• Journal of Korean Society of Industrial and Systems Engineering
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• v.32 no.2
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• pp.158-170
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• 2009

This paper considers how the optimal export level is influenced by export risk, the degree of risk-averseness for exporting firms, and those firms' cost structure. In addition, export insurance is incorporated into some simple theoretical model to analyze the optimal export level. This paper applies genetic algorithm simulation to show that the exporting firms'risk-averseness do not affect the optimal export decision while export risk and cost function characteristic have relatively more significant effects on the optimal export level. Finally, our findings suggest that the most influential factor for the optimal export levels seems to be the monopoly power of exporting firms.

• Proceedings of the KIEE Conference
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• 2000.07d
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• pp.2545-2547
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• 2000

In this paper, a hybrid fuzzy controller using genetic algorithm based on parameter estimation mode to obtain optimal control parameter is presented. First, The control input for the system in the HFC is a convex combination of the FLC's output in transient state and PID's output in steady state by a fuzzy variable, namely, membership function of weighting coefficient. Second, genetic algorithms is presented to automatically improve the performance of hybrid fuzzy controller utilizing the conventional methods for finding PID parameters and estimation mode of scaling factor. The algorithms estimates automatically the optimal values of scaling factors, PID parameters and membership function parameters of fuzzy control rules according to the rate of change and limitation condition of control input. Computer simulations are conducted to evaluate the performance of proposed hybrid fuzzy controller. ITAE, overshoot and rising time are used as a performance index of controller.

• Korean Journal of Biological Psychiatry
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• v.17 no.2
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• pp.65-69
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• 2010

Gene-environment interactions are important in pathogenesis of suicide or suicidal behavior. Twin and adoption studies and family studies show that genetic factors play a critical role in suicide or suicidal behavior. Given the strong association between serotonergic neurotransmission and suicide, recent molecular genetic studies have focused on polymorphisms of serotonin genes, especially on serotonin transporter and tryptophan hydroxylase genes. Some studies have revealed a significant interaction between s allele of the serotonin transporter gene and the risk of suicide attempt associated with childhood trauma. In addition, the polymorphism of brain-derived neurotrophic factor gene also may influence the effect of childhood trauma in relation to the risk of attempting suicide. Future studies should explore genetic and environmental factors in suicide or suicidal behavior and examine for gene and environment interaction.

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.11b
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• pp.177-177
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• 2002

In order to investigate the association of genetic factor with asthma and contribution of the genetic interactions to the incidence of asthma in Korean population, the genetic polymorphisms of Epoxide Hydrolase(EH), CD14 and ${\beta}$2-adrenergic receptor genese(${\beta}$2AR) among 33 asthma patients and 66 controls were examined.(omitted)

• Steel and Composite Structures
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• v.19 no.2
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• pp.503-519
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• 2015

This paper presents an optimization process using Genetic Algorithm (GA) for minimum weight by selecting suitable standard sections from a specified list taken from American Institute of Steel Construction (AISC). The stress constraints obeying AISC-LRFD (American Institute of Steel Construction-Load and Resistance Factor Design), lateral displacement constraints being the top and inter-storey drift, mid-span deflection constraints for the beams and geometric constraints are considered for optimum design by using GA that mimics biological processes. Optimum designs for three different space frames taken from the literature are carried out first without considering concrete slab effects in finite element analyses for the constraints above and the results are compared with the ones available in literature. The same optimization procedures are then repeated for the case of space frames with composite (steel and concrete) beams. A program is coded in MATLAB for the optimization processes. Results obtained in the study showed that consideration of the contribution of the concrete on the behavior of the floor beams results with less steel weight and ends up with more economical designs.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.20 no.11
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• pp.108-114
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• 2021

In this study, a multivariate function was applied to the genetic algorithm for D-type lugs currently used in shipyards to closely analyze the behavioral form of weight loss without double plates. An optimal lifting lug structure design without attachments is proposed. MATLAB R2016a was used to design features by applying multivariate functions to genetic algorithms. Furthermore, the design was achieved by deriving the optimal shapes of lugs using genetic algorithms. The shapes of the designed lugs were validated for structural bonding using the structural analysis program ANSYS 2020 R2, and a robust design of lugs with no appendages was developed.

• Journal of Genetic Medicine
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• v.18 no.1
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• pp.60-63
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• 2021

Gabriel-de Vries syndrome, caused by the mutation of YY1, is a newly defined genetic syndrome characterized by developmental delay, facial dysmorphism, and intrauterine growth retardation. A 7-month-old girl presented developmental delay and subtle facial dysmorphism including facial asymmetry, micrognathia, and low-set ears. Whole exome sequencing identified a de novo heterozygous missense variant in the YY1 (c.1220A>G; p.His407Arg) gene. Here, we examined the clinical and genetic characteristics of an infant with a novel likely pathogenic variant of YY1. This case expands the phenotypic spectrum of Gabriel-de Vries syndrome.

• Molecules and Cells
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• v.45 no.11
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• pp.763-770
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• 2022

Caenorhabditis elegans has been used as a major model organism to identify genetic factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) regulates aging in many species, ranging from nematodes to humans. C. elegans is a nonpathogenic genetic nematode model, which has been extensively utilized to identify molecular and cellular components that function in organismal aging and longevity. Here, we review the recent progress in the role of IIS in aging and longevity, which involves direct regulation of protein and RNA homeostasis, stress resistance, metabolism and the activities of the endocrine system. We also discuss recently identified genetic factors that interact with canonical IIS components to regulate aging and health span in C. elegans. We expect this review to provide valuable insights into understanding animal aging, which could eventually help develop anti-aging drugs for humans.

• Korean Journal of Agricultural Science
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• v.49 no.3
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• pp.431-440
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• 2022

Hanwoo cattle are a unique and historical breed in Korea that have been genetically improved and maintained by the national evaluation and selection system. The aim of this study was to provide information that can help improve the accuracy of the estimated breeding values in Hanwoo cattle by showing the difference between the imputation reference chip platforms of genomic data and the scaling factor of the genetic relationship matrix (GRM). In this study, nine sets of data were compared that consisted of 3 reference platforms each with 3 different scaling factors (-0.5, 0 and 0.5). The evaluation was performed using MTG2.0 with nine different GRMs for the same number of genotyped animals, pedigree, and phenotype data. A five multi-trait model was used for the evaluation in this study which is the same model used in the national evaluation system. Our results show that the Hanwoo custom v1 platform is the best option for all traits, providing a mean accuracy improvement by 0.1 - 0.3%. In the case of the scaling factor, regardless of the imputation chip platform, a setting of -1 resulted in a better accuracy increased by 0.5 to 1.6% compared to the other scaling factors. In conclusion, this study revealed that Hanwoo custom v1 used as the imputation reference chip platform and a scaling factor of -0.5 can improve the accuracy of the estimated breeding value in the Hanwoo population. This information could help to improve the current evaluation system.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.25 no.5
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• pp.592-600
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• 2014

This paper proposes an enhanced adaptive genetic algorithm(EAGA) dedicated to pattern synthesis of array antenna which conforms to a curved surface of rotation with quadratic function. EAGA combines adaptive genetic algorithm(AGA) with invasive weed optimization(IWO) for the faster convergence and the lower cost value of the cost function. The amplitude and phase of each excited weighting factor are optimized to meet the required goals using EAGA. The EAGA results indicate that the proposed algorithm is superior to AGA when applied to the problem of conformal array antenna pattern synthesis.