Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Monoamine Oxidase Inhibitory Flavonoids from the Root Bark of Cudrania tricuspidata

  • Han, Xiang-Hua (College of Pharmacy, Chungbuk National University) ;
  • Hwang, Ji-Hye (College of Pharmacy, Chungbuk National University) ;
  • Hong, Seong-Su (College of Pharmacy, Chungbuk National University) ;
  • Choe, Sang-Gil (College of Pharmacy, Chungbuk National University) ;
  • Lee, Chul (College of Pharmacy, Chungbuk National University) ;
  • Lee, Moon-Soon (College of Agriculture, Life & Environmental Sciences, Chungbuk National University) ;
  • Lee, Dong-Ho (School of Life Sciences and Biotechnology, Korea University) ;
  • Lee, Myung-Koo (College of Pharmacy, Chungbuk National University) ;
  • Lee, Mi-Kyeong (College of Pharmacy, Chungbuk National University) ;
  • Hwang, Bang-Yeon (College of Pharmacy, Chungbuk National University)
  • Received : 2010.05.10
  • Accepted : 2010.06.16
  • Published : 2010.06.30
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Abstract

Two new benzylated flavonoids, 5,7,4'-trihydroxy-6-p-hydroxybenzylflavanone (1) and 5,7,4'-trihydroxy-6,8-di-p-hydroxybenzylflavanone (2) together with six known flavonoids, kaempferol (3), artocarpesin (4), cycloartocarpesin (5), cudraflavone D (6), gericudranin E (7), and leachianone G (8) have been isolated from the root bark of Cudrania tricuspidata. The structures of 1 and 2 were characterized based on spectroscopic data including 1D- and 2D-NMR. All the isolates were evaluated for their inhibitory effects of monoamine oxidase (MAO). Among them, kaempferol (3), artocarpesin (4), and cudraflavone D (6) showed moderate inhibitory effects with $IC_{50}$ values of 82.3, 30.8, and $71.8\;{\mu}M$, respectively.

Keywords

References

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