Archives of Pharmacal Research
- Volume 15 Issue 1
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- Pages.91-94
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- 1992
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Kotoketene gem-Dithiols:Synthesis of Some Sulphur Heterocycles as Antimicrobial Agents
- Zayed, Salem E. (Faculty of Science, Qena, Assiut University) ;
- Hussin, Ibrahim A. (National Organization for Drug Control and Research)
- Published : 1992.03.01
Abstract
A convenient method for the preparation of N-aryl thiazolines 4a b, 2, 2-dichlorothiophene 5, thiazolinones 6 and 8 and 2, 6-dihydrothiopyran 2-thione 9 derivatives is described. This depends on interaction of 3, 3-dimercapto-1(4-biphenyl)-2-propen-1-one 1 with dichloroethane, amines, trichloroacetylchloride, chloroacetamide, ethylene oxide and epichlorohydrin. Antimicrobial activity of the obtained products was studied.
Keywords
- Ketoketen gem dithiols;
- $\alpha$-oxoteten gem-dithiols;
- thiazolines;
- sulphurheterocycles;
- antimicrobial activity