• Korean Journal of Pharmacognosy
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• v.28 no.4
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• pp.215-224
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• 1997

Gamijiyu-tang (GJT) described originally in the Dong Eui Bo Gam, a traditional reference for oriental medicine in the Korea, has been clinically used for treatment of chronic liver disease. In order to evaluate scientifcally a hepatoprotective effect of GJT in the liver fibrotic disease, the present study investigated how GJT improves a hepatic function in the dimethylnitrosamine (DMN)-treated rat. DMN treatment caused a significant increase of relative liver weight to the body at 28 days after DMN induction. Administration of with a clinical dose decreased significantly the sAST level $(158.8{\pm}7.76\;IU/L)$ elevated by DMN in jection (p<0.01). A similar phenomenon was also observed at change of both Salt and Salt level in the GJT and/or DMN-treated animal (p<0.01, p<0.05, respectively). A remarkable increase of hydroxyproline was observed by treatment of DMN with comparing to the normal rat $(361.9{\pm}7.35\;vs.\;1278.1{\pm}52.9\;{\mu}g/g\;tissue,\;p<0.01)$. This was significantly reduced by a simultaneous treatment of GJT with DMN for 21 days (p<0.05), but not recovered completely to its normal value. In addition. GJT administration ameliorated conspicuously the DMN-induces histopathological changes of liver such as hemorrhage. Cell necrosis and fibrosis. Tak'en together, results described here demonstrated scientifically in first the medicinal efficacy of GJT by using in vivo animal model, indicating that GJT improves the DMN-induced hepatic injury through reducing an excessive accumulation of collagen and histopathological changes. The decreased collagen content may be a pivotal process for GJT to improve hepatic function in the DMN-induced liver fibrosis. The present study suggests that GJT may be useful for and applicable to the treatment of hepatic fibrosis in chronic liver disease.

• The Journal of Korean Medical History
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• v.25 no.2
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• pp.155-193
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• 2012

From the part "歷代醫學姓氏(Historic Doctors)" in "醫林撮要(Uirimchualyo)", the following has been noticed and concluded. 1. Because acupuncture was originated from stony needle, the word "石(sok)" contains the meaning of needle, and from this point on, words like 石(sok), 砭石(pyumsok), 箴石(Jamsok), 鑱石(Chamsok) had been derived. 2. The word 砭石(pyumsok) used in "Hwangjenaekyong(Yellow Emperor's Canon of Medicine or Hwangdineijing)" should be interpreted as acupuncture in a verb form, not a noun form. 3. 鑱石(Chamsok) or 鑱鍼(Chamchim) was used for surgical treatment for tumor, by cutting open tumors and pressing the pus out. Therefore, 砭石(pyumsok), 鑱石(Chamsok) are the same kind of needles, and 鑱鍼(Chamchim) is the tool improved from 鑱石(Chamsok) used in the Bronze Age. 4. Kwakpak put a note on 鑱石(Chamsok) in "山海經(Sanhaekyong)" that reads "it is defined as 砥鍼(Jichim) and treats tumor." This let us know the shape of 石(sok), 砭石(pyumsok), 鑱(Chamsok), 鑱鍼(Chamchim), and the stone that can be used as a surgical tool with slim & sharp shape is obsidian. 5. Because obsidian is only found around Mt. Baekdu and limited area in South Korea & Japan in Asia, it is closely related with the life & medical environment of the tribe "Mt. Baekdu". 6. The development of 鑱鍼(Chamchim) was influenced by surgical treatment used in early stage of civilization, and its origin is traced upto Gochosun dynasty. Korea's own traditional medical knowledge is derived from this surgical treatment skill. 7. Because the acupuncture is originated from Gochosun dynasty, 鍼(chim) was derived from 箴(Jam) of 箴石(Jamsok), 䥠(Chim) & 䥠(Chim) both were used for a time being, and finally settled into 鍼(Chim). 8. The word 針(Chim) showed up at Myung dynasty, and started to be used in Korea from early Chosun dynasty. 9. In the early Chosun dynasty, 鍼(Chim) was used for medical term, and 針(Chim) for non-medical term. In the mid Chosun dynasty, 針(Chim) was used as a term for tool, and 鍼(Chim) as a term for acupunctural medical treatment. 10. Under the order of King Sunjo, Dr. Yesoo Yang published "醫林撮要(Uirimchualyo)", added "醫林撮要續集(Sequel to Uirimchualyo)", and added "歷代醫學姓氏(Historic Doctors)" again which eventually made totally 13 books of "醫林撮要(Uirimchualyo)". In addition, many parts of "醫林撮要續集(Sequel to Uirimchualyo)" were quoted in "東醫寶鑑(Donguibogam)", and influenced much in publishing "Donguibogam". 11. In "歷代醫學姓氏(Historic Doctors)" of "醫林撮要(Uirimchualyo)", the same way in "Donguibogam", referred to 針(Chim) as a term for a needle, and 鍼(Chim) as a term for Acupuncture. 12. From the usage of 針(Chim) & 鍼(Chim), shown in "鄕藥集成方(Hyangyakjipsungbang)", "醫林撮要(Uirimchualyo)" and "東醫寶鑑(Donguibogam)", we can notice the spirit of doctors who tried to take over the legitimacy of Korean tradition, and their elaboration & historical view that expresses confidence on our own medical technology, through the wording 鍼(Chim).

• The Journal of Korean Philosophical History
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• no.31
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• pp.321-346
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• 2011

This is a preliminary study in order to deal intensively with the overall characteristics of Korean military science in the future days. First off, the history of military science of China based on the precedent studies was recapitulated, and a comparative study on the acceptance process of the books on military art and science, as well as on understanding patterns of literati on the subject through literature searches, ranging from the Three Kingdoms Period to the Goryeo Dynasty in Korean peninsula, was conducted. In case of Korea, the Chinese books on military strategy, including Sun Tzu's the Art of War, had already been passed down during the Three Kingdoms Period, and broadly read by scholarly people. They had utilized diverse methods based on their knowledge of Confucianism. In the reference materials, the authors of Korean military strategy books had greatly relied upon the Chinese books on military strategies, however, they had made the military principles run in their own way. At the end of Goryeo Dynasty, 'Military Science' had been well established as a subject in academia, and this curriculum had been taught not only at the National Confucian Academy, Seonggyun-gwan, in the capital but also at the country public school ("Hyanggyo") in the province together with Confucianism. Because of the limits of reference materials, however, it was difficult to confirm whether or not such strategic experiences were actually led to the publication of the books on military art and science, or how many books on military strategies and tactics had been published up until the end of Goryeo Dynasty. But, the facts that there were not many publications of the books on military strategies during the era of Three Kingdoms and of Goryeo Dynasty don't mean that Korean military science had entirely relied upon the Chinese military art and science. For instance, such strategies, tactics and leaderships as exhibited in the process of the Great Victory at Salsu River ("Salsu Daecheop") achieved by General Eulji Mun-deok, as well as the Great Victory at Gwiju ("Gwiju Daecheop") achieved by General Kang Gam-chan could never happen by chance.

• Proceedings of the Korea Water Resources Association Conference
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• 2017.05a
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• pp.7-7
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• 2017

범람파동 개념에 따르면 하도와 홍수터의 횡적 연결성은 하천 생태계의 생물다양성과 생산성 증대에 중요한 역할을 한다. 제방에 의하여 제내지 홍수터가 하도와 차단된 우리나라 하천에서 생태적 서비스를 증대하기 위해서 횡적 연결성을 복원하는 기술 개발이 필요하다. 횡적 연결성의 복원 기술을 개발하기 위해서는 우선 하도와 홍수터 사이에 생태적 연결성의 현황을 파악하고 연결성을 저해하는 요인을 진단하는 평가 기술 개발이 시급히 요청되고 있다. 따라서 본 연구에서는 제방에 의하여 차단된 제내지 하천환경에서 수리적, 생태적 횡적 연결성을 평가하고 진단하는 기술을 개발하고 연결성 회복 방안을 제안하고자 한다. 차단된 제내지 하천환경 평가는 1) 지리정보시스템을 이용하여 차단된 하천공간을 탐색하고, 2) 탐색된 전체 재내지에서 원격평가에 의하여 간편하게 횡적 연결성 평가를 실시하고, 3) 선정된 특정 제내지 대상지에서 현장평가에 의하여 상세하게 연결성을 평가하는 순서로 수행된다. 차단된 하천공간의 획정은 홍수가 범람할 수 있는 제내지 공간을 잠재적 하천공간으로 정의하고 수치표고모델 (DEM)과 하천기본계획의 30년 빈도 홍수위 자료를 이용하여 제내지 홍수터를 탐색하였다. 제내지 홍수터의 원격 연결성평가는 지리정보시스템에서 수치지도와 토지피복도 등 공간자료를 이용하여 수리 및 서식처 환경성, 제방 차단성과 하도 및 육상 연결성을 평가하고 원격평가 결과를 토대로 현장평가 대상지를 선정하였다. 횡적 연결성의 현장평가를 위하여 크게 하도-홍수터 연결성과 제내지 서식처 보존성으로 평가 항목을 선정하였다. 또한 연결성 평가는 수리연결성과 생물연결성으로, 서식처 보존성 평가는 습지유지율, 습지보존성, 육역지보존성을 세부항목으로 구성하였다. 평가 항목별로 5 등급의 평가 기준에 따라서 평가 점수를 부여하고 평가 총점을 산출하여 최종 연결성 평가 등급을 5 단계로 구분하였다. 현장평가를 위한 MS Access 기반 소프트웨어를 개발하여, 데이터 입력과 관리 및 평가 결과 산출과 비교를 편리하게 하였다. 개발된 제내지 하천환경 평가법을 청미천과 만경강에 적용하여 검증하였다. 개발된 평가법을 바탕으로 차단된 제내지 하천환경에서 연결성 회복에 따른 어류와 식생의 분포를 예측하는 수리생태 결합모델을 개발하였다. 먼저 차단된 제내지에서 연결 수로를 복원하여 유속, 수심 분포를 준이차 수리수문 모델로 예측하였다. 예측된 수리 환경에 따라서 지표어종의 서식처 적합도 지수 (HSI)를 이용하여 서식 분포 확률을 모의하였다. 또한 일반화가법모델 (GAM)을 이용하여 환경구배에 의한 우점식생의 분포를 예측하였다. 차단된 제내지 하천환경의 생태적 연계성 평가 기술을 기반으로 제방제거, 제방후퇴, 제방고 하강, 수문 및 연결수로 개선, 생물이동 저해 장벽 제거 등의 다양한 복원기술이 개발되어야 할 것으로 생각된다.

• Applied Chemistry for Engineering
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• v.29 no.6
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• pp.726-733
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• 2018

The rice's waste byproduct is known as a rice bran and produced annually about 400,000 to 600,000 tons. Most of the rice bran are used as a livestock feed or waste disposal, and needed to be used to produce high-added substances, such as bioactive materials. In this study, extraction conditions of the ultrasound-assisted extraction (UAE) of the rice bran were optimized using a statistically-based optimization. The influence of extraction variables including the extraction time ($X_1$), extraction temperature ($X_2$) and ethanol concentration ($X_3$) were investigated using the response surface methodology in order to determine optimum extraction conditions which maximize total phenolic compounds (TPC), total flavonoid compounds (TFC) and electron donating abilities (EDA). The optimal UAE from rice bran was achieved under the extraction temperature of $94.9^{\circ}C$, extraction time of 41.6 minute and ethanol concentration of 74.0% (v/v) with maximum yields of TPC 2.78 mg GAE/g DM, TFC 1.63 mg QE/g DM and EDA 42.86%. The UAE process shows its potential to the extraction of bioactive and antioxidant compounds from rice bran in a short extraction time and low temperature. Also, it is proposed that rice bran could be considered as food additives and cosmeceutical products.

• Journal of The Korean Society of Agricultural Engineers
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• v.61 no.4
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• pp.11-22
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• 2019

The objective of this study was to improve the cross-sectional area and height estimation method using stream width. Stream water levels should be calculated together to simulate inundation of agricultural land. However, cross-sectional survey data of small rural rivers are insufficient. The previous study has developed regression equations between the width and the cross-sectional area and between the width and the height of stream cross-section, but can not be applied to a wide range of stream widths. In this study, cross-sectional survey data of 6 streams (Doowol, Chungmi, Jiseok, Gam, Wonpyeong, and Bokha stream) were collected and divided into upstream, midstream and downstream considering the locations of cross-sections. The regression equations were estimated using the complete data. $R^2$ between the stream width and cross-sectional area was 0.96, and $R^2$ between width and height was 0.81. The regression equations were also estimated using divided data for upstream, midstream and downstream considering the locations of cross-sections. The range of $R^2$ between the stream width and cross-sectional area was 0.86 - 0.91, and the range of $R^2$ between width and height was 0.79 ? 0.92. As a result of estimating the cross-sections of 6 rivers using the regression equations, the regression equations considering the locations of cross-sections showed better performance both in the cross-sectional area and height estimation than the regression equations estimated using the complete data. Hydrologic Engineering Center - River Analysis System (HEC-RAS) was used to simulate the flood stage analysis of the estimated and the measured cross-sections for 50-year, 100-year, and 200-year frequency floods. As a result of flood stage analysis, the regression equations considering the locations of cross-sections also showed better performance than the regression equations estimated using the complete data. Future research would be needed to consider the factors affecting the cross-sectional shape such as river slope and average flow velocity. This study can be useful for inundation simulation of agricultural land adjacent to an unmeasured stream.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.3
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• pp.408-414
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• 2021

This study aimed to improve the production of bioactive materials with antioxidant activity using a fermented Luffa aegyripia extract and improve the anticancer effect by enhancing UV absorption and inhibiting melanoma cell growth. The total phenolic content (TPC) and antioxidant activity of the fermented extract were 30.23 mg GAE/g DM and 45.12%, respectively, which was 1.4 times higher than that of the hot-water extract (HWE). The fermented extract showed a UV adsorption rate of 53.9%, which was 1.5 times higher than HWE, and it was concluded that UV absorption was increased by TPC, which was increased through the fermentation of L. aegyptiaca extracts using Lactobacillus. In the anticancer effect test, fermented and HWE extracts had carcinogenic effects of 1.0 and 2.0 mg/mL, respectively. This suggests that the increased antioxidant activity due to the increase in TPC caused by fermentation contributed to the anticancer effect. The UV absorption rate of fermented extracts was 2.4 times higher than HWE, giving them potential use as cosmetics and pharmaceutical materials with high polyphenol contents and antioxidant properties and skin cancer prevention.

• Journal of Nutrition and Health
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• v.54 no.1
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• pp.116-128
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• 2021

Purpose: The extraction conditions for bioactive components from peanut shells, which is a byproduct of peanut processing, were optimized to enhance the total phenolic content (TPC, Y1), total flavonoid content (TFC, Y2), and 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity (RSA, Y3). In addition, this study evaluated the anti-obesity effect of peanut shell extract. Methods: Optimization of ultrasonic-assisted extraction (UAE) was performed using a response surface methodology. The independent variables applied for extraction were time (X1: 5.0-55.0), temperature (X2: 26.0-94.0), and ethanol concentration (X3: 0.0%-99.5%). Quadratic regression models were derived based on the results of 17 experimental sets, and an analysis of the variance was performed to verify its accuracy and precision of the regression equations. Results: When evaluating the effects of independent variables on responses using statistically-based optimization, the independent variable with the most significant effect on the TPC, TFC, and RSA was the ethanol concentration (p = 0.0008). The optimal extraction conditions to satisfy all three responses were 35.8 minutes, 82.7℃, and 96.0% ethanol. Under these conditions, the inhibitory activities of α-glucosidase and pancreatic lipase by the extract were 86.4% and 78.5%, respectively. Conclusion: In this study, UAE showed superior extraction efficiency compared to conventional hot-water extraction in the extraction of polyphenols and bioactive materials. In addition, α-glucosidase and pancreatic lipase inhibitory effects were identified, suggesting that peanut shells can be used as effective antioxidants and anti-obesity agents in functional foods and medicines.

• Journal of Korean Medical Ki-Gong Academy
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• v.20 no.1
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• pp.15-67
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• 2020

Objective : The purpose of this study is to identify the trends of vibration(or wave) therapy in Korea, to actively utilize vibration(or wave) therapy, and to help research activities of vibration therapy in Korean Medicine. Methods : The following Korean words "진동기", "진동요법", "진동운동", "진동치료", "파동요법", "파동운동", "파동치료" were searched on three specialized search sites (RISS, NAL, DBpia). Trends of vibration therapy were analyzed through the selected researches suitable for this study among these searched researches in an overview format. Results : 1. A total of 8,116 studies were searched and a total of 365 studies were finally selected 2. From 2000 to 2019, when research began to increase in earnest, there were 17.45±10.28 studies per year, and the AGR(Average Annual Growth Rate) was 11.92%. 3. In the main field of research, the 'Medicine and Pharmacy' was the largest with 147(40.16%) studies. In the Middle Field, the 'Kinesiology' was the largest with 99(27.05%) studies. In the study design, 'RCT(Randomized Controlled trial)' was the largest with 138(47.75%) studies. In the Age Group, 'Youth' was the largest with 126(48.84%) studies. 4. The average of the number of participants was 24.90±17.44. 5. The most used Intervention was the 'WBV(Whole Body Vibration)' with 177(61.25%) studies. 6. The average of Intervention Period was 5.99±4.14 weeks, while the maximum was 36 weeks. 7. The journal that published the most research papers is 'K. J. of Sports Science(체육과학연구;13)', and the society is 'Rehabilitation Engineering And Assistive Technology Society of Korea(한국재활복지공학회; 14)'. The University that published the most dissertations is 'Sahmyook University(11)'. 8. The authors who published the most studies are Ju-Hwan O(8) as the main author and Tae Kyu Kwon(18) as the co-author (including the thesis Director). In an integrated analysis of the authors and co-authors, Tae Kyu Kwon published the most numerous studies(19) Conclusions : 1. The study of vibration or wave therapy has been increasing noticeably every year. 2. The major academic Fields studying vibration or wave therapy are the 'Kinesiologic Field', 'Physical Therapy Field', and 'Biomedical Engineering Field'. 3. The most chosen method of study design on vibration or wave treatment was 'RCT', and there was no significant change in the annual presentation rate. 4. Types of vibration or wave therapy could be classified as 'LVS(Local Vibration Stimulation)', 'WBV(Whole Body Vibration)', 'MV(Micro Vibration)', 'BV(Bio Vibration)' and 'SWV(Sound Wave Vibration)', and the study on Whole Body Vibration is most active. 5. Most of the studies of vibration or wave therapy were on musculoskeletal systems, but there were very few studies on internal diseases.

• Journal of Korean Medical Ki-Gong Academy
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• v.20 no.1
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• pp.85-103
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• 2020

Objective : A common treatment for hypothyroidism is to supplement the deficient hormones. However, taking hormone medication does not improve clinical symptoms or side effects, so it is necessary to develop other improved treatments. The purpose of this study is to report that the Korean medicine treatment along with Whidam's Gokgol(CV2) Sugi therapy has improved symptoms of hypothyroidism and related the level of TSH, free T4 after halting the use of levothyroxine. Methods : We employed Korean medicine treatment; herbal-medication(延齡固本丹 and 加減平胃散), acupuncture, and cupping therapy, and so forth. At the same time, we treated the patient with Whidam's Sugi therapy(especially, Gokgol Sugi therapy). We treated the patient more than five times a week for the first month and treated more than three times a week for the next three months. Since then, we have treated the patient once or twice a week. The patient took a total of four blood tests during her treatment in 2012 and 2017. Results : 1. Both TSH and free T4 levels and clinical symptoms were normalized for patient with hypothyroidism who stopped taking levothyroxine by treating the patient with Korean medicine treatment and Whidam's Sugi therapy. 2. The combination of Korean medicine treatment and Whidam's Sugi therapy was also used in the case of subclinical hypothyroidism patient. 3. The combination of Korean medicine treatment and Whidam's Sugi therapy for hypothyroidism lasted for five years, not just for a short period of time. Conclusions : The combination of Korean medicine treatment and Whidam's Sugi therapy(especially, Gokgol Sugi therapy) was effective in the treatment of hypothyroidism and it helped to normalize the level of TSH, free T4. It is hoped that further clinical research will continue in the future so that it can be used not only for hypothyroidism but also for other endocrine diseases.