• Clinical and Experimental Pediatrics
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• v.46 no.6
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• pp.541-547
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• 2003

Purpose : Gap junction intercellular communication(GJIC) is an important mechanism of the bystander effect in herpes simplex thymidine kinase/ganciclovir(HSVtk/GCV) gene therapy Therefore, we attempted to enhance the bystander effect in vitro by exogenous overexpressing connexin 37(Cx37) in cells to increase GJIC. Methods : NIH3T3 cells were transfected with the Cx37 and HSVtk gene or the HSVtk gene alone by the calcium phosphate method, and we detected their expression from these cells by RT-PCR. GCV-mediated cytotoxicity and the bystander effect of each transfectant was then assessed and compared. Results : Cells transfected with HSVtk became sensitive to low concentration of GCV. We found significantly increased cytotoxicity in HSVtk/GCV gene therapy after introduction of the HSVtk and Cx37 genes together compared with the cytotoxicity seen after introduction of the HSVtk gene in vitro. Co-expression of the HSVtk and Cx37 genes potentiates HSVtk/GCV gene therapy through the bystander effect. Conclusion : These results indicated that the increase of GJIC using Cx37 have potentiated the bystander effect of HSVtk/GCV therapy, and may be a new approach to improve response in suicidal cancer gene therapy.

• Korean journal of communication and information
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• v.43
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• pp.173-208
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• 2008

This study analyses the business performance according to the business diversification of Korean mass media enterprises from year 2003 to 2006. The conclusions drawn which could be divided into five main parts are the followings: First, newspaper companies pursue unrelated diversification in various industrial areas, in order to gain maximum profit while broadcasting companies exert themselves to provide better service by diversifying the major contents. Second, overall the interviewed companies display a constant decline in profit gained from their major business area thus establishing strategies to broaden their focus on diversification of any sort. Third, the researcher completed group analysis in regard of diversification measure resulting in division of three groups. The group which had the most immense diversification range gained the highest ROE, the lowest ROE volatility, and lesser probability of risk taking. The analysis adresses the companies broadening their business areas by researching and focusing on diversification are relatively stable in terms of the profit they gain. Fourth, the middle level group in terms of sales scale, debts, enterprise history, major share rate and high ROE group carry out diversification progressively. The sales scale affects positively to diversification, while the major share rate affects negatively to diversification. Fifth, in accordance to the research, diversification overall contributes to obtainance of successful outcome. Since there was not an immense amount of studies to be referred in the media area, the researcher interviewed and did panel discussion with numerous strategists and managers who are in charge of diversification of media companies. However, collection of only 4 years of data limits the research to be considered to be a generalized study, and does not reflect time gap between business diversification and business performance. Development is required in future studies to be established regarding the media companies' specificity different to other industries, classified the media companies into media types, and consider the time gap in the diversification activities and business performance.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.4
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• pp.491-499
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• 2015

Purpose: This study was to examine how decline of visual function affects visual perception by assessing visual perception after improving visual function through visual training, and observing the change in the cognitive ability of visual perception. Methods: This study analyzes the visual perceptual evaluation (TVPS_R) of 23 children below age 13($8.75{\pm}1.66$) who have visual abnormalities, and improves visual function after conducting vision training (vision therapy) of the children. Results: Convergence increased from average $3.39{\pm}2.52{\Delta}$ (prism) to $13.87{\pm}6.04{\Delta}$ in the measurement of long-distance disparate points, and from average $5.48{\pm}3.42{\Delta}$ to $18.43{\pm}7.58{\Delta}$ in the measurement of short-distance disparate points. Short-distance diplopia points increased from $25.87{\pm}7.33cm$ to $7.48{\pm}2.87cm$, and as for accommodative insufficiency, short-distance blur points increased from $19.57{\pm}7.16cm$ to $7.09{\pm}1.88cm$. In the visual perceptual evaluation performed before and after improving visual function, 6 items except visual memory showed statistically significant improvement. By order of significant improvement, response gap was highest with $17.74{\pm}16.94$(p=0.000) in visual closure, followed by $15.65{\pm}17.11$(p=0.000) in visual sequential-memory, $13.65{\pm}16.63$(p=0.001) in visual figure-ground, $12.74{\pm}18.41$(p=0.003) in visual form-constancy, $6.48{\pm}10.07$ (p=0.005) in visual discrimination, and $4.17{\pm}9.33$(p=0.043) in visual spatial-relationship. In the visual perception quotient that added up these scores, the response gap was $15.22{\pm}8.66$(p=0.000), showing a more significant result. Conclusions: Vision training enables efficient visual processing and improves visual perceptual ability. It was confirmed that improvement of visual function through visual training not only improves abnormal visual function but also affects visual perception of children such as learning, perception and recognition.

• Journal of the korean academy of Pediatric Dentistry
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• v.33 no.1
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• pp.43-52
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• 2006

Topical fluoride application for children is a widely peformed procedure in the field of pediatric dentistry to prevent dental caries. However, it is recently recognized as having some unwanted effects on several esthetic restorative materials as it roughens the surface of the restorative materials. The aim of this study was to evaluate the surface changes in composite resins to topical fluoride. Composite resins(Z $250^{(R)}$, Ultraseal $XT^{(R)}$ Filtek $flow^{(R)}$ $Revolution^{(R)}$, $Denfil^{(R)}$) in topical fluoride agents were immersed and their surface roughness, weight loss and SEM were evaluated. The results were as follows : 1. The 4 minutes-immersion groups showed more roughened surface than 1 minute-immersion groups and the control groups showed the smoothest surface among all the materials, and there was statistically significant difference except the revolution between the groups. 2. There was no significant difference between the 1 minute-immersion groups and 4 minutes-immersion groups in weight loss. 3. The experimental group treated with topical fluoride gel showed the generally mere roughened surface than control group in the SEM findings.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.4 no.1 s.6
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• pp.43-56
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• 2005

This research has examined a time series analysis(TSA) of an every hour traffic information such as occupancy, a traffic flow, and a speed, a statistical model of a surveyed data on the traffic fundamental diagram and an expand aspect of a traffic jam by many Parts of the traffic flow. Based on the detected data from traffic accidents on the Cheonan-Nonsan high way and events when the road volume decreases dramatically like traffic accidents it can be estimated from the change of occupancy right after accidents. When it comes to a traffic jam like events the changing gap of the occupancy and the mean speed is gentle, in addition to a quickness and an accuracy of a detection by the time series analyse of simple traffic index is weak. When it is a stable flow a relationship between the occupancy and a flow is a linear, which explain a very high reliability. In contrast, a platoon form presented by a wide deviation about an ideal speed of drivers is difficult to express by a statical model in a relationship between the speed and occupancy, In this case the speed drops shifty at 6$\~$8$\%$ occupancy. In case of an unstable flow, it is difficult to adopt a statistical model because the formation-clearance Process of a traffic jam is analyzed in each parts. Taken the formation-clearance process of a traffic jam by 2 parts division into consideration the flow having an accident is transferred to a stopped flow and the occupancy increases dramatically. When the flow recovers from a sloped flow to a free flow the occupancy which has increased dramatically decrease gradually and then traffic flow increases according as the result analyzed traffic flow by the multi regime as time series. When it is on the traffic jam the traffic flow transfers from an impeded free flow to a congested flow and then a jammed flow which is complicated more than on the accidents and the gap of traffic volume in each traffic conditions about a same occupancy is generated huge. This research presents a need of a multi-regime division when analyzing a traffic flow and for the future it needs a fixed quantity division and model about each traffic regimes.

• Journal of the Korean Association of Geographic Information Studies
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• v.12 no.2
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• pp.34-43
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• 2009

Based on previous research on ways of reducing an urban heat island phenomenon via an introduction of wind corridors, I conducted this study to see what influence a change in land cover arising of or going through urbanization has on wind corridors of urban space. As a target place, I chose Daegu city where is a representative extreme heat place in Korea and has been also largely expanded in size by incorporating its neighboring areas since the 1980s, expecially Dalseo District whose surface temperature gap is large. The population of Dalseo District has been sharply increased since its creation as a new administrative district in 1988. I studied on the urban microclimate change for a 20-year period by using satellite images on summer months in 1987, 1997 and 2007 in time frames. The finding of this study found that a reduction of natural land cover and an increase of artificial land cover serves as a disadvantageous factor for cold air creation and flowing and strikingly lowers the amount and height of cold air in the downtown area. It seemed that the cold air creation and flowing functions are influenced by land cover. In order to steadily create cold air and secure its flowing, it is thought that urban development or urban regeneration should be implemented by analysing the characteristics of the space surrounding the city. By doing so, a pleasant and healthy city could be formed.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.28 no.3
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• pp.213-221
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• 2006

Purpose This study was aimed to evaluate the effect of the location and angle of drilling on the changes of the distance between the two block specimens. Materials and methods In experimental group 1, the screw holes were prepared by drilling in the distal portion of compression part of the plate at $90^{\circ}$. In experimental group 2, the drilling was performed at an angle of $30^{\circ}$ proximal to the miniplate, and in experimental group 3, at $30^{\circ}$ distal respectively. In control group, the drilling was performed to the center of hole at $90^{\circ}$. The fixation screw length was 5 mm, 7 mm, and 9 mm in all groups. The results were as follows. Results 1. In control group, the mean changes between two specimens were 0.01 mm, 0.02 mm, and 0.00 mm in 5 mm, 7 mm, and 9 mm screws respectively. 2. In experimental group 1, the compression part was moved toward the retention part. The range of mean changes were from -0.39 mm to -0.43 mm. 3. In experimental group 2, the compression part was moved toward the retention part. The range of mean changes were from -0.51 mm to -0.56 mm. 4. In experimental group 3, the compression part was moved apart from the retention part and the range of mean changes were from 0.55 mm to 0.56 mm. 5. The changes were significantly different between all groups(p<0.01). Conclusion These results suggest that 0.4$\sim$0.5 mm of compressive effect can be achieved by drilling on the distal area of the screw hole at an angle of $90^{\circ}$ and by the proximal angulation to the miniplate, and the gap between specimens can be increased by distal angulation to the miniplate during drilling.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.14 no.5
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• pp.1-12
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• 2015

Length and the number of tunnels has increased 10% annually. Tunnel construction has positive effect in nature and driving condition. However, the structure of tunnels lead to a greater probability of major accidents. For this reason, tunnel is focusing its attention on the rapid incident handling and disaster management to build a tunnel management system in recently. In this study, tunnel management system adequacy analyzed in terms of operational safety using IPA and AHP analysis. IPA analysis results using the portfolio chart, incident management factors has a large gap between important and satisfaction. Disaster management is analyzed high ranking in priority. However, incident management factors are derived first priority in AHP analysis. This study determined that the results are meaningful to practitioners in the field is determined. In addition, practitioners comments should be reflected primarily for tunnel operational safely.

• Informatization Policy
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• v.24 no.2
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• pp.43-67
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• 2017

In 2015, Korea won the first place among 30 countries in Open, Useful, and Reusable (OUR) Data Index, which is an OECD's open government data indicator. On the other hand, Korea was ranked the 17th among 86 countries in Open Data Barometer (ODB) of World Wide Web Foundation. In this study, the research subject comes from two reasonable academic doubts on why the gap is wide between the two indicators of Korea and whether the OUR Data Index made proper evaluation on Korea's open government data. Based on the assumption that there may be some critical points in the measuring method of OUR Data Index, the study conducted a comparison of the two indicators. The result found that first, the two indicators almost had no correlation to each other; second, OUR Data Index had a more vague evaluation framework as well as less amount of government data for evaluation than ODB; third, while the government support takes a significant share in the OUR Data Index, it is considered as a mere input element; and fourth, the OUR Data Index does not evaluate the impact of open government data, whereas ODB includes the impact of open data on the government, economy, and society.

• The Journal of Industrial Distribution & Business
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• v.10 no.9
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• pp.37-43
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• 2019

Purpose - The self quality inspection which is mandatory in Republic of Korea can play an important role in promoting food safety, but the cost for self quality inspection is also a big burden especially for small businesses. In addition, excessive or duplicated inspection costs resulting from the standard gaps of various ministries and agencies ultimately effect negative social utility. Thus, this paper aims to suggest ways to improve the analysis of self quality inspection for the Ready-to-Eat Foods in terms of dried laver, in order to reduce costs caused by overinclusion. Research design, data, and methodology - The focus of interest is seaweed in Kimbab, which is to be exempted from the Vibrio parahaemolyticus test on the three grounds. First, existing literature provides little support for the necessity of performing a microbiological test. Second, laver products do not require the V.parahaemolyticus test by international standards such as the CODEX. Third, no case was found for seaweed products on the list of information on failed food items over the 2015~16 period. Results - Other types of seaweed such as exportable and seasoning seaweed are not subject to the test. Hence, exclusion of the V.pahaemolyticus test on seaweed is a valid point, bringing about large expected cost savings to many small businesses. Conclusions - Based on a complete survey of 75 food-testing agencies from March 20th to 30th, 2018, this paper finds that the proposed revision of the Kimbab test is likely to save an average of 130,000 won per business per year. Especially, in the case of the testing fee of Salmonella spp.(n,c,m,M), the cost difference by agencies was found to be up to five times. The regional gap in testing fees can be considered an unfair barrier. Accordingly, it is necessary to examine whether the testing fee is set at an appropriate level through the cost-extraction program proposed by the Ministry Food and Drug Safety. Hence, the survey results also point out that harmonization of testing fees charged by different food-testing agencies is appropriate with respect to transparency and efficiency.