• Journal of Korean Neurosurgical Society
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• 제66권2호
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• pp.133-143
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• 2023

Objective : The types and functions of lipids involved in glioblastoma (GB) are not well known. Lipidomics is a new field that examines cellular lipids on a large scale and novel aplication of lipidomics in the biomedical sciences have emerged. This study aimed to investigate the potential of blood lipids for use as biomarkers for the diagnosis of GB via untargated lipidomic approach. Gaining a deeper understanding of lipid metabolism in patients with GB can contribute to the early diagnosis with GB patiens and also development of novel and better therapeutic options. Methods : This study was performed using blood samples collected from 14 patients (eight females and six males) and 14 controls (eight females and six males). Lipids were extracted from blood samples and quantified using phosphorus assay. Lipid profiles of between patients with GB and controls were compared via an untargeted lipidomics approach using 6530 Accurate-Mass Q-TOF LC/MS mass spectrometer. Results : According to the results obtained using the untargeted lipidomics approach, differentially regulated lipid species, including fatty acid (FA), glycerolipid (GL), glycerophospholipid (PG), saccharolipid (SL), sphingolipid (SP), and sterol lipid (ST) were identified between in patients with GB and controls. Conclusion : Differentially regulated lipids were identified in patients with GB, and these lipid species were predicted as potential biomarkers for diagnosis of GB.

• Korean Journal of Acupuncture
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• 제25권2호
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• pp.211-224
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• 2008

Objectives : To investigate the effect of electro-acupuncture (EA) at GB34 on hepatotoxicity in $CCl_4$-intoxicated rats. Methods : Rats were injected with $CCl_4$ and treated with acupuncture or 2 Hz electro-acupuncture (EA) at left GB34 three times a week for 10 weeks. A non-acupoint in left gluteal area was selected as a sham point. To estimate the effects of EA on hepatotoxicity in rats, body weight, liver weight and liver index were measured, and biochemical assays for serum ALT, AST, ALP and total cholesterol, and hematological analysis for RBC, WBC, PLT, hemoglobin, lymphocytes, neutrophils and monocytes, and histology analysis of liver tissue were performed. Results : 1. Lymphocyte level in blood was significantly decreased by $CCl_4$-intoxication and significantly increased by acupuncture and 2 Hz EA at left GB34. 2. Neutrophill and monocyte level in blood was increased by $CCl_4$-intoxication and significantly reduced by acupuncture and 2 Hz EA at left GB34. 3. Acupuncture and 2 Hz EA at left GB34 significantly reduced serum ALT and AST which were increased by $CCl_4$-intoxication. 4. EA at GB34 significantly reduced serum ALT and AST as compared with EA at sham point in $CCl_4$-intoxicated rat. 5. No significant difference was found between the effects of acupuncture and that of 2 Hz EA on $CCl_4$-induced liver damage in rats. Conclusions : 2 Hz EA at GB34 has hepatoprotective effects on $CCl_4$-induced liver damage in rats and the point-specificity of GB34 may be involved in these effects.

• 한국정보통신학회논문지
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• 제20권1호
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• pp.110-116
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• 2016

본 논문에서는 디지털 임피던스 보정 회로와 이퀄라이저 회로를 가진 1.2V 5Gb/s SLVS 차동 송신단을 제안한다. 제안하는 송신단은 4-위상 출력 클록을 갖는 위상 고정 루프, 4-to-1 직렬변환기, 레귤레이터, 출력 드라이버, 그리고 신호보존성을 향상하기 위한 이퀄라이저 회로를 포함한다. 또한, built-in self-test를 위해 pseudo random bit sequence 발생기를 함께 구현한다. 제안하는 SLVS 송신단은 80mV에서 500mV의 차동 출력 전압범위를 지원한다. SLVS 송신단은 1.2V의 공급전압을 가지는 65nm CMOS공정을 이용하여 구현한다. 측정된 5Gb/s SLVS 송신단의 peak-to-peak 시간 지터는 46.67ps이며, 전력소모는 1.88mW/Gb/s이다.

• 대한한의학방제학회지
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• 제11권2호
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• pp.125-134
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• 2003

We have examined the relaxational response to the water extract of Angelica gigas $N_{AKAI}$ (AG), Gingko biloba $L_{INNE}$ (GB), Acanthopanax senticosus $H_{ARMS}.$ (AP) and Augumented-Four-Substance Decoction (AG-FSD, GB-FSD, AP-FSD) in isolated thoracic aorta from sprague dawley(SD) rat. Rat thoracic aorta was investigated in vessel segments suspended for isometric tension recording by polygraph. Responses to AG, GB, AP and AG-FSD, GB-FSD, AP-FSD were investigated in vessels precontracted with 5-hydroxytryptamine(5-HT) were compared in vasodilation effect. We found that the thoracic aorta segments responded to AG, GB, AP and AG-FSD, GB-FSD, AP-FSD with a dose-dependent vasodilation. The 5-hydroxytryptamine induced contraction at $10^{-4}M$ were inhibited by 26.3%, 75.8%, 87.5% and 6.9%, 22.6%, 30.8% after addition of the 0.1 g/mL water extract of AG, GB, AP and AG-FSD, GB-FSD, AP-FSD. In conclusion, AG, GB, AP and AG-FSD, GB-FSD, AP-FSD induced relaxation in the isolated rat thoracic aorta were composed of dose-dependent relaxation. AP-FSD has very potent vasodilation.

• 대한전자공학회논문지SD
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• 제44권8호
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• pp.22-29
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• 2007

[ $0.18{\mu}m$ ] CMOS공정을 이용하여 supply voltage 1.8V에서 2.5Gb/s 이상의 데이터 처리속도를 가지는 2:1 Multiplexer(MUX) 설계를 하였다. High speed 동작을 위한 주파수의 한계를 극복하기 위해서 4.7 nH의 on-chip micro spiral micro inductor $(20\times20{\mu}m2)$가 설계 되었고, 10개 이상의 inductor를 사용하고도 칩 면적 증가가 거의 없으면서 inductive peaking 효과를 극대화할 수 있었다. 칩 측정은 on-wafer로 진행되었고, micro spiral inductor가 있는 2:1 MUX와 그것이 없는 2:1 MUX 각각 측정하여 그 결과를 비교하였다. 측정결과 micro spiral inductor를 가진 2:1MUX가 rise time과 fall time이 1.25Gb/s에서는 rise time이 23%, fall time은 3%의 peaking 개선 효과가 있는 것을 확인하였다. 2.5Gb/s에서는 fall time이 약 5.3%, rise time 3.5%의 개선 효과를 보았다. 전체 소비전력은 61.2mW, 2.5Gb/s에서 voltage output swing은 $180mV_{p-p}$로 측정되었다.

• 정보과학회 컴퓨팅의 실제 논문지
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• 제20권10호
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• pp.525-533
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• 2014

SCST(The generic SCSI target subsystem for Linux)는 개발자가 SCSI 타겟 스토리지를 구성할 수 있게 하는 오픈소스 소프트웨어이며, 스토리지 네트워크 구성을 위해 iSCSI, FC, SRP 등의 다양한 SCSI 네트워크 프로토콜을 지원한다. 본 논문에서는 SCST를 이용한 스토리지 가상화 방법을 제안하고 고성능 스토리지인 All Flash Array를 4Gb 파이버 채널, 10Gb 이더넷, 40Gb 인피니밴드를 통해 가상화하며, 가상화된 All Flash Array의 성능을 고찰한다. 실험 결과 40Gb 인피니밴드를 통해 가상화된 All Flash Array가 세 경우 중 가장 높은 성능을 보였다. 40Gb 인피니밴드를 통해 가상화된 All Flash Array는 SCSI 타겟 시스템에 연결된 All Flash Array에 비해 순차/임의 읽기의 경우에 각각 78%, 79%의 성능을 보였으며, 순차/임의쓰기의 경우에는 83%, 88%의 성능을 보임을 확인하였다.

• Korean Journal of Acupuncture
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• 제30권1호
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• pp.47-55
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• 2013

Objectives : The purpose of this study was to determine whether electroacupuncture(EA) is effective in reducing pain on the severe ankle sprain classified as grade 3 in rats. Methods : The severe(grade 3) ankle sprain model was induced surgically by ankle ligament injury(the anterior talofibular, the calcaneofibular and the posterior talofibular) in the Sprague-Dawley rats(180~250 g). The effects of EA on weight bearing forces(WBR) of the affected foot were examined in a rat model of ankle sprain. EA was applied to either SI6, ST37, GB34, GB39 or GB42 acupoints by trains of electrical pulses(2 Hz, 1 ms pulse width, 2 mA intensity) for 15 min. Results : Cutting of the lateral ankle ligament complex produced the severe ankle sprain symptoms as grade 3. EA of the contralateral SI6 resulted in more analgesic effect than one of ipsilateral SI6 even though there was significant effect. EA of the ipsilateral GB34 and GB39 produced potent analgesic effects on the surgical ankle sprained pain behaviors. However, there were no significant analgesic effects in the contralateral GB34 and GB39 EA groups. In addition, both side of ST37 and GB42 did not result in analgesic effect on the surgical ankle sprained rat. Conclusions : The data suggest that EA induced analgesia shows point specificity on the severe ankle sprained pain model classified as grade 3.

• Korean Journal of Acupuncture
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• 제35권1호
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• pp.27-35
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• 2018

Objectives : The purpose of this study was to investigate the analgesic effect of electroacupuncture(EA) and radio-frequency warm needling(RFWN) stimulation in acupoint combination on ankle sprained pain in rats. Methods : The lateral ligaments of the Sprague-Dawley rats ankle were injured surgically resulting in sprain, of which was divided into EA, RFWN treatment groups and control group without treatment. The level of pain was measured through foot weight bearing force ratio followed by calculating pain relief. To stimulate proximal or distal area in ankle sprain, combination of proximal acupoints(GB34-GB39) and distal acupoints(GB39-GB42) from sprain area were applied, respectively, to either EA or RFWN stimulation. In addition, naltrexone or phentolamine was injected intraperitoneally before the stimulation to observe the pathway of analgesic effects. Results : In the proximal combination of GB34-GB39, EA and RFWN significantly increased pain relief compared to the control group (p<0.05). However, in distal combination with GB39-GB42, both EA and RFWN stimulation did not relieve pain due to ankle sprains. In the combination of GB34-GB39, the analgesia of EA was inhibited by blockade of the ${\alpha}$-adrenoceptor receptor. The analgesia of RFWN was inhibited by blockade of the ${\alpha}$-adrenoceptor receptor as well as ${\mu}$-opioid receptor. Conclusions : We observed that the proximal combination was effective in relieving pain when the treatment by acupoint combination was applied to the ankle sprain pain. Also, it was confirmed that this analgesia was also related to the pathways of ${\mu}$-opioid receptors and/or ${\alpha}$-adrenoceptors.

• Korean Journal of Acupuncture
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• 제31권4호
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• pp.195-207
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• 2014

Objectives : The purpose of this study is to examine the effects of laser acupuncture according to the wavelength(532 nm, 650 nm, 830 nm, 904 nm, and 1064 nm) at the acupoint of GB34 GB39 on neuropathic pain rat induced by tibial and sural nerve transection(TST). Methods : Neuropathic pain in rats was induced by tibial nerve and sural nerve transection. The rats were divided into the intact group, the TST control group, and the laser acupuncture therapy group. The laser acupuncture therapy groups were then divided into subgroups with 532 nm(L532), 650 nm(L650), 830 nm(L830), 904 nm(L904), and 1064 nm(L1064) laser acupuncture therapy. The acupoint of GB34 GB39 was selected, and laser acupuncture therapy was provided on both sides alternatively twice a week in a total of 6 sessions. Results : All the laser acupuncture groups showed a significant decrease in reaction time and force intensity. L532, L904, and L1064 groups showed a significant decrease in Bax, the L532 group showed a significant increase in Bcl-2, L532 and L1064 groups showed a significant decrease in the Bax/Bcl-2 ratio, and L532 and L650 groups showed a significant increase in mGluR5, as compared with the TST control group, among nerve tissue reaction. Conclusions : These results showed that laser acupuncture therapy at each of the wavelengths had some significance on neuropathic pain.

• Korean Journal of Acupuncture
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• 제26권2호
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• pp.177-195
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• 2009

Objectives : This study is performed to investigate the acupuncture on Sciatica through the literature of oriental medicine. Methods : We collected the oriental medical literature from ancient to modern times, and extracted the causes, symptoms, treatments and acupoints of sciatica. Results : The findings of this study are as follows: 1. The etiology of Sciatica is differentiated into the exogenous pathogenic factors(wind, cold, dampness, trauma, bad posture) and the internal pathogenic factors(deficiency of the kidney energy, congenital debility). 2. The symptoms of Sciatica are pain, weakness and dysesthesia in the low back, hip and lower limb. 3. In the treatment of Sciatica, The Leg Greater Yang Bladder (BL) Meridian and The Leg Lesser Yang Gall Bladder (GB) Meridian out of 12 meridians were mainly used and the acupoint GB30(Hwando) was most frequently used in the acupuncture literature. 4. The number of acupoints used for sciatica was 95, and those acupoints in the order of frequency were GB30(Hwando), GB34(Yangnungch'on), BL40(Wijung), BL60(Kollyun), GB31(P'ungshi), GB39(Hyonjong), BL57(Sungsan), ST36(Chok-samni). Conclusion : The most frequently used acupoints for the treatment of sciatica are as follows; GB30(Hwando), GB34(Yangnungch'on), GB31(P'ungshi), GB39(Hyonjong) of The Leg Lesser Yang Gall Bladder Meridian, BL40(Wijung), BL60(Kollyun), BL57(Sungsan) of The Leg Greater Yang Bladder Meridian.