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Macrophage Migration Inhibitory Factor (MIF) Interacts with Bim and Inhibits Bim-mediated Apoptosis  

Liu, Lingfeng (State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University)
Chen, Jinzhong (State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University)
Ji, Chaoneng (State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University)
Zhang, Jiayi (State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University)
Sun, Junlei (Department of Biochemistry and Molecular Biology, 108 Althouse Laboratory, The Pennsylvania State University)
Li, Yao (State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University)
Xie, Yi (State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University)
Gu, Shaohua (State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University)
Mao, Yumin (State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University)
Publication Information
Molecules and Cells / v.26, no.2, 2008 , pp. 193-199 More about this Journal
Abstract
The pro-apoptotic Bcl-2 family member Bim acts as a sensor for apoptotic stimuli and initiates apoptosis through the mitochondrial pathway. To identify novel regulators of Bim, we employed the yeast two-hybrid system and isolated the human gene encoding macrophage migration inhibitory factor (MIF), a ubiquitously expressed proinflammatory mediator that has also been implicated in cell proliferation, the cell cycle and carcinogenesis. The interaction between MIF and Bim was confirmed by both in vitro and in vivo protein interaction assays. Intriguingly, protein complexes between MIF and the three major Bim isoforms (BimEL/BimL/BimS) could be detected in HEK293 and K562 cells, especially in cells undergoing apoptosis. Moreover, exogenous expression of MIF partially inhibited Bim-induced apoptosis in HEK293 cells. SiRNA-mediated knockdown of MIF increased apoptosis in K562 cells exposed to the chemical oxidant diamide. Endogenous MIF may regulate the pro-apoptotic activity of Bim and inhibit the release of cytochrome c from mitochondria.
Keywords
apoptosis; Bim; macrophage migration inhibitory factor;
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