• Journal of Korean Medical classics
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• v.23 no.4
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• pp.63-102
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• 2010

Purpose : To propose various types of clinical research which is feasible for botanical new drug (IND) development processes, and suggest essential steps to development of study protocol for IND. Methods : Literature-based discussions and one research group's experience is given regarding domestic act, regulation, and system. Results : In order to get an approval of IND for botanical drug in Korea there are several types of clinical research to conduct. In quality control steps for standardized medicinal herbs, case reports or case series can be conducted, and for good manufacturing practice(GMP) steps, we can conduct case reports, case series, and retrospective cohort studies. In addition, as long as we gathered good laboratory practice(GLP) data we can conduct up to quasi-experimental studies and clinical trials including investigator initiated trials. In order to conduct these studies development of study protocol is essential. First, we obtain historical evidence including target disease and indication, efficacy, safety, and endpoints by reviewing medical classics. Second, we obtain clinically and statistically important data by conducting non-clinical studies, observation studies, and quasi-experimental studies. Third, we generate research hypotheses and purposes and explore methodologies, endpoints, clinical practice guidelines, cost-effectiveness, and commercial potential. Finally, we develop study protocol with aid of biostatistician or expert in contract research organization. Discussions and conclusions : This study have obvious limitations in that most thoughts, suggestions, and proposes are from one research group's experience. Therefore, we hope to see various types of research in this topic and process from other research group as well.

• Journal of KIISE:Software and Applications
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• v.36 no.4
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• pp.253-260
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• 2009

Many algorithms for computer vision and pattern recognition have recently been implemented on GPU (graphic processing unit) for faster computational times. However, the implementation has two problems. First, the programmer should master the fundamentals of the graphics shading languages that require the prior knowledge on computer graphics. Second, in a job that needs much cooperation between CPU and GPU, which is usual in image processing and pattern recognition contrary to the graphic area, CPU should generate raw feature data for GPU processing as much as possible to effectively utilize GPU performance. This paper proposes more quick and efficient implementation of neural networks on both GPU and multi-core CPU. We use CUDA (compute unified device architecture) that can be easily programmed due to its simple C language-like style instead of GPU to solve the first problem. Moreover, OpenMP (Open Multi-Processing) is used to concurrently process multiple data with single instruction on multi-core CPU, which results in effectively utilizing the memories of GPU. In the experiments, we implemented neural networks-based text extraction system using the proposed architecture, and the computational times showed about 15 times faster than implementation on only GPU without OpenMP.

• Proceedings of the KSRS Conference
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• v.2
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• pp.551-554
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• 2006

House management is very important in water resource protection in order to provide sustainable drinking water for about four millions population in northern Taiwan. House management can be a simple job that can be done without any ingredient of remote sensing or geographic information systems. Remote sensing and GIS integration for house management can provide more efficient management prescription when land use enforcement, soil and water conservation, sewage management, garbage collection, and reforestation have to be managed simultaneously. The objective of this paper was to integrate remote sensing and GIS to manage houses in a water resource protection district. More than four thousand houses have been surveyed and created as a house data base. Site map of every single house and very detail information consisting of address, ownership, date of creation, building materials, acreages floor by floor, parcel information, and types of house condition. Some houses have their photos in different directions. One house has its own card consists these information and these attributes were created into a house data base. Site maps of all houses were created with the same coordinates system as parcel maps, topographic maps, sewage maps, and city planning maps. Visual Basic.NET, Visual C#.NET have been implemented to develop computer programs for house information inquiry and maps overlay among house maps and other GIS map layers. Remote sensing techniques have been implemented to generate the background information of a single house in the past 15 years. Digital orthophoto maps at a scale of 1:5000 overlay with house site maps are very useful in determination of a house was there or not for a given year. Satellite images if their resolutions good enough are also very useful in this type of daily government operations. The developed house management systems can work with commercial GIS software such as ArcView and ArcPad. Remote sensing provided image information of a single house whether it was there or not in a given year. GIS provided overlay and inquiry functions to automatically extract attributes of a given house by ownership, address, and so on when certain house management prescriptions have to be made by government agency. File format is the key component that makes remote sensing and GIS integration smoothly. The developed house management systems are user friendly and can be modified to meet needs encountered in a single task of a government technician.

• Journal of the Korean Society of Marine Environment & Safety
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• v.25 no.6
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• pp.678-686
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• 2019

In this study, marine heat waves on coastal waters of Republic of Korea were detected using satellite-based Sea Surface Temperature Anomaly (SSTA). The detected results were compared with the warm water issues reported by the National Institute of Fisheries Science (NIFS). Marine heat waves detection algorithm using SSTA based on a threshold has proposed. The threshold value was defined as 2℃ for caution and 3℃ for warning issues, respectively. Daily averaged SST data from July to September of 2017-2018 were used to generate SSTA. The satellite-based detection results were classified into nine areas according to the place names used in the NIFS warm water issues. In the comparison of frequency of marine heat waves occurrence to each area with the warm water issue, most areas in the southern coast showed a similar pattern, that is probably NIFS uses spatially well distributed buoys. On the other hand, other sea areas had about two times more satellite detection results. This result seems to be because NIFS only considers the water temperature data measured at limited points. The results of this study are expected to contribute to the development of a satellite-based warm/cold water monitoring system in coastal waters.

• Journal of Cadastre & Land InformatiX
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• v.47 no.1
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• pp.111-126
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• 2017

Small-scale UAS(Fusion technique of Unmanned Aerial Vehicles platform and Sensors, 'sUAS') opens various new applications in construction fields and so becoming progressively common due to the considerable potentials in terms of accuracy, costs and abilities. The purpose of this study is that the investigation of the validation on the utilization of sUAS for earth stockpile volume calculations on sites. For this, generate 3D models(DSM) with sUAS aerial images on an cone shaped soil stockpile approximately $270m{\times}300m{\times}20m$, which located at Baegot Life Park in Siheung-si, compared stockpile volume estimates produced by sUAS image analysis, against volume estimates obtained by GNSS Network-RTK ground surveying method which selected as the criteria of earth stockpile volume. The result through comparison and examination show(demonstrate) that there was under 2% difference between the volume calculated with the GNSS Network RTK data and the sUAV data, especially sUAS imaged-based volume estimate of a stockpile can be greatly simplified, done quickly, and very cost effective over conventional terrestrial survey methods. Therefore, with consideration of various plan to assess the height of vegetation, sUAS image-based application expected very useful both volume estimate and 3D geospatial information extraction in small and medium-sized sites.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.30 no.4
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• pp.331-338
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• 2004

Stress transfer to the surrounding tissues is one of the factors involved in the design of dental implants. Unfortunately, insufficient data are available for stress transfer within the regenerated bone surrounding dental implants. The purpose of this study was to investigate the concentration of stresses within the regenerated bone surrounding the implant using three-dimensional finite element stress analysis method. Stress magnitude and contours within the regenerated bone were calculated. The $3.75{\times}10-mm$ implant (3i, USA) was used for this study and was assumed to be 100% osseointegrated, and was placed in mandibular bone and restored with a cast gold crown. Using ANSYS software revision 6.0, a program was written to generate a model simulating a cylindrical block section of the mandible 20 mm in height and 10 mm in diameter. The present study used a fine grid model incorporating elements between 165,148 and 253,604 and nodal points between 31,616 and 48,877. This study was simulated loads of 200N at the central fossa (A), at the outside point of the central fossa with resin filling into screw hole (B), and at the buccal cusp (C), in a vertical and $30^{\circ}$ lateral loading, respectively. The results were as follows; 1. In case the regenerated bone (bone quality type IV) was surrounded by bone quality type I and II, stresses were increased from loading point A to C in vertical loading. And stresses according to the depth of regenerated bone were distributed along the implant evenly in loading point A, concentrated on the top of the cylindrical collar loading point B and C in vertical loading. And, In case the regenerated bone (bone quality type IV) was surrounded by bone quality type III, stresses were increase from loading point A to C in vertical loading. And stresses according to the depth of regenerated bone were distributed along the implant evenly in loading point A, B and C in vertical loading. 2. In case the regenerated bone (bone quality type IV) was surrounded by bone quality type I and II, stresses were decreased from loading point A to C in lateral loading. Stresses according to the depth of regenerated bone were concentrated on the top of the cylindrical collar in loading point A and B, distributed along the implant evenly in loading point C in lateral loading. And, In case the regenerated bone (bone quality type IV) was surrounded by bone quality type III, stresses were decreased from loading point A to C in lateral loading. And stresses according to the depth of regenerated bone were distributed along the implant evenly in loading point A, B and C in lateral loading. In summary, these data indicate that both bone quality surrounding the regenerated bone adjacent to implant fixture and load direction applied on the prosthesis could influence concentration of stress within the regenerated bone surrounding the cylindrical type implant fixture.

• Korean Journal of Food Science and Technology
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• v.32 no.4
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• pp.964-969
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• 2000

Di-(2-ethylhexyl) adipate(DEHA) has been used extensively as a plasticizer in the manufacture of plastic products such as PVC films. Though, phthalate esters plasticizers have been known to induce endocrine system-mediated responses, few studies have been conducted for the screening of estrogenic activity of DEHA, an adipate plasticizer. This study was initiated to evaluate the estrogenic activity of DEHA by in vitro E-screen assay and in vivo uterotrophic assay. MCF-7 human breast cancer cells were treated with $DEHA(5{\times}10^{-9}{\sim}5{\times}10^{-4}\;M)$, for 144 hr, and cell proliferation was determined by sulforhodamine B(SRB) assay. DEHA dissolved in corn oil was administered subcutaneously to ovariectomized(OVX) female Sprague-Dawley rats at dosage levels of 0, 2, 20 and 200 mg/kg/day for three consecutive days. Rats were sacrificed 24 hr after final treatment and vagina and uterus(wet and blotted) weights were obtained. E-screen assayed DEHA did not generate cell proliferation at treated concentrations$(5{\times}10^{-9}{\sim}5{\times}10^{-4}\;M)$, whereas 17 ${\beta}-estradiol$(E2), the positive control, induced cell proliferation at low concentrations$(5{\times}10^{-14}{\sim}5{\times}10^{-9}\;M)$. In the uterotrophic assay, DEHA did not change vagina and uterus(wet and blotted) weights at dosage levels up to 200 mg/kg/day treatment. These results demonstrated that DEHA did not exhibit the estrogenic activity as determined by in vitro E-screen assay and in vivo uterotrophic assay.

• Journal of the Korean earth science society
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• v.32 no.6
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• pp.674-686
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• 2011

Choosing a seismic source and geophone type including a coupling method can be the most important factor in shallow seismic surveys. We studied the characteristics of seismic signals by analyzing 6 different seismic data sets that collected from several sources and geophone conditions. Geophones attached to weight plate (1.8 kg) can be easily and economically installed on the paved road where geophones with spikes would cause the coupling problem. In addition, experiments in this study revealed that a small handy hammer can be used as a seismic source by striking the paved road to generate the seismic signals within 200 ms two-way travel time. Attaching weight plates to geophones may change the geophone response curve which generally depends on the geophone mass, but the change seems not to give significant differences in the first arrival of refracted wave and in the pattern of reflection events. Consequently, using weight plates on paved roads can be an efficient and cost-saving method in the near-surface high-resolution seismic surveys.

• Journal of the Korean Geotechnical Society
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• v.19 no.6
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• pp.261-271
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• 2003

A condition evaluation procedure for the pavement foundations using multi-load level Falling Weight Deflectometer(FWD) deflections is presented in this paper. A dynamic finite element program incorporating a stress-dependent material model, was used to generate the synthetic deflection database. Based on this synthetic database, the relationships between surface deflections and critical responses, such as stresses and strains in base and subgrade layers, have been established. FWD deflection data, Dynamic Cone Penetrometer(UP) data, and repeated load resilient modulus testing results used in developing this procedure were collected from the Long Term Pavement Performance (LTPP) and North Carolina Department of Transportation (NCDOT) database. Research effort focused on investigation of the effect of the FWD load level on the condition evaluation procedures. The results indicate that the proposed procedure can estimate the pavement foundation conditions. It is also found that structurally adjusted Base Damage Index (BDI) and Base Curvature Index (BCI) are good indicators for the prediction of stiffness characteristics of aggregate base and subgrade respectively. A FWD test with a load of 66.7 kN or less does not improve the accuracy of this procedure. Results from the study for the nonlinear behavior of a pavement foundations indicate that the deflection ratio obtained from multi-load level deflections can predict the type and quality of the pavement foundation materials.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.48 no.4
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• pp.39-50
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• 2011

In this paper, we presents a CDR circuit for $2^{nd}$-generation AiPi+, one of the Intra-panel Interface. The speed of the proposed clock and data recovery is increased to 1.25 Gbps compared with that of AiPi+. The DLL-based CDR architecture is used to generate the multi-phase clocks. We propose the simple scheme for frequency detector (FD) to mitigate the harmonic-locking and reduce the complexity. In addition, the duty cycle corrector that limits the maximum pulse width is used to avoid the problem of missing clock edges due to the mismatch between rising and falling time of VCDL's delay cells. The proposed CDR is implemented in 0.18 um technology with the supply voltage of 1.8 V. The active die area is $660\;{\mu}m\;{\times}\;250\;{\mu}m$, and supply voltage is 1.8 V. Peak-to-Peak jitter is less than 15 ps and the power consumption of the CDR except input buffer, equalizer, and de-serializer is 5.94 mW.