• Journal of Ginseng Research
• /
• v.39 no.1
• /
• pp.46-53
• /
• 2015

Background: Glucocorticoids (GCs) are commonly used in many chemotherapeutic protocols and play an important role in the normal regulation of bone remodeling. However, the prolonged use of GCs results in osteoporosis, which is partially due to apoptosis of osteoblasts and osteocytes. In this study, effects of Korean Red Ginseng (KRG) on GC-treated murine osteoblastic MC3T3-E1 cells and a GC-induced osteoporosis mouse model were investigated. Methods: MC3T3-E1 cells were exposed to dexamethasone (Dex) with or without KRG and cell viability was measured by the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Realtime polymerase chain reaction was performed to evaluate the apoptotic gene expression; osteogenic gene expression and alkaline phosphatase (ALP) activity were also measured. Western blotting was performed to evaluate the mitogen-activated protein kinase (MAPK) proteins. A GC-induced osteoporosis animal model was used for in vivo study. Results and conclusion: The MTT assay revealed that Korean Red Ginseng (KRG) prevents loss of cell viability caused by Dex-induced apoptosis in MC3T3E1 cells. Real-time polymerase chain reaction data showed that groups treated with both Dex and KRG exhibited lower mRNA levels of caspase-3 and -9, whereas the mRNA levels of Bcl2, IAPs, and XIAP increased. Moreover, groups treated with both Dex and KRG demonstrated increased mRNA levels of ALP, RUNX2, and bone morphogenic proteins as well as increased ALP activity in MC3T3-E1 cells, compared to cells treated with Dex only. In addition, KRG increased protein kinase B (AKT) phosphorylation and decreased c-Jun N-terminal kinase (JNK) phosphorylation. Moreover, microcomputed tomography analysis of the femurs showed that GC implantation caused trabecular bone loss. However, a significant reduction of bone loss was observed in the KRG-treated group. These results suggest that the molecular mechanism of KRG in the GC-induced apoptosis may lead to the development of therapeutic strategies to prevent and/or delay osteoporosis.

• Journal of the Korea Convergence Society
• /
• v.10 no.1
• /
• pp.339-351
• /
• 2019

This study was conducted to identify the factors associated with the ruptured intracranial aneurysm (RIA) among demographic, admission to hospital, clinical, aneurysym itself and lifestyle characteristics. Medical records of RIA patients and un-RIA patients which had been admitted to undergo treatment including surgery (From January to December 2016) were included into data analysis. Multiple logistic regression showed that two and more than warning signs (14.14 (CI: 1.25-159.40)) indicated the greatest odds ratio with RIA, was followed by headache more than 3 scores (13.95 (CI: 3.68-52.83)), the admission via emergency room (13.62 (CI: 4.85-38.26)), single marital status (9.72 (CI: 2.22-42.49)), 1 mmHg increased systolic blood pressure (1.04 (CI: 1.01-1.08)), 1 score increased GCS (0.58 (CI: 0.37-0.90)), arrythmia finding in electrocardiogram (3.70 (CI: 1.22-11.22)) and increased age (0.95 (CI: 0.91-0.99)). The risk groups having factors associated with RIA were identified. Preventive activities including routine assessment should be done before developing the rupture and urgent care should be needed after developing the rupture for risk groups.

• Journal of The Korean Society of Emergency Medicine
• /
• v.29 no.5
• /
• pp.500-508
• /
• 2018

Objective: The aim of this study was to evaluate the clinical characteristics of heat stroke in a bath facility and investigate predictive factors of multiple major complications in heat stroke patients. Methods: This was a retrospective study on heat stroke patients who visited an urban emergency center from January 2010 to March 2018. We compared clinical characteristics, complication, and outcomes of heat stroke patients in bath and non-bath facilities. Multivariate logistic regression analysis were performed to identify independent predictors of multiple major complications in heat stroke patients. Results: A total of 67 heat stroke patients with heat stroke were enrolled, of which 42 (62.6%) were in a bath facility and 25 (37.3%) were in a non-bath facility. Patients with heat stroke in the bath facility were characterized by old age, past medical history of hypertension and diabetes mellitus, and high incidence of hypotension compared with those in the non-bath facility but also low incidence of acute renal failure, seizure, and multiple major complications. In the multivariate analysis, predictive factors of multiple major complications in heat stroke patients were non-bath facility (odds ratio [OR], 5.4; 95% confidence interval [CI], 1.2-29.9), Glasgow Coma Scale (GCS)${\leq}8$ (OR, 8.2; 95% CI, 1.3-49.4), and mean arterial pressure (MAP), body temperature above $40.5^{\circ}C$ (OR, 8.1; 95% CI, 1.1-58.8) <60 mmHg (OR, 14.8; 95% CI, 1.8-122.9). Conclusion: Heat stroke in the bath facility resulted in less major complications, and high body temperature, GCS ${\leq}8$, and MAP <60 mmHg were independent predictive factors of multiple major complications in heat stroke patients.

• Journal of Korea Entertainment Industry Association
• /
• v.15 no.4
• /
• pp.349-357
• /
• 2021

Recently, drones are rapidly becoming common and expanding. There is a great need for diversity in whether drone flight data can be used as entertainment technology analysis data. In particular, it is necessary to check whether it is possible to analyze and utilize the flight and operation process of entertainment drones, which are developing through autonomous and intelligent methods, through data analysis and machine learning. In this paper, it was confirmed whether it can be used as a machine learning technology by using FC data in the evaluation of drones for entertainment. As a result, FC data from DJI and Parrot such as Mavic2 and Anafi were unable to analyze machine learning for entertainment. It is because data is collected at intervals of 0.1 second or more, so that it is impossible to find correlation with other data with GCS. On the other hand, it was found that machine learning technologies can be applied in the case of Fixhawk, which used an ARM processor and operates with the Nuttx OS. In the future, it is necessary to develop technologies capable of analyzing the characteristics of entertainment by dividing fixed-wing and rotary-wing flight information. For this, a model shoud be developed, and systematic big data collection and research should be conducted.

• Journal of Korean Neurosurgical Society
• /
• v.66 no.3
• /
• pp.332-339
• /
• 2023

Objective : The present study aimed to investigate the clinical characteristics of electrolyte imbalance in patients with moderate to severe traumatic brain injury (TBI) who underwent craniotomy and its influence on prognosis. Methods : A total of 156 patients with moderate to severe TBI were prospectively collected from June 2019 to June 2021. All patients underwent craniotomy and intracranial pressure (ICP) monitoring. We aimed to explore the clinical characteristics of electrolyte disturbance and to analyze the influence of electrolyte disturbance on prognosis. Results : A total of 156 patients with moderate and severe TBI were included. There were 57 cases of hypernatremia, accounting for 36.538%, with the average level of 155.788±7.686 mmol/L, which occurred 2.2±0.3 days after injury. There were 25 cases of hyponatremia, accounting for 16.026%, with the average level of 131.204±3.708 mmol/L, which occurred 10.2±3.3 days after injury. There were three cases of hyperkalemia, accounting for 1.923%, with the average level of 7.140±1.297 mmol/L, which occurred 5.3±0.2 days after injury. There were 75 cases of hypokalemia, accounting for 48.077%, with the average level of 3.071±0.302 mmol/L, which occurred 1.8±0.6 days after injury. There were 105 cases of hypocalcemia, accounting for 67.308%, with the average level of 1.846±0.104 mmol/L, which occurred 1.6±0.2 days after injury. There were 17 cases of hypermagnesemia, accounting for 10.897%, with the average level of 1.213±0.426 mmol/L, which occurred 1.8±0.5 days after injury. There were 99 cases of hypomagnesemia, accounting for 63.462%, with the average level of 0.652±0.061 mmol/L, which occurred 1.3±0.4 days after injury. Univariate regression analysis revealed that age, Glasgow coma scale (GCS) score at admission, pupil changes, ICP, hypernatremia, hypocalcemia, hypernatremia combined with hypocalcemia, epilepsy, cerebral infarction, severe hypoproteinemia were statistically abnormal (p<0.05), while gender, hyponatremia, potassium, magnesium, intracranial infection, pneumonia, allogeneic blood transfusion, hypertension, diabetes, abnormal liver function, and abnormal renal function were not statistically significant (p>0.05). After adjusting gender, age, GCS, pupil changes, ICP, epilepsy, cerebral infarction, severe hypoproteinemia, multivariate logistic regression analysis revealed that hypernatremia or hypocalcemia was not statistically significant, while hypernatremia combined with hypocalcemia was statistically significant (p<0.05). Conclusion : The incidence of hypocalcemia was the highest, followed by hypomagnesemia, hypokalemia, hypernatremia, hyponatremia and hypermagnesemia. Hypocalcemia, hypomagnesemia, and hypokalemia generally occurred in the early post-TBI period, hypernatremia occurred in the peak period of ICP, and hyponatremia mostly occurred in the late period after decreased ICP. Hypernatremia combined with hypocalcemia was associated with prognosis.

• Journal of Korean Neurosurgical Society
• /
• v.66 no.5
• /
• pp.582-590
• /
• 2023

Objective : Trauma is a leading causes of death and disability in all ages. The aim of this study was to describe the demography and characteristics of paediatric head trauma in our institution and examine the predictors of outcome and incidence of injury related mortality. Methods : We examined our institutional Trauma Registry over a 2 year period. Results : A total of 1100 trauma patients were seen over the study period. Of the 579 patients who had head injury 99 were in the paediatric age group. Of the paediatric head trauma patients 79 had documented Glasgow coma score (GCS), 38 (48.1%), 17 (21.5%) and 24 (30.4%) had mild, moderate and severe head injury respectively. The percentage mortality of head injury in the paediatric age group was 6.06% (6/99). There is an association between mortality and GCS (p=0.008), necessity for intensive care unit (ICU) admission (p=0.0001), associated burns (p=0.0001) and complications such as aspiration pneumonia (p=0.0001). The significant predictors of outcome are aspiration (p=0.004), the need for ICU admission (p=0.0001) and associated burns (p=0.005) using logistic binary regression. During the study period 46 children underwent surgical intervention with extradural haematoma 16 (34.8%), depressed skull fracture 14 (30.4%) and chronic subdural haematoma five (10.9%) being the commonest indication for surgeries. Conclusion : Paediatric head injury accounted for 9.0% (99/1100) of all trauma admissions. Majority of patients had mild or moderate injuries. Burns, aspiration pneumonitis and the need for ICU admission were important predictors of outcome in children with traumatic brain injury.

• The Journal of the Society of Stroke on Korean Medicine
• /
• v.17 no.1
• /
• pp.29-38
• /
• 2016

This case report is to show the effects of Traditional Korean medicine (TKM) on the patient with delayed encephalopathy after carbon monoxide poisoning. A patient with delayed encephalopathy after carbon monoxide poisoning occurs rarely and only a few cases have been reported. We treated a patient with cognitive deficit, gait disturbance was treated with herbal medicine(Boshiniknoe-tang-gami), acupuncture, moxibustion. We evaluated the improvements of symptoms by Korean Version of Mini Mental Status Examination score(K-MMSE), Modified Barthel Index(MBI) and Glasgow Coma Scale(GCS). After 3 weeks, total score of K-MMSE was increased from 12 to 17 and it was maintained to week 6. After 6 weeks, total score of MBI was increased from 30 to 86. And GCS was increased from 11 to 14. This report proved effect of Traditional Korean medicine on the improvement of delayed encephalopathy after carbon monoxide poisoning

• Journal of Korean Academy of Nursing
• /
• v.34 no.7
• /
• pp.1255-1264
• /
• 2004

Purpose: The purpose of this study was to determine the effect of a 3-week somatosensory stimulation program on the integrity of the somatosensory pathway of patients with brain damage. Method: The sample consisted of two groups of patients with brain damage matched by Glasgow Coma Scale (GCS) scores and age:8 patients with a mean age of 56.75 years who were treated with somatosensory stimulation, and 8 patients with a mean age of 58.88 years, who were not treated with sensory intervention program. A repeated measures matched-control group design was used to assess functional recovery of the brain. The instrument used in this study was SSEP (somatosensory evoked potentials), a neurophysiological parameter, for the integrity of the somatosensory pathway. Results: The hypothesis that patients with brain damage who were treated with the somatosensory stimulation program will show higher SSEP wave form scores than the non-treatment group was supported (3rd week.: U=13.000, p=.014). Additional repeated measures analysis showed that there were no significant differences in recovery trends between the groups (F=1.945, p=.159). Conclusion: This study demonstrates that a somatosensory stimulation program is effective in promoting recovery of the integrity of the somatosensory pathway of patients with brain damage.

• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.32 no.10
• /
• pp.127-133
• /
• 2004

This paper described development of the portable ground control system(PGCS) for unmanned aerial vehicle. In the design of GCS, it upload mission planning that aircraft has to perform and has to receive position, attitude, state, navigation information all about the aircraft. Aircraft states and trajectory are displayed using this system on line. The PGCS is composed of commercial notebook computer, RF modem for communication between aircraft and PGCS, input/output board, remote control receiver, switches and lamps. Performance of this system is verified by flight test of small unmanned aerial vehicle.

• The Bulletin of The Korean Astronomical Society
• /
• v.40 no.2
• /
• pp.34.2-34.2
• /
• 2015

We aim to investigate the formation of primordial globular clusters (GCs) in the isolated dwarf galaxy (${\sim}10^{10}M_{sun}$) with cosmological zoom-in simulations. For this, we modified cosmological hydrodynamic code, GADGET-3, in a way to include the radiative heating/cooling that enables gas particles cool down to T~10K, reionization (z < 8.9) of the Universe, UV shielding ($n_{shield}$ > $0.014cm^{-3}$), and star formation. Our simulation starts in a cubic box of a side length 1Mpc/h with 17 million particles from z = 49. The mass of each dark matter (DM) and gas particle is $M_{DM}=4.1{\times}10^3M_{sun}$ and $M_{gas}=7.9{\times}10^2M_{sun}$, respectively, thus the GC candidates can be resolved with more than hundreds particles. We found the following results: 1) mini halos with the more interactions before merging into the main halo form the more stars and thus have the higher star mass fraction ($M_{star}/M_{total}$), 2) the mini halos with the high $M_{star}/M_{total}$ can survive longer and thus spiral into closer to the galactic center, 3) the majority of them spiral into bulge, but some of them can survive until the last as baryon-dominated system, like the GC.