• Journal of Preventive Medicine and Public Health
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• 제40권1호
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• pp.16-22
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• 2007

Objective : The purpose of this study was to evaluate the levels of DNA damage in human lymphocytes caused by smoking and other lifestyle factors. Methods : The study population consisted of 173 normal healthy male adults from 21 to 59 years old. The demographic and lifestyle variables were obtained from administered questionnaires. The level of lymphocytic DNA damage in the peripheral blood was evaluated by the Comet assay. Statistical analyses were done by general linear model analysis and Dunnett's multiple comparison. Results : The difference in DNA damage between smokers and non-smokers was statistically significant. The means for the Tail%DNA were found to be 10.48 in the current smokers and 9.60 in the non-smokers (p < 0.05). The tail moment means were 1.58 and 1.45 (p < 0.05) for the current smokers and non-smokers, respectively. The number of cigarettes smoked per day did not result in a significant difference in the level of DNA damage among the smokers. Other lifestyle factors such as age, and drinking and exercise habits were not related to DNA damage. Conclusions : The DNA damage in the lymphocytes of smokers was found to be significantly higher than that for non-smokers. However, the number of cigarettes smoked per day was not related to DNA damage. Further study is needed to evaluate the relationship between the amount of smoking and level of damage to DNA. In addition, the status of DNA repair activities should be assessed.

• 전자공학회논문지S
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• 제36S권2호
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• pp.46-56
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• 1999

제어기와 플랜트가 공간상으로 분리되어 폐루프 내부에 시간지연이 불가피하게 존재하는 제어시스템의 시간지연 문제를 보상하기 위하여 확률 모델에 기반하여 설계된 예측제어기를 제안한다. 예측제어기는 지연된 이전의 값들로부터 선형예측 기법과 확률함수를 이용하여 실제의 현재값을 추정하며, 이를 제어기에 적용하여 시간지연에 의하여 발생되는 문제점을 최소화하였다. 제안된 방법의 타당성을 검증하기 위하여 DC 서보모터 시스템에 본 알고리즘을 실현하였으며, 상이한 시간지연에 따른 제어시스템의 영향을 관측하였다. 실험결과에서 예측제어기는 시간지연에 대하여 PID 제어기보다 우수한 수렴특성을 나타내었으며, 제어기의 안정범위 내에서 허용할 수 있는 최대 시간지연 값도 증가시킬 수 있음을 보였다. 제안된 예측제어기는 플랜트의 모델링을 요구하지 않고 출력의 통계적 정보만을 사용하므로 모델링이 어려운 시스템의 제어나 PID 제어의 보상기로 활용할 수 있는 범용적인 기법이다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2007-2017
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• 2016

Background: Modifying lifestyle factors such as diet and exercise can reduce the risk of cancer. Psychological stress (PS) might be indirectly associated with cancer because it alters lifestyle factors. However, the relationship among these variables has not been fully investigated. Thus, we examined interactions between self-reported PS (SRPS) and habitual exercise on diet. Materials and Methods: In all, 5,587 men and 2,718 women were divided into "exerciser" and :non-exerciser" groips, based on whether they exercised reguarly, and classified into three SRPS levels: low, moderate and high. Diet was estimated using a validated food frequency questionnaire. Using a general linear model, food and nutrient consumption was estimated for each SRPS level in the 2 exercise groups, and the interactions between SRPS levels and exercise were calculated. Results: In women, the intake of pork and beef, low fat milk and yogurt, natto (fermented soybean), carrots and squash, other root vegetables, mushrooms, seaweeds, and wine along with the nutrients vegetable protein, soluble, insoluble and total dietary fiber, daidzein, genistein, carotene, retinol equivalents, vitamin B2, pantothenic acid, potassium, calcium, magnesium, phosphorus and iron demonstrated significant interaction with SRPS and habitual exercise (p for interaction <0.05). In men, raw and green leafy vegetable and fruit and vegetable juice significantly interacted with SRPS and habitual exercise (p for interaction <0.05). Conclusions: We suggest that certain foods and nutrients, which are thought to have a protective effect against cancer, interact with SRPS and habitual exercise, especially in women. This information is valuable for understanding and improving interventions for cancer prevention.

• Asian-Australasian Journal of Animal Sciences
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• 제28권6호
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• pp.782-787
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• 2015

The myogenic regulatory factors is a family of transcription factors that play a key role in the development of skeletal muscle fibers, which are the main factors to affect the meat taste and texture. In the present study, we performed candidate gene analysis to identify single-nucleotide polymorphisms in the MyoD, Myf5, MyoG, and Mrf4 genes using polymerase chain reaction-single strand conformation polymorphism in 360 Erlang Mountain Chickens from three different housing systems (cage, pen, and free-range). The general linear model procedure was used to estimate the statistical significance of association between combined genotypes and muscle fiber traits of chickens. Two polymorphisms (g.39928301T>G and g.11579368C>T) were detected in the Mrf4 and MyoD gene, respectively. The diameters of thigh and pectoralis muscle fibers were higher in birds with the combined genotypes of GG-TT and TTCT (p<0.05). Moreover, the interaction between housing system and combined genotypes has no significant effect on the traits of muscle fiber (p>0.05). Our findings suggest that the combined genotypes of TT-CT and GG-TT might be advantageous for muscle fiber traits, and could be the potential genetic markers for breeding program in Erlang Mountain Chickens.

• 한국정보통신학회논문지
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• 제9권5호
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• pp.995-1001
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• 2005

효율적인 옷감 애니메이션 생성을 위해 암시적 적분법이 표준적 접근법으로 자리 잡았다. 이 기법은 시스템의 안정성이 보장되므로 큰 시간 간격을 사용할 수 있으며, 옷감 모델의 실시간 혹은 상호작용적 애니메이션을 위한 최선의 선택으로 받아들여지고 있다. 암시적 방법이 옷감 애니메이션에 도입된 이후 다양한 종류의 암시적 적분 기반 옷감 애니메이션 기법들이 제안되었으며 일반적인 PC 환경에서 수천 개의 질점을 가진 옷감 모델을 실시간에 시뮬레이션 할 수 있는 수준에 도달해 있다. 암시적 적분법이 안정성을 보장한다는 장점을 가지지만 명시적 기법에 비해 구현이 조금 더 복잡하며 병렬화가 어렵다는 문제를 가지고 있다. 암시적 적분법을 통해 옷감 애니메이션을 생성하는 것은 대규모 희소행렬을 가진 선형 시스템을 푸는 것으로 정형화된다. 본 논문에서는 암시적 적분법의 특성을 이용하여 안정적으로 복잡한 옷감 모델의 동작을 생성하면서도 매우 쉽게 병렬화가 가능한 기법을 제안한다. 옷감 애니메이션은 동작 시뮬레이션과 함께 자체충돌을 고려해야만 사실적인 결과를 얻을 수 있다. 그런데 자체충돌 감지 역시 중요한 계산상의 병목으로 작용한다. 본 논문에서는 효율적인 자체 충돌 처리 기법도 같이 제안한다.

• 대한토목학회논문집
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• 제13권3호
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• pp.207-219
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• 1993

지진진파(地震津波)(쓰나미)의 전파(傳播)와 범람(氾濫)에 관한 수치모형(數値模型)을 사용(使用)하여 1983년(年) 동해(東海) 중부지진(中部地震)에 의해 발생(發生)된 쓰나미를 산정(算定)하였다. 선형(線形) 및 비선형모형(非線形模型)을 사용(使用)하여 쓰나미 전파(傳波) 및 연안역(沿岸域)에서의 쓰나미의 파고(波高)를 계산(計算)하였다. 격자(格子)의 세분화(細分化)를 위해 한국(韓國) 동해안(東海岸)의 세부역(細部域)에 대한 2회의 세분화(細分化)를 실시(實施)하였는데 내역(內城)에서 다시 10m 간격(間隔)의 격자체계(格子體系)에서 범람모형(氾濫模型)을 적용(適用)하였다. 산정(算定)된 연안역(沿岸域)에서의 쓰나미 파고분포(波高分布)는 연안관측치(沿岸觀測値)와 비교(比較)하여 정성적(定性的)으로 일치(一致)하였다. 동해안(東海岸) 중앙부(中央部)의 보다 상세(詳細)한 격자체계(格子體系)를 사용(使用)한 임원항(臨院港)에서의 범람(氾濫)이 수치모형(數値模型)을 사용(使用)하여 잘 재현(再現)되었다.

• 보건행정학회지
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• 제24권3호
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• pp.254-260
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• 2014

Background: The purpose of this study is to assume appropriate outpatient consultation time for each clinical department on the basis of measured outpatient consultation time and satisfaction of outpatient. Methods: We surveyed the feeling and satisfactory outpatient consultation time, satisfaction, revisiting intention and recommendation to others to 1,105 patients of single general hospital in Gyeonggi-do and measured their real outpatient consultation time from October 28 to November 27 in 2013. On the basis of satisfaction, we estimated appropriate outpatient consultation time through area under the receiver operating characteristic curve in logistic regression model. Results: Feeling outpatient consultation time was 5.1 minutess, satisfactory outpatient consultation time which was suggested by patient was 6.3 minutes, and real outpatient consultation time was 4.2 minutes. Department which had longest real outpatient consultation time was infection (7 minutes) and department which had longest satisfactory outpatient consultation time was neurology (9.4 minutes). From the univariate and the multiple linear regression analysis, real outpatient consultation time was longer in pulmonology patient, new patient and afternoon patient, satisfactory outpatient consultation time was longer in infection, neurology, neuropsychiatry, neurosurgery, and rehabilitation patient. Appropriate real outpatient consultation time was suggested as 5.6 minutes which differentiated high and low satisfied patient group. However, we could not assume appropriate outpatient consultation time for each clinical department because the number of patient who had bad satisfaction was too low. Conclusion: To improve patient's satisfaction, we hope outpatient reservation system is operated as each patient's outpatient consultation time is at least 5.6 minutes.

• Imaging Science in Dentistry
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• 제42권2호
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• pp.89-93
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• 2012

Purpose : Clinicians commonly encounter cases in which it is difficult to determine whether adjacent radiopacities are normal or pathologic. The ideal radiopacity of composite resin is equal to or higher than that of the same thickness of aluminum. We aimed to investigate the possible effects of different curing times on the post-24-hour radiopacity of composite resins on digital radiographs. Materials and Methods : One mm thick samples of Filtek P60 and Clearfil resin composites were prepared and cured with three regimens of continuous 400 mW/$cm^2$ irradiance for 10, 20 and 30 seconds. Along with a 12-step aluminum step wedge, digital radiographs were captured and the radiopacities were transformed to the equivalent aluminum thicknesses. Data were compared by a general linear model and repeated-measures of ANOVA. Results : Overall, the calculated equivalent aluminum thicknesses of composite resins were increased significantly by doubling and tripling the curing times (F(2,8)=8.94, p=0.002). Notably, Bonferroni post-hoc tests confirmed that the radiopacity of the cured Filtek P60 was significantly higher at 30 seconds compared with 10 seconds (p=0.04). Although the higher radiopacity was observed by increasing the time, other comparisons showed no statistical significance (p>0.05). Conclusion : These results supported the hypothesis that the radiopacity of resin composites might be related to the duration of light curing. In addition to the current standards for radiopacity of digital images, defining a standard protocol for curing of dental materials should be considered, and it is suggested that they should be added to the current requirements for dental material.

• 한국음향학회지
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• 제24권4호
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• pp.210-216
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• 2005

본 논문에서는 잡음에 강인한 음성인식을 위하여 고유공간에 기반을 둔 새로운 특징 정규화 기법을 제안한다. 일반적으로 평균과 분산의 정규화 (MVN)는 켑스트럼 상에서 수행된다. 그러나 최근에 고유공간을 이용한 MVN기법이 소개되었고, 그 고유공간 정규화 기법에서는 하나의 고유공간을 이용하였다. 이 과정에는 켑스트럼 상의 특징 벡터를 선형 주성분 분석 (PCA)행렬을 통하여 고유공간으로 변환시킨 후 MVN을 수행하는 과정이 포함된다. 이 방법에서는 전체 39차의 특징분포를 하나의 고유공간으로 표현하였다. 그러나 이 기법의 경우 전체 특징 분포를 표현함에 세밀함이 떨어지기 때문에 더욱 세밀한 분포의 표현을 위해 본 논문에서는 static 특징, 1차 미분 계수, 2차 미분계수에 각각 유일하고 독립적인 분리된 고유공간을 적용하는 것을 제안하였다. 또한 고유공간에서 정규화 된 훈련 데이터를 이용하여 모델을 만든다. 마지막으로 훈련 데이터의 분포와 잡음환경에서의 테스트 데이터의 분포 특성의 차이를 줄이기 위해 켑스트럼 상에서의 회전 기법을 적용시킨다. 그 결과, 기본적인 고유공간 정규화 기법보다 향상된 성능을 얻을 수 있었다.

• Structural Engineering and Mechanics
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• 제42권5호
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• pp.715-728
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• 2012

This paper deals with determining the fundamental frequency of tall buildings that consist of framed tube, shear core, belt truss and outrigger systems in which the framed tube and shear core vary in size along the height of the structure. The effect of belt truss and outrigger system is modeled as a concentrated rotational linear spring at the belt truss and outrigger system location. Many cantilevered tall structures can be treated as cantilevered beams with variable cross-section in free vibration analysis. In this paper, the continuous approach, in which a tall building is replaced by an idealized cantilever continuum representing the structural characteristics, is employed and by using energy method and Hamilton's variational principle, the governing equation for free vibration of tall building with variable distributed mass and stiffness is obtained. The general solution of governing equation is obtained by making appropriate selection for mass and stiffness distribution functions. By applying the separation of variables method for time and space, the governing partial differential equation of motion is reduced to an ordinary differential equation with variable coefficients with the assumption that the transverse displacement is harmonic. A power-series solution representing the mode shape function of tall building is used. Applying boundary conditions yields the boundary value problem; the frequency equation is established and solved through a numerical process to determine the natural frequencies. Computer program has been developed in Matlab (R2009b, Version 7.9.0.529, Mathworks Inc., California, USA). A numerical example has been solved to demonstrate the reliability of this method. The results of the proposed mathematical model give a good understanding of the structure's dynamic characteristics; it is easy to use, yet reasonably accurate and suitable for quick evaluations during the preliminary design stages.