• 한국산학기술학회:학술대회논문집
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• 한국산학기술학회 2011년도 춘계학술논문집 1부
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• pp.29-34
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• 2011

비접촉 거리측정 장치인 레이저스캐너를 이용하여 무인차량의 평행주차 및 직각주차 알고리즘 개발을 목적으로 하였다. 이 알고리즘을 검증하기 위하여 GPS와 차량에 6대의 레이저스캐너를 장착하여 이용하였고, 레이저스캐너를 이용한 위치 계산의 오차를 줄이기 위해 타이어 미끄러짐을 최소로 할 수 있도록 5km/h로 차량의 이동 속도를 제한하였다.

• Journal of Pharmaceutical Investigation
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• 제37권2호
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• pp.107-111
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• 2007

Epigallocatechin gallate (EGCC), a flavonoid, is the main component of green tea extracts. EGCG has been reported to be an inhibitor of P-glycoprotein (P-gp) and cytochrom P450 3A(CYP3A4). This study investigated the effect of long-term administration of EGCG on the pharmacokinetics of verapamil in rats. Pharmacokinetic parameters of verapamil were determined after oral administration of verapamil (9 mg/kg) in rats pretreated with EGCG (7.5 mg/hg) for 3 and 9 days. Compared to oral control group, the presence of EGCG significantly (p<0.01) increased the area under the plasma concentration-time curve (AUC) of verapamil by 102% (coad), 83.2% (3 days) and 52.3% (9 days), and the peak concentration $(C_{max})$ by 134% (coad), 120% (3 days) and 66.1% (9 days). The absolute bioavailability (A.B.%) of verapamil was significantly (p<0.01) higher by 8.4% (coad), 7.7% (3 days), 6.4% (9 days) compared to control (4.2%), and presence of EGCG was no significant change in the terminal half-life $(t_{1/2})$ and the time to reach the peak concentration $(T_{max})$ of verapamil. Our results indicate that EGCG significantly enhanced oral bioavailability of verapamil in rats, implying that presence of EGCG could be effective to inhibit the CYP3A4-mediated metabolism and P-gp efflux of verapamil in the intestine. Drug interactions should be considered in the clinical setting when verapamil is coadministrated with EGCG or EGCG-containing dietary.

• Journal of Ecology and Environment
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• 제43권3호
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• pp.320-331
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• 2019

Background: Dioecious plant species having both male and female plants have been investigated regarding sex-related characteristics such as sex ratio, sex-differential resource requirements, and spatial segregation of the sexes. Habitat loss and fragmentation are major threats to the survival of plant populations, but dioecious species are particularly more prone to such habitat degradation than non-dioecious species because of their dimorphic sexual system. We examined the sex-related demographics of two Ilex cornuta populations being different regarding land use history. Methods: During 2016-2017, we examined I. cornuta trees with a basal diameter ${\geq}1.5cm$ in the Yongsu-ri population (YS population) and the Gotjawal Provincial Park population (GP population). Plant sex (male, female, or unsexed) was identified. The tree size (basal diameter and height of the main stem), clonal production (the ramet numbers per genet), and vitality for each clone were measured. The associations between population, sex, tree size, clonal production, and vitality were examined using ANOVAs and contingency table analyses. Finally, point pattern analyses using O-ring statistics were conducted to assess spatial patterns. Results: Upon excluding unsexed trees, the YS population with 74 trees was significantly male-biased (0.66), while the GP population with only 26 trees had a 1:1 sex ratio. In both populations, males and females did not differ in tree size. Although the mean number of ramets differed significantly between populations, females tended to produce more ramets than males. The proportion of weak trees was significantly higher in the YS than in the GP population. Neither population showed evidence of spatial segregation of the sexes. Conclusions: The two populations of dioecious I. cornuta are characterized by the small number of trees and relatively high frequencies of non-reproductive trees. Both indicate that these populations are quite susceptible to environmental and genetic stochasticity. On the other hand, the differences between populations in sex ratio, clonal production, and vitality suggest that conservation efforts for I. cornuta need to be population-specific. In order to help recover and enable this vulnerable species to persist, it is necessary to find ways to enhance their sexual reproduction and simultaneously reduce habitat disturbances due to anthropogenic activities.

• Molecules and Cells
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• 제38권6호
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• pp.540-547
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• 2015

Attention deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders, affecting approximately 5% of children. However, the neural mechanisms underlying its development and treatment are yet to be elucidated. In this study, we report that an ADHD mouse model, which harbors a deletion in the Git1 locus, exhibits severe astrocytosis in the globus pallidus (GP) and thalamic reticular nucleus (TRN), which send modulatory GABAergic inputs to the thalamus. A moderate level of astrocytosis was displayed in other regions of the basal ganglia pathway, including the ventrobasal thalamus and cortex, but not in other brain regions, such as the caudate putamen, basolateral amygdala, and hippocampal CA1. This basal ganglia circuit-selective astrocytosis was detected in both in adult (2-3 months old) and juvenile (4 weeks old) $Git1^{\check{s}/\check{s}}$ mice, suggesting a developmental origin. Astrocytes play an active role in the developing synaptic circuit; therefore, we performed an immunohistochemical analysis of synaptic markers. We detected increased and decreased levels of GABA and parvalbumin (PV), respectively, in the GP. This suggests that astrocytosis may alter synaptic transmission in the basal ganglia. Intriguingly, increased GABA expression colocalized with the astrocyte marker, GFAP, indicative of an astrocytic origin. Collectively, these results suggest that defects in basal ganglia circuitry, leading to impaired inhibitory modulation of the thalamus, are neural correlates for the ADHD-associated behavioral manifestations in $Git1^{\check{s}/\check{s}}$ mice.

• Asian Pacific Journal of Cancer Prevention
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• 제16권4호
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• pp.1519-1523
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• 2015

Infection of the uterine cervix by human papilloma viruses (HPV) may be associated with cervical pre-cancer and invasive cervical carcinoma if left untreated. With advance in molecular techniques, it has become easier to detect the resence of HPV DNA long before the appearance of any lesion. This study concerned cervical scrape samples of 310 married non-pregnant women attending a gynecology outpatient department for both Pap and PCR testing to detect HPV DNA. Nested PCR using primers for L1 consensus gene with My9/My11 and GP6+/GP5+followed by multiplex PCR were carried out to detect HPV 16 and HPV18. Result: HPV prevalence was 11.9% out of which 3.67% cases of negative for intra-epithelial lesion or malignancy (NILM) and in 71.1% (27/38) of atypical cervical smears were HPV positive. There was increasing trend of high-risk-HPV positivity (HR HPV 16 and 18), from 20% in benign cytology (NILM) to 42.9 % in LSIL, 71.41% in HSIL and 100% in SCC. There was highly significant association of HPV infection with cervical lesion ($x^2=144.0$, p<0.01) and also with type specific HPV prevalence ($x^2=7.761^*$, p<0.05).

• 전기전자학회논문지
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• 제23권1호
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• pp.181-187
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• 2019

In this paper, we demonstrated a power amplifier monolithic microwave integrated circuit (MMIC) for X-band radar applications. It utilizes commercial $0.25{\mu}m$ GaN-based high electron mobility transistor (HEMT) technology and delivers more than 20 W of output power. The developed GaN-based power amplifier MMIC has small signal gain of over 22 dB and saturated output power of over 43.3 dBm (21.38 W) in a pulse operation mode with pulse width of $200{\mu}s$ and duty cycle of 4% over the entire band of 9 to 10 GHz. The chip dimensions are $3.5mm{\times}2.3mm$, generating the output power density of $2.71W/mm^2$. Its power added efficiency (PAE) is 42.6-50.7% in the frequency bandwidth from 9 to 10 GHz. The developed GaN-based power amplifier MMIC is expected to be applied in a variety of X-band radar applications.

• 한국산학기술학회논문지
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• 제17권6호
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• pp.372-378
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• 2016

본 연구의 목적은 농경지 상태 이미지 취득 장치와 농작업 데이터, 날씨 데이터를 데이터베이스화하여 관리할 수 있는 시스템을 구성하는 것이다. 농업관련 외국 회사들은 이미 다양한 방법으로 농업에 관한 데이터베이스를 구축하고 농업의 과학화를 이루어내고 있다. 본 연구의 시스템의 구성은 무인항공기에 탑재되는 GPS와 디지털카메라, PC를 이용한 영상취득 장치, 취득한 여러 영상을 하나의 이미지로 정합하는 부분, GPS와 정합된 영상 간 매칭, 최종적으로 일자별 기상청 날씨정보와 농작업 데이터, 이미지를 데이터베이스화 하는 부분으로 구성된다. 본 연구의 결과로 우리나라 농업의 총 생산량만의 데이터가 아닌 기후와 농작업 데이터 등의 요인과 함께 농경지 이미지로써 결과 확인 및 데이터베이스화 할 수 있는 시스템을 제안하였다. 제안한 시스템을 통해 인공위성 사진에 비하여 최대 약 5배 좋은 화질의 이미지를 얻을 수 있었으며, 농작업과 환경요인 등이 농경지 전체에 미치는 영향 분석 사용 될 기초 데이터를 얻을 수 있었다. 무인항공기를 이용한 농경지 모니터링 시스템을 통하여 우리나라 농업의 과학적 분석에 기여할 것으로 기대된다.

• The Korean Journal of Physiology and Pharmacology
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• 제9권2호
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• pp.109-115
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• 2005

Endothelial activation and subsequent recruitment of inflammatory cells are important steps in atherogenesis. The increased levels of cell adhesion molecules (CAM) have been identified in diabetic vasculatures, but the underlying mechanisms remain unclear. To determine the relationship among vascular production of superoxide, expression of CAM and diabetes, superoxide generation and expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E- and P-selectin in the aorta from control (C57BL/6J) and diabetic mice (ob/ob) were measured. In situ staining for superoxide using dihydroethidium showed an increased superoxide production in diabetic aorta, accompanied with an enhanced NAD(P)H oxidase activity. Immunohistochemical analysis revealed that the endothelial expression of ICAM-1 ($3.5{\pm}0.4$) and VCAM-1 ($3.8{\pm}0.3$) in diabetic aorta was significantly higher than those in control aorta ($0.9{\pm}0.5$ and $1.6{\pm}0.3$, respectively), accompanied with the enhanced expression of gp91phox, a membrane subunit of NAD(P)H oixdase. Furthermore, there was a strong positive correlation (r=0.89, P＜0.01 in ICAM-1 and r=0.88, P＜0.01 in VCAM-1) between ICAM-1/VCAM-1 expression and vascular production of superoxide. The present data indicate that the increased production of superoxide via NAD(P)H oxidase may explain the enhanced expression of CAM in diabetic vasculatures.

• 대한토목학회논문집
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• 제32권1D호
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• pp.81-88
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• 2012

본 연구는 해안선의 변화양상을 분석하기 위하여 두 가지 부분(측량 부분과 프로그램 부분)으로 나누어 진행하였다. 첫 번째는 다년간 GPS 측량을 통하여 자료를 취득하여 해안선 정보를 수집하였다. 두 번째는 다중영상정보를 이용하여 해안선 변화에 대한 자동경계검출 알고리즘을 개발하여 비교 분석하였다. 실험대상지역은 한국의 대표적인 해안인 부산시 해운대해수욕장을 선정하였고, 실험은 RTK-GPS의 경우 2005년 9월부터 2009년 9월까지 총 8회, 그리고 항공 Lidar는 2006년 12월과 2009년 3월에 실험을 수행하였다. 그 결과 RTK-GPS으로 나타난 평균 해안선의 길이는 약 1,364.6m이고, 항공 Lidar의 결과는 약 1,402.5m로 나타났다. 본 연구에서는 Visual C++ MFC(Microsoft Foundation Class)를 이용하여 해안선 경계 추출 알고리즘을 고안하였으며, 항공사진과 위성영상을 이용하여 해안선을 추출한 결과 평균 1,391.0m로 나타났다. 실측한 정보와의 상호비교를 통하여 약 98.1%의 정확도로 해안선 자동경계 추출이 되는 것으로 제시되었다.

• 대한토목학회논문집
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• 제29권4B호
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• pp.329-337
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• 2009

본 연구에서는 GPS와 RF 통신을 이용하여 개발한 전자부자 시스템을 간략하게 설명하고 현장 실측 결과를 분석하고 제시 하였다. 개발된 시스템은 15개의 전자부자를 동시에 이용하여 유량측정에 활용할 수 있다. 전자부자는 GPS를 이용하여 실제 유하경로를 측정할 수 있으며, 이를 통해 기존 부자법에 비해 10% 정도의 유속 측정 정확도의 개선이 가능하였다. 또한 ADCP와 유속 측정값을 비교한 결과 대체로 일치하는 결과를 보였다. 전자부자와 일반 부자법에 의해 계산된 소단면별 단면적 차이는 -79~71%에 달하였으며, 특히 부자의 중앙 수렴 경향으로 인해 좌우안 부근의 단면적 차이가 증가하였다. 부자의 유하경로와 단면의 배치가 불규칙한 지점에서 전자부자는 댐 방류량 대비 5~6%의 유량 개선 효과를 가지는 것으로 나타났다. 전자부자는 GPS에 기반한 측위 정보를 제공함으로써 정확한 유속과 단면적 산정이 가능하며, 현장 여건과 관계없이 적은 인력으로 측정과 분석, 유량계산을 신속하게 실시간으로 수행함으로써 홍수 유량측정의 효율성을 높일 수 있을 것으로 기대된다.