• 동의생리병리학회지
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• 제23권6호
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• pp.1292-1298
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• 2009

Sipjeon-Daebo-Tang (SDT) is indicated for deficiency syndrome of both gi and blood, marked by pale or sallow complexion, dizziness, lassitude, shortness of breath, dislike for talking, poor appetite, pale tongue with thin whitish fur, thready and weak pulse. Gami-Sipjeon-Daebo-Tang(GSDT) is composed of 10 herbs within SDT and Cervi Pantotrichum Cornu (CPC). CPC can noursh kidney-yang, promote the production of the essence and blood, strengthen tendons and bones. Recently SDT is known as anti-cancer drug. Especially CPC is reported to have anti-oxidative action. For these reasons, we investigated the protective effects on cell death induced by chemicals such as paraquat, hydrogen peroxide and anti-oxidative effects in C6 glioma cells. In our results, GSDT accelerated proliferation rates of C6 cells in vitro. In addition, protective effects on cell death induced by hydrogen peroxide and rotenone. In addition, SOD activities were increased by treatment with both SDT and GSDT. In conclusion, these results suggest the possibility of GSDT to protect brain cell or neuronal cell from damage induced by oxidative stress. And also suggest that related mechanisms are involved in SOD activities.

• 대한한의학원전학회지
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• 제21권1호
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• pp.43-62
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• 2008

After parturition, woman in childbed's health can grow worse. Because when woman in childbed gives birth, Genital organ can be damaged, and lost a lot of blood, and also consume a lot of physical strengths. So, after parturition, woman in childbed is easy to fall in disease if do not take care in health specially. So after parturition, woman in childbed should be careful in stress, sleep, food etc. This thesis described Postpartum Spasm[痙病], Oppressive Feeling and Dizziness[鬱冒], Constipation[便秘], Abdominal Pain[腹痛], Diarrhea[下利], Annoyance[煩亂] and Vomitting Sickness[嘔逆]. Postpartum Spasm[痙病]'s major symptom is rigided body. This disease corresponds to Tetanus in modem medicine, and bacterial infection is assumed for cause. By Oriental medicine, after parturition, when blood is lacking, if patient takes wind, this disease breaks out. Oppressive Feeling and Dizziness[鬱冒]'s major symptom is dizzy head and gloomy eye. After parturition, when blood is lacking, if patient sweats too much and take cold, this disease breaks out. After parturition, if patient consumes a lot of resins of human body, Constipation[使秘] breaks out. There are four causes to Abdominal pain[腹痛]. First, due to deficiency and cold treats by Danggwisaenggangyangyuktang(當歸牛薑羊肉湯). Second, due to stagnation of Gi(氣) treats by Jisiljakyaksan(枳實芍藥散). Third, due to blood stasis treats by Ha-eohyeoltang(下瘀血湯). Fourth, due to lochiorrhea treats by Daeseunggitang(大承氣湯). After parturition, Annoyance[煩亂] and Vomitting Sickness[嘔逆] due to fever of difficiency treat by Jukpidaehwan(竹皮大丸). After parturition, Febrile diarrhea[熱性下利] treats by Baekduonggagamchoagyotang(白頭翁加甘草阿膠湯). This disease is similar with present Bacillary Dysentery. After parturition, Exteroceptive disease due to taking wind treats by Yangdaltang. Due to wind and fever treats by Jukyeoptang(竹葉湯).

• 한국육종학회지
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• 제40권3호
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• pp.223-227
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• 2008

In rice, tillering is an important trait determining yield. To study tillering at the agricultural and molecular aspects, we have examined a spontaneous rice mutant that showed reduction in the number of culms. The mutant was derived from a $F^6$ line of the cross of Junambyeo*4 / IR72. It could produce, on average, 4 tillers per hill in the paddy field while wild-type plants usually have 15. Except the reduced culm numbers, they also show pale green phenotypes. The phenotypes of this mutant were co-segregated as the monogenic Mendelian ratio (${\chi}^b=0.002$, p=0.969). In order to locate a gene responsible for the rcn phenotype, the mutant with the japonica genetic background was crossed with Milyang21 of the indica background. Bulked segregant analysis was used for rapid determination of chromosomal location. Three SSR markers (RM551, RM8213, and RM16467) on chromosome 4 were genetically associated with the mutant phenotype. Each of the 217 $F_2$ plants was genotyped with simple sequence length polymorphisms. The data showed that RM16572 on chromosome 4 was the closest marker that showed perfect co-segregation among the $F_2$ population. We suggest the new rcn gene studied here name as $rcn10^t$ because there was no report which exhibit a rcn phenotype with a pleiotropic effect of pale green (chlorophyll deficiency), and mapped at same position on chromosome 4.

• Animal Bioscience
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• 제34권5호
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• pp.811-823
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• 2021

Objective: Eggshell color is an important indicator of egg quality for consumers, especially for brown eggs. Various factors related to laying hens and their environment affect brown eggshell coloration. However, there have been no studies investigating hepatic functions of laying hens with variable intensity of brown eggshell color. Therefore, this study was aimed to identify potential factors affecting brown eggshell coloration in aged laying hens at the hepatic transcriptomic level. Methods: Five hundred 92-wk-old Hy-line Brown laying hens were screened to select laying hens with different intensity of brown eggshell color based on eggshell color fans. Based on eggshell color scores, hens with dark brown eggshells (DBE; eggshell color fan score = 14.8) and hens with light brown eggshells (LBE; eggshell color fan score = 9.7) were finally selected for the liver sampling. We performed RNA-seq analysis using the liver samples through the paired-end sequencing libraries. Differentially expressed genes (DEGs) profiling was carried out to identify their biological meaning by bioinformatics. Results: A total of 290 DEGs were identified with 196 being up-regulated and 94 being down-regulated in DBE groups as compared to LBE groups. The Kyoto encyclopedia of genes and genomes (KEGG) analysis revealed that these DEGs belong to several biological pathways including herpes simplex infection (toll-like receptor 3 [TLR3], cyclin-dependent kinase 1, etc.) and influenza A (TLR3, radical S-adenosyl methionine domain containing 2, myxovirus [influenza virus] resistance 1, etc.). Genes related to stress response (ceremide kinase like) and nutrient metabolism (phosphoenolpyruvate carboxy-kinase 1, methylmalonic aciduria [cobalamin deficiency] cblB type, glycine receptor alpha 2, solute carrier family 7 member 11, etc.) were also identified to be differentially expressed. Conclusion: The current results provide new insights regarding hepatic molecular functions related to different intensity of brown eggshell color in aged laying hens. These insights will contribute to future studies aiming to optimize brown eggshell coloration in aged laying hens.

• 한국산학기술학회논문지
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• 제22권4호
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• pp.570-579
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• 2021

현재의 농어촌은 고령화로 인한 인력 및 장비부족, 농산물 가격하락 등 여러 환경이 갈수록 열악해지고 있는 실정이다. 본 연구는 이러한 문제를 해결하기 위하여 수 많은 농업기반시설물 중 중요 관리대상인 관정, 양수장, 취입보 등을 대상으로 데이터베이스 구축하여 점검, 고장 및 수리 등의 이력사항을 관리하기 위하여 수행되었다. 특히, 관정의 경우에는 무분별한 설치와 공간정보 부재로 인하여 경제적 손실 및 환경오염 등의 문제를 야기시키기 때문에 수문지질도, 수맥도, 지하수 심도 등의 공간정보를 이용하여 관정의 최적위치를 결정하였다. 따라서, 본 연구는 시스템 개발을 통하여 농촌지역에 산재되어 있는 수 많은 시설물들을 효율적으로 관리할 수 있었고, 공간정보를 이용하여 14개 관정에 대한 현황을 분석한 결과 6개 지점에서의 위치정보가 잘못된 것으로 나타났으나, 현장조사결과 1개 지점에서는 수맥도 분석이 잘못된 것으로 분석되었다.

• Genomics & Informatics
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• 제19권4호
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• pp.40.1-40.11
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• 2021

Mutation signatures represent unique sequence footprints of somatic mutations resulting from specific DNA mutagenic and repair processes. However, their causal associations and the potential utility for genome research remain largely unknown. In this study, we performed PanCancer-scale correlative analyses to identify the genomic features associated with tumor mutation burdens (TMB) and individual mutation signatures. We observed that TMB was correlated with tumor purity, ploidy, and the level of aneuploidy, as well as with the expression of cell proliferation-related genes representing genomic covariates in evaluating TMB. Correlative analyses of mutation signature levels with genes belonging to specific DNA damage-repair processes revealed that deficiencies of NHEJ1 and ALKBH3 may contribute to mutations in the settings of APOBEC cytidine deaminase activation and DNA mismatch repair deficiency, respectively. We further employed a strategy to identify feature-driven, de novo mutation signatures and demonstrated that mutation signatures can be reconstructed using known causal features. Using the strategy, we further identified tumor hypoxia-related mutation signatures similar to the APOBEC-related mutation signatures, suggesting that APOBEC activity mediates hypoxia-related mutational consequences in cancer genomes. Our study advances the mechanistic insights into the TMB and signature-based DNA mutagenic and repair processes in cancer genomes. We also propose that feature-driven mutation signature analysis can further extend the categories of cancer-relevant mutation signatures and their causal relationships.

• 지적과 국토정보
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• 제46권2호
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• pp.325-340
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• 2016

Dangermond(2009)에 의해 GIS의 다음 패러다임으로서 제시된 Geodesign은 공간계획 및 설계의 바탕이 된다. 또한 고재용(2015)은 공간정보를 기초로 하여 진행되는 조경설계의 관점에서 Geodesign 방법론을 제시하였다. 그러나 그의 방법론은 효율성 향상을 위한 연구인 반면 Geodesign의 한계점이자 공간설계의 핵심인 '창의성 지원'은 다루지 못하였다. 이러한 문제점을 보완하기 위해서는 공간설계의 관점에서 전 과정에 대한 정보를 효과적으로 다룰 수 있도록 지원하는 개념으로써 개념화를 통해 $7{\pm}2$ 개라는 인간의 인지능력의 한계를 극복해야 한다. 따라서 본 논문에서는 그러한 한계점을 극복하고자 조경설계 분야의 사용자에게 더 나은 경험을 제공하기 위해 인간의 인지능력한계 극복과 그것을 통한 창의성 향상을 목표로 연구를 진행하였다. 선행연구의 고찰을 통해 창의성 향상을 위한 방안을 도출하였으며, 이 방안을 바탕으로 창의적 공간설계의 지원이 가능한 Geodesign 방법론을 제시하였다. 제시된 방법론의 과정을 수행하기에 가장 적합하다고 판단된 ESRI사의 GeoPlanner for ArcGIS에 방법론을 적용하여 Interface 설계의 과정을 수행하였다. 먼저 스크립트를 작성하고 기능요소와 정보요소를 판단하여 Interaction을 도출하였고, 도출된 Interaction을 바탕으로 Interface 설계를 진행하였다. 창의성 향상이라는 것은 물리적으로 증명하기는 어려운 부분이다. 그러나 Interface 설계를 통해 잠재의식 속에 있던 새로운 질서를 찾아내어 개념화를 통한 창의적 지원이 가능하며, 순간적으로 떠오르는 아이디어를 놓치지 않고 표현하여 인지능력의 한계를 극복할 수 있는 환경을 제안하였다.

• 한국지리정보학회지
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• 제6권1호
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• pp.132-142
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• 2003

하천 홍수터 분석을 위해 사용되는 대부분의 컴퓨터 모형에 있어서의 중대한 결점은 홍수에 영향을 받는 도로, 건물 및 교량과 같은 구조물의 위치가 홍수터의 위치와 효과적으로 비교될 수 없다는 것이다. 본 연구에서는 홍수터 결정과 묘사를 위한 지역적 모형을 개발하기 위해 ArcView GIS와 HEC-RAS 모형을 통합하고, ArcView 상에서 2차원 및 3차원 홍수터 구현 및 분석이 가능하도록 하는데 그 목적이 있다. 연구대상 유역은 남한강 유역에 위치하는 경기도 여주 지역으로서, 대상 유역의 수치지형모형(digital terrain model)은 HEC-RAS 132-142단면 자료와 수치표고모형(digital elevation model)를 합성하여 제작하였다. 연구방법으로 Arcview에서 제작된 홍수터 자료는 HEC-RAS 운영에 있어 정확한 수로 및 제방 자료를 반영하도록 전체 홍수터 단면도를 작성하기 위해 수로 현장측량 자료와 결합하였다. HEC-RAS에서 계산된 수위 자료는 홍수터 경계(flood plain limits)가 ArcView에서 정확하게 표현되도록 하였다. 본 연구는 하천 수로의 일반 지형 및 세부 사항들의 효과적 표현 방법을 제시하였으며, 전체적으로 HEC-RAS와 연계한 지리정보시스템(GIS)이 홍수 재해지도의 자동생성 및 홍수터 분석에 있어 매우 유용하며, 효과적인 환경이라는 것을 입증하였다.

• 동국한의학연구소논문집
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• 제8권1호
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• pp.133-144
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• 1999

담음(痰飮)은 질병(疾病)의 경과중에 발생되는 병리적(病理的)인 산물(産物)로, 담음(痰飮) 자체가 질병(疾病)의 원인(原因)이 될 수 있으며, 질병(疾病)의 결과물로 생길수도 있다. 저자는 <내경(內經)> 이후의 역대(歷代) 문헌(文獻) 고찰(考察)을 통해 담음(痰飮)이 중풍(中風)의 발생에 미치는 영향과, 아울러 담음(痰飮)과 진액(津液)의 관계, 진액(津液)과 뇌(腦)의 관계, 담음(痰飮)과 어혈(瘀血)의 관계 등을 연구하였다. 담음(痰飮)은 칠정(七情)의 부조(不調), 정기휴손(精氣虧損), 음식실조(飮食失調), 외감육음(外感六淫), 체질적(體質的) 소인(素因)등의 인자(因子)로 인해 발생되어 열담(熱痰), 풍담(風痰), 습담(濕痰)으로 화(化)하고 장부(臟腑) 경락(經絡)에 울체(鬱滯)하여 기혈(氣血)의 순환을 막아 중풍(中風)을 유발하게 된다. 한편 담음(痰飮)은 진액(津液)으로부터 형성되고, 진액(津液)은 기체(氣滯), 화울(火鬱), 한응(寒凝)의 병리과정(病理過程)을 통하여 담음(痰飮)으로 전화(轉化)되며, 뇌(腦)는 진액(津液)의 자윤(滋潤)과 충양(充養)에 의해 그 기능을 유지한다. 따라서 진액(津液)이 담음(痰飮)으로 전화(轉化)되어 기혈운행(氣血運行)을 막으면 뇌(腦)에도 영향을 미칠 수 있을 것으로 사료된다. 담음(痰飮)과 어혈(瘀血)의 관계를 보면 담음(痰飮)은 어혈(瘀血)과 병리변화(病理變化)에 있어 밀접한 관계에 있으며, 중풍발생(中風發生)에 있어서 담음(痰飮)이 어혈(瘀血)에 선행(先行)하거나, 어혈(瘀血)이 먼저 형성된 후에 담음(痰飮)이 형성되거나, 혹은 서로 겸(兼)하여 발생할 수도 있다.

• 대한한의학원전학회지
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• 제3권
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• pp.399-443
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• 1989

In this thesis, I intend to study the translational and clinical interpretation through the syndrom of "Pyong-Yeol-Byong", and reached the following conclusions. 1. Eum-Yang-Kyo (陰陽交)' 1) Meaning: "Eum" means "Essential and vital energy" "Yang" means "Evil factor affecting health" and "Kyo" means "cross-struggle." 2) Location of disease: Heat evil enter Hyeol-Bun (血分) 3) Pathogenesis: Heat evil invade Eum-Bun (陰分) and struggles with Health energy, therefore Eum-Chung (陰精) is exhausted and Heat-evil doesn't disapper, it damage Eum and exhaust fluid. Reach fever, rapid pulse raving and unable to take meal, not controled by sweating and sceach death. 4) Particularity of Syndrome: Heat enter Hyol-Bun, and Evil factor is enough and Health energy is insufficient, so that reveal the symptoms of high fever, delirium with coma, unable to take meals. 5) Therapy: It clears Gi-Bun heat evil (氣分熱邪) by Gypsum, Rhizoma Anemarrhenae, Flos Lonicerae, Fructus Forsythiae, Fructus Gardeniae, Radix Scutellanae Rhizoma Coptidis, and cools Blood by Cornu Rhinoceri Asiatici, Radix Rehmanniae, Cortex Moutan Radicis, Dae-Chung-Yob (大靑葉) Radix Arnebiae Seu Lithospermi. 2. Poong Gweol (風厥) 1) Meaning: Poong means wind-evil, Gweol means reversing up. 2) Location of disease: Disease complexes with TaeYang (太陽) in outer part, and with So-Eum (少陰) in inner part. 3) Pathogenesis: Tae-Yang-Gyeong (太陽經) accept wind-evil and So-Eum-Gyeong (少陽經) Kidney Energy reverse up so that fidgetiness not resolves by sweating. 4) Particularity of Syndrome: There are outer symptoms of fever, hydrosis with inner symptoms of fidgetinessis. 5) Therapy: Reduce Jok-Tae-Yang (足太陽) and Supply Jok-So-Eum (足少陰) by accupuncture, so cure Poong Gweol and make balance between Yeong (營) and Wi (衛). 3. Scrofula coused by wind-evil (勞風) 1) Meaning: It means accepting wind evil rest less. 2) Location of Disease: It locates lung 3) Pathogenesis: Because of accepting wind-evil restless, he take scrofula with damaging lung. 4) Particularity of disease: It is lung disease of aversion to wind and shiver, nape-stiffiness, dim eyesight, cough, disphea, vomitting sputum, if one camnot vomit sputum, he died by damage of lung. 5) Therapy: The period of therapy is different by age or strength of health energy, so I think must prevent Eum deficiency and clear fever no reduced in lung. 4. Shin-Poong (腎風) 1) Meaning: It means taking edema by accepting wind-evil, because the kidney controls water. 2) Location of Disease: It is that wind-evil envade kidney. 3) Pathogenesis : Water evil of kidney with wind-heat rises up to face, reach edema, puffines s of the lower eyelid, floating pulse, bombus, yellowish urine, hydrosis and hand-heating, drymouth and excessive thirsty, walkless by heaviness, menstrual disfunction, restless and unable to take meals, unable to lie flat, heavy cough if lie flat, and accepting wind-evil by deficiency of kidney function, so the function of dredging the water passage is not smooth, symptom of water and symptom of wind reveal together. 4) Therapy: Remove wind-heat, promote diuresis to eliminate tile wetness-evil, supplement the dificiency of kidney's Eum. Finally, we can know that later Fever Disease Medicime (溫病學) is affected to the theory of "Pyong Yeol Byong" in 33th Chapter of SoMoon (素問).