• 대한핵의학회지
• /
• 제22권1호
• /
• pp.77-81
• /
• 1988

Tumor localizing properties of $^{67}Ga$ citrate and $^{169}Yb$ citrate were studies with sarcoma 180 bearing mice. To compare precisely the accumulation of $^{67}Ga$ citrate and $^{169}Yb$ citrate in tumor tissue itself, $^{67}Ga$ and l63yb were administered simultaneously as a mixture of same chemical form of citrate. The yield of $^{169}Yb$ labeled citrated and the of radiopharmaceuticals purity was identified more than 90% by chromatography on silica gel plates. $^{67}Ga$ and $^{169}Yb$ were injected into mice and the mice were killed at 3, 24, and 48 hours following intraperitoneal injection of the radiopharmaceuticals. The retention value of $^{67}Ga$ and $^{169}Yb$ in tumor was similar but they differ from each other markedly in normal tissue distribution. $^{169}Yb$ citrate is cleared up from blood more rapidly than $^{67}Ga$ citrate, and a high tumor to blood ratio is achieved shortly after injection.

• 대한핵의학회지
• /
• 제24권2호
• /
• pp.337-342
• /
• 1990

A case of a 39-year-old man with granulocytic sarcoma documented by positive Ga-67 scan is described and brief review of literature was performed. He was diagnosed as acute myelogenous leukemia and got complete remission with antileukemic chemotherapy for 7 months. On admission, picture of his bone marrow and peripheral blood showed remission state of leukemia. Radiologic examinations were performed for evaluation of lesions in head and chest, and findings of granulocytic sarcoma were suspected. So we got $^{67}Ga-citrate$ scan and pleural biopsy for identification of causes of intractable pleural effusion and skin lesion. Myeloblastomas (or granular sarcomas) proved by pleural biopsy were correctly identified by $^{67}Ga-citrate$ scan, and disease extent was clearly delineated. We believe that $^{67}Ga-scintigraphy$ is very helpful in localizing and follow-up evaluation of granulocytic sarcoma.

• 대한핵의학회지
• /
• 제26권2호
• /
• pp.318-326
• /
• 1992

Ga-67 citrate scan has been requested for detection or follow-up of inflammatory or neoplastic disease. Visualization of Ga-67 citrate in the kidneys at 48 and 72 hr post injection is usually interpreted as evidence of renal pathology. But precise mechanisms of abnormal Ga-67 uptake in kidneys were unknown. We undertook a study to determine the clinical value of Ga-67 citrate imaging of the kidneys in 68 patients with primary or secondary nephropathy confirmed by renal biopsy and 66 control patients without renal disease. Renal uptake in 48 to 72 hr images was graded as follows: Grade 0=back-ground activity:1=faint uptake greater than background;2=definite uptake, but less than lumbar vertebrae; 3=same uptake as lumbar vertebrae, but less than liver; 4=same or higher uptake than liver. The results were as follows. 1) 42 of 65 (62%) patients with noninfectious nephritis showed grade 2 or higher Ga-67 renal uptake but only 10 percent of control patients showed similar uptake. 2) In 14 patients with systemic lupus erythematosus, 8 of 9 (89%) patients with lupus nephritis exhibited marked renal uptake 3) 36 of 41 patients (88%) with combined nephrotic syndrome showed Grade 2 or higher renal uptake. 4) Renal Ga-67 uptake was correlated with clinical severity of nephrotic syndrome determined by serum albumin level, 24 hr urine protein excretion and serum lipid levels. 5) After complete remission of nephrotic syndrome, renal uptake in all 8 patients who were initially Grade 3 or 4, decreased to Grade 1 or 0. In conclusion, we think that the mechanism of renal Ga-67 uptake in nephrotic syndrome might be related to the pathogenesis of nephrotic syndrome. In systemic lupus erythematosus, Ga-67 citrate scan is useful in predicting renal involvement.

• Nuclear Medicine and Molecular Imaging
• /
• 제43권4호
• /
• pp.366-367
• /
• 2009

Ga-67 scintigraphy demonstrated increased uptake in the lungs and stomach in a 26-year-old man with hypercalcemia. A primitive neuroectodermal tumor was confirmed by bone marrow examination. Tc-99m MDP uptake in the same locations as Ga-67 revealed by bone scintigraphy was consistent with metastatic calcification. Although the mechanism of Ga-67 uptake in metastatic calcification is not understood, the presence of an inflammatory process is suggested.

• 대한핵의학회지
• /
• 제19권1호
• /
• pp.83-93
• /
• 1985

The ability of $^{67}Ga$, administered carrier free as the citrate complex, to localize in human and animal tumors to an extent sufficient to permit visualization of the lesion by scanning is well established. However, neither the mechanism of $^{67}Ga$ uptake by tumors or inflammatory cells nor its relationship to cell type or to the biochemical status of the cell is yet understood. Author investigated the uptake of $^{67}Ga-citrate$ using subcellular tissue fractionation of rat livers treated with $CCl_4$ associated with the $^3H-thymidine$ incorporation rate to detect subcellular localization of $^{67}Ga$ and it's relationship in DNA synthesis. Large amounts of $^{67}Ga$ associated with the soluble portion of tissue homogenate rather than with isolated cell organelles and not related nuclei residue in the regenerating period after hepatocellular injury caused by $CCl_4$. The elevated uptake of $^{67}Ga$ in the livers of $CCl_4$ treated rats was also inhibited when protein synthesis was stopped by cyclohexamide. Thus protein and the soluble portion of issue homogenates seems to play an important role in the elevated uptake of $^{67}Ga$ in liver injury induced by $CCl_4$ treated rats.

• 대한핵의학회지
• /
• 제33권4호
• /
• pp.381-387
• /
• 1999

목적: 직업성 질병은 원인 규명과 함께 병의 진행정도를 정확히 평가하는 것이 중요하여 ILO에서 흉부 X-선 소견을 기준으로 국제표준화를 시행하여 왔으나 사진의 질에 영향을 받을 수 있고, 초기 병변을 발견하기에는 어려움이 많다. 본 연구자들은 Ga-67의 섭취정도를 규폐증의 진행 정도를 나타내는 지표로 이용하기 위하여 폐기능검사 및 흉부 X-선 소견에 의한 임상적 병기 분류와의 상관관계를 보고자하였다. 대상 및 방법: 25명의 규폐증 환자를 대상으로 Ga-67 신티그라피를 분석하였으며 10명의 정상인을 대조군으로 하였다. 검사방법은 Ga-67 citrate, 5 mCi를 정맥 주사한 후 48시간 후 전신 스캔 및 흉부, 복부 스캔 영상을 얻어 후면상에서 간과 폐병변의 최대 섭취 부위의 관심영역을 설정하여 픽셀당 방사능 섭취 정도의 비를 구하여 임상적 병기 분류와의 상관관계를 비교 분석하였다. 결과: L/L Ratio 값은 정상군 0형(n=10): $0.3948{\pm}.0692$0, 1형(n=10): $0.5763{\pm}$0.1837, 2형(n= 11): $0.6849{\pm}0.1459$, 3형(n=4): $0.9913{\pm}0.0712$였으며 흉부 X-선의 분류형과 서로 유의한 상관관계를 보였다(r=0.618, p<0.05). 그러나 L/L Ratio 값과 폐기능검사 지표와는 통계적으로 유의하지 않았다. 결론: 저자들의 연구에 따르면 규폐증의 진행과정을 평가하여 환자의 병기를 결정하는 데 Ga-67 신티그라피의 정량적인 분석이 도움을 주었다. 그러나 폐기능과는 상관관계가 없어 폐기능을 평가하는 지표가 되지 못하였다.

• 동위원소회보
• /
• 제7권1호
• /
• pp.4-5
• /
• 1992

• 대한핵의학회지
• /
• 제26권1호
• /
• pp.116-123
• /
• 1992

$^{123}I$ has ideal half life of 13 hours, suitable 159 keV gamma energy for imaging, and easy labeling methods. In Korea Cancer Center Hospital, $^{123}I$ has been produced by MC-50 cyclotron. The purpose of this study is looking for good labeling condition of $^{123}I$ and $^{99m}Tc$ to nonspecific human polyclonal IgG, and comparing these with $^{67}Ga-citrate$ in the abscess bearing mice. Human polyclonal nonspecific IgG was labeled with 0.2 M phosphate buffer added $^{123}I$ by chloramine T method. Human polyclonat nonspecific IgG was labeled with $^{99m}Tc-gluconate$ after activation with $\beta-mercaptoethanol$. In the abscess bearing mice, the radioactivity in the abscess was higher in 24 hours than 6 hours after injection. In the abscess, $^{123}I$ nonspecific IgG had higher uptake than $^{99m}Tc-IgG\;or\;^{67}Ga-citrate$. There was no significant difference in absecess uptake of $^{123}I-IgG$ among 24, 72, 120 hours abscess age. Further clinical researches with $^{123}I-nonspecific$ IgG, and other immunoscintigraphies using $^{123}I$ are expected.

• Nuclear Medicine and Molecular Imaging
• /
• 제40권3호
• /
• pp.177-185
• /
• 2006

목적 : 본 연구의 목적은 $^{99m}Tc$-방사성표지 트렌스페린 ($^{99m}Tc$-transferrin)을 개발하여 감염/염증병소의 진단에 이용할 수 있는지 알아보고, 이를 $^{67}Ga$-Citrate 영상과 비교하고자 하였다. 대상 및 방법 : Succinimidyl 6-hydrazino-nicotinate hydrochloride -chitosan -transferrin (Transferrin)을 합성하고, 여기에 $^{99m}Tc$ 방사성 표지를 시행하였다. $^{99m}Tc$-transferrin의 방사성표지효율은 표지 후 10분, 30분, 1시간, 2시간, 4시간, 8시간에 측정하였다. 포도상구균(ATCC 25923, $2{\times}10^8$ colony forming unite, 0.2 ml)을 접종한 쥐농양모델에서 $^{99m}Tc$-transferrin과 $^{67}Ga$-citrate의 생체내 분포를 평가하고 영상 검사를 실시하였다. 결과: 질량분석계를 이용하여 Transferrin이 성공적으로 제조되었음을 알 수 있었다. $^{99m}Tc$-transferrin의 방사성표지효율은 10분, 30분, 1시간, 2시간, 4시간, 8시간에 각각 $96.2{\pm}0.7%,\;96.4{\pm}0.5%,\;96.6{\pm}1.0%,\;96.9{\pm}0.5%,\;97.0{\pm}0.7%\;and\;95.5{\pm}0.7%$ 이었다. $^{99m}Tc$-transferrin의 단위섭취량은 감염병소에서 $0.18{\pm}0.01\;and\;0.18{\pm}0.01$, 정상근육에서 $0.05{\pm}0.01\;and\;0.04{\pm}0.01$이었고, 감염병소 대 정상근육 섭취비는 30분과 3시간에 각각 $3.7{\pm}0.6\;and\;4.7{\pm}0.4$이었다. $^{99m}Tc$-transferrin 영상에서 10분, 30분, 1시간, 2시간, 4시간 그리고 10시간에서의 병소/배후방사능비는 각각 $2.18{\pm}0.03,\;2.56{\pm}0.11,\;3.08{\pm}0.18,\;3.77{\pm}0.17,\;4.70{\pm}0.45$ 그리고 $5.59{\pm}0.40$이었고, $^{67}Ga$-citrate의 경우 2시간, 24시간, 48시간에 $3.06{\pm}0.84,\;4.12{\pm}0.54\;4.55{\pm}0.74 $이었다. 결론 : Transferrin에 $^{99m}Tc$을 이용한 방사성표지가 성공적으로 이루어졌고, $^{99m}Tc$-transferrin의 표지효율은 8시간까지 95% 이상의 안정된 방사성표지효율을 보였다. $^{99m}Tc$-transferrin을 이용한 감염영상을 성공적으로 얻을 수 있었으며, $^{67}Ga$-citrate 영상과 비교하여 더 빠른 시간 안에 우수한 영상을 얻을 수 있었다. 그러므로 $^{99m}Tc$-transierrin이 감염 병소의 영상진단에 사용될 수 있을 것으로 기대된다.

• 대한핵의학회:학술대회논문집
• /
• 대한핵의학회 1988년도 제27차 춘계학술대회
• /
• pp.145-145
• /
• 1988