus Toolkit을 미들웨어로 사용하며, 각 자원 제공자가 기존 시스템 관리 기능을 넘지 않는 한도 내에서 정책기반 그리드 어카운팅을 사용할 수 있도록 하였다.

• Proceedings of the Korean Information Science Society Conference
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• 2003.04d
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• pp.124-126
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• 2003

그리드 컴퓨팅은 광범위 분산 컴퓨팅 시스템(wide area distributed computing system)으로, 고성능의 유휴 컴퓨팅 자원을 서로 공유하여 효율적으로 작업을 수행하는 것을 목적으로 한다. 그리드 컴퓨팅에서 사용자가 요구하는 자원의 검색, 선택, 할당하는 문제는 시스템 성능에 큰 영향을 미친다. 그리드 컴퓨팅을 지원하는 대표적인 미들웨어인 글로버스(Globus Toolkit)에서는 위와 같은 과정들이 사용자에 의해 수동적으로 이루어지며, 검색된 후보 자원의 최적 선택 방법은 제공하지 않고 있다. 본 논문에서는 글로버스에서 사용자의 요구에 의해 검색된 후보 자원들 중 최적화된 자원 선택과 할당 요청을 담당하는 최적 자원 선택 브로커를 설계하였다. 이 브로커는 유전자 알고리즘을 이용하여 최적 자원을 선택하므로 사용자의 임의적 자원 선택으로 인한 시스템의 성능 저하를 막아준다. 자원 검색, 선택, 할당 요청이 하나의 브로커에서 이루어짐으로써 작업 수행 시 발생하는 사용자의 불필요한 관여를 막아 작업 수행에 대한 편의성을 제공한다.

• Korean Journal of Head & Neck Oncology
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• v.35 no.1
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• pp.45-48
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• 2019

Osseous choristoma is a rare, benign proliferative osseous lesion, which is defined as the growth of normal tissue in an abnormal location. The etiopathogenesis for its formation is unknown, but various hypotheses have been proposed. Treatment of choice is en-bloc resection, and no recurrence has been reported. Here, we report the two cases of osseous choristoma, presented with a mass on the base of the tongue with/without globus symptom and were treated with surgical excision.

• Journal of Korean Neurosurgical Society
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• v.65 no.5
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• pp.640-651
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• 2022

Clinical studies on neuromodulation intervention for trigeminal neuralgia have not yet shown promising results. This might be due to the fact that the pathophysiology of chronic trigeminal neuropathy is not yet fully understood. Chronic trigeminal neuropathy includes trigeminal autonomic neuropathy, painful trigeminal neuropathy, and persistent idiopathic facial pain. This disorder is caused by complex abnormalities in the pain processing system, which is comprised of the affective, emotional, and sensory components, rather than mere abnormal sensation. Therefore, integrative understanding of the pain system is necessary for appropriate neuromodulation of chronic trigeminal neuropathy. The possible neuromodulation targets that participate in complex pain processing are as follows : the ventral posterior medial nucleus, periaqueductal gray, motor cortex, nucleus accumbens, subthalamic nucleus, globus pallidus internus, anterior cingulate cortex, hypothalamus, sphenopalatine ganglion, and occipital nerve. In conclusion, neuromodulation interventions for trigeminal neuralgia is yet to be elucidated; future advancements in this area are required.

• Journal of Korean Neurosurgical Society
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• v.29 no.8
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• pp.1024-1029
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• 2000

Objectives : With recent improvements in neuroimaging and the development of third and fourth-generation radiosurgical dose-planning soft ware, came a renewed interest in using radiosurgery for the treatment of movement disorders. Radiosurgery involves no opening of the cranium and no incisions, eliminating both the risk of hemorrhage from passing an electrode to the depths of meningitis from operative infection. It is for these reasons stereotactic radiosurgical treatment of movement disorders has value in a small subgroup of patients. The authors report four cases of Parkinson's disease and one case of dystonia that were treated by Gamma knife. Methods : Radiosurgical nucleus ventralis intermedius thalamotomy using the gamma knife unit was performed to make lesion in two Parkinson's disease patients. A radiation dose of 120Gy was delivered to nucleus using a single 4-mm collimator plug pattern following classic anatomical landmarks. Patients were followed for a median of 10.5 months(range 9-12 months). An independent neurological evaluation of tremor, based on the change in the United Parkinson's Disease Rating Scale tremor score(UPDRS), was correlated with a subjective evaluation. Gamma knife ventrolateral(V.O.P) thalamotomy was performed in one case of dystonia. A central dose of 150Gy was delivered and the patient was followed for 18 months. Gamma knife globus pallidus interna pallidotomy was performed in two Parkinson's disease patients. A radiation dose of 130Gy(range 120-140Gy) was delivered. Patients were followed for a median of 13 months(range 9-14 months). Result : Ventrolateral thalamotomy in dystonia produced regained left hand usage in order to be able to use the telephone. Ventralis intermedius thalamotomy produced an excellent improvement of the tremor in one case, mild improvement of the tremor in the other case of Parkinson's disease. A globus pallidus internalis(GPi) pallidotomy produced improvement of rigidity and dyskinesia : one other showed no change. There were no neurological complications. Conclusion : Gamma Knife thalamotomy considered a safe and effective technique for the treatment of tremor in Parkinson's disease. Although the results from Longer follow-up is not available yet, the short-term results seem to be encouraging.

• Molecules and Cells
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• v.43 no.4
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• pp.360-372
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• 2020

The basal ganglia network has been implicated in the control of adaptive behavior, possibly by integrating motor learning and motivational processes. Both positive and negative reinforcement appear to shape our behavioral adaptation by modulating the function of the basal ganglia. Here, we examined a transgenic mouse line (G2CT) in which synaptic transmissions onto the medium spiny neurons (MSNs) of the basal ganglia are depressed. We found that the level of collaterals from direct pathway MSNs in the external segment of the globus pallidus (GPe) ('bridging collaterals') was decreased in these mice, and this was accompanied by behavioral inhibition under stress. Furthermore, additional manipulations that could further decrease or restore the level of the bridging collaterals resulted in an increase in behavioral inhibition or active behavior in the G2CT mice, respectively. Collectively, our data indicate that the striatum of the basal ganglia network integrates negative emotions and controls appropriate coping responses in which the bridging collateral connections in the GPe play a critical regulatory role.

• The KIPS Transactions:PartD
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• v.13D no.7 s.110
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• pp.1009-1016
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• 2006

Under foundational precepts of Grid computing, two important requirements that all Grid application systems should satisfy are to accommodate the dynamic nature of Virtual Organizations (VOs), and to enforce different levels of security among different VOs. For the research described in this paper, we developed two different use-case scenarios addressing the two requirements, and then showed how the requirements can be met by implementing a Grid information retrieval (GIR) system prototype. The dynamic nature of VO applies not only to increasing and decreasing number of users, but also to the dynamically changing requirement of computing power among the different subcomponents that consist in overall system configuration. This implies that a request to increase computing power by a certain subcomponent can be satisfied by other idling subcomponents taking advantage of overall system flexibility. This paper describes how we implemented a Grid IR system using VO and security mechanisms provided by Globus toolkit 3.0, and shows how GIR system scalability and security can be improved for dynamic VOs. In order to manage different VOs, we implemented VO management service (VOMS), and registered it to Globus as an additional service.

• Journal of KIISE:Computer Systems and Theory
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• v.35 no.6
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• pp.237-247
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• 2008

A virtual screening is the process of reducing an unmanageable number of compounds to a limited number of compounds for the target of interest by means of computational techniques such as molecular docking. And it is one of a large-scale scientific application that requires large computing power and data storage capability. Previous applications or softwares for molecular docking such as AutoDock, FlexX, Glide, DOCK, LigandFit, ViSION were developed to be run on a supercomputer, a workstation, or a cluster-computer. However the virtual screening using a supercomputer has a problem that a supercomputer is very expensive and the virtual screening using a workstation or a cluster-computer requires a long execution time. Thus we propose a service-based virtual screening system using Grid computing technology which supports a large data intensive operation. We constructed 3-dimensional chemical molecular database for virtual screening. And we designed a resource broker and a data broker for supporting efficient molecular docking service and proposed various services for virtual screening. We implemented service based virtual screening system with DOCK 5.0 and Globus 3.2 toolkit. Our system can reduce a timeline and cost of drug or new material design.