• 한국전산유체공학회:학술대회논문집
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• 2006.05a
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• pp.209-210
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• 2006

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.1
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• pp.99-103
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• 2002

Geopungdodam-tang(GDT) have been used in oriental medicine for many centuries as a therapeutic agent of apoplexy. The mechanism of GDT on the cerebral blood flow is not known. The purpose of this Study was to investigate effects of GDT on the pial arterial diameter and action mechanism of GDT-induced increased regional cerebral blood flow(rCBF). The changes of regional cerebral blood f1ow(rCBF) was determinated by Laser-Doppler Flowmetry(LDF), and the changes of pial arterial diametet were determinated by video microscopy methods and video analyzer. The results were as follows ; 1. Pial arterial diameter was significantly increased by GDT in a dose-dependent manner. 2. Pretreatment with L-NNA significantly inhibited GDT induced increased rCBF. 3. Pretreatment with methylene blue significantly inhibited GDT induced increased rCBF. 4. Pretreatment with indomethacin inhibited GDT induced increased rCBF. These results suggest that GDT causes a diverse response of cerebral hemodynamics(rCBF and pial arterial diameter). The cerebral hemodynamics is also mediated by nitric oxide synthase, cyclic GMP(guanylyl cydase) and prostaglandin(cyclooxygenase).

• The Journal of Korean Medicine
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• v.28 no.3 s.71
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• pp.183-196
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• 2007

Objective : This study was conducted in order to find the effects of Gammaekdaejo-tang (Ganmaidazao-tang, GDT) by subjecting rats to immobilization stress, thereby inducing depression, anxiety and acquisition-retention defects. Method : Rats treated with normal saline, GDT 200mg/kg and GDT 400mg/kg were subjected to stress by immobilization. Afterwards, behavior changes were observed by elevated plus maze test, acquisition test and retention test in the Morris water maze. The results were obtained by immunohistochemically measuring stress hormone (corticosteroid) levels in the blood. Results and Conclusions : 1. The open arm test in the elevated plus maze showed that compared with the normal group, the time spent decreased in the control group and increased in the GDT 400mg/kg group. 2. The locomotor activity test in the elevated plus maze revealed that the control group showed significant activity decrease compared with the normal group but significant increase in the GDT 400mg/kg group. 3. The acquisition test in the Morris water maze showed that the acquisitive ability of the control group significantly deteriorated on the 3rd and 4th day compared with the normal group, but improved significantly in the GDT 200mg/kg and GDT 400mg/kg groups. 4. The retention test on the 7th day in the Morris water maze revealed that the retentive ability of the control group significantly deteriorated compared with the normal group, but the retentive ability of the GDT 400mg/kg group significantly improved. 5. The blood levels of corticosteroid in the control group increased significantly compared with the normal group but the levels of corticosterone in the blood of the GDT 400mg/kg group significantly decreased.

• The Journal of Internal Korean Medicine
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• v.39 no.1
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• pp.1-8
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• 2018

Objectives: This study seeks to investigate the effects of Gamidohongsamul-tang (GDT) on the Gene expression levels of eNOS, KLF2, ICAM-1 and VCAM-1 in HUVEC cells. Methods: HUVEC cells were treated at a concentration of 1, 10, 100 (${\mu}g/ml$) of Gamidohongsamul-tang (GDT). To measure the NOS, KLF2, ICAM-1 and VCAM-1 gene expression in HUVEC cells, the synthesized cDNA was subjected to polymerase chain reaction (PCR) and electrophoresis was performed to verify gene expression level. Results: 1. GDT significantly increased eNOS and KLF2 gene expression. 2. GDT significantly reduced ICAM-1 and VCAM-1 gene expression. Conclusions: These experiments suggest that Gamidohongsamul-tang (GDT) regulates gene expression related with anti-dyslipidemic effects in HUVEC cells. In order to clinically apply this to diseases related to dyslipidemia, such as cardiovascular disease, additional in vivo experiments are needed to verify the anti-dyslipidemic effects of GDT.

• Journal of Korean Medicine Rehabilitation
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• v.19 no.2
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• pp.89-102
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• 2009

Objectives : This study was carried out to understand the immunity responses and anti-oxidation effect of the Gamidaeganghwal-tang(GDT) on rheumatoid arthritis by using the THP-1 cells and the serum of CIA mice. Methods : For this purpose, GDT was orally administerd to mice with rheumatoid arthritis induced by collagen II. To investigate the immunity responses, value of cytokine and gene expression in the THP-1 cell, levels of cytokines in the serum of CIA(collagen type II induced arthritis) mice, number of immunocyte in PBMC of CIA mice were measured. Then, anti-oxidant activity, scavenging activity on DHHP(2,2-diphenyl-1-picrylhydrazyl) free radical and SOD(Superoxide dismutae)-like activity of GDT was observed. Results : 1. The levels of IL-$1{\beta}$, IL-6, IL-8, MCP-1 at 100, $50{\mu}g/m{\ell}$ of GDT were significantly reduced in the THP-1 cell. 2. The levels of TNF-${\alpha}$, COX-2 mRNA expression at 100, $50{\mu}g/m{\ell}$ of GDT and IL-$1{\beta}$, IL-6 at $100{\mu}g/m{\ell}$ of GDT were significantly reduced in the THP-1 cell line. 3. The levels of IL-6, TNF-${\alpha}$ and IL-$1{\beta}$ were significantly reduced in the serum of CIA mice. 4. The absolute number of CD3+, CD4+ and CD8+ cells were significantly induced, CD3+/CD69+, CD3+/CD49+, CD19+, B220+/CD23+ cells were significantly reduced in PBMC. 5. Scavenging activity on DPPH free radical and SOD-like activity were significantly induced in a concentration dependent manner. Conclusions : Taking all these observations, GDT considered to be effective in treating rheumatoid arthritis. Therefore we have to survey continuously in looking for the effective substance and mechanism in the future.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.26 no.7
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• pp.92-98
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• 2012

It is made compulsory to install SPD for the purpose of protecting electric and electronic devices when an abnormal voltage such as lightning occurs to power line using power frequency of 60Hz. Recently, the high speed communication technology utilizing power line is receiving attention again as a communication technology for smart grid. The SPD influences the performances of power line communication when using SPD and power line communication system together. In order to improve the performance of power line communication, a proposed scheme for series connection of gas discharge tube to ZnO varistor was presented. This paper measured the impacts of series connection of GDT to SPD using ZnO varistor on the limit voltage of Class III SPD. This paper also presented the DC operating voltage of GDT which satisfies the limit voltage of power line communication system and SPD simultaneously.

• Applied Chemistry for Engineering
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• v.21 no.2
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• pp.205-210
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• 2010

In this study, a brass electrode gas discharge tube (GDT) was prepared to investigate its discharge characterization, which affects surge protection efficiency and lifetime of GDT. Discharge characterization of GDT using a brass electrode was investigated by changing applied voltage gradient and nitrogen gas pressure inside the GDT. As applied voltage gradient in GDT increased, electrical breakdown voltage and threshold energy largely increased and electrical breakdown time delay decreased. It was found that electrical breakdown voltage, electrical breakdown time delay, and threshold energy were largely decreased with decreasing the nitrogen gas pressure in GDT. As a result, electrical breakdown voltage, electrical breakdown time delay, threshold energy needed to be decreased to increase surge protection efficiency and lifetime. It was also found that the nitrogen gas pressure of GDT influenced strongly the performances as well as life span of it.

• Biomedical Science Letters
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• v.26 no.3
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• pp.210-216
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• 2020

The purpose of this study was to evaluate GDH & Toxin (GDT) tests for the identification of the presence of Clostridioides difficile (C. difficile) as well as to detect whether any toxin was present in the feces of patients suspected of diarrhea associated with C. difficile. Data related to the results of toxin and culture (TC) tests and GDT tests conducted on patients with diarrhea and suspected CDI between January 2017 and august 2018, positive test rates, patient ages and sexes, whether the patients were hospitalized, and turnaround time (TAT) were analyzed retrospectively. Of the 7,554 total tests conducted for CDI diagnosis, 1,010 TC tests (14.9%) were positive, while 92 GDT tests (12.0%) were positive. Of these positive cases, 815 (80.7%) identified through TC test and 80 (87%) identified through GDT test were inpatients. also, among the patients with positive test results, 497 (49.2%) diagnosed through TC test and 45 (48.9%) diagnosed through GDT test were aged 61 years or older. The total time required to complete a TC test was 83.6 hours, while the time required for a GDT test was 11.2 hours, equating to an approximately three-day difference between the two tests. The detection of toxin-producing C. difficile is important in CDI diagnosis, but the commonly used Enzymeimmunoassay (EIA) toxin tests with low sensitivity result in delayed CDI diagnosis time. Therefore, primary screening tests for CDI diagnosis using the GDT method and secondary tests using additional methods are considered most effective.

• Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
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• 2006.05a
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• pp.355-359
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• 2006

ZnO varistor and GDT(gas discharge tube) have proven to be good protective devices because of their flexibility and high reliability. ZnO varistors are characterized by their excellent nonlinear properties. GDTs are used for applications in communication or signaling circuits because they have very low capacitance. Therefore, It is very important to understand the V-I characteristic of ZnO varistor and GDT for designing SPD to protect apparatus or personnel from high transient voltage. This paper gives experimental V-I characteristic data of ZnO varistor and GDT for protecting electronic equipments from surge up to maximum discharge current.

• The Journal of the Acoustical Society of Korea
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• v.41 no.1
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• pp.58-63
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• 2022

This study was conducted to examine the characteristics of pitch perception and temporal resolution through Within-/Cross-Channel Gap Detection Thresholds (WC/CC GDTs) using low-frequency pure tones (such as 264 Hz, 373 Hz and 528 Hz related to C4, C4#, and C5 musical tones. 40 young people and 20 elderly people with normal hearing participated in this study. The results of WC GDTs were approximately 2 ms ~ 4 ms threshold values regardless of frequencies in two groups. There was no statistically significant difference in WC GDTs between groups. In both groups, CC GDTs were larger than WC GDTs, and as the frequency difference increased, the CC GDTs also increased. In particular, in the comparison between groups of CC GDTs, the results of the elderly group were 8 times ~ 10 times larger than that of the young group, and there was a statistically significant difference between the groups. These data also showed a different trend of GDTs in comparison with the previous data obtained from musical stimuli.This study suggests that GDTs may influence pitch perception mechanisms and can be used as psychoacoustic evidence for nonlinear responses of auditory nervous system.