• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.20 no.4
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• pp.83-94
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• 2021

In this paper, we proposed a microstrip antenna (center frequency 118 MHz) with an omnidirectional radiation pattern that can replace the antennae used in VDB systems in GBAS. First, to obtain an omnidirectional radiation pattern from a microstrip antenna, we constructed a folded antenna. We then designed a miniaturized triple-folded antenna using perturbation effects. Thus we obtained suitable characteristics with a S₁₁ of -13.91dB, -10 dB bandwidth of 1.5 MHz (1.27%) in the center frequency of 118 MHz. Furthermore, in the yz-plane and xy-plane, the component exhibits an omnidirectional radiation pattern, and the size of the antenna achieves miniaturization of 64.2% compared to the reference antenna. Finally, it is suitable as an antenna for VDB systems in GBAS.

• Journal of Interdisciplinary Genomics
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• v.1 no.2
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• pp.15-18
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• 2019

Gaucher disease (GD) is an autosomal recessive inborn error of metabolism resulting from a deficiency in ${\beta}$-glucocerebrosidase (GBA) activity that leads to the accumulation of glucocerebroside in macrophages in multiple organs, such as the bone marrow, liver, spleen, and brain. GD can be classified into three clinical types: type 1 (non-neuropathic form, OMIM #230800); type II (acute neuropathic form, OMIM #230900); and type III (chronic neuropathic form, OMIM #231000). Type III is the subacute form of neuropathic GD. The best available treatment for GD is long-term enzyme (imiglucerase) replacement therapy (ERT) performed every two weeks. This report describes the long-term clinical course of a patient with type III GD who was treated with ERT for 18 years.

• Coupled systems mechanics
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• v.13 no.1
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• pp.1-19
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• 2024

The effectiveness of coupling with a bolted rim is assessed in this research using a newly designed optimization algorithm. The current study, which is provided here, evaluates 10 contemporary metaheuristic approaches for enhancing the coupling with bolted rim design problem. The algorithms used are particle swarm optimization (PSO), crow search algorithm (CSA), enhanced honeybee mating optimization (EHBMO), Harmony search algorithm (HSA), Krill heard algorithm (KHA), Pattern search algorithm (PSA), Charged system search algorithm (CSSA), Salp swarm algorithm (SSA), Big bang big crunch optimization (B-BBBCO), Gradient based Algorithm (GBA). The contribution of the paper isto optimize the coupling with bolted rim problem by comparing these 10 algorithms and to find which algorithm gives the best optimized result. These algorithm's performance is evaluated statistically and subjectively.

• Journal of Periodontal and Implant Science
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• v.47 no.2
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• pp.77-85
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• 2017

Purpose: Guided bone regeneration (GBR) is the most widely used technique to regenerate and augment bones. Even though augmented bones (ABs) have been examined histologically in many studies, few studies have been conducted to examine the biological potential of these bones and the healing dynamics following their use. Moreover, whether the bone obtained from the GBR procedure possesses the same functions as the existing autogenous bone is uncertain. In particular, little attention has been paid to the regenerative ability of GBR bone. Therefore, the present study histologically evaluated the regenerative capacity of AB in the occlusive space of a rat guided bone augmentation (GBA) model. Methods: The calvaria of 30 rats were exposed, and plastic caps were placed on the right of the calvaria in 10 of the 30 rats. After a 12-week healing phase, critical-sized calvarial bone defects (diameter: 5.0 mm) were trephined into the dorsal parietal bone on the left of the calvaria. Bone particles were harvested from the AB or the cortical bone (CB) using a bone scraper and transplanted into the critical defects. Results: The newly generated bone at the defects' edge was evaluated using micro-computed tomography (micro-CT) and histological sections. In the micro-CT analysis, the radiopacity in both the augmented and the CB groups remained high throughout the observational period. In the histological analysis, the closure rate of the CB was significantly higher than in the AB group. The numbers of cells positive for runt-related transcription factor 2 (Runx2) and tartrate-resistant acid phosphatase (TRAP) in the AB group were larger than in the CB group. Conclusions: The regenerative capacity of AB in the occlusive space of the rat GBA model was confirmed. Within the limitations of this study, the regenerative ability of the AB particulate transplant was inferior to that of the CB particulate transplant.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.17 no.2
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• pp.63-68
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• 2017

Gaucher disease (GD) is caused by the deficiency of glucocerebrosidase. In pediatric patients with GD, especially Type I GD, enzyme replacement therapy (ERT) can reduce the hepatosplenomegaly and improve the hematologic finding and growth velocity. Herein, we report a 2-year-old girl with Type I GD presented with hepatosplenomegaly, bone pain and growth retardation. A 2 year-old-girl was referred to our hospital due to severe hepatosplenomegaly and growth retardation. She suffered from both leg pain and chronic fatigue. Simple x-ray showed widened distal long bones like that of an 'Erlenmeyer flask' which is associated with GD. The laboratory test showed anemia and thrombocytopenia. The enzyme activity was markedly reduced and the direct sequencing of the GBA gene showed the compound heterozygous mutations, p.G46E and p.L444P. As the G46E have been considered as the protective gene against neuronopathic genotype, we could assess the Type I GD in this patient. After one year of ERT, the growth velocity became 11 cm per year. Bone pain and fatigue disappeared. The volume of liver and spleen was reduced from $683cm^3$ and $703cm^3$ to $590cm^3$ and $235cm^3$, respectively. Although GD is an extremely rare disease in Korea, growth retardation and bone pain in children are the important signs which lead to early detection of GD and a simple radiologic finding is helpful to assess the GD at outpatient clinic. We highlight that the early diagnosis and early ERT is important for good growth and outcome for pediatric patients with GD.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.20 no.1
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• pp.1-13
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• 2020

Purpose: Gaucher disease (GD), which is the most prevalent lysosomal storage disorder worldwide, is caused by mutations in the glucocerebrosidase gene (GBA). GD is divided into three clinical subtypes based on the appearance of neurological symptoms. Type 1 GD is a chronic non-neuronopathic disease, and types 2 and 3 are acute neuronopathic and chronic neuronopathic forms, respectively. Neuronopathic GD types 2 and 3 are characterized by increased levels of glucosylceramide (GlcCer) and glucosylsphingosine (GlcSph) in the brain, leading to massive loss of neurons. Methods: DNA damage and subsequent apoptosis of H4 cells were observed following neuroglioma H4 cell culture with GlcCer or GlcSph. Neuronal cell apoptosis was more prominent upon treatment with GlcSph. Results: When H4 cells were treated with GlcSph in the presence of tubacin, a histone deacetylase 6 inhibitor (HDAC6i), attenuation of both DNA damage and a reduction in the protein expression levels of GlcSph-induced apoptosis-associated factors were observed. Conclusion: These findings indicated that GlcSph played a prominent role in the pathogenesis of neuronopathic GD by inducing apoptosis, and that HDAC6i could be considered a therapeutic candidate for the treatment of neuronopathic GD.

• Journal of Advanced Navigation Technology
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• v.17 no.6
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• pp.625-632
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• 2013

Since GBAS is a navaid facility to provide precision approach service to aircrafts landing at airports, it must be approved by the air navigation service provider or the aviation regulator to be declared operational. However, Korea has no experience in developing or operating the system so there is no approval criteria for GBAS. In order to develop the criteria in case of the future GBAS procurement, Korea Aerospace Research Institute has been testing the installed commercial GBAS station, SLS-4000, in Gimpo International Airport. This paper summarizes the criteria development results focusing on the system design approval. The criteria have been outlined based on the other leading nations' cases and documentations and established in detail on the basis of the FAA SDA artifacts. Those will be directly used for GBAS approval procedure in Korea and are expected to be useful in system requirement analysis, design, development and artifact management in case of own GNSS-based navaid system development in the future.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.35 no.12
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• pp.1101-1107
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• 2007

this paper, integrity analysis in Korean region using GPS, modernized GPS, Galileo, SBAS and GBAS is given. The simulation results show that Cat. I requirement can be met using modernized GPS and Galileo alone, however, Cat. II and III are not met even augmenting SBAS because of VPL. A more efficient augmentation such as GBAS reduces VPL to meet Cat. II and III requirements in Korean region. This result will be used to design and implement not only an augmentation system but also regional satellite navigation system.

• Journal of Advanced Navigation Technology
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• v.19 no.1
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• pp.1-6
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• 2015

Due to the rapid increase in air traffic worldwide, ICAO has replaced the existing navigation equipment with equipment based on satellite navigation. As a part of that work, ICAO was planning to replace conventional takeoff and landing service using ILS with GBAS. Unlike ILS, GBAS which uses precision approach service inducing aircraft to airport and satellite based augmentation system providing precise position information service surrounding airport is capable of providing a required performance by only a system, regardless of the number of systems, and has an advantage that it is possible curved approach. In this paper, fuel reduction of ILS approach procedures and GBAS curved approach procedures is estimated and determined by flight test in Taean Airport.

• Journal of Satellite, Information and Communications
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• v.8 no.1
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• pp.40-44
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• 2013

In this paper, we describe on the position error of GBAS. In reality, there are many sources which make errors into the calculation of receiver position. It is well known that the DOP of GBAS is an important position error source and is dependent on the numbers and positions of the transmitters. Here, we develop an algorism to calculate the DOP of the GNSS with 2-line transmitters into Korean area. The result is useful to predict the DOP of the positions where transmitters and receivers are located.