• Nuclear Engineering and Technology
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• 제53권4호
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• pp.1369-1377
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• 2021

Nowadays, it is necessary to accelerate the construction of new power plant in face of rising energy demand in such a way that the electricity will be generated at the lowest cost while reducing emissions caused by that generation. The expansion planning is one of the most important issues in electricity management. Nuclear energy comes forward with the low-carbon technology and increasing competitiveness to expand the share of generated energy by introducing Gen IV reactors. In this paper, the generation expansion planning of these new Gen reactors is investigated using the WASP software. Iran power grid is selected as a case of study. We present a comparison of the twenty-one year perspective on the future with the development of (1) traditional thermal power plants and Gen II reactors, (2) Gen III + reactors with traditional thermal power plants, (3) Gen IV reactors and traditional thermal power plants, (4) Gen III + reactors and the new generation of the thermal power plant, (5) the new generation of thermal power plants and the Gen IV reactors. The results show that the Gen IV reactors have the most developing among other types of power plants leading to reduce the operating costs and emissions. The obtained results show that the use of new Gen of combined cycle power plant and Gen IV reactors make the emissions and cost to be reduced to 16% and 72% of Gen II NPPs and traditional thermal power plants, respectively.

• Molecules and Cells
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• 제45권11호
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• pp.792-805
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• 2022

Repairing damaged DNA and removing all physical connections between sister chromosomes is important to ensure proper chromosomal segregation by contributing to chromosomal stability. Here, we show that the depletion of non-SMC condensin I complex subunit H (NCAPH) exacerbates chromosome segregation errors and cytokinesis failure owing to sister-chromatid intertwinement, which is distinct from the ultra-fine DNA bridges induced by DNA inter-strand crosslinks (DNA-ICLs). Importantly, we identified an interaction between NCAPH and GEN1 in the chromatin involving binding at the N-terminus of NCAPH. DNA-ICL activation, using ICL-inducing agents, increased the expression and interaction between NCAPH and GEN1 in the soluble nuclear and chromatin, indicating that the NCAPH-GEN1 interaction participates in repairing DNA damage. Moreover, NCAPH stabilizes GEN1 within chromatin at the G2/M-phase and is associated with DNA-ICL-induced damage repair. Therefore, NCAPH resolves DNA-ICL-induced ultra-fine DNA bridges by stabilizing GEN1 and ensures proper chromosome separation and chromosome structural stability.

• ETRI Journal
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• 제44권3호
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• pp.450-461
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• 2022

The Gen-Z protocol is a memory semantic protocol between the memory and CPU used in computer architectures with large memory pools. This study presents the implementation of the Gen-Z hardware system configured using Gen-Z specification 1.0 and reports its performance. A hardware prototype of a DDR4 Gen-Z memory pool with an optimized character, a block device driver, and a file system for the Gen-Z hardware was designed. The Gen-Z IP was targeted to the FPGA, and a 512 GB Gen-Z memory pool was configured on an ×86 server. In the experiments, the latency and throughput of the Gen-Z memory were measured and compared with those of the local memory, SATA SSD, and NVMe using character or block device interfaces. The Gen-Z hardware exhibited superior throughput and latency performance compared with SATA SSD and NVMe at block sizes under 4 kB. The MySQL and File IO benchmark of Gen-Z showed good write performance in all block sizes and threads. Besides, it showed low latency in RocksDB's fillseq dbbench using the ext4 direct access filesystem.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2008년도 추계학술발표대회
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• pp.288-291
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• 2008

전세계 인터넷 사용자 수가 약 12억 6천 만명에 이르며 2012년에는 17억명 이상이 인터넷을 사용할 것이라고 추정되는 가운데 웹 데이터베이스 응용에 대한 수요가 비즈니스를 포함하는 모든 분야에서 급속히 증가되고 있다. [1] 그러나 급증하는 수요에 비해 웹 응용의 생성 및 유지·보수는 대부분 수작업에 의존하기 때문에 많은 시간과 노력이 소요되고 있다. 본 논문에서 소개하는 WebAppGen은 ScriptGen과 InteraceGen으로 구성된 웹 응용 자동 생성기로서 웹 응용을 전자동으로 생성해 생산성을 향상시킨다. ScriptGen은 웹 응용에 필요한 폼들과 이 폼들을 통해 이루어지는 질의에 대해 데이터베이스와 연동하여 처리하는 웹 스크립트들을 자동생성하고 InterfaceGen은 ScriptGen을 통해 생성된 폼들을 엮어 접근하기 쉬운 트리 형태의 인터페이스를 제공한다. 상용 웹 응용 생성기들과 달리, WebAppGen은 웹 응용의 전 과정을 자동화 시킴으로써 생산성을 한 단계 더 향상시키고, 생성된 응용은 직관적인 계층구조를 가지는 트리 형태의 인터페이스를 지원한다. WebAppGen이 생성한 응용에서, 한 개의 폼은 관심의 대상인 엔티티 외에 이 엔티티와 직·간접적으로 연관된 모든 엔티티들에 대한 정보를 표현한다. 또한, WebAppGen은 생성될 응용의 기본 틀인 템플릿을 기반으로 하기 때문에 생성된 응용 및 WebAppGen 자체의 유지·보수를 용이하게 한다.

• 한국응용과학기술학회지
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• 제40권4호
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• pp.589-605
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• 2023

대두 이소플라본은 갱년기 증상에 대한 유익한 효과 때문에 폐경여성들의 관심을 끌고 있다. 본 연구는 난소절제 쥐에서 대두 이소플라본인 제니스테인과 수영운동의 동시처리(Gen+SE)가 제니스테인 단독처리(Gen)와 수영운동 단독처리(SE)에 비해 비만과 간 기능 개선에 유익한 시너지 효과를 나타낼 것인지를 조사하였다. 난소절제 쥐는 무작위로 대조군(Con), Gen, SE 및 Gen+SE으로 나누어 8주 동안 고지방식이를 섭취하였다. 몸무게, 백색지방조직의 무게, 간 조직의 지질추적 및 혈청 속 ALT와 AST 수치를 조사한 결과, Con에 비해 Gen과 SE는 감소하였고 Gen+SE는 Gen과 SE에 비해 더 효과적으로 감소하였다. 간 조직에서 염증성 사이토카인인 IL-6와 TNF-𝛼 유전자의 발현은 Con에 비해 Gen과 SE 모두에서 감소하였고, Gen+SE는 Gen과 SE에 비해 더욱 감소하였다. 그러나 adiponectin 유전자의 발현은 반대의 결과가 나타났다. 간 조직에서 지방산 산화와 관련된 유전자의 발현은 Con에 비해 Gen과 SE에서 증가하였고 Gen+SE는 Gen과 SE에 비해 더 증가하였다. 따라서 본 연구는 대두 이소플라본과 수영운동의 상호작용은 난소절제 비만 쥐에서 비만 조절과 저하된 간 기능 개선에 매우 효과적이며, 이것은 난소절제 쥐에서 간의 지방산 산화를 촉진함으로써 발생한 것이라는 것을 제안한다.

• The Plant Pathology Journal
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• 제34권1호
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• pp.65-70
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• 2018

Co-infection with two virus species was previously reported in some cactus plants. Here, we showed that Notocactus leninghausii f. cristatus can be co-infected with six different viruses: cactus mild mottle virus (CMMoV)-Nl, cactus virus X (CVX)-Nl, pitaya virus X (PiVX)-Nl, rattail cactus necrosis-associated virus (RCNaV)-Nl, schlumbergera virus X (SchVX)-Nl, and zygocactus virus X (ZyVX)-Nl. The coat protein sequences of these viruses were compared with those of previously reported viruses. CMMoV-Nl, CVX-Nl, PiVX-Nl, RCNaV-Nl, SchVX-Nl, and ZyVX-Nl showed the greatest nucleotide sequence homology to CMMoV-Kr (99.8% identity, GenBank accession NC_011803), CVX-Jeju (77.5% identity, GenBank accession LC12841), PiVX-P37 (98.4% identity, GenBank accession NC_024458), RCNaV (99.4% identity, GenBank accession NC_016442), SchVX-K11 (95.7% identity, GenBank accession NC_011659), and ZyVX-B1 (97.9% identity, GenBank accession NC_006059), respectively. This study is the first report of co-infection with six virus species in N. leninghausii f. cristatus in South Korea.

• BMB Reports
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• 제38권2호
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• pp.198-205
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• 2005

Resveratrol (RES) and genistein (GEN) are the dietary natural products known to possess chemopreventive property and also the ability to repair DNA damage induced by mutagens/carcinogens. It is believed that the therapeutic activity of these compounds could be primarily due to their interaction with nucleic acids but detailed reports are not available. We here explore the interaction of these drugs with nucleic acids considering DNA and RNA as a potential therapeutic target. The interaction of RES and GEN has been analysed in buffered solution with DNA [saline sodium citrate (SSC)] and RNA [tris ethylene diammine tetra acetic acid (TE)] using UV-absorption and Fourier transform infrared (FTIR) spectroscopy. The UV analysis revealed lesser binding affinity with nucleic acids at lower concentration of RES (P/D = 5.00 and 10.00), while at higher drug concentration (P/D = 0.75, 1.00 and 2.50) hyperchromic effect with shift in the ${\lambda}_{max}$ is noted for DNA and RNA. A major RES-nucleic acids complexes was observed through base pairs and phosphate backbone groups with K = $35.782\;M^{-1}$ and K = $34.25\;M^{-1}$ for DNA-RES and RNA-RES complexes respectively. At various concentrations of GEN (P/D = 0.25, 0.50, 0.75, 1.00 and 2.50) hyperchromicity with shift in the ${\lambda}_{max}$ from 260 $\rightarrow$ 263 om and 260 $\rightarrow$ 270 nm is observed for DNA-GEN and RNA-GEN complexes respectively. The binding constant (from UV analysis) for GEN-nucleic acids complexes could not be obtained due to GEN absorbance overlap with that of nucleic acids at 260 nm. Nevertheless a detailed analysis with regard to the interaction of these drugs (RES/GEN) with DNA and RNA could feasibly be understood by FTIR spectroscopy. The NH band of free DNA and RNA which appeared at $3550-3100\;cm^{-1}$ and $3650-2700\;cm^{-1}$ shifted to $3450-2950\;cm^{-1}$ and $3550-3000\;cm^{-1}$ in DNA-RES and RNA-RES complexes respectively. Similarly shifts corresponding to $3650-3100\;cm^{-1}$ and $3420-3000\;cm^{-1}$ have been observed in DNA-GEN and RNA-GEN complexes respectively. The observed reduction in NH band of free nucleic acids upon complexation of these drugs is an indication of the involvement of the hydroxyl (OH) and imino (NH) group during the interaction of the drugs and nucleic acids (DNA/RNA) through H-bonded formation. The interaction of RES and GEN with bases appears in the order of G $\geq$ T > C > A and A > C $\geq$ T > G. Further interaction of these natural compounds with DNA and RNA is also supported by changes in the vibrational frequency (shift/intensity) in symmetrical and asymmetrical stretching of aromatic rings of drugs in the complex spectra. No appreciable shift is observed in the DNA and RNA marker bands, indicating that the B-DNA form and A-family conformation of RNA are not altered during their interaction with RES and GEN.

• The Korean Journal of Physiology and Pharmacology
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• 제28권2호
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• pp.153-164
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• 2024

This study aimed to identify metabolic biomarkers and investigate changes in intestinal microbiota in the feces of healthy participants following administration of Lactococcus lactis GEN-001. GEN-001 is a single-strain L. lactis strain isolated from the gut of a healthy human volunteer. The study was conducted as a parallel, randomized, phase 1, open design trial. Twenty healthy Korean males were divided into five groups according to the GEN-001 dosage and dietary control. Groups A, B, C, and D1 received 1, 3, 6, and 9 GEN-001 capsules (1 × 10¹¹ colony forming units), respectively, without dietary adjustment, whereas group D2 received 9 GEN-001 capsules with dietary adjustment. All groups received a single dose. Fecal samples were collected 2 days before GEN-001 administration to 7 days after for untargeted metabolomics and gut microbial metagenomic analyses; blood samples were collected simultaneously for immunogenicity analysis. Levels of phenylalanine, tyrosine, cholic acid, deoxycholic acid, and tryptophan were significantly increased at 5-6 days after GEN-001 administration when compared with predose levels. Compared with predose, the relative abundance (%) of Parabacteroides and Alistipes significantly decreased, whereas that of Lactobacillus and Lactococcus increased; Lactobacillus and tryptophan levels were negatively correlated. A single administration of GEN-001 shifted the gut microbiota in healthy volunteers to a more balanced state as evidenced by an increased abundance of beneficial bacteria, including Lactobacillus, and higher levels of the metabolites that have immunogenic properties.

• 한국통신학회논문지
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• 제34권12B호
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• pp.1444-1451
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• 2009

본 논문은 EPCglobal C1 Gen 2 표준에서 제안한 Q 알고리즘에서 사용되는 C값에 대한 다양한 모델을 제시하고 시뮬레이션을 통하여 그 성능을 비교, 평가한다. EPCglobal C1 Gen 2 표준에서는 다중 태그 인식을 위해서 slot-count (Q) Selection Algorithm을 제안하고 있지만, Q 알고리즘에서 태그의 충돌과 무응답의 상태에 따라서 Q값을 변화시키는 값인 C 값에 대한 정확한 정의가 내려져 있지 않다. Q 알고리즘에서는 태그 충돌의 경우 C를 Q에 더하고 무응답인 경우에는 C를 감산하여 변화되는 Q값으로 태그들의 새로운 slot-count를 결정하기 때문에 다중 태그 인식 환경에 있어서 이 C값은 태그 인식 속도에 커다란 영향을 준다. 하지만 기존 연구들에서는 C값에 따른 태그 인식 속도 성능 평가나 비교 없이, Q 알고리즘을 변형하거나 새로운 방법을 제안하여 태그 인식 속도를 늘리기 위한 연구들이 존재한다. 본 연구에서는 EPCglobal C1 Gen 2 표준을 만족하는 C값의 다양한 모델을 제시하고 각각에 대해 다중 태그 인식 환경에 있어서 그 성능을 비교하고 평가한다. 본 연구의 결과물은 향후 EPCglobal C1 Gen 2 C 모델에 대한 연구나 태그 인식 성능 연구를 위한 하나의 지표로 쓰일 수 있다.

• Journal of Information Technology Applications and Management
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• 제21권1호
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• pp.1-16
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• 2014

Cyberloafing is as counterproductive behavior because it is the act of using internet for personal purposes which can affect employees' productivity, especially when done excessively (more than 4 hours a week). The objective of this study was to analyze whether gender and education level had significant effect on cyberloafing among generations in the workplace. From 267 respondents, gender was not found to have impact on cyberloafing because female and male respondents had the same frequency of low level cyberloafing. However, female had higher excessive cyberloafing than male. Gen Y had significant impact on the relationship between education and cyberloafing but Gen Y with diploma degree was revealed to have excessive cyberloafing. Furthermore, Gen X had started combining professional and personal lives throughout their daily lives. Hence, organizations should foster a culture of hard work by giving challenging job with clear target and worthy incentive but still implementing internet usage policy.