• 동의생리병리학회지
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• 제22권4호
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• pp.943-947
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• 2008

This study is designed to evaluate the effects of an oriental herbal medication namely Bojungikki-tang-gamibang on vascular dementia. The Clinical data was analyzed on a patient with vascular dementia due to deficiency of Spleen Gi, whose symptoms were dementia, Rt. side hemiparesis, insomnia, anorexia et al. The patient visited at the internal medicine department of Daegu Haany University affiliated Kumi Oriental Hospital on February 14, 2008 to March 28, 2008. The improvement of symptoms were checked by Mini Mental Status Examination-Korea(MMSE-K). After treatment, dementia, Rt. side hemiparesis, insomnia, anorexia got improved and MMSE-K score increased as well. This study suggests that Bojungikki-tang-gamibang is significantly effective in treatment of vascular dementia.

• 대한의료기공학회지
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• 제11권1호
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• pp.1-58
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• 2009

1. The rapid increasing elderly population represents a significant increase in the population with dementia. So, studies on the method for the prevention of dementia are necessary. 2. In oriental medicine, the causes of dementia are based on the deficiency of Jeong(精;essence of the body), the lack of bone marrow, and abnormal brain function. Emotional stress, bad habits of lifestyle including eating habits are also responsible for dementia. They causes dementia by blocking the circulation of Gi(氣) such as Suseunghwagang(水升火降;ascending kidney water and descending heart fire) and suppressing the function of Danjeon(丹田; the hypogastric center). 3. Gochi(叩齒) is a sort of mastication that facilitate salivation and secretion of parotin, next step is swallowing saliva. These supplement Jeong(精) of the five viscera and the six entrails(五臟六腑), promote Suseunghwagang(水升火降), and advance the function of the hypogastric center (丹田) and activate the brain. 4. So this paper draw a conclusion that Gochi(叩齒) is negatively related to the causes of dementia and it will be useful in preventing dementia.

• Clinical and Experimental Reproductive Medicine
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• 제43권4호
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• pp.199-206
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• 2016

Objective: This study was carried out to investigate the correlations of the sperm DNA fragmentation index (DFI) with semen parameters and apoptosis, and to investigate the effects of density-gradient centrifugation (DGC) and magnetic-activated cell sorting (MACS) on reducing the proportion of sperm with DNA fragmentation and protamine deficiency. Methods: Semen analysis and a sperm DNA fragmentation assay were performed to assess the correlations between semen parameters and the DFI in 458 semen samples. Sperm with progressive motility or non-apoptosis were isolated by DGC or MACS, respectively, in 29 normozoospermic semen samples. The effects of DGC or MACS alone and of DGC and MACS combined on reducing the amount of sperm in the sample with DNA fragmentation and protamine deficiency were investigated. Results: The sperm DFI showed a significant correlation (r=-0.347, p< 0.001) with sperm motility and morphology (r=-0.114, p< 0.05) but not with other semen parameters. The DFI ($11.5%{\pm}2.0%$) of semen samples was significantly reduced by DGC ($8.1%{\pm}4.1%$) or MACS alone ($7.4%{\pm}3.9%$) (p< 0.05). The DFI was significantly further reduced by a combination of DGC and MACS ($4.1%{\pm}1.3%$, p< 0.05). Moreover, the combination of DGC and MACS ($1.6%{\pm}1.1%$, p< 0.05) significantly reduced the protamine deficiency rate of semen samples compared to DGC ($4.4%{\pm}3.2%$) or MACS alone ($3.4%{\pm}2.2%$). Conclusion: The combination of DGC and MACS may be an effective method to isolate high-quality sperm with progressive motility, non-apoptosis, high DNA integrity, and low protamine deficiency in clinical use.

• 한방안이비인후피부과학회지
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• 제21권3호
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• pp.150-165
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• 2008

Objective : An adequate measurement for Atopic Dermatitis(AD) is essential for studies about the treatment of AD. To establish a new and adequate scoring system for AD in Korean medicine, we reviewed existing studies on AD outcome measurement in Korean medicine. Method : We searched for reviews on measurements of AD or studies which used an AD outcome measurement at the Korean Traditional Knowledge Portal from 1995 to June, 2008. And then we reviewed the pattern identification in AD patients and the outcome measurements for AD in each study. Results : 1. Among 25 studies, the most common measurement for AD was SCORAD(the severity SCORing of Atopic Dermatitis index), there were 16 studies. There was one study which used the Jakob T scoring system, one study which used ADSI(the Atopic Dermatitis Severity Index), and there were 7 studies which established or used a new severity scoring system for AD. 2. In Korean medicine, AD caused by Damp-Heat is accompanied by erythema, papulation, oozing and crust, Damp-Heat accompanied by Spleen-Gi deficiency is frequently found in pediatric patients, and in adults who have indigestion. Symptoms of AD caused by blood deficiency and Wind-Dryness include lichenification, dryness, scale and pigmentation. AD caused by toxic Heat in the blood system has symptoms similar to some Damp-Heat pattern along with symptoms of blood deficiency and Wind-Dryness. Conclusion : We need to establish a new severity scoring system which reflects pattern identifications and treatments with Korean medicine, and we should assess the validity, reliability, and sensitivity of the new scoring system.

• 대한약침학회지
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• 제9권1호
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• pp.59-67
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• 2006

Objectives : This study planed to evaluate effect of oriental medicine therapy treatment method of dyspnea that happen from cancer of the pancreas patient who accompany Multiple metasis Methods : Patient complained dyspnoea during admission into dept. Of internal medicine, college of oriental medicine, Dong-eui Univ, was appealed patient treated by Oriental medicine therapy that is of use Herb Medication and Herbal -acupuncture Treatment being diagnosed in lung asthenia including deficiency of Eum and insufficiency of Gi of the lung(肺虛), the fire due to deficiency(虛火), and loving warfare of symptoms evaluated through VAS (visual analog scales). Results & Conclusion : Patient's difficulty in breathing symptoms took a favorable turn after treatment. This study means that Oriental medicine therapy that is difficulty in breathing symptoms that happen from patient surely has effectiveness.

• 대한한방내과학회지
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• 제11권1호
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• pp.1-13
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• 1990

We objerved the following results from The Yellow Emperior's Canon of Internal medicine through the investigation of literature about fever. 1. Fever is divieded two type asthenic fever sthenic heat and It accused two type of excess of Yang-exoganous heat, deficiency of Yin-internal fever 2. The cause of fever is divieded three type, exoganous cause, internal cause non-exoganouse and internal cause Among the cause of fever Exoganous cause is almost affected by cold-evil Internal cause is affected by deficiency of Yin and seven emotion caused by having sex after intoxigation or over-exertion, and non-exoganous and internal cause bring about the difference of a personal life and food and drink 3. The sympton produced by fever is appeared differently through-pulse and meridian and they are indication of Diagnosis 4. The theory of treatment about fever are as follows Drinking cold-water Practising acupuncture Trerating hot-evil by cold Dispel cold by warm Treating cold-evil by heat Promote vital energy circulation by cold Treating warm-evil by cold Promating circulation by cold Treating cold-evil by warm Promoting circulation by heat.

• 대한한의학원전학회지
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• 제24권5호
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• pp.131-145
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• 2011

I had come at the conclusion of the development history of Disease Bi(痞病) reflected in Yi Cheon (李梴)'s work, "Euhakibmun(醫學入門)" in the respects of the causes, mechanism, symptoms, differential diagnosis and treatments. The causes of Disease Bi(痞病) mentioned at "Euhakibmun(醫學入門)" followed the Ju Dan-Gyeo(朱丹溪)'s theory. The mechanism of it went after the viewpoints of "Nae-Gyeong(內經)", Jang Jung-Gyeong(張仲景), Yi Dong-Won(李東垣) and Wang Ho-Go(王好古). The symptoms of it kept the Ju Dan-Gyeo(朱丹溪)'s theory. Yi Cheon distinguished Disease Bi(痞病) from Gyeol-Hyung(結胸) according to Jang Jung-Gyeong's theory. He knew it from abdominal dropsy(脹滿) according to Ju Dan-Gyeo's theory. He also divided it into two respects of deficiency(虛) and excessive(實) from Yi Dong-Won's viewpoint. Jang Jung-Gyeong first suggested that treatments of it could be selected according to the difference of deficiency, excessive(實), cold(寒), hot(熱), sputum(痰), fluid(飮), blood(血) and food(食). Yi Dong-Won insisted many doctors could make a mistake because they only used herbs for Gi(氣藥) instead of herbs for blood(血藥) together. Wang Ho-Go(王好古) maintained his opinion that treatments of both digestion(消導) and assistance(補益), remedies of bitter and hot herbs can recover patients from Disease Bi(痞病). Yi Cheon followed their theories properly.

• 한국한의학연구원논문집
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• 제14권2호
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• pp.41-46
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• 2008

The study was to investigate the agreement rate between the statistical diagnosis of pattern identification by discriminant analysis and the clinical diagnosis of pattern identification by medical specialist in obese patients with BMI$\geqq$23. The agreement rate of deficiency of the spleen, phlegm-retention, deficiency of Yang, retention of undigested food, stagnation of liver Gi, and blood stagnation are 0.40, 0.33, 0.52, 0.76, 0.71, and 0.66, respectively and accuracy rate and prediction rate using linear discriminant function are 0.59 and 0.61, respectively. Therefore, the complementary management in CRF questionnaires and/or consultation from experts will improve the accuracy and prediction rate, which will be helpful for pattern identification of obesity by clinical experts.

• Molecules and Cells
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• 제21권3호
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• pp.356-359
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• 2006

The transcription factor E2F1 coordinates cell cycle progression and induces apoptosis in response to DNA damage stress. Aside from DNA damage, the role of E2F1 in the endoplasmic reticulum (ER) stress signaling pathways is unclear. We found that $E2F1^{-/-}$ murine embryonic fibroblasts (MEFs) are resistant to apoptosis triggered by the ER stress inducer thapsigargin. In addition, E2F1 deficiency results in enhanced phosphorylation of eukaryotic translation initiation factor $2{\alpha}$ ($elF2{\alpha}$). These results therefore indicate that E2F1 deficiency increases phosphorylation of $elF2{\alpha}$ in response to ER stress triggered by thapsigargin, and suggest that the reduction in ER stress-induced apoptosis in E2F1-deficient cells is related to the high level of $elF2{\alpha}$ phosphorylation.

• 동의생리병리학회지
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• 제20권6호
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• pp.1375-1387
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• 2006

Through abdominal diagnoses, deficiency and excess, and cold and heat of the eight principles for differentiating syndromes can be determined, pathogens such as fluid retention, dry stool, retention of undigested food, abdominal mass, blood stagnation, stagnation of Gi, deficiency of Kidney Yang, and, spermatorrhea can be identified, nature and stages of the symptoms can be understood and then pathogenesis analyzed. Abdominal diagnosis can be one of primary factors in deciding treatment, expecting prognosis and treatment effect, and choosing herbal prescriptions. Representative herbs for epigastric stuffiness/fullness are Radix Ginseng, Pericarpium Citri, etc; for fullness of epigastrium, Rhizoma Pinelliae, Pericarpium Citri, Rhizoma Rhei, etc.; for severely rigid epigastrium, Radix Glycyrrhizae, Radix Ginseng, etc.; for epigastric pain, Rhizoma Pinelliae, Pericarpium Citri, etc.; for epigastric fullness and rigidity, Rhizoma Coptidis, Radix Ginseng, etc.; for feeling of obstruction in the epigastirum, Radix Bupleuri, Radix Ginseng, etc.; for palpitation in the epigastrium, Radix Glycyrrhizae, Ramulus Cinnamomi, etc. It is essential to rightly diagnose through comprehensive analysis of the data gained by the four methods of diagnosis, and in doing this, further studies on how to utilize abdomen diagnosis for clinical practice.