• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.6
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• pp.1602-1607
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• 2004

3-O-D-galactopyranosylglyceride (GPG; fatty acids R1, R2 = myristic acid 11.62%, palmitic acid 61.90% and oleic acid 26.48%) was isolated from Chrysanthemum coronarium L that has been used for treating renal and cardiovascular diseases as one of vegetables or medicinal drug. However, little was known about the anti-angiogenic activity of GPG. Thus, anti-angiogenic effect of GPG was evaluated in human umbilical vein endothelial cells (HUVECs) in vitro and in vivo. GPG effectively inhibited bFGF-induced migration and invasion of HUVECs in a concentration-dependent manner, whereas it did not inhibit bFGF-induced proliferation and capillary-like tube formation of HUVECs. To examine the mechanism of anti-angiogenic activity of GPG, gelatin zymography was carried out. GPG downregulated the expression of matrix metalloproteinase-2 in a concentration-dependent manner. Furthermore, GPG significantly disrupted bFGF-induced neovascularization on the chick chorioallantoic membrane assay in vivo. These results suggest that 3-O--D-galactopyranosylglyceride may inhibit neovascularization by inhibiting angiogenic activity of endothelial cells via regulation of matrix metalloproteinase-2 (MMP-2).

• Journal of the Korean Chemical Society
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• v.37 no.4
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• pp.378-389
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• 1993

The release of steroids such as progesterone, testosterone, estrone and estradiol were investigated in two types of block copolymer matrices, which were AB type block copolymer composed of poly(γ-benzyl-L-glutamate)[PBLG] as the A segment and polyoxypropylene[POP] as the B segment and ABA type triblock copolymer composed of the A segment and poly(propylene glycol)[PPG] as the B segment. The release rates of progesterone, estradiol and testosterone through PBLG-POP1 and PBLG-POP2 matrices and those of progesterone, estrone and testosterone through GPG1 of ABA type triblock copolymer were higher in an acidic solution than in a basic one. However, the release rate of estrone through PBLG-POP1 and PBLG-POP2 matrices and that of estradiol through GPG1 of ABA type triblock copolymer were higher in a basic and neutral solutions than in an acidic one. The order of release rate in three different matrices was GPG1 > PBLG-POP1 > PBLG-POP2. The results also showed that the molecular weight of steroids is inversely proportional to the rate of release.

• Journal of the Korea Organic Resources Recycling Association
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• v.28 no.1
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• pp.37-51
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• 2020

Following the Paris Agreement adopted at the end of 2015, global stock-taking has been planned to be carried out on a 5-year basis from 2023, and it is mandatory to report on national GHG inventory and progress toward achieving greenhouse gas reduction targets. To prepare for this, it is important to improve the reliability of estimation of the greenhouse gas emission, identify the characteristics of each greenhouse gas emission source, and manage the amount of emissions. As such, this study compared and analyzed the amount of emissions from the landfill sector using the 2000 GPG, the 2006 IPCC Guidelines, and the 2019 Refinement estimation method. As a result, in comparison to 2016, there were 2,287 Gg CO₂_eq. in scenario 1, 1,870 Gg CO₂_eq. in scenario 2-1, 10,886 Gg CO₂_eq. in scenario 2-2, 10,629 Gg CO₂_eq. in scenario 2-3, and 12,468 Gg CO₂_eq. in scenario 3. Thus, when the 2006 IPCC Guidelines were applied with respect to 2000 GPG, it was revealed that greenhouse gas emissions have increased. Such difference in the emission changes was due to the changes in the calculation method and the emission factor values applied. Therefore, it is urgent to develop national-specific values of the emission factor based on characteristics of greenhouse gas emission in Korea.

• Resources Recycling
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• v.25 no.5
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• pp.28-35
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• 2016

The purpose of this study was to estimate greenhouse gas emissions using IPCC 1996 Guideline Tier 1, Good Practice Guidance 2000 Tier 2 and IPCC 2006 Guideline First Order Decay methods from landfill disposal facility. In addition, a comparative analysis evaluating the pros and cons of each method based on assumptions and default factors was considered for each method. The greenhouse gas emission computed using IPCC 1996 Guideline Tier 1 method (2,760 ton/yr) was higher than the estimation of GPG 2000 Tier 2 and IPCC 2006 Guideline First Order Decay Model which showed 1500 and 880 ton/yr respectively between 2000 and 2013.

• Journal of Pharmaceutical Investigation
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• v.27 no.1
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• pp.39-49
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• 1997

Nicotinic acid was mixed with glass powders such as controlled pore glass (CPG), glyceryl controlled pore glass (GPG) and glass beads (GB) at room temperature. The physicochemical properties of nicotinic acid in the various mixtures were examined by differential thermal analysis, X-ray diffraction study. Infrared spectroscopy and BET gas adsorption measurements. The peak area at the melting point from the various mixtures of nicotinic acid and CPG was increased with an increase of nicotinic acid concentration while the broad peak area was remained unchanged in the DTA curve. As shown in the powder X-ray diffraction patterns, the crystalline peaks of nicotinic acid disappeared in mixture with CPG, suggesting the interaction of nicotinic acid and porous powders. It was found that the larger the content of CPG, the higher the ratio of an amorphous state to a crystalline state. BET isotherm showed that as the amount of nicotinic acid was increased, the specific surface area was reduced proportionally to nicotinic acid content of up to 40% and remained constant thereafter. Sublimation of nicotinic acid from the mixture of nicotinic acid and CPG was examined. A large quantity of nicotinic acid was retained in the mixture when stored on various temperatures in vacuo for 10 hours. The nicotinic acid mixtures with CPG or GPG showed a high dissolution rates of nicotinic acid in aqueous solution, especially in the initial dissolution stage. CPG is expected to be a good pharmaceutical excipient to reduce the crystallinity of drugs and to prevent sublimation of drugs.

• Journal of Korean Society of Rural Planning
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• v.19 no.4
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• pp.125-135
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• 2013

Analysis and evaluation of uncertainty is adopting the advanced methodology among the methods for greenhouse gas emission assessment that was defined in GPS2000 (Good practice guideline 2000) and GPG-LULUCF (GPG Land Use, Land-Use Change and Forestry). In 2006 IPCC guideline, two approaches are suggested to explain the uncertainty for each section with a national net emission and a prediction value on uncertainty as follows; 1) Spread sheet calculation based on the error propagation algorithm that was simplified with some assumptions, and 2) Monte carlo simulation that can be utilized in general purposes. There are few researches on the agricultural field including greenhouse gas emission that is generated from livestock and cultivation lands due to lack of information for statistic data, emission coefficient, and complicated emission formula. The main objective of this study is to suggest an evaluation method for the uncertainty of greenhouse gas emission in agricultural field by means of intercomparison of the prediction value on uncertainties which were estimated by spread sheet calculation and monte carlo simulation. A statistic analysis for probability density function for uncertainty of emission rate was carried out by targeting livestock intestinal fermentation, excrements treatment, and direct/indirect emission from agricultural lands and rice cultivation. It was suggested to minimize uncertainty by means of extraction of emission coefficient according to each targeting section.

• Proceedings of the Korean Society of Toxicology Conference
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• 2001.10a
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• pp.189-189
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• 2001

For a continuous expression of human cytochrome p450 3A5 (CYP3A5) and NADPH-cytochrome P450 reductase (CYPR) proteins, bicistronic construct (CYP3A5BC-LNCX2) was made using internal ribosome entry site (IRES). As for mammalian cell expression, we used pLNCX2 retroviral vector; and using calcium phosphate, plasmid transfer was achieved in 293GPG cell and transduced in Chinese hamster ovary (CHO) cell.(omitted)

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.11
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• pp.1673-1685
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• 2019

Objective: To evaluate the efficacy of treatments based on gonadotrophin-releasing hormone (GnRH), GnRH-prostaglandin $F2{\alpha}$ ($PGF2{\alpha}$), and/or intense exposure to novel rams to induce fertile estrus without the use of steroid hormones in seasonally anestrous Suffolk ewes. Methods: In the first experiment, ewes were treated with one injection of GnRH, two injections of GnRH administered 7 days apart, or a sequence of GnRH-$PGF2{\alpha}$-GnRH (GPG). In the second experiment anestrous ewes were exposed, for 36 days starting on the day of weaning, to groups of four rams of three different breeds that were alternated every day. Besides exposure to the male effect (ME), the ewes were injected with saline solution (ME group, n = 20), with GnRH (ME-GnRH group, n = 20) or with a sequence of GnRH-$PGF2{\alpha}$-GnRH (ME-GPG group, n = 20). The rams used for male-effect were fitted with aprons to prevent mating, and ewes detected in estrus were bred to selected fertile rams. Ovarian activity was monitored by progesterone determinations in both experiments. Results: In the first experiment sustained induction of ovarian activity was not achieved and no ewe was detected in estrus. In the second experiment induction of sustained ovarian activity was achieved in all groups. Most of the ewes were detected in estrus, 76.7% of the ewes were mated during a 36-d breeding period and 71.7% of all the ewes became pregnant during that period. No significant differences between groups were found for any of these variables. However, estrus detection efficiency was higher in the ME-GnRH group than in the ME group (p<0.05). Conclusion: An intense male-effect, that included the continuous presence and frequent alternation of several rams of different breeds, was sufficient to induce ovarian activity and fertile estrus in Suffolk ewes during the period of deep anestrus without the use of hormones, although addition of GnRH improved the efficiency of estrus detection.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• v.2
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• pp.107-112
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• 2006

The previous acquisition method of GPS receiver for reference station adopts not only the coherent integration method but also the non-coherent integration method in order to enhance sensitivity under noisy environment. However, under noisy environment, the previous GPS signal acquisition method causes the non-coherent integration loss which is a major factor among losses that can be caused during GPS signal acquisition. The non-coherent integration loss also increases with the strength of the received noise. This paper has intention of analyzing the performance of the GPS signal acquisition method proposed to effectively enhance sensitivity of DGPS reference receiver under noisy environment. This paper presents that the proposed GPS signal acquisition method suppresses the non-coherent integration loss through post-processing simulation. Furthermore, with regard to the mean acquisition time, it is shown that the number of search cells of the proposed GPS signal acquisition method is much fewer than that of the previous GPS signal acquisition method.

• Journal of Climate Change Research
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• v.9 no.1
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• pp.81-90
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• 2018

"The Framework Act on Low-Carbon Green Growth" specifies the requirements for the development and verification of emission factors for establishing reliable national greenhouse gas statistics. The scope of the regulations covers the development and validation of energy, industrial processes, solvents and other product use, agriculture, land use, land use change and emission and absorption coefficients of the forestry and waste sector as defined in the 1996 IPCC Guideline and GPG 2000, The minerals sector to be covered in this study belongs to industrial processes. As a representative method for quantifying and evaluating GHG emission factors, there are emission grade quality grading and DARS (Data Rating Rating System) in the 'Procedures for Preparing Emission Factor Documents (1997)' reported by US-EPA. However, the above two methods are not specific and comprehensive, and lack the details for accurate emission factor verification. Therefore, there is a need for a method for verifying and quantifying certified greenhouse gas emission factors that reflects characteristics of each industry sector in Korea and accord with IPCC G/L and GHG target management. In this study, we conducted a weighted study on quantitative and evaluation lists of emission factor using questionnaires to develop a more accurate methodology for quantifying national greenhouse gas emission factors in the mineral sector. Quantification and evaluation of emission factor are classified into essential verification and quality evaluation. The essential verifications are : administrative compatibility, method of determining emission factors, emission characteristics, sampling methods and analysis methods, representativeness of data. The quality evaluations consisted of the quality control of the data, the accuracy of the measurement and analysis, the level of uncertainty, not directly affect the emission factor, but consisted of factors that determine data quality.