• Earthquakes and Structures
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• v.14 no.3
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• pp.215-227
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• 2018

Supplemental passive control devices are widely considered as an important tool to mitigate the dynamic response of a building under seismic excitation. Nevertheless, a systematic method for strategically placing dampers in the buildings is not prescribed in building codes and guidelines. Many deterministic and stochastic methods have been proposed by previous researchers to investigate the optimum distribution of the viscous dampers in the steel frames. However, the seismic performances of the retrofitted buildings that are under large earthquake intensity levels or near collapse state have not been evaluated by any seismic research. Recent years, an increasing number of studies utilize genetic algorithms (GA) to explore the complex engineering optimization problems. GA interfaced with nonlinear response history (NRH) analysis is considered as one of the most powerful and popular stochastic methods to deal with the nonlinear optimization problem of damper distribution. In this paper, the effectiveness and the efficiency of GA on optimizing damper distribution are first evaluated by strong ground motions associated with the collapse failure. A practical optimization framework using GA and NRH analysis is proposed for optimizing the distribution of the fluid viscous dampers within the moment resisting frames (MRF) regarding the improvements of large drifts under intensive seismic context. Both a 10-storey and a 20-storey building are involved to explore higher mode effect. A far-fault and a near-fault earthquake environment are also considered for the frames under different seismic intensity levels. To evaluate the improvements obtained from the GA optimization regarding the collapse performance of the buildings, Incremental Dynamic Analysis (IDA) is conducted and comparisons are made between the GA damper distribution and stiffness proportional damping distribution on the collapse probability of the retrofitted frames.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.10
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• pp.1372-1381
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• 2017

Objective: Our study provides information on phenotypes of local chickens and guinea fowl and their body measures as well as on major genes in local chickens in northern Ghana. Methods: Qualitative and morphometric traits were recorded on 788 local chickens and 394 guinea fowl in urban households in Tamale, Ghana. Results: The results showed considerable variation of color traits and numerous major genes in local chickens, while color variations and related genotypes in guinea fowl were limited. In local chickens, white was preferred for plumage, whereas dark colors were preferred for beak and shanks. More than half of the chickens carried at least one major gene, but the contributions of single gene carriers were low. All calculated allele frequencies were significantly lower than their expected Mendelian allele frequencies. We observed higher mean body weight and larger linear body measures in male as compared to female chickens. In female chickens, we detected a small effect of major genes on body weight and chest circumference. In addition, we found some association between feather type and plumage color. In guinea fowl, seven distinct plumage colors were observed, of which pearl grey pied and pearl grey were the most prevalent. Male pearl grey pied guinea fowl were inferior to pearl grey and white guinea fowl in terms of body weight, body length and chest circumference; their shank length was lower than that of pearl grey fowl. Conclusion: Considerable variation in qualitative traits of local chickens may be indicative of genetic diversity within local chicken populations, but major genes were rare. In contrast, phenotypic and genetic diversity in local guinea fowl is limited. Broader genetic diversity studies and evaluation of trait preferences of local poultry producers are required for the design of appropriate breeding programs.

• Journal of Animal Science and Technology
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• v.47 no.2
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• pp.147-158
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• 2005

The purpose of this study was to find out the effects that daughters' incomplete lactation records affect sire's breeding values through genetic evaluation using RRTDM(random regression test-day model). First, we estimated genetic parameters and breeding values on sires having complete lactation records of daughter by RRTDM, second, we changed complete lactation records of specific sires into incomplete records by various methods. Third, the breeding values were compared between complete and incomplete records. Finally, this study aimed to find out the methods to minimize the estimation errors of young bulls' breeding values. Data used in this study were collected from the dairy herd improvement program, and a total of 97,562 records were composed of 10,929 first parity with both parents known, since 1999. Breeding values on the daughters from randomly chosen sires were calculated and compared with among 90 day, 150day, and 200 day's incomplete records. For milk yields, sire's ranks of breeding values used by complete lactation records were very different from sire's ranks of breeding values obtained by incomplete lactation records(Rank_90 cut, 150cut, 200 cut).The differences were also obtained between complete lactation records(per305_full) and incomplete lactation record (per_90 cut, 150cut, 200 cut) in breeding values regarding persistency. Especially, the differences between per_90 cut and per305_full were very large(from 1.8 kg to 145kg).

• Proceedings of the Korean Information Science Society Conference
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• 2011.06c
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• pp.176-179
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• 2011

본 연구에서는 T-Test와 Genetic Algorithm을 사용해 Luminex 사용 환경에서 난소암을 진단할 수 있는 바이오마커의 조합을 찾고 Cancer와 Normal간의 분류 성능을 평가해 보았다. 바이오마커는 혈액, 체액 내의 특정 질환 여부나 상태를 나타내는 단백질, DNA들의 지표 물질이다. 정상인과는 다른 분포를 가진 성분이 환자의 혈액이나 체액에서 발견되면 이를 토대로 질병유무와 상태를 판단할 수 있다. 난소암을 진단할 수 있는 바이오마커 조합을 찾기 위해 T-Test와 Genetic Algorithm를 사용하여 분류성능이 좋은 바이오마커 조합을 각각 선별해 보았고, 선별된 각각의 마커조합을 선형분류기(LDA)를 사용해 평균 민감도, 특이도, 정확도를 비교해 보았다. 실험데이터는 두 곳의 병원에서 제공받은 총 58명(Cancer 27명, Normal 31명)의 혈청에서 21 종류의 바이오마커 데이터를 Luminex-PRA를 통해 얻었다. 본 연구에서는 T-Test로 만들어진 마커조합이 Genetic algorithm으로 만들어진 마커조합 보다 더 좋은 민감도, 특이도, 분류정확도를 보여주었다.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.48 no.8
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• pp.621-629
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• 2020

LRU layout is a complex problem that requires consideration of various criteria such as airworthiness, performance, maintainability and environmental requirements. As aircraft functions become more complex, the necessary equipment is increasing, and unmanned aerial vehicles are equipped with more equipment as a substitute for pilots. Due to the complexity of the problem, the increase in the number of equipment, and the limited development period, the placement of equipment is largely dependent on the engineer's insight and experience. For optimization, quantitative criteria are required for evaluation, but criteria such as safety, performance, and maintainability are difficult to quantitatively compare or have limitations. In this study, we consider the installation and maintenance of the equipment, simplify the deployment model to the traveling salesman problem, Optimization was performed using a genetic algorithm to minimize the weight of the connecting cable between the equipment. When the optimization results were compared with the global calculations, the same results were obtained with less time required, and the improvement was compared with the heuristic.

• Journal of the Korean Geotechnical Society
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• v.28 no.8
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• pp.55-63
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• 2012

The evaluation of shear modulus (or shear wave velocity) profile of the site is very important in various fields of geotechnical engineering and various surface wave methods have applied to determine the shear wave velocity profiles and showed good performance. Surface wave methods evaluate the dispersion curve in the field and determine the shear wave velocity profile through the inversion process. In this paper, the automated inversion process using the genetic algorithm is developed for HWAW method which is one of surface wave methods recently developed. The proposed method uses the error function based on the wavelength domain dispersion curve and can determine the reliable shear wave velocity profile not only in shallow depth but also in deep depth. To estimate the validity of the proposed method, numerical simulations and field test were performed and the proposed method was applied to determine the shear wave velocity profiles. Through the numerical simulations and field applications, the promising potential of the proposed method was verified.

• Genomics & Informatics
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• v.10 no.3
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• pp.167-174
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• 2012

AKT is a signal transduction protein that plays a central role in the tumorigenesis. There are 3 mammalian isoforms of this serine/threonine protein kinase-AKT1, AKT2, and AKT3-showing a broad tissue distribution. We first discovered 2 novel polymorphisms (AKT2 -9826 C/G and AKT3 -811 A/G), and we confirmed 6 known polymorphisms (AKT2 -9473 C/T, AKT2 -9151 C/T, AKT2 -9025 C/T, AKT2 -8618G/A, AKT3 -675 A/-, and AKT3 -244 C/T) of the AKT2 and AKT3 promoter region in 24 blood samples of Korean lung cancer patients using direct sequencing. To evaluate the role of AKT2 and AKT3 polymorphisms in the risk of Korean lung cancer, genotypes of the AKT2 and AKT3 polymorphisms (AKT2 -9826 C/G, AKT2 -9473 C/T, AKT2 -9151 C/T, AKT2 -9025 C/T, AKT2 -8618G/A, and AKT3 -675 A/-) were determined in 360 lung cancer patients and 360 normal controls. Statistical analyses revealed that the genotypes and haplotypes in the AKT2 and AKT3 promoter regions were not significantly associated with the risk of lung cancer in the Korean population. These results suggest that polymorphisms of the AKT2 and AKT3 promoter regions do not contribute to the genetic susceptibility to lung cancer in the Korean population.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.34 no.6
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• pp.1845-1850
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• 2014

Railway operators have given a lot of efforts to determine the railway route of the minimum cost. In order to determine the optimal alignment, the alignment should be allocated satisfying the design criteria on various geographical condition with the minimum earth works. The determination of the optimal railway alignment is a kind of combination optimization because that must consider various design elements. This study developed a numerical model to determine the optimal railway alignment with the minimum construction cost. The problem was analyzed by the genetic algorithm, and the concept of the optimal alignment was established with the results from the analyses. The methodology was applied to a fictitious rail construction section and the result was evaluated. This methodology is meaningful considering the fact that the cost for energy is greater than that of the construction.

• Convergence Security Journal
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• v.11 no.1
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• pp.11-18
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• 2011

Wireless mesh network technology with transmission speeds similar to wired and wireless technology means to build, compared with wired networks, building a more efficient network to provide convenience and flexibility. The wireless mesh network router nodes in the energy impact of the mobility is less constrained and has fewer features entail. However, the characteristics of various kinds due to network configuration settings and the choice of multiple paths that can occur when the system overhead and there are many details that must be considered. Therefore, according to the characteristics of these network routing technology that is reflected in the design and optimization of the network is worth noting. In this paper, a multi-path setting can be raised in order to respond effectively to the problem of the router node data loss and bandwidth according to traffic conditions and links to elements of the hop count evaluation by using a genetic algorithm as a workaround for dynamic routing the routing metric for wireless mesh network scheme is proposed.

• Journal of Genetic Medicine
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• v.8 no.2
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• pp.125-129
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• 2011

Stickler syndrome is a very rare connective tissue disorder. The authors of the present study describe an 11-month-old girl with high myopia, retinal abnormalities, flat nose, cleft palate, retrognathia, micrognathia, short stature and arthrogryposis. Radiological evaluation also showed irregularity of the epiphysis of the femur and tibia and spondyloepiphyseal dysplasia. Genetic analysis using a peripheral blood sample revealed a novel variant c.787G>A (p.Gly246Asp) mutation of the COL2A1 gene. This is the first Korean case with Stickler syndrome confirmed by genetic testing.