• 디자인학연구
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• 제19권1호
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• pp.303-316
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• 2006

새로운 미의식의 창조를 위해 이질적이고 대립적인 요소를 융합 혼합하는 절충주의는 다양성, 다원화에 기초하므로서 개성화, 다양화를 추구하는 현대인의 요구에 부합되어 각광 받고 있다. 본 연구는 현대직물디자인에 표현된 절충주의 양식을 파악하기 위하여 현대예술분야를 통해 그 특성을 규명하고 이를 직물디자인에 적용시켜 새로운 경향이 제시한 미적 효과와 조형적 특성을 고찰하므로서 현대직물디자인의 변화양상을 이해하고자 하였다. 연구결과 현대 직물디자인에 나타난 경향은 다음의 3개로 구별되는데, 1) 문화적 절충에 의한 고급문화와 저급문화의 복합, 2) 시대적 절충에 의한 다양한 시대적 감각의 융합, 3) 지역적 절충에 의한 지역적 특성의 혼합으로 나타나며, 이러한 경향으로 본 직물디자인의 특징은 1) 직물디자인에 대한 시각의 전환을 가져왔고, 2) 유희적 표현을 중시하였으며 3) 다문화적 표현이 강조되고 있다. 이와 같이 직물디자인의 절충주의적 경향은 다변화되고 있는 현대 사회를 대변해주고 미래 직물디자인을 위한 하나의 가능성을 제시하여 주므로서 이에 대한 연구는 지속적으로 필요하다.

• 디자인학연구
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• 제16권3호
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• pp.341-350
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• 2003

21세기의 문화라는 화두를 보면 디지털미디어의 등장이다. 이는 산업혁명에 버금가는 새로운 전환을 이루었으며 이제 우리사회는 디지털 미디어 매체가 지배하는 사회가 되었다. 변화와 발전을 거듭하는 디자인 학문으로서 시각디자인의 정체성이 디지털매체가 들어오면서 어떻게 진화하고 있는지를 조사ㆍ분석하여 현재 시각디자인 교육의 방향을 가늠하기 위한 것이 본 연구의 주된 목표이다. 또한 디지털 매체는 젊은 계층이 주 타깃이 되기에 시각언어의 표현기법이 달라지는 것도 필연적이라고 볼 수 있는데, 실제 디지털 매체의 등장으로 시각커뮤니케이션이 창조되고 분배되어 온 방법들이 많은 변화를 거쳐 온 것이 사실이다. 과거 대부분의 디자인 교육기관들은 서로 비슷한 교육목표와 커리큘럼, 교수법으로 학생들이 실무현장에 대비할 수 있는 교육을 제공해왔다. 그러나 지금과 같은 디지털 미디어시대에 시각디자인의 적용과 활용은 비할 수 없이 다각화되었으며 그것은 상호자강(Interaction)으로 대별된다. 본 연구에서는 디지털 시대 시각디자인 분야의 전문 인재 양성 방안을 찾는 것을 목적으로 이를 위해 기존의 전통교육과 디지털 교육의 융합으로 현실 사회의 요구에 부응하는 새로운 교육시스템을 도출하고, 사회의 요구를 앞서가는 디자인 교육기관으로서의 위상을 제시하고자 한다.

• Journal of Microbiology and Biotechnology
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• 제25권2호
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• pp.280-287
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• 2015

Current influenza vaccines are produced in embryonated chicken eggs. However, egg-based vaccines have various problems. To address these problems, recombinant protein vaccines have been developed as new vaccine candidates. Unfortunately, recombinant proteins frequently encounter aggregation and low stability during their biogenesis. It has been previously demonstrated that recombinantly expressed proteins can be greatly stabilized with high solubility by fusing stabilizing peptide (SP) derived from the C-terminal acidic tail of human synuclein (ATS). To investigate whether SP fusion proteins can induce protective immunity in mice, we produced influenza HA and SP fusion protein using a baculovirus expression system. In in vitro tests, SP-fused recombinant HA1 (SP-rHA1) was shown to be more stable than recombinant HA1 (rHA1). Mice were immunized intramuscularly with baculovirus-expressed rHA1 protein or SP-rHA1 protein ($2{\mu}g/mouse$) formulated with aluminum hydroxide. Antibody responses were determined by ELISA and hemagglutination inhibition assay. We observed that SP-rHA1 immunization elicited HA-specific antibody responses that were comparable to rHA1 immunization. These results indicate that fusion of SP to rHA1 does not negatively affect the immunogenicity of the vaccine candidate. Therefore, it is possible to apply SP fusion technology to develop stable recombinant protein vaccines with high solubility.

• Computers and Concrete
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• 제24권6호
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• pp.541-553
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• 2019

Alkali-silica reaction (ASR) in concrete can induce degradation in its mechanical properties, leading to compromised serviceability and even loss in load capacity of concrete structures. Compared to other properties, ASR often affects the modulus of elasticity more significantly. Several empirical models have thus been established to estimate elastic modulus reduction based on the ASR expansion only for condition assessment and capacity evaluation of the distressed structures. However, it has been observed from experimental studies in the literature that for any given level of ASR expansion, there are significant variations on the measured modulus of elasticity. In fact, many other factors, such as cement content, reactive aggregate type, exposure condition, additional alkali and concrete strength, have been commonly known in contribution to changes of concrete elastic modulus due to ASR. In this study, an artificial intelligent model using artificial neural network (ANN) is proposed for the first time to provide an innovative approach for evaluation of the elastic modulus of ASR-affected concrete, which is able to take into account contribution of several influence factors. By intelligently fusing multiple information, the proposed ANN model can provide an accurate estimation of the modulus of elasticity, which shows a significant improvement from empirical based models used in current practice. The results also indicate that expansion due to ASR is not the only factor contributing to the stiffness change, and various factors have to be included during the evaluation.

• 디지털융복합연구
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• 제16권7호
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• pp.393-400
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• 2018

현대사회 속에서 주류로 부상한 1인가구를 위한 맞춤형 가구에 관해 디자인하고자 한다. 특히 삶의 질을 높이려는 세대의 경향에 주목하여 아트퍼니처에 가까운 심미적인 가구들을 디자인하고자 했으며 이를 위해 현재 발표되고 있는 국내외의 아트퍼니처를 살피고 그 경향들을 토대로 조합형 커스텀디자인이라는 개념을 제시하고자 한다. 조합형 커스텀 디자인은 기존의 것과는 달리 파츠별로 구분하여 독립된 디자인을 만들고 이를 융합함으로서 보다 다양하면서도 적극적인 조형을 가능하게 하는 것으로 삶의 질에 많은 관심을 보이는 1인가구들의 능동적인 성향과 궤적을 같이 하며 특히나 다품종 소량생산에 적합하기에 기존의 공예공방 체계 속에서 생산이 가능할 것이며 실제 조합형 커스텀 디자인을 통한 두 개의 테이블을 통해 가능성을 확인할 수 있었다.

• Molecules and Cells
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• 제39권4호
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• pp.286-291
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• 2016

Epstein-Barr virus (EBV) is the prototypical ${\gamma}$-herpesvirus and an obligate human pathogen that infects mainly epithelial cells and B cells, which can result in malignancies. EBV infects these target cells by fusing with the viral and cellular lipid bilayer membranes using multiple viral factors and host receptor(s) thus exhibiting a unique complexity in its entry machinery. To enter epithelial cells, EBV requires minimally the conserved core fusion machinery comprised of the glycoproteins gH/gL acting as the receptor-binding complex and gB as the fusogen. EBV can enter B cells using gp42, which binds tightly to gH/gL and interacts with host HLA class II, activating fusion. Previously, we published the individual crystal structures of EBV entry factors, such as gH/gL and gp42, the EBV/host receptor complex, gp42/HLA-DR1, and the fusion protein EBV gB in a postfusion conformation, which allowed us to identify structural determinants and regions critical for receptor-binding and membrane fusion. Recently, we reported different low resolution models of the EBV B cell entry triggering complex (gHgL/gp42/HLA class II) in "open" and "closed" states based on negative-stain single particle electron microscopy, which provide further mechanistic insights. This review summarizes the current knowledge of these key players in EBV entry and how their structures impact receptor-binding and the triggering of gB-mediated fusion.

• 복식문화연구
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• 제27권4호
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• pp.384-397
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• 2019

The purpose of this study is to analyze the eco-friendly design characteristics of contemporary children's collections. Photos from FirstviewKorea were utilized for analysis; 29 brands were selected that included children's clothing collections featuring eco-friendly characteristics from 2007 to 2018. The results are as follows. First, naturalness was the most frequent characteristic of environmentally friendly children's collections. It was not conveyed in an eccentric way in any season, showed a relatively uniform distribution, and was seen in various ways, including printed on the fabric and expressed in $appliqu\acute{e}s$ and embroidery. Second, handcrafted features frequently changed according to seasonal trends. Various methods such as beading, embroidery, applique, sewing techniques, and handbags were used, which enhanced manual workability, discrimination from other designs. Third, traditionality is divided into the characteristics of ethnicity and revivalism. National traditions were expressed in the clothing and reflected the current generation while connecting to the past. Fourth, simplicity appeared in classic designs such as simple silhouettes, sparse decoration, natural colors, and comfortable dress length that is not tight on the body. Simplicity was not a frequent feature due to the characteristics of the children's clothing collections. Fifth, playfulness functioned to enhance the children's clothing's wear frequency. Although it was the least frequent of all the characteristics, it seemed to increase the design fun and the clothing's value by fusing with other characteristics such as handcraftedness and naturalness.

• Current Optics and Photonics
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• 제5권3호
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• pp.270-277
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• 2021

The adaptive sparse representation (ASR) can effectively combine the structure information of a sample dictionary and the sparsity of coding coefficients. This algorithm can effectively consider the correlation between training samples and convert between sparse representation-based classifier (SRC) and collaborative representation classification (CRC) under different training samples. Unlike SRC and CRC which use fixed norm constraints, ASR can adaptively adjust the constraints based on the correlation between different training samples, seeking a balance between l₁ and l₂ norm, greatly strengthening the robustness and adaptability of the classification algorithm. The correlation coefficients (CC) can better identify the pixels with strong correlation. Therefore, this article proposes a hyperspectral image classification method called correlation coefficients and adaptive sparse representation (CCASR), based on ASR and CC. This method is divided into three steps. In the first step, we determine the pixel to be measured and calculate the CC value between the pixel to be tested and various training samples. Then we represent the pixel using ASR and calculate the reconstruction error corresponding to each category. Finally, the target pixels are classified according to the reconstruction error and the CC value. In this article, a new hyperspectral image classification method is proposed by fusing CC and ASR. The method in this paper is verified through two sets of experimental data. In the hyperspectral image (Indian Pines), the overall accuracy of CCASR has reached 0.9596. In the hyperspectral images taken by HIS-300, the classification results show that the classification accuracy of the proposed method achieves 0.9354, which is better than other commonly used methods.

• Nuclear Medicine and Molecular Imaging
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• 제42권2호
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• pp.83-87
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• 2008

지난 몇 년 동안 핵의학 영상 물리 및 기기 관련 융합영상기기 분야에 많은 발전이 있었다. 최근 몇 년 동안 국내 PET/CT 설치의 급속한 증가는 이들의 임상에서의 역할 및 그 중요성을 입증하고 있다. 그러나 PET/CT는 고가이고, 임상적으로 아직도 그 유용성이 입증되는 과정에 있으며, 특히 치료계획을 위한 장비로는, 미국의 경우 다소 많이 설치되었다는 평가가 공존하고 있다. 또한 저가로 해 결할 수 있는 소프트웨어 융합도 가능하기 때문에 PET 대신 반드시 PET/CT가 필요하다는 주장에는 위의 관점에서 그 한계가 있을 수 있다. 그림에도 불구하고 PET/CT 설치는 계속 증가하고 있어 영상획득 또는 영상판독 모두 PET과 CT 분야의 훈련과 교육이 매우 중요하며 이에 대한 지침서가 발간되었다. PET/CT에 비하여 SPECT/CT는 발전속도가 다소 떨어지지만 이에 대한 지침서도 발간되었다. PET/CT와 SPECT/CT 모두 CT는 앞 부분에 PET과 SPECT는 뒷부분에 설치된다. 이는 환자 영상을 얻을 때 동시에 얻는 것이 아니고 CT영상을 얻은 후 PET과 SPECT영상을 얻게되는 단점이 있다. 이와는 달리 MRI/PET경우 뇌영상을 얻을 때 동시에 MRI와 PET영상을 얻을 수 있어 뇌영상 연구에 큰 도움이 될 것으로 예상하고 있다. 앞으로 기술이 발전함에 따라 전신용 MRI/PET과 유방영상을 위한 PET/US 융합영상장치의 개발 가능성이 매우 높다. 이와 함께 SPECT/CT, PET/CT 및 MRI/PET 기기의 발전도 계속될 것으로 판단된다. 핵의학 영상 물리 및 기기 분야는 최첨단 융합영상 장치의 개발과 함께 하드웨어, 소프트웨어 물리적 특성에 대한 보정기술, 영상 재구성 분야의 다양한 연구도 많은 진전이 필요하다. 또한 영상기기의 설계 및 정량화 기법을 연구하기 위한 몬테카를로 시뮬레이션, 영상장비의 성능평가, 동력학 분석, 선량평가, 움직임 보정 및 융합영상의 정량화 및 분석 기법에 대한 연구도 더욱 활발히 진행될 것으로 예측된다.

• 공학교육연구
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• 제21권4호
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• pp.53-62
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• 2018

The purpose of this study is to investigate the current conditions of the domestic and foreign curricula in the field of chemical engineering and to draw implications. The results of the study are as follows. Most of the domestic research universities (including non-certified universities) have curricula organized within the scope of the ABEEK certification, which is the minimum standard guide for chemical engineering curricula. However, we are concerned that chemical engineering education in some domestic universities may lack in education quality and program relevance. Graduates from these universities may not have equivalent qualifications as international graduates. It is considered that most of the 12 domestic universities organize their subjects according to the certificate of accreditation standard and to the traditional subjects of chemistry in the 'Department of Chemical Engineering' or 'Department of Chemical and Biological Engineering Chemical and Biological Engineering'. However, due to the increase in the number of overlapping subjects with other majors because of the movement towards academic diversity, the integrity of the chemical engineering curricula is at risk. In addition, after surveying the major and research areas of the department professors, it has been found that there is a shortage of professors who have majored in chemical engineering. Therefore, there is a concern that students may lack understanding of the core principles of chemical engineering. The results of the analysis of the curricula of overseas research universities (including non-certified universities) are as follows. Although the chemical engineering industry in developed countries like the United States and Europe is advancing and changing very quickly, the chemical engineering education in these countries is highly focused on traditional subjects and other related subjects in order to cultivate traditionally trained chemical engineers. The Department of Chemical Engineering at overseas universities still maintains the academic integrity of the chemical engineering field. This is a significant suggestion for our country. On the other hand, domestic universities are changing the name of their chemical engineering major, or even if the name is maintained, they are fusing their curriculum with other majors such as material engineering. Therefore, it is very necessary at this point to start a discussion regarding the integrity of the department of chemical engineering in Korea. We hope that the departments of chemical engineering in domestic universities maintain the integrity of traditional chemical engineering while operating the curriculum within the scope of the standards of the engineering education certification system.