• Title/Summary/Keyword: Gericudranin E

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Synthesis and Antitumor Activity of Novel Gericudranin E Derivatives (새로운 항암성 제리쿠드라닌 E 유도체의 합성 및 항암활성)

  • 박재호;박경란;호현순;김희두;표명윤
    • YAKHAK HOEJI
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    • v.43 no.5
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    • pp.559-565
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    • 1999
  • The two gericudranin E derivatives, GER-I & II, were synthesized and evaluated their antitumour activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules GER-I and GER-B in 5 steps via sequential protection, aldol condensation, Michael type-cyclization, regioselective C-benzylation. The cellular growth inhibition of compounds GER-I and GER-II were investigated against P388, L1210, K562, HCT-15, SK-HepG-1, MCF-7 as cancer cell lines and mouse splenocytes as a normal cell by MTT assay.

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Monoamine Oxidase Inhibitory Flavonoids from the Root Bark of Cudrania tricuspidata

  • Han, Xiang-Hua;Hwang, Ji-Hye;Hong, Seong-Su;Choe, Sang-Gil;Lee, Chul;Lee, Moon-Soon;Lee, Dong-Ho;Lee, Myung-Koo;Lee, Mi-Kyeong;Hwang, Bang-Yeon
    • Natural Product Sciences
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    • v.16 no.2
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    • pp.75-79
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    • 2010
  • Two new benzylated flavonoids, 5,7,4'-trihydroxy-6-p-hydroxybenzylflavanone (1) and 5,7,4'-trihydroxy-6,8-di-p-hydroxybenzylflavanone (2) together with six known flavonoids, kaempferol (3), artocarpesin (4), cycloartocarpesin (5), cudraflavone D (6), gericudranin E (7), and leachianone G (8) have been isolated from the root bark of Cudrania tricuspidata. The structures of 1 and 2 were characterized based on spectroscopic data including 1D- and 2D-NMR. All the isolates were evaluated for their inhibitory effects of monoamine oxidase (MAO). Among them, kaempferol (3), artocarpesin (4), and cudraflavone D (6) showed moderate inhibitory effects with $IC_{50}$ values of 82.3, 30.8, and $71.8\;{\mu}M$, respectively.