• Molecules and Cells
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• v.37 no.9
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• pp.699-704
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• 2014

Themetastasis-associated gene 1 (MTA1) oncogene hasbeen suggested to be involved in the regulation of cancer progression. However, there is still no direct evidence that MTA1 regulates cisplatin (CDDP) resistance, as well as cancer stem cell properties. In this study, we found that MTA1 was enriched in CNE1/CDDP cells. Knock down of MTA1 in CNE1/CDDP cells reversed CSCs properties and CDDP resistance. However, ectopic expression of MTA1 in CNE1 cells induced CSCs phenotypes and CDDP insensitivity. Interestingly, ectopic overexpression of MTA1-induced CSCs properties and CDDP resistance were reversed in CNE1 cells after inhibition of PI3K/Akt by LY294002. In addition, MTA1 expression and Akt activity in CNE1/CDDP cells was much higher than that in CNE1 cells. These results suggested that MTA1 may play a critical role in promoting CDDP resistance in NPC cells by regulatingcancer stem cell properties via thePI3K/Akt signaling pathway. Our findings suggested that MTA1 may be a potential target for overcoming CDDP resistance in NPC therapy.

• Journal of Korean Society for Quality Management
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• v.44 no.3
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• pp.473-486
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• 2016

Purpose: Although the price reduction policy is established for military supplies, it is more focused on general military items. Therefore, it is hard to apply the current price reduction policy directly to the major weapon system. The purpose of this study is to develop an evaluation model which generates appropriate outputs for price reduction of military supplies. Methods: To improve the current policy, we first analyze the relevant policies of price reduction of similar organizations. We gather the opinions of related organization through survey including DAPA, Logistics Command, DTaQ and Defense industry companies. Then, we develop a price reduction model based on the analytic hierarchical process(AHP) method to find out important factors for price reduction. Results: The results of AHP analysis show that the important factors when applying price reduction of military supplies. From the analysis, the proposed method effectively generates the amounts of price reduction for the nonconformance items. Conclusion: The results of this research will be used as guidelines to improve military supplies policy of price reduction.

• Parasites, Hosts and Diseases
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• v.47 no.2
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• pp.159-165
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• 2009

House-residual spraying and insecticide-treated bed nets have achieved some success in controlling anthropophilic and endophagic vectors. However, these methods have relatively low efficacy in Korea because Anopheles sinensis, the primary malaria vector, is highly zoophilic and exophilic. So, we focused our vector control efforts within livestock enclosures using ultraviolet black light traps as a mechanical control measure. We found that black light traps captured significantly more mosquitoes at 2 and 2.5 m above the ground (P<0.05). We also evaluated the effectiveness of trap spacing within the livestock enclosure. In general, traps spaced between 4 and 7m apart captured mosquitoes more efficiently than those spaced closer together (P>0.05). Based on these findings, we concluded that each black light trap in the livestock enclosures killed 7,586 female mosquitoes per trap per night during the peak mosquito season (July-August). In May-August 2003, additional concurrent field trials were conducted in Ganghwa county. We got 74.9% reduction (P<0.05) of An. sinensis in human dwellings and 61.5% reduction (P>0.05) in the livestock enclosures. The black light trap operation in the livestock enclosures proved to be an effective control method and should be incorporated into existing control strategies in developed countries.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.44 no.6
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• pp.492-501
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• 2016

Three-Loop autopilot is generally used for the acceleration control of guided missiles. Because the acceleration command to the three-loop autopilot is given as values at the center of gravity, feedback information of IMU should be obtained at the same position. However, the position of IMU might not be located at the center of gravity due to the sub-system assignment. This paper presents the stability analysis of three-loop autopilot with respect to the arbitrary position of IMU and variation rate of center of gravity. Gain and phase margins are calculated for several trim points for general anti-tank missiles.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.1
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• pp.175-182
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• 2011

In this paper, we implemented a high-performence memory controller which can accommodate processing blocks(multiple masters) in SoC for video signal processing. The memory controller is arbitrated by the internal arbiter which receives request signals from masters and sends grant and data signals to masters. The designed memory controller consists of Master Selector, Mster Arbiter, Memory Signal Generator, Command Decoder, and memory Signal Generator. It was designed using VHDL, and verified using the memory model of SAMSING Inc. For FPGA synthesis and verification, Quartus II of ATERA Inc. was used. The target device is Cyclone II. For simulation, ModelSim of Cadence Inc was used. Since the designed H/W can be stably operated in 174.28MHz, it satisfies the specification of SDRAM technology.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.36S no.9
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• pp.103-112
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• 1999

In this paper, a speaker-independent isolated world recognition system for a car navigation system is implemented using a general digital signal processor. This paper presents a method combining SNR normalization with RAS as a noise processing method. The semi-continuous hidden markov model is adopted and TMS320C31 is used in implementing the real-time system. Recognition word set is composed of 69 command words for a car navigation system. Experimental results showed that the recognition performance has a maximum of 93.62% in case of a combination of SNR normalization and spectral subtraction, and the performance improvement rate of the system is 3.69%, Presented noise processing method showed good speech recognition performance in 5dB SNR in car environment.

• Journal of Korean Academy of Nursing
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• v.24 no.2
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• pp.313-318
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• 1994

To build a suitable National Health Care System for the coming 21s1 century, Nursing must also be renewed. The future Korea will be united and the majority of its population will raidly consist of the aged. Economically standing on the same level with developed countries the growth of scientific technologies will foster communications, firing astounding changes in the medical field. While the overall life style pattern of Koereans not to mention the structure of diseases undergo change, the possibility that the reckless induction of high-tech health care may only cause medical fees to eascafate. It can전so be expected that the health care system will evolve towards the consumers. Nursing in the 21s1 century will be of two scenarios according to WHO, which presents the role of the nurse. The first scenario is that "a gen-eric health care work force" namely a "care giver" will replace all other health professions. If Nursing does not become the compatent profession fitting to this purpose it will eventually dei out. The second scenario is that nurses who are educated in a well grounded and extensive general background and have command of a specialized area will undertake services varying from health pro-motion to treatment and rehabilitation both direct and indirectly, while supervising other personnel. The nurse here would become the "care giver". To become the necessary health care profession in the 21s1 century, nurses should be provided with more educational opportunities, variating in its con-tents, course, and system, enabling them to grow. Clair Faign points out that the minimal educational entry for the nursing profession is a 4 year undergraduate education in this aspect, now in the time to set the future of Nursing into the course of the first scenario. A new educational system stipulating a baccalaureate nursing degree is in urgent need, and aside from govermental actions nurse themseives should formaily officiallze this process, striving for quality assurance. While considering 6 years nursing education programs, multifarious degree courses for existing 3 years educated nurse should be provided Junior nursing schools must devise measures to grow into baccalaucate institutions, also. Among the existing courses, the Self Study Degree Program should be converted into RN, BSN courese provided by universities, and clinical training for the University on the Air must be supplimented, The possibility of establishing nursing courses into commercial high school programs only jeopardizes the development of the nursing profession.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.4A
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• pp.345-349
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• 2005

In this paper, the enhanced ATA(AT Attachment Interface with Extension) interface that combines the price of ATA and intelligent operation of SCSI(Small Computer System Interface) is realized both performance and structure of general interface used to connect peripheral devices that are used in PC(Personal Computer). SCSI bus is for peripheral devices that have intelligent operation. It is excellent bus that has well-arranged command system and stable hardware structure. But is aspect of price this peripheral device has the difficulty in purchase because there is price difference more than two times compared with ATA peripheral device. Whereas, although ATA peripheral device had low performance in the early period, after the improvement its speed has almost etched to SCSI and its price is also excellent. In this paper, the enhanced interface structure to fulfill price and performance was suggested and materialized as the hardware using such two advantages.

• Publications of The Korean Astronomical Society
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• v.27 no.3
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• pp.95-103
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• 2012

We analyzed the current status of the telescope control system (TCS2) of the 1.8 m telescope in Bohyunsan Optical Astronomy Observatory (BOAO), and suggest a new TCS (TCS3) for the long term development of BOAO. The TCS2 was constructed in 1998 to replace the TCS1 which was installed with the telescope itself at the commencement of BOAO. One of the important parts of TCS is PMAC (Programmable Multi-Axis Controller), which is a general-purpose multi-axis motion controller. PMAC provides the direct interactive communication environment permitting users to command the controller directly with simple operations. This makes the setup, debugging, and diagnostics very easy. The TCS2 was operated stable for a long time, but the hardware and TCS computers have been deteriorated and are out of date now. The new TCS3 needs to be constructed based on a modern computer system. And functions such as pre-calculations of telescope limiting position, interworking with virtual observatory tools, and using GUI, etc should be added. Construction of the TCS3 will be a step creating a better observation environment for the Korean astronomical society.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.1
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• pp.387-392
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• 2020

This paper proposes a flow-rate control system for industrial valves. Industrial valves are used in piping systems to control the flow rate and pressure. In general, valves used in pipelines are classified into globe valves, butterfly valves, and ball valves according to the shape. Motor, hydraulic, and pneumatic systems are used for operating valves. The flow meter should measure the flow rate when configuring the flow-rate control system. On the other hand, because the flow rate of the valve can be expressed by flow coefficient, a control scheme is proposed using the pressure deviation, which measures at the front and rear of the valve. The transfer function for the valve, according to the control input, was estimated using the signal compression method. Based on the induced transfer function, the disturbance observer was designed to improve the command following the performance of the valve stem. The performance of the proposed control method is compared with the flow-rate control result using the flow meter used.