Browse > Article

Antiangiogenic Effect of 3--O-D-galactopyranosylglyceride Isolated from Chrysanthemum Coronarium L.  

Lee Hyun Cheol (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Song Ho Chul (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Lim Jin Ki (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Khil Jae Ho (Department of Sports Medicine, College of Sports Science, Kyunghee University)
Kim Sung Hoon (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.6, 2004 , pp. 1602-1607 More about this Journal
Abstract
3-O-D-galactopyranosylglyceride (GPG; fatty acids R1, R2 = myristic acid 11.62%, palmitic acid 61.90% and oleic acid 26.48%) was isolated from Chrysanthemum coronarium L that has been used for treating renal and cardiovascular diseases as one of vegetables or medicinal drug. However, little was known about the anti-angiogenic activity of GPG. Thus, anti-angiogenic effect of GPG was evaluated in human umbilical vein endothelial cells (HUVECs) in vitro and in vivo. GPG effectively inhibited bFGF-induced migration and invasion of HUVECs in a concentration-dependent manner, whereas it did not inhibit bFGF-induced proliferation and capillary-like tube formation of HUVECs. To examine the mechanism of anti-angiogenic activity of GPG, gelatin zymography was carried out. GPG downregulated the expression of matrix metalloproteinase-2 in a concentration-dependent manner. Furthermore, GPG significantly disrupted bFGF-induced neovascularization on the chick chorioallantoic membrane assay in vivo. These results suggest that 3-O--D-galactopyranosylglyceride may inhibit neovascularization by inhibiting angiogenic activity of endothelial cells via regulation of matrix metalloproteinase-2 (MMP-2).
Keywords
3-O--D-galactopyranosylglyceride; proliferation, migration; tube formation; CAM; MMP-2;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Antifungal activity of the essential oil of flowerheads of garland chrysanthemum (Chrysanthemum coronarium) against agricultural pathogens /
[ Alvarez-Castellanos PP;Bishop CD;Pascual-Villalobos MJ. ] / Phytochemistry.   ScienceOn
2 /
[ 허준 ] / 동의보감
3 Antibacterial activity of fresh flower heads of Chrysantemum coronarium /
[ Urzua A;Mendoza L. ] / Fitoterapia.   ScienceOn
4 /
[ 대한병리학회 ] / 병리학
5 /
[ Folkman, J.;Siegel, Y. Angiogenesis. ] / J Biol Chem.
6 Signaling vascular morphogenesis and maintenance /
[ Hanahan, D. ] / Science.
7 Anti-metastastic effects of Xuefuzhuyutang /
[ Lee JH;Shim BS;Ahn KS;Choi SH. ] / Journal of Korean Oriental Oncology
8 Inhibition by galloylglucose(GG6-10) of tumor invasion through extracellular matrix and gelatinase-mediated degradation of type IV collagens by metastatic tumor cells /
[ Ata, N;Oku, T;Hattori, M;Fujii, H;Nakajima, M;Saiki, I. ] / Oncology Research
9 Evalulation of a soluble tetrazolium/ formazan assay for cell growth and drug sensivity in culture using human and other tumor cell lines /
[ Scudiero, D.A.;Shoemaker, R.H.;Paull, K.D.;Monks, A.;Tierney, S.;Nofziger, T.H.;Currens, M.J.;Seniff, D.;Boyd, M.R. ] / Cancer Res.
10 Inhibition by galloylglucose(GG6-10) of tumor invasion through extracellular matrix and gelatinase-mediated degradation of type IV collagens by metastatic tumor cells /
[ Ata, N;Oku, T;Hattori, M;Fujii, H;Nakajima, M;Saiki, I. ] / Oncology Research
11 Vegetable, fruit and meat consumption and potential risk modifying genes in relation to colorectal cancer /
[ Turner F;Smith G;Sachse C;Lightfoot T;Garner RC;Wolf CR;Forman D;Bishop DT;Barrett JH. ] / Int J Cancer.   ScienceOn
12 Sesquiterpene lactones from Chrysanthemum coronarium /
[ EI-Masry,S.;Abou-Dania, A. H. A.;Darwish, F. A.;Abou- Karum, M. A.;Grenz, M.;Bohlmann F. ] / Phytochemistry
13 New acetylenes from Chrysanthemum coronarium L. /
[ Sanz, J. F.;Falco, E.;Marco, J. A. ] / Liebigs. Ann Chem.
14 Antifungal activity of the essential oil of flowerheads of garland chrysanthemum (Chrysanthemum coronarium) against agricultural pathogens /
[ Alvarez-Castellanos, P. P.;Bishop, C. D.;Pascual- Villalobos, M. J. ] / Phytochemistry.   ScienceOn
15 Endostatin: an endogenous inhibitor of angiogenesis and tumor growth /
[ O'Reilly MS;Boehm T;Shing Y;Fukai N;Vasios G;Lane WS(et al.) ] / Cell
16 Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma /
[ O'Reilly MS;Holmgren L;Shing Y;Chen C;Rosenthal RA;Moses M(et al) ] / Cell
17 Oxyanthraquinones and flavonoids from garland chrysanthemum /
[ Gins VK;Kolesnikov MP;Kononkov PF;Trishin ME;Gins MS. ] / Prikl Biokhim Mikrobiol.
18 Human dermal microvascular endothelial cells produce matrix metalloproteinases in response to angiogenic factors and migration /
[ Cornelius L. A.;Nehring L. C;Roby J. D;Parks W. C.;Welgus H. G. ] / J Invest Dermatol.   ScienceOn
19 Stability and bioavailability of antioxidants in garland (Chrysanthemum coronarium L.) /
[ Takenaka M;Nagata T;Yoshida M. ] / Biosci Biotechnol Biochem.   ScienceOn