• Journal of Nutrition and Health
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• v.52 no.4
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• pp.323-331
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• 2019

Purpose: Glucocorticoids (GCs) are implicated in secondary osteoporosis, and the resulting fractures cause significant morbidity. Polyunsaturated fatty acids (PUFAs) play a vital role in bone metabolism. However, few trials have studied the impact of omega-3 PUFA-containing oils against GC-induced osteoporosis. Therefore, the present study was undertaken to determine whether supplementation with omega-3 PUFA-containing dietary oils such as fish oil, flaxseed oil or soybean oil can impede the development of GC-induced osteoporosis. Methods: The fatty acids (FAs) content of oils was determined using gas chromatography. Male rats were subdivided into 5 groups (8 rats each): normal control (balanced diet), prednisolone control (10 mg/kg prednisolone daily), soybean oil (prednisolone 10 mg/kg + soybean oil 7% w/w), flaxseed oil (prednisolone 10 mg/kg + flaxseed oil 7% w/w), and fish oil (from cod liver; prednisolone 10 mg/kg + fish oil 7% w/w). Results: The study data exhibited a significant depletion in bone mineral density (BMD) and femur mass in the prednisolone control compared to the normal control, accompanied with a marked decrease in the levels of plasma calcium and 1,25-$(OH)_2$-vitamin $D_3$, and elevated levels of C-terminal telopeptide (CTX), tumor necrosis factor-alpha (TNF-${\alpha}$) and malondialdehyde (MDA). Supplementation with fish oil, soybean oil or flaxseed oil helped to improve plasma calcium levels, and suppress oxidative stress and inflammatory markers. Additionally, bone resorption was suppressed as reflected by the decreased CTX levels. However, fish oil was more effective than the other two oils with a significant improvement in BMD and normal histological results compared to the normal control. Conclusion: This study demonstrated that supplementation with dietary oils containing omega-3 PUFAs such as fish oil, soybean oil or flaxseed oil can play a role in the prevention of bone loss and in the regulation of bone metabolism, especially fish oil which demonstrated a greater level of protection against GC-induced osteoporosis.

• Journal of The Korean Society of Clinical Toxicology
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• v.17 no.1
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• pp.7-13
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• 2019

Purpose: Owing to the increased agricultural use of the herbicide glufosinate ammonium (GLA), the incidence of GLA poisoning has recently increased. Therefore, we investigated the possible predictive factors associated with severe complications following GLA poisoning. Methods: A retrospective analysis of medical records was conducted based on 76 patients who had visited our regional emergency medical center with GLA poisoning from 2006 to 2017. Severe complications were defined as respiratory failure requiring intubation, systolic blood pressure less than 90 mmHg, Glasgow Coma Scale (GCS) less than 8, and presence of seizure. Results: Age, ingested amount and ingested amount per weight were significantly greater in the severe group (p<0.001). PSS grade 2 or higher was more common in the severe group (p<0.001), and In addition, the APACHE II score was significantly higher in the severe group (p<0.001), as were the SOFA scores (p=0.002). Serum ammonia levels were significantly higher in the severe group (p=0.007), while MDRD-GFR was smaller in the severe group (p=0.002). The spot urine protein levels were significantly higher in the severe group (p=0.005), as was the urine protein to creatinine ratio (p=0.001). Upon multivariate analysis, the amount ingested per weight and PSS grade 2 or higher were identified as significant predictors. Conclusion: Our study showed that MDRD-GFR was significantly lower in the severe group after GLA poisoning. PSS grade 2 or higher and ingested amount per weight may be useful to evaluate the severity of complications after GLA poisoning.

• Journal of The Korean Society of Clinical Toxicology
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• v.17 no.1
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• pp.14-20
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• 2019

Purpose: This study estimated the incidence of delirium and associated risk factors and outcomes in ICU patients with acute poisoning. Methods: Data were collected from ICU patients over 18 years of age that were admitted via the emergency center after presenting with poisoning from 2010 to 2015. Delirium was assessed retrospectively using the Intensive Care Delirium Screening Checklist (ICDSC). Risk factors were evaluated by univariate and multivariate analysis. Results: A total of 199 patients participated in this study and 68 (34.2%) were diagnosed with delirium based on the ICDSC score. The delirium group showed a significantly higher association with prolonged length of stay in the hospital and ICU in comparison with the non-delirium group. The delirium group was associated with greater use of physical restraint. A statistically greater number of patients with pharmaceutical substance poisoning developed delirium over a short period of time than those with non-pharmaceutical substance poisoning. There was no significant difference between the two groups with respect to age, sex, past history, GCS score, vital signs, application of ventilator care and renal replacement therapy. Conclusion: The finding that the delirium group had a greater length of stay in both the hospital and the ICU is consistent with the results of previous worldwide studies of the effects of delirium on the prognosis of patients who were admitted to the ICU, suggesting the possibility for domestic application. Additionally, use of physical restraint was positively related to the incidence of delirium. Thus, interventions for minimizing the use of physical restraints and considering alternatives are needed.

• Journal of Microbiology and Biotechnology
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• v.31 no.1
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• pp.79-91
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• 2021

γ-Glutamylcysteine synthetase (Gcs1) and glutathione reductase (Glr1) activity maintains minimal levels of cellular methylglyoxal in Candida albicans. In glutathione-depleted Δgcs1, we previously saw that NAD(H)-linked methylglyoxal oxidoreductase (Mgd1) and alcohol dehydrogenase (Adh1) are the most active methylglyoxal scavengers. With methylglyoxal accumulation, disruptants lacking MGD1 or ADH1 exhibit a poor redox state. However, there is little convincing evidence for a reciprocal relationship between methylglyoxal scavenger genes-disrupted mutants and changes in glutathione-(in)dependent redox regulation. Herein, we attempt to demonstrate a functional role for methylglyoxal scavengers, modeled on a triple disruptant (Δmgd1/Δadh1/Δgcs1), to link between antioxidative enzyme activities and their metabolites in glutathione-depleted conditions. Despite seeing elevated methylglyoxal in all of the disruptants, the result saw a decrease in pyruvate content in Δmgd1/Δadh1/Δgcs1 which was not observed in double gene-disrupted strains such as Δmgd1/Δgcs1 and Δadh1/Δgcs1. Interestingly, Δmgd1/Δadh1/Δgcs1 exhibited a significantly decrease in H2O2 and superoxide which was also unobserved in Δmgd1/Δgcs1 and Δadh1/Δgcs1. The activities of the antioxidative enzymes erythroascorbate peroxidase and cytochrome c peroxidase were noticeably higher in Δmgd1/Δadh1/Δgcs1 than in the other disruptants. Meanwhile, Glr1 activity severely diminished in Δmgd1/Δadh1/Δgcs1. Monitoring complementary gene transcripts between double gene-disrupted Δmgd1/Δgcs1 and Δadh1/Δgcs1 supported the concept of an unbalanced redox state independent of the Glr1 activity for Δmgd1/Δadh1/Δgcs1. Our data demonstrate the reciprocal use of Eapx1 and Ccp1 in the absence of both methylglyoxal scavengers; that being pivotal for viability in non-filamentous budding yeast.

• Journal of The Korean Society of Clinical Toxicology
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• v.19 no.1
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• pp.44-50
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• 2021

Purpose: This study aimed to analyse the effect of End-Tidal Carbon Dioxide (ETCO2) monitoring on patients who had been poisoned and presented in the emergency department with decreased consciousness. Methods: The data of patients over 18 years old presenting with poisoning from 2016 to 2020 was collected from the emergency department. We retrospectively analyzed their medical records, and defined patients with a Glasgow Coma Scale (GCS) score of 9 or less as having decreased consciousness. We divided the patients into two groups, one with ETCO2 monitoring and the other without, and the difference between the two groups was compared. Results: 168 patients participated in this study and 83 (49.4%) of them belonged to the ETCO2 monitoring group. In this group, the interval between arterial blood tests was statistically significantly longer and the rate of intubation was lower. In addition, in the monitoring group, the incidence of pneumonia and the rate of poor prognosis was not significantly higher. Conclusion: Although ETCO2 monitoring does not directly affect the prognosis of poisoned patients with decreased consciousness, it should be actively done as it can help to adequately treat patients while avoiding invasive techniques or unnecessary intubation.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.50 no.7
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• pp.489-496
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• 2022

This paper introduces the system for KAU-SPUAV, which is designed and developed by Korea Aerospace University, and verifies its performance through flight test. Specification of two versions of KAU-SPUAV, avionics system, and Ground Control System (GCS) are introduced. Three missions are performed with suggested UAVs: LTE signal mapping, circumnavigation of Jeju island seashore, and long endurance flight. Each mission consists of long distance and long endurance flight which takes advantage of KAU-SPUAV. Research team of KAU-SPUAV confirmed its versatility through suggested flight data. Also based on flight results, the team found the potential of performance improvement of KAU-SPUAV.

• Animal Bioscience
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• v.35 no.2
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• pp.166-176
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• 2022

Objective: Sperm is particularly susceptible to reactive oxygen species (ROS) stress. Glutathione (GSH) is an endogenous antioxidant that regulates sperm redox homeostasis. However, it is not clear whether boar sperm could utilize cysteine for synthesis GSH to protect sperm quality from ROS damage. Therefore, the present study was undertaken to elucidate the mechanism of how cysteine is involved in protecting boar sperm quality during liquid storage. Methods: Sperm motility, membrane integrity, lipid peroxidation, 4-hydroxyIlonenal (4-HNE) modifications, mitochondrial membrane potential, as well as the levels of ROS, GSH, and, ATP were evaluated. Moreover, the enzymes (GCLC: glutamate cysteine ligase; GSS: glutathione synthetase) that are involved in glutathione synthesis from cysteine precursor were detected by western blotting. Results: Compared to the control, addition of 1.25 mM cysteine to the liquid storage significantly increased boar sperm progressive motility, straight-line velocity, curvilinear velocity, beat-cross frequency, membrane integrity, mitochondrial membrane potential, ATP level, acrosome integrity, activities of superoxide dismutase and catalase, and GSH level, while reducing the ROS level, lipid peroxidation and 4-HNE modifications. It was also observed that the GCLC and GSS were expressed in boar sperm. Interestingly, when we used menadione to induce sperm with ROS stress, the menadione associated damages were observed to be reduced by the cysteine supplementation. Moreover, compared to the cysteine treatment, the γ-glutamylcysteine synthetase (γ-GCS) activity, GSH level, mitochondrial membrane potential, ATP level, membrane integrity and progressive motility in boar sperm were decreased by supplementing with an inhibitor of GSH synthesis, buthionine sulfoximine. Conclusion: These data suggest that boar sperm could biosynthesize the GSH from cysteine in vitro. Therefore, during storage, addition of cysteine improves boar sperm quality via enhancing the GSH synthesis to resist ROS stress.

• Atmosphere
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• v.31 no.5
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• pp.563-576
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• 2021

The performance of East Asian summer monsoon is assessed for GC2 and GC3.1, which are climate change models of the current and next climate prediction system in the Korea Meteorological Administration (KMA), GloSea5 and GloSea6. The most pronounced characteristics of GC models are strong monsoon trough and the weakening of the Western North Pacific Subtropical High (WNPSH). These are related to the weakening of the southwesterly wind and resulting weak monsoon band toward the Korean Peninsula. The GC3.1 is known to have improved the model configuration version compared to GC2, such as cloud physics and ocean parameters. We can confirm that the overall improvements of GC3.1 against GC2, especially in pressure, 850 hPa wind fields, and vertical wind shear. Also, the precipitation band stagnant in the south of 30°N in late spring is improved, therefore the biases of rainy onset and withdrawal on the Korean Peninsula are reduced by 2~4 pentad. We also investigate the impact of initialization in comparison with GloSea5 hindcast. Compared with GCs, hindcast results show better simulation within 1 month lead time, especially in pressure and 850 hPa wind fields, which can be expected to the improvement of WNPSH. Therefore, it is expected that the simulation performance of WNPSH will be improved in the result of applying the initialization of GloSea6.

• International conference on construction engineering and project management
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• 2007.03a
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• pp.642-652
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• 2007

Many contracting firms and project managers in the construction industry have started to utilize multi objective optimization methods to handle multiple conflicting goals for completing the project within the stipulated time and budget with required quality and safety. These optimization methods have increased the pressure on decision makers to search for an optimal resources utilization plan that optimizes simultaneously the total project cost, completion time, and crashing cost by considering indirect cost, contractual penalty cost etc., practically charging them in terms of direct cost of the project which is fuzzy in nature. This paper presents a multiple fuzzy goal programming model (MFGP) that supports decision makers in performing the challenging task. The model incorporates the fuzziness which stems from the imprecise aspiration levels attained by the decision maker to these objectives that are quantified through fuzzy linear membership function. The membership values of these objectives are then maximized which forms the fuzzy decision. The problem is solved using LINGO 8 optimization solver and the best compromise solution is identified. Comparison between solutions of MFGP, fuzzy multi objective linear programming (FMOLP) and multiple goal programming (MGP) are also presented. Additionally, an interactive decision making process is developed to enable the decision maker to interact with the system in modifying the fuzzy data and model parameters until a satisfactory solution is obtained. A case study is considered to demonstrate the feasibility of the proposed model for optimization of project network parameters in the construction industry.

• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.82-82
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• 2023

홍수기 하천에서 유량측정은 예산, 인력, 안전 및 측정 시 편의성 등의 이유로 측정에 제한이 많다. 특히, 태풍 등으로 인한 호우사상 발생 시 위와 같은 문제로 홍수량 측정에 어려움이 따른다. 이러한 문제점을 개선하기 위해 Lee et al.(2021)은 드론과 전자파표면유속계의 기능을 융합한 DSVM(Dron and Surface Veloctity Meter using doppler radar) 측정방법을 개발하였다. 전자파표면유속계 측정의 제한 요소인 진동을 감소시키기 위해 댐퍼플레이트를 개발하였고 금강의 지류인 봉황천에 현장 적용을 통해 DSVM 측정방법의 실용성을 확인하였다. 기존 연구에서 DSVM 방법은 드론의 각 측선 이동을 위한 조종과 전자파표면유속계 측정의 제어를 측정자가 수행하였는데 본 연구에서는 통합 드론측정시스템(IDMS, Integrated Drone Measurement System) 개발을 통해 측정자의 조종 의존도를 줄임과 동시에 안전하고 정확한 유량측정을 위해 노력하였다. 기존 댐퍼플레이트의 상하 진동 흡수 기능뿐만 아니라 전자파표면유속계의 흔들림 현상 등 자세 제어 기능을 보완하기 3축 모터를 적용한 방수짐벌을 개발하여 측정 정확도를 향상시켰다. 미션컴퓨터 개발로 측정지점의 측정 임무정보를 DB화하여 각 측선별 헤딩, 고도, 이동 등 자동항법 기능과 기체의 안정화 이후 전자파표면유속계를 자동으로 제어하여 측정을 실시하는 기능을 구현하였다. 또한 통합 GCS(Ground Control System)를 통해 비행 및 측정에 대한 모든 정보를 확인하고 컨트롤 할 수 있게 하였다. 2022년 금산군(제원대교), 무주군(취수장), 경주시(서천교) 지점에서 홍수기 유량측정에 도입하여 중간단면적법, 지표유속법을 적용하여 통합드론측정시스템의 실용성을 검증 완료하였다. 2023년 현장에 18대의 통합 드론측정시스템을 도입하여 홍수기 유량측정에 활용할 계획이다.