• Journal of Life Science
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• v.17 no.3 s.83
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• pp.305-311
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• 2007

Glucocorticoids (GCs) alter metabolism, synaptogenesis, apoptosis, neurogenesis, and dendritic morphology in the hippocampus. To better understand how glucocorticoids regulate these aspects of hippocampal biology, we studied gene expression patterns in the CA3 (Hippocampal pyramidal cell field CA3) and dentate gyrus (DG). Litter-matched Lewis inbred rats treated for 20 days with either 9.5 mg per day sustained-release corticosterone or placebo pellets were compared with high-density oligonucleotide microarray analysis (Rat Neurobiology U34 Arrays, Affymetrix). In placebo-treated rats, 32 genes were expressed at greater levels in CA3 than DG, whereas 3 genes were expressed at great levels in DC than CA3. Regional differences were also apparent in corticosterone-induced changes in the hippocampal transcriptome. Six genes in CA3 and 41 genes in DC were differentially regulated by corticosterone. As per the glucocorticoid effects on gene transcription in the brain, forty three of these genes were upregulated, and 4 genes were downregulated. Genes differentially expressed in hippocampus included those for 13 neurotransmitter proteins, 5 ion channel related proteins, 4 transcription factors, 3 neurotrophic factors, 1 cytokine, 1 apoptosis related protein, and 5 genes involved in synaptogenesis. Interestingly, GCs can have suppressive effects on brain BDNF mRNA transcription, one of the neurotrophic factors. These results indicate the diversity of targets affected by chronic exposure to corticosterone and highlight important regional differences in hippocampal neurobiology.

• Journal of Korean Neurosurgical Society
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• v.66 no.5
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• pp.582-590
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• 2023

Objective : Trauma is a leading causes of death and disability in all ages. The aim of this study was to describe the demography and characteristics of paediatric head trauma in our institution and examine the predictors of outcome and incidence of injury related mortality. Methods : We examined our institutional Trauma Registry over a 2 year period. Results : A total of 1100 trauma patients were seen over the study period. Of the 579 patients who had head injury 99 were in the paediatric age group. Of the paediatric head trauma patients 79 had documented Glasgow coma score (GCS), 38 (48.1%), 17 (21.5%) and 24 (30.4%) had mild, moderate and severe head injury respectively. The percentage mortality of head injury in the paediatric age group was 6.06% (6/99). There is an association between mortality and GCS (p=0.008), necessity for intensive care unit (ICU) admission (p=0.0001), associated burns (p=0.0001) and complications such as aspiration pneumonia (p=0.0001). The significant predictors of outcome are aspiration (p=0.004), the need for ICU admission (p=0.0001) and associated burns (p=0.005) using logistic binary regression. During the study period 46 children underwent surgical intervention with extradural haematoma 16 (34.8%), depressed skull fracture 14 (30.4%) and chronic subdural haematoma five (10.9%) being the commonest indication for surgeries. Conclusion : Paediatric head injury accounted for 9.0% (99/1100) of all trauma admissions. Majority of patients had mild or moderate injuries. Burns, aspiration pneumonitis and the need for ICU admission were important predictors of outcome in children with traumatic brain injury.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.2
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• pp.34.2-34.2
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• 2015

We aim to investigate the formation of primordial globular clusters (GCs) in the isolated dwarf galaxy (${\sim}10^{10}M_{sun}$) with cosmological zoom-in simulations. For this, we modified cosmological hydrodynamic code, GADGET-3, in a way to include the radiative heating/cooling that enables gas particles cool down to T~10K, reionization (z < 8.9) of the Universe, UV shielding ($n_{shield}$ > $0.014cm^{-3}$), and star formation. Our simulation starts in a cubic box of a side length 1Mpc/h with 17 million particles from z = 49. The mass of each dark matter (DM) and gas particle is $M_{DM}=4.1{\times}10^3M_{sun}$ and $M_{gas}=7.9{\times}10^2M_{sun}$, respectively, thus the GC candidates can be resolved with more than hundreds particles. We found the following results: 1) mini halos with the more interactions before merging into the main halo form the more stars and thus have the higher star mass fraction ($M_{star}/M_{total}$), 2) the mini halos with the high $M_{star}/M_{total}$ can survive longer and thus spiral into closer to the galactic center, 3) the majority of them spiral into bulge, but some of them can survive until the last as baryon-dominated system, like the GC.

• Asian Oncology Nursing
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• v.10 no.1
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• pp.103-111
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• 2010

Purpose: This study was undertaken to establish the framework for development of the curriculum of genetics in Nursing Education. Methods: The Internet search, literature review of the US system of genetic nurses, genetic graduate nursing education programs and curricula for nurse in Korea were reviewed and analyzed. Results: American Nurses genetic system consists of APNG and the GCS and all the APNG credential provided by the GNCC of ISONG. The curriculums of genetic nursing education in the US are mainly conducted in of master's program and genetically related subjects consists of basic genetics subjects, basic applied genetics subjects, genetics in nursing subjects and practical training subjects. Lastly a genetic nursing education program in Korea 44 hr of lectures and practical training of 4 hr is composed of basic genetics, genetic cancer, genetics in nursing and practicum in the computer lab and online include family history assessment, pedigree construction, breast and colorectal cancer risk calculations, and ELSI discussions. Conclusion: This study suggested that genetic nursing education course needs in master's program as detailed subjects. Also the establishment of the genetic nurse system is an urgent needed.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.12 no.6
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• pp.141-146
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• 2012

This paper introduces development of multi-rotor system and vision based autonomous landing system. Multi-rotor platform is modeled by rigid body motion with Newton Euler concept. Also Multi-rotor platform is simulated and tuned by LQR control algorithm. Vision based Autonomous Landing system uses a single camera that is mounted Multi-rotor system. Augmented reality algorithm is used as marker detection algorithm and autonomous landing code is test with GCS for the precision landing.

• 제어로봇시스템학회:학술대회논문집
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• 1990.10a
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• pp.218-224
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• 1990

A motor group control system is developed for continuous manufacturing processes such as rolling process or electrolytic tinning process. The control system consists of four subsystems ; Multi-Function Controller (MFC), Flexible Motor Drive (FMD), Bulky Input/Output (BIO), Graphic Console and Simulator (GCS). A graphic control language, called Function Block Language, is used to configure the control algorithms for each subsystem. All subsystem are linked together thru a field bus to communicate data with each other.

• Nuclear Engineering and Technology
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• v.55 no.9
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• pp.3291-3300
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• 2023

Recently molybdenum alloys have been introduced as accident tolerating materials for cladding of fuel rods. Molybdenum element has seven stable isotopes with different neutron absorption cross section used in various fields, including nuclear physics and radioisotope production. This study presents separation approaches for all intermediate isotopes of molybdenum element by squared-off cascades using a newly developed numerical code with Salp Swarm Algorithm (SSA) optimization algorithm. The parameters of cascade including feed flow rate, feed entry stage, cascade cut, input feed flow rate to gas centrifuges (GCs), and cut of the first stage are optimized to maximize both isotope recovery and cascade capacity. The squared off and squared cascades are studied, and the efficiencies are compared. The results obtained from the optimization showed that for the selected squared off cascade, Mo⁹⁴ in four separation steps, Mo⁹⁵ in five steps, Mo⁹⁶ in six steps, Mo⁹⁷ in seven steps, and Mo⁹⁸ in two steps are separated to the desired concentrations. The highest recovery factor is obtained 63% for Mo⁹⁴ separation and lowest recovery factor is found 45% for Mo⁹⁵.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.2
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• pp.41.3-42
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• 2021

Coma cluster (Abell 1656) is one of the most massive local galaxy clusters such as Virgo, Fornax, and Perseus, which holds a large collection of globular clusters. Globular cluster systems (GCSs) in a galaxy cluster tell us a history of hierarchical cluster assembly and intracluster GCs (ICGCs) are known to trace the gravitational potential of the galaxy cluster. Previous studies of GCSs in Coma mainly utilized data obtained using Hubble Space Telescope (HST) with high spatial resolution. However, most of the data were based on narrow-field pointing observations. In this study we present the widest survey of GCSs in the Coma cluster using the archival Subaru/Hyper Suprime-Cam (HSC) g and r images, supplemented with the archival HST images. The Coma GCSs are largely extended in E-W and SW direction, along the general direction of Coma-Abell 1367 filament. This global structure of the GCSs is consistent with the spatial distribution of the intracluster light (ICL). ICGC spatial distribution is largely extended to almost ~50% of the virial radius. Most of these ICGCs are blue and metal-poor, which supports the scenario that ICGCs are mainly originated from dwarf galaxies and some proportion from brighter galaxies. Implications of the results will be discussed.

• Journal of The Korean Astronomical Society
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• v.49 no.5
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• pp.175-192
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• 2016

CCD photometric observations of the globular cluster (GC), M53 (NGC 5024), are performed using the 1.8 m telescope at the Bohyunsan Optical Astronomy Observatory in Korea on the same nights (2002 April and 2003 May) as the observations of the GC M92 (NGC 6341) reported by Cho and Lee using the same instrumental setup. The data for M53 is reduced using the same method as used for M92 by Cho and Lee, including preprocessing, point-spread function fitting photometry, and standardization etc. Therefore, M53 and M92 are on the same photometric system defined by Landolt, and the photometry of M53 and M92 is tied together as closely as possible. After complete photometric reduction, the V versus B − V , V versus V − I, and V versus B − I color-magnitude diagrams (CMDs) of M53 are produced to derive the relative ages of M53 and M92 and derive the various characteristics of its CMDs in future analysis. From the present analysis, the relative ages of M53 and M92 are derived using the Δ(B − V ) method reported by VandenBerg et al. The relative age of M53 is found to be 1.6 ± 0.85 Gyr younger than that of M92 if the absolute age of M92 is taken to be 14 Gyr. This relative age difference between M53 and M92 causes slight differences in the horizontal-branch morphology of these two GCs.

• Journal of Korean Neurosurgical Society
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• v.39 no.4
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• pp.271-276
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• 2006

Objective : Despite the recent progress that has been made in intracerebral monitoring, it is still difficult to quantify the exact extent of primary brain damage after severe head injury. In this work, we investigate the role of S-100B protein as a serum marker of brain damage after severe head injury. Methods : 21 patients with severe head injury [GCS score <9] were selected for this prospective study. A venous blood sample was taken as soon as possible after head injury and the serum concentration of S-100B protein was measured daily for five consecutive days. The serum level of S-100B protein was compared with the patients' outcome. The outcome was measured twice, at hospital discharge and after 6 months of follow-up using the Glasgow Outcome Scale[GOS]. Results : Those patients who died within two weeks [after head injury] had a significantly higher serum S-100B value than those who survived [median, 9.64ug/L versus 2.91ug/L]. Seven [78%] of the nine patients who died had a maximum S-100B value of 2ug/L or higher, while three [25%] of the twelve surviving patients showed a maximum S-100B protein value of more than 2ug/L [P<005]. Conclusion : These results indicate that S-100B protein appears to be the most reliable index for estimating the extent of brain damage.