• Journal of The Korean Association For Science Education
• /
• v.34 no.4
• /
• pp.407-415
• /
• 2014

Genetic determinism of human behaviors is considered as a philosophical perspective that genes in humans determine biological as well as social traits. However, many biologists agree that human traits are determined by interactions between genes and genes, as well as between genes and environments. In this context, genetic determinism still affect ideas of the general public as well as research directions of biologists. According to Cl$\acute{e}$ment's KVP model (Cast$\acute{e}$ra & Cl$\acute{e}$ment, 2012), teachers' conceptions of genetic determinism influence students' concepts of genetics. This study intends to investigate teachers' conceptions on genetic determinism of human behaviors. For this end, a questionnaire adopted from a previous research (Cast$\acute{e}$ra & Cl$\acute{e}$ment, 2012) has been administered to 308 teachers including 151 pre-service and 157 in-service. Factor analysis has been conducted to extract major factors and one-way ANOVA has been employed to find out differences in extracted factors among different groups of teachers. Four factors have been extracted from 14 items of questionnaire, including factor 1, a perspective of genetic determinism of gender differences in intellectual ability, social status, and emotional traits; factor 2, a perspective of genetic determinism of individual differences in intellectual ability; factor 3, a perspective of genetic determinism of individual differences in biological immune function and behavioral trait; and factor 4, a perspective of genetic determinism of ethnic differences. From the results of One-way ANOVA among teacher groups on four factors, first, it has shown a significant difference in factor 1 (F=3.325, p=.006), factor 3 (F=3.320, p=.006) and factor 4 (F=4.325, p=.001) due to their subject matters. In post-hoc comparison there have been no significant difference between biology teachers and other teachers. It has also been found that there was a significant difference between pre-service and in-service teachers in factor 1 (t=-3.938, p=.000) and factor 4 (t=-3.121, p=.002) and in-service teachers are more genetic deterministic than pre-service teachers. Finally, different religions have no influence on teachers' conceptions of genetic determinism of human behaviors.

• BMB Reports
• /
• v.49 no.8
• /
• pp.437-442
• /
• 2016

We aimed to study the role of protein L-isoaspartyl methyltransferase (PIMT) in neuronal differentiation using basic fibroblast growth factor (bFGF)-induced neuronal differentiation, characterized by cell-body shrinkage, long neurite outgrowth, and expression of neuronal differentiation markers light and medium neurofilaments (NF). The bFGF-mediated neuronal differentiation of PC12 cells was induced through activation of mitogen-activated protein kinase (MAPK) signaling molecules [MAPK kinase 1/2 (MEK1/2), extracellular signal-regulated kinase 1/2 (ERK1/2), and p90RSK], and phosphatidylinositide 3-kinase (PI3K)/Akt signaling molecules PI3Kp110β, PI3Kp110γ, Akt, and mTOR. Inhibitors (adenosine dialdehyde and S-adenosylhomocysteine) of protein methylation suppressed bFGF-mediated neuronal differentiation of PC12 cells. PIMT-eficiency caused by PIMT-specific siRNA inhibited neuronal differentiation of PC12 cells by suppressing phosphorylation of MEK1/2 and ERK1/2 in the MAPK signaling pathway and Akt and mTOR in the PI3K/Akt signaling pathway. Therefore, these results suggested that PIMT was critical for bFGF-mediated neuronal differentiation of PC12 cells and regulated the MAPK and Akt signaling pathways.

• Journal of Genetic Medicine
• /
• v.7 no.1
• /
• pp.1-8
• /
• 2010

Hemophilia A is a sex-linked recessive coagulation disorder associated with diverse mutations of the factor VIII gene and a variety of phenotypes. The type of mutation involved dictates the activity of factor VIII, and in turn the severity of bleeding episodes and development of alloantibodies against factor VIII (inhibitors). Missense mutations are the most common genetic risk factors for hemophilia A, especially mild to moderate cases, but carry the lowest risk for inhibitor development. On the other hand, intron 22 inversion is the most common mutation associated with severe hemophilia A and is associated with high risk of inhibitor formation. Large deletions and nonsense mutations are also associated with high risk of inhibitor development. Additional mutations associated with hemophilia A include frameshift and splice site mutations. It is therefore valuable to assess the mutational backgrounds of hemophilia A patients in order to to interpret their symptoms and manage their health problems.

• Korean Journal of Agricultural Science
• /
• v.50 no.4
• /
• pp.869-881
• /
• 2023

A genetic improvement program in Korea was implemented to improve the performance of Hanwoo cattle by generating livestock with genetically desirable economic characteristics. In particular, in response to external changes, such as the expansion of Free Trade Agreement (FTA), the livestock genetic improvement program has increased farm income by improving the productivity and quality of Hanwoo cattle. Using production cost data from Statistics Korea, the total input and output indices of Hanwoo feeding cattle from 2008 - 2021 were estimated and the growth and productivity changes were analyzed. The productivity change measures results were used to estimate the cumulative effects of the Hanwoo genetic improvement program on quality improvement, another purpose of the program, using a finite distributed lag model. The average annual increase in output (market weight) of Hanwoo was 0.9%. However, total input increased by 1.6%, resulting in a 0.6% decline in total factor productivity. In contrast, the Hanwoo genetic improvement program contributed significantly to the production of high quality beef, rather than contributing to improved productivity of the cattle. Hanwoo carcass weight, which is used as a performance indicator for the livestock genetic improvement program, has significantly improved and is projected to increase at a slower rate. The collective findings indicate the need for new performance indicators that can comprehensively indicate the performance of the genetic improvement of Hanwoo.

• The Journal of Pediatrics of Korean Medicine
• /
• v.24 no.3
• /
• pp.138-149
• /
• 2010

Objectives: The purpose of this study is to estimate genetic and environmental factors which can effect growth, and predict final height using this factors. Methods: Correlation analysis and regression analysis were conducted between measurements of height and Genetic & environmental factors through survey from 1352 child & adolescent patients. Results: Factors which have correlation with height percentile are MPH(Mid-Parental Height), NBW(Neonatal body weight), anorexia, dyspepsia, atopic dermatitis, frequency of breakfast and quality of sleeping time. MPH has moderate relation, NBW and anorexia have fair relation, and other factors have linear but poor relation. Regression equation from factors which have correlation and height percentile has 26.9% of predictive power. Regression equation considering only genetic factor has 20.4%. MPH has the most effect on height percentile. Anorexia has more effect than NBW. Other factors also have small and similar effect. Conclusions: Height of parents has the most effect on growth, anorexia, dyspepsia, atopic dermatitis, frequency of breakfast and quality of sleeping time also has effect.

• Molecules and Cells
• /
• v.26 no.2
• /
• pp.193-199
• /
• 2008

The pro-apoptotic Bcl-2 family member Bim acts as a sensor for apoptotic stimuli and initiates apoptosis through the mitochondrial pathway. To identify novel regulators of Bim, we employed the yeast two-hybrid system and isolated the human gene encoding macrophage migration inhibitory factor (MIF), a ubiquitously expressed proinflammatory mediator that has also been implicated in cell proliferation, the cell cycle and carcinogenesis. The interaction between MIF and Bim was confirmed by both in vitro and in vivo protein interaction assays. Intriguingly, protein complexes between MIF and the three major Bim isoforms (BimEL/BimL/BimS) could be detected in HEK293 and K562 cells, especially in cells undergoing apoptosis. Moreover, exogenous expression of MIF partially inhibited Bim-induced apoptosis in HEK293 cells. SiRNA-mediated knockdown of MIF increased apoptosis in K562 cells exposed to the chemical oxidant diamide. Endogenous MIF may regulate the pro-apoptotic activity of Bim and inhibit the release of cytochrome c from mitochondria.

• Journal of Gifted/Talented Education
• /
• v.17 no.2
• /
• pp.280-306
• /
• 2007

The purpose of this study is to investigate the two assertions of hereditarianism and environmentalism in the intellectual abilities, which is one of the most important factors of giftedness, and thus to discuss and understand giftedness. As the result of various investigations about the two opposing opinions, it is general view that about 50% of the intellectual abilities are endowed by genetic factors, but they are not fixed life long but changed and developed by posterior experiences. In other word, it is said that giftedness itself of which an important factor is intellectual abilities is determined by heredity, but the degree of revelation of the potential faculty is determined by environmental factors. Therefore, the recent major concerns in this field seem to be on how to make unfold most the children's giftedness rather than arguments about the degree of genetic and environmental factors. It can be said that giftedness is sprung up and accelerated only when an excellent genetic factor and a special environmental factor are transacted dynamically and amplified exquisitely.

• Genomics & Informatics
• /
• v.11 no.2
• /
• pp.83-92
• /
• 2013

Genetic studies on facial morphology targeting healthy populations are fundamental in understanding the specific genetic influences involved; yet, most studies to date, if not all, have been focused on congenital diseases accompanied by facial anomalies. To study the specific genetic cues determining facial morphology, we estimated familial correlations and heritabilities of 14 facial measurements and 3 latent factors inferred from a factor analysis in a subset of the Korean population. The study included a total of 229 individuals from 38 families. We evaluated a total of 14 facial measurements using 2D digital photographs. We performed factor analysis to infer common latent variables. The heritabilities of 13 facial measurements were statistically significant (p < 0.05) and ranged from 0.25 to 0.61. Of these, the heritability of intercanthal width in the orbital region was found to be the highest ($h^2$ = 0.61, SE = 0.14). Three factors (lower face portion, orbital region, and vertical length) were obtained through factor analysis, where the heritability values ranged from 0.45 to 0.55. The heritability values for each factor were higher than the mean heritability value of individual original measurements. We have confirmed the genetic influence on facial anthropometric traits and suggest a potential way to categorize and analyze the facial portions into different groups.

• KIEAE Journal
• /
• v.15 no.3
• /
• pp.29-36
• /
• 2015

Purpose: This study is as only basic research for the model Development of the New-Hanok Type Service Facilities in Apartment Housing, which is as a decisive factor used as a planning element for developing the model inherited tradition, There aimed at extracting the genetic factor of Korea's traditional architecture. Method: For this purpose, Consider the concept and regulations of the New-Hanok Type Service Facilities in Apartment Housing and examined the Domestic Application Status of the New-Hanok Type Service Facilities in Apartment Housing. It sets direction of the New-Hanok Type models development based on Expert advice and the literature, and was reviewed a primal reason system of Korea as an extraction base of genetic factors. Result: Then Through the framework of the vertical axis (the form), the horizontal axis (space), It extracted the genetic factors of the Korea Traditional Architecture, classified the genetic factors extracted as the structure(layout, construction, space), features, traditional beauty, investigated the content of the form representation and spatial meaning, and were characterized. Based on the result, It were comprehensive the genetic factors extracted as plan Elements for inheriting of the traditions.

• Asian-Australasian Journal of Animal Sciences
• /
• v.21 no.3
• /
• pp.309-313
• /
• 2008

The insulin-like growth factor binding protein 3 (IGFBP3) has been investigated as a candidate gene for growth promoting effects in beef cattle and a modulator of IGF bioactivity. Previously, we have reported twenty two sequence variants discovered in Korean native cattle (Hanwoo). In this study, we examined the association between gene-specific polymorphisms of IGFBP3 and cold carcass weight (CW) and marbling score (MS) among Korean native cattle. Among twenty two polymorphisms, four common polymorphic sites (-854G>C, -100G>A, +421G>T and +3863C>A) were genotyped in our beef cattle (n = 437). Statistical analysis revealed that one common polymorphism in the promoter region (-854G>C) showed putative associations with MS (p = 0.03). IGFBP3 variation/haplotype information analyzed in this study will provide valuable information into strategies for the production of a commercial line of beef cattle.