• Korean Journal of Food Science and Technology
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• v.30 no.1
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• pp.192-198
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• 1998

In this study, we intended to evaluate the modulatory effects of natural products, ${\beta}-carotene$, aloesin and semiessential amino acid, taurine on the toxicitiy of paraquat. In the taurine treated groups, serem glutamic oxaloacetic transaminase (s-GOT), serem glutamic pyruvic transaminase (s-GPT). blood urea nitrogen (BUN), creatinine, malondialdehyde (MDA), alkaline phosphatase (ALP) activity in serum and MDA, ALP activity, collagen in lung tissue were decreased to the normal values. In the aloesin treated groups, s-GPT, BUN, creatinine, MDA level in serum were decreased to the normal values significantly. In the ${\beta}-carotene$ treated group, only s-GPTactivity was reduced to the normal values. In the lung tissue of taurine treated groups, MDA value, G-6-phosphatase activity and collagen synthesis were recovered to the normal valuse and ALP activity was increase about 40%. From these results, we concluded that taurine is an effective agent to inhibit the pulmonary and internal organs toxicities induced by paraquat and the inhibition effects of taurine are due to remove free radicals directly.

• The Korea Journal of Herbology
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• v.28 no.6
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• pp.31-38
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• 2013

Objectives : The purpose of this study was to determine whether NMED-01 or NMED-02 improves laboratory test results in participants with liver function disorder. Methods : This is a randomized, placebo-controlled trial in which participants, treating physicians and data management staff were blinded to treatment group. The study was conducted at Semyung university oriental medicine hospital in Jecheon where participants with high level of serum ${\gamma}$-GTP (60-350 U/L) were enrolled. The intervention consisted of three times daily ingestion of either two capsules of placebo, NMED-01 (NeuMed. co. ltd., Seoul), or NMED-02 (NeuMed. co. ltd., Seoul) for twelve weeks. To evaluate the efficacy and safety of NMED-01 and NMED-02, we primarily evaluated the degree of decrement of serum ${\gamma}$-GPT level among three groups. Secondarily the decrement of serum ALT, AST, and triglyceride level in each group were also evaluated. Adverse effects were monitored during the twelve weeks treatment. Results : The change of ${\gamma}$-GTP level of NMED-01 group was lower than that of placebo group at the end of 12-week administration ($28.1{\pm}38.7U/L$ vs. $9.3{\pm}27.0U/L$, p=0.046). Other variables including AST, ALT, and triglyceride level were not significantly reduced. The decrement of ${\gamma}$-GPT, AST, ALT, and triglyceride level of NMED-02 group was not significant. There were no significant adverse effects or toxicities during treatment period. Conclusions : Participants receiving NMED-01 had improvement in laboratory test results. Despite a modest sample size, our results suggest that NMED-01 are safe and may be potentially effective in improving liver function. However, NMED-02 have lack of a detectable effect in this study.

• Journal of Veterinary Clinics
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• v.17 no.1
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• pp.28-31
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• 2000

An animall health monitoring system in Gyeongnam area(near Chinju) was studied to analysis of biochemical risk factors in 617 herds. Clinical serum factors such as glutamate oxaloacetate transaminase(GOT), glutamate pyruvate transaminase(GPT), Ca, P, Mg, glucose, and cholesterol were measured with automatic biochemical analyzer(Ra-X7T Techmmicon, USA). In serum analysis, 613 cattle were within normal llimits(GOT: 9.5-85 IU-dl, GPT: 25-77IU/dl, total protein: 5.8-8.5g/dl, Ca: 4.2-12.4mg/dl, P: 4.6-9.7mg/dl, Mg: 1.5-3.0mg/dl, glucose: 48-120mg/dl, Cholesterol: 70-170mg/dl), the other cattle showed high glucose and high cholesterol level. It is proposed that clinical serum factors to be estimated may be valuable for developing of animal health monitoring system model.

• The Journal of Pediatrics of Korean Medicine
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• v.9 no.1
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• pp.237-256
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• 1995

Maduryung Extract, one of herbal medicine was tested for inhibitory effect to alcohol, acetaminophen and d-galactosamine induced hepatitis in rats. The results were as follows. 1. Increaced serum GOT, GPT levels by alcohol were significantly decreased by Maduryung extract.(p<0.01) 2. Maduryung extract decreaced GOT value in acetaminophen induced hepatitis and this effect may be due to increace of GSH level in liver tissue.(p<0.05) 3. Repeat administration of Maduryung extract showed inhibitory effect on s-GOT, s-GPT levels in d-galactosamine induced hepatitis. (p<0.05) According to the above results, it seems that Maduryung could be use as drug for alcohol or drug induced hepatitis treatment.

• Journal of fish pathology
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• v.15 no.2
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• pp.57-64
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• 2002

Phenanthrene-induced changes in blood organic components. transaminase and ALP activities of Paralichthys oIivaceus were investigaled. The aim of this study was to obtain a holistic view of the toxic responses, and compensations of fish exposed to waterborne phenanthrene. Fish were exposed to 0, 0.5, 1, 2$\mu$M of phenanthrene for 4 weeks. The most noticeable changes were concentration-dependent increase in levels of blood GOT and GPT activities. At concentrations 1.0 and 2.0 $\mu$M of phenanthrene GOT, GPT and ALP enzyme activities in plasma were increased. Plasma albumin concentration was stable in phenanthrene-exposed fish, however, plasma total protein level was reduced significantly at the 4-week sampling points (2.0$\mu$M). Plasma glucose levels were found to be increased significantly over the cootrol throughout duration of the experiment with phenanthrene. Overall the results suggest that phenanthrene has the potential to alter some physiological functions in olive flounder.

• The Korean Journal of Food And Nutrition
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• v.7 no.2
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• pp.108-113
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• 1994

This study was carried out to evaluate the effect of Cnidi rhizoma (CR) water extract on fat accumulation In fatted rats induced by the oral high fat administration for six weeks. To accomplish this evaluation, the serum and liver tissue have been examined for enzyme activity, cortisol and insulin level. The change of liver or tissue have been observed by the light microscope. GOT GPT and LDH activities were lower than the control group. Insulin and cortisol were higher than the control group, due to the fat accumulation. The liver of the control group observed by the tight microscope appeared to the fatty liver, but CR group showed some improvement of the fatty liver Based on the above results, it was shown that it is possible to improve fat accumulation induced by high fat dietary through using the oral administration of Cnidi rhizoma water extract.

• The Korean Journal of Pharmacology
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• v.9 no.1
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• pp.47-51
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• 1973

A benzomorphan derivative, pentazocine has both opioid agonistic actions and weak narcotic antagonistic activity. In this paper, authors attempted to study the dose response of pentazocine on the blood sugar level, serum transaminase and alkaline phosphatase activity in rabbits. Eighteen rabbits were devided into 3 groups, and each group were injected with pentazocine 5mg, 15mg, and 30mg/kg respectively. And metabolic effects were investigated measuring the change of blood sugar contents, serum transaminase (S-GOT, S-GPT) activities and alkaline phosphatase activities in rabbits. The results were obtained as follows; 1. Pentazocine significantly increased the blood sugar content in rabbits. 2. Pentazocine significantly increased the serum GOT activity but in the serum GPT activity, it significantly increased in large dose. 3. Pentazocine significantly increased serum alkaline phosphatase activity.

• Korean Journal of Pharmacognosy
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• v.22 no.1
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• pp.36-44
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• 1991

This study was attempted to investigate the acute toxicity of Liocolae vermiculus(Liocola brevitarsis) extract in mice, the effect on GOT, GPT Al.p, LDH activities and level of total cholesterol in serum of $CCl_4-intoxicated$ rats. In acute toxicity test, Liocolae vermiculus extract showed 10% mortality at 2,000 mg/kg, p.o. and at 1,000 mg/kg, i.p.. The Liocolae verculus extract caused a remarkable decrease in serum transaminase as well as Al.p activities in $CCl_4-intoxicated$ rats at $300{\sim}1,000{\;}mg/kg$ dosage ranges. The activities of -LDH and the level of total cholesterol were significantly decreased in all sample-treated group, when compared with the control group. The body weight decreased, and the liver and spleen weight increased in $CCl_4-intoxicated$ rats were significantly recovered by the administration of the extracts.

• Journal of fish pathology
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• v.2 no.2
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• pp.91-98
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• 1989

The effects of Miyairi (Clostridium butyricum) on blood constituents and growth of cultured freshwater fishes, such as carp, tilapia and israeli carp were studied and then the following results were obtained : 1) All fishes produced the most efficient growth in 0.1% Miyairi-treated group. 2) Blood constituents of Miyairitreated group compared with those of contrul gruop showed no changes in RBCs. hemoglobin and hemato crit. and the increase in plasma protein and glucose. and the decrease in plasma cholesterol. 3) GOT level and GPT level in blood of Miyairi-treated group were almost equal to those in blood of control group.

• Korean Journal of Plant Resources
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• v.11 no.2
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• pp.173-178
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• 1998

The feeding effects of Herba hottuynia extracts on the lipids profiles and the content of TAB-reactive substances were evaluated in rats fed a high cholesterol diet. Hot water or ethanol extracts of the dried leave were evaporated and lyophilized . The experimental animals wer edevided to four groups and fed the following diets for 4 weeks : BAsal (cholesterol-free diet), CHOL(cholesterol-enriched diet),CW (cholesterol plus water extract) and CE(cholesterol plus ethanol extract). Dietary cholesterol increased significantly the activities of serum GOT and GPT, but the extracts feeding (0.5% of diet) did not influence the activities induced by dietary cholesterol. Although dietary cholesterol increased significantly the concentrationof serum andliver cholesterol, it tended to decrease the concentation of serum triglycerides. CHolesterol feeding had a lowering effect on the lipid peroxidation value of serum, but not inliver.Furthermore, the extracts feeding, especially water extract, decreased markedly the liver peroxidation value. The results suggest that Houttyunia cordata extracts have an in vivo antioxidant effect, judged from the TBA value in the liver rats fed a high cholesterol diet.