• Journal of Korea Water Resources Association
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• v.52 no.6
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• pp.381-395
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• 2019

The purpose of this study is to predict agricultural reservoir storage rate (RSR) in a month. This algorithm was developed by multiple linear regression model (MLRM) which included the past 3 months RSRs data and the future climate change scenarios. In order to improve use of predicted RSR, this study need the severe criteria in terms of drought. So, the predicted RSR was indexed as the 3 months reservoir drought index (RDI3) and then it was disaggregated into drought duration, severity, and intensity. For the future RSR estimation by climate change scenarios, the 6 RCP 8.5 scenarios of HadGEM2-ES, CESM1-BGC, MPI-ESM-MR, INM-CM4, FGOALS-s2, and HadGEM3-RA were used in three future evaluation periods (S1: 2011~2040, S2: 2041~2070, S3: 2071~2099). The future S3 period of HadGEM2-ES scenario which has the biggest increase in precipitation and temperature showed the largest decrease to 60.2% among the 6 scenarios compared to the historical RSR (1976~2005) 77.3%. In contrast, INM-CM4 scenario which has smallest changes in precipitation and temperature in S3 period showed the smallest decrease to 72.8%. For the CESM1-BGC and MPI-ESM-MR, FGOALS-s2, and HadGEM3-RA, the S3 period RSR showed 72.6%, 72.6%, 67.4%, and 64.5% decrease respectively. The future severe drought condition of RDI3 below -0.25 showed the increase trend for the number and severity up to -2.0 during S3 period.

• Nuclear Engineering and Technology
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• v.52 no.6
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• pp.1277-1281
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• 2020

A novel ceramic Gas Electron Multiplier (GEM) has been developed to meet the demand of high counting rate for the neutron detection which is an alternative to ³He-based detector at China Spallation Neutron Source (CSNS). An experiment was performed to measure the neutron transmittance of ceramic-GEM and FR4-GEM at the small angle neutron scattering (SANS) instrument. The result showed the ceramic-GEM has higher transmittance and less self-scattering especially for cold neutrons. One single ceramic GEM could give a gain of 10²-10⁴ in the mixture gas of Ar and CO₂ (90%:10%) and its energy resolution was about 27.7% by using ⁵⁵Fe X ray of 5.9 keV. A prototype has been developed in order to investigate the performances of the ceramic GEM-based neutron detector. Several neutron beam tests, including detection efficiency, spatial resolution, two-dimensional imaging, and wavelength spectrum, were carried out at CSNS and China Mianyang Research Reactor (CMRR). The results show that the ceramic GEM-based neutron detector is a good candidate to measure the high intensity neutrons.

• Archives of Pharmacal Research
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• v.15 no.1
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• pp.91-94
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• 1992

A convenient method for the preparation of N-aryl thiazolines 4a b, 2, 2-dichlorothiophene 5, thiazolinones 6 and 8 and 2, 6-dihydrothiopyran 2-thione 9 derivatives is described. This depends on interaction of 3, 3-dimercapto-1(4-biphenyl)-2-propen-1-one 1 with dichloroethane, amines, trichloroacetylchloride, chloroacetamide, ethylene oxide and epichlorohydrin. Antimicrobial activity of the obtained products was studied.

• Atmosphere
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• v.25 no.1
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• pp.85-97
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• 2015

This study is to investigate future changes in carbon cycle using the HadGEM2-Carbon Cycle simulations driven by $CO_2$ emissions. For experiment, global carbon budget is integrated from the two (8.5/2.6) representative concentration pathways (RCPs) for the period of 1860~2100 by Hadley Centre Global Environmental Model, version 2, Carbon Cycle (Had-GEM2-CC). From 1985 to 2005, total cumulative $CO_2$ amount of anthropogenic emission prescribed as 156 GtC. The amount matches to the observed estimates (CDIAC) over the same period (136 GtC). As $CO_2$ emissions into the atmosphere increase, the similar increasing tendency is found in the simulated atmospheric $CO_2$ concentration and temperature. Atmospheric $CO_2$ concentration in the simulation is projected to be 430 ppm for RCP 2.6 at the end of the twenty-first century and as high as 931 ppm for RCP 8.5. Simulated global mean temperature is expected to rise by $1.6^{\circ}C$ and $3.5^{\circ}C$ for RCP 2.6 and 8.5, respectively. Land and ocean carbon uptakes also increase in proportion to the $CO_2$ emissions of RCPs. The fractions of the amount of $CO_2$ stored in atmosphere, land, and ocean are different in RCP 8.5 and 2.6. Further study is needed for reducing the simulation uncertainty based on multiple model simulations.

• Bulletin of the Korean Chemical Society
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• v.35 no.10
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• pp.2906-2910
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• 2014

This report introduces Gaussian electrostatic models (GEMs) to account for charge penetration effects in water-water interactions, allowing electrostatic interactions to be accurately described. Three different Gaussian electrostatic models, GEM-3S, GEM-5S, and GEM-6S are designed with s-type Gaussian functions. The coefficients and exponents of the Gaussian functions are optimized using the electrostatic potential (ESP) fitting procedure based on that of the MP2/aug-cc-pVTZ method. The electrostatic energies of ten different water dimers that were calculated with GEM-6S agree well with the results of symmetry-adapted perturbation theory (SAPT), indicating that this designed model can be effectively applied to future water models.

• Biomolecules & Therapeutics
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• v.29 no.2
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• pp.184-194
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• 2021

Histone acetylation is a well-characterized epigenetic modification controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs). Imbalanced histone acetylation has been observed in many primary cancers. Therefore, efforts have been made to find drugs or small molecules such as HDAC inhibitors that can revert acetylation levels to normal in cancer cells. We observed dose-dependent reduction in the endogenous and exogenous protein expression levels of KAT8 (also known as human MOF), a member of the MYST family of HATs, and its corresponding histone acetylation at H4K5, H4K8, and H4K16 in chemotherapy drug gemcitabine (GEM)-exposed T24 bladder cancer (BLCA) cells. Interestingly, the reduction in MOF and histone H4 acetylation was inversely proportional to GEM-induced γH2AX, an indicator of chemotherapy drug effectiveness. Furthermore, pGL4-MOF-Luc reporter activities were significantly inhibited by GEM, thereby suggesting that GEM utilizes an MOF-mediated anti-BLCA mechanism of action. In the CCK-8, wound healing assays and Transwell® experiments, the additive effects on cell proliferation and migration were observed in the presence of exogenous MOF and GEM. In addition, the promoted cell sensitivity to GEM by exogenous MOF in BLCA cells was confirmed using an Annexin V-FITC/PI assay. Taken together, our results provide the theoretical basis for elucidating the anti-BLCA mechanism of GEM.

• Journal of The Korean Astronomical Society
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• v.41 no.3
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• pp.59-64
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• 2008

To detect exoplanets and study pulsation of K giant stars, we have observed precise RV (radial velocity) of about 55 early K giant (K0 - K4) stars brighter than V = 5 magnitude since 2003 by using BOES, a high resolution Echelle spectrograph attached to the 1.8 m telescope at BOAO (Bohyunsan Optical Astronomy Observatory). We detected periodic RV variation of KO III star $\beta$ Gem (HD 62509) with a period $P\;=\;596.6\;{\pm}\;2.3$ days and a semi-amplitude $K\;=\;44.8\;{\pm}\;0.7\;ms^{-1}$. If we adopt 1.7 $M_{\odot}$ for the mass of $\beta$ Gem, this yields the minimum mass of the companion m sin i = 2.64 $M_{Jupiter}$. Our results agree well with Hatzes et al. (2006) and Reffert et al. (2006), and confirm their discovery of a planetary object around $\beta$ Gem. We also confirmed about 192 minutes short period stellar oscillation found by Hatzes and Zechmeister (2007). This is the first report of exoplanet detection using BOES and demonstrates that the RV observation using BOES is accurate and stable enough to detect exoplanets around bright K giant stars.

• Atmosphere
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• v.29 no.4
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• pp.367-380
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• 2019

Global warming causes various problems such as the increase of the sea surface temperature, the change of coastlines, ocean acidification and sea level rise. Sea level rise is an especially critical threat to coastal regions where massive population and infrastructure reside. Sea level change is affected by thermal expansion and mass increase. This study projected future sea level changes in the 21st century using the HadGEM2-AO with RCP8.5 scenario. In particular, sea level change due to water mass input from ice-sheets and glaciers melting is studied. Sea level based on surface mass balance of Greenland ice-sheet and Antarctica ice-sheet rose 0.045 m and -0.053 m over the period 1986~2005 to 2081~2100. During the same period, sea level owing to dynamical change on Greenland ice-sheet and Antarctica ice-sheet rose 0.055 m and 0.03 m, respectively. Additionally, glaciers melting results in 0.145 m sea level rise. Although most of the projected sea level changes from HadGEM2-AO are slightly smaller than those from 21 ensemble data of CMIP5, both results are significantly consistent each other within 90% uncertainty range of CMIP5.

• Atmosphere
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• v.23 no.4
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• pp.527-538
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• 2013

In this study, climate over Korea based on the Historical scenario induced by HadGEM2-AO is simulated by WRF. For this purpose, a system that can be used be for numerical integration over the Far East Asian area of the center of the Korean Peninsula with 12.5 km-horizontal resolution was set-up at "Haebit", the early portion of KMA Supercomputer Unit-3. Using the system, the downscaling experiments were conducted for the period 1979-2010. The simulated results of HadGEM2-AO and WRF are presented in terms of 2 m-temperature and precipitation during boreal summer and winter of Historical for the period 1981~2005, compared with observation. As for the mean 2 m-temperature, the general patterns of HadGEM2-AO and WRF are similar with observation although WRF showed lower values than observation due to the systematic bias. WRF reproduced a feature of the terrain-following characteristics reasonably well owing to the increased horizontal resolution. Both of the models simulated the observed precipitation pattern for DJF than JJA reasonably, while the rainfall over the Korean Peninsula in JJA is less than observation. HadGEM2-AO in DJF 2 m-temperature and JJA precipitation has warm and dry biases over the Korean Peninsula, respectively. WRF showed cold bias over JJA 2 m-temperature and wet bias over DJF precipitation. The larger bias in WRF was attributed to the addition of HadGEM2-AO's bias to WRF's systematic bias. Spatial correlation analysis revealed that HadGEM2-AO and WRF had above 0.8 correlation coefficients except for JJA precipitation. In the EOF analysis, both models results explained basically same phase changes and variation as observation. Despite the difference in mean and bias fields for both models, the variabilities of the two models were almost similar with observation in many respects, implying that the downscaled results can be effectively used for the study of regional climate around the Korean Peninsula.

• Proceedings of the Korea Water Resources Association Conference
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• 2011.05a
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• pp.122-122
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• 2011

수자원 분야에서 기후변화 관련 연구는 치수 측면 보다는 이수 측면에서 주로 이뤄지고 있다. 이는 홍수분석을 위한 시간 단위를 충족시켜주는 전지구 대기순환모형(Global Circulation Model: GCM)의 자료가 드물고, 시간 단위의 GCM 자료라 하더라도 극치값(extreme value) 표현에는 한계가 있기 때문이다. 이를 극복하기 위하여 과거 관측자료의 통계적 특성으로 극치자료의 편의(bias)를 보정하고 시간 단위로 분해하기도 한다. 하지만 이런 통계적 상세화(statistical downscaling)는 미래 기후는 과거자료와 통계적 차이가 유의하지 않음을 가정하고 있어, 미래 기후는 현재와 다를 것이라는 공감대에 는 적합하지 않다. 이와 같은 이유로 타당한 극치수문변수 결과를 얻기 위해서는 시간 단위의 고분해능(high resolution) GCM이나 지역기후모델(regional climate model)과 같은 고해상도의 미래 기후변화 자료가 필요하게 된다. 이에 국립기상연구소에서는 영국 기상청의 통합모델(UM)기반의 지역기후모델(HadGEM3)을 사용하여 50 km 및 12.5 km 격자 단위로 역학적 상세화(dynamic downscaling)를 수행하였다. 본 연구에서는 개발된 HadGEM3-RA 결과의 극치수문변수 검증을 위하여 한강유역의 관측 자료와 다양한 방법으로 비교하였다. 두 자료의 극치값을 GEV (Generalized Extreme Value) 분포에 적합(fitting)시켜 비초과확률별 극치사상과, 특정 임계값(threshold value) 이상의 극치사상 발생확률을 비교하였다. 검토 결과, HadGEM3-RA는 통계적 상세화로 구한 극치값 보다는 작았으나 기존의 지역 기후모델에 비하여 현실성 있는 극치값이 계산되었음을 확인하였다.