• Asian Pacific Journal of Cancer Prevention
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• v.15 no.4
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• pp.1817-1822
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• 2014

Objective: The aim of this study was to screen for possible biomarkers of metastatic osteosarcoma (OS) using a DNA microarray. Methods: We downloaded the gene expression profile GSE49003 from Gene Expression Omnibus database, which included 6 gene chips from metastatic and 6 from non-metastatic OS patients. The R package was used to screen and identify differentially expressed genes (DEGs) between metastatic and non-metastatic OS patients. Then we compared the expression of DEGs in the two groups and sub-grouped into up-regulated and down-regulated, followed by functional enrichment analysis using the DAVID system. Subsequently, we constructed an miRNA-DEG regulatory network with the help of WebGestalt software. Results: A total of 323 DEGs, including 134 up-regulated and 189 down-regulated, were screened out. The up-regulated DEGs were enriched in 14 subcategories and most significantly in cytoskeleton organization, while the down-regulated DEGs were prevalent in 13 subcategories, especially wound healing. In addition, we identified two important miRNAs (miR-202 and miR-9) pivotal for OS metastasis, and their relevant genes, CALD1 and STX1A. Conclusions: MiR-202 and miR-9 are potential key factors affecting the metastasis of OS and CALD1 and STX1A may be possible targets beneficial for the treatment of metastatic OS. However, further experimental studies are needed to confirm our results.

• Tunnel and Underground Space
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• v.19 no.5
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• pp.397-406
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• 2009

Recently, the number of industrial structures that must be demolished due to structural deterioration and unsatisfactory functional conditions has been increased. To minimize environmental hazardous factors created during the process of demolition, the explosive demolition method has been applied increasingly. This execution case was intended to describe an application of the explosive demolition method to the demolition of a Crusher & Screen structure, which was a large-section reinforced concrete special structure. It was deemed necessary due to its structural deterioration and unsatisfactory functional condition. Various pre-weakening processes and blasting patterns were applied to the large-section reinforced concrete members, and to reduce blasting vibration and impact vibration, time intervals were established for blasting in the same column and for blasting between blasting blocks. By applying the explosive demolition method to the demolition of a large-section reinforced concrete special structure, the explosive demolition was completed safely and efficiently, without causing any damage to surrounding facilities.

• Journal of the Korean Society of Physical Medicine
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• v.13 no.4
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• pp.85-94
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• 2018

PURPOSE: This study was conducted to determine the effects of therapeutic exercise on range of motion (ROM), the manual muscle test (MMT), functional movement screen (FMS) and radiological evaluation in a youth football player with football-specific anterior pelvic tilt (APT). METHODS: The subject of this case report was a 12-year-old youth football player, who presented with football-specific APT. Therapeutic exercise consisted of hamstring stretch, prone hip extension, abdominal crunch, bridging with isometric hip abduction, plank exercise with posterior tilt and posterior pelvic tilting exercise using a swiss-ball for 40 min/day, twice a week for 8-weeks. ROM, MMT, FMS (deep squat, hurdle step, inline lunge, shoulder mobility, active straight-leg raise, rotary stability and trunk stability push-up) and radiographs (lumbar lordotic and sacral horizontal angle) were analyzed before and after week 8 of therapeutic exercise. RESULTS: The ROM, MMT, and FMS increased and the lumbar lordotic angle and sacral horizontal angle improved after 8-weeks of therapeutic exercise. CONCLUSION: The results of this case report suggest that therapeutic exercise improves ROM, MMT and radiography associated parameters in youth football players with football-specific APT. These findings have clinical implications for therapeutic exercise in youth football players with football-specific APT.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.2 no.2
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• pp.14-21
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• 2003

Rapid prototyping(RP) has been used for design verification and proto sample or mold manufacturing. Many RP systems have been introduced into the market during the past 15 years. However, until now, the systems have used mainly for external physical models (mono function), and have the basic but critical limitation of one material on one stage (mono material). To overcome the limitations of mono-material and mono-function of conventional. RP systems, the concept of Functional Phototype Development (FPD) is newly proposed in this paper FPD provides the necessary prototype functions such as mechanical, optical, chemical and electrical properties in order to meet the broad requirements of the industry. The paper illustrates the representative achievements of electronic components such as the multi-layer printed circuit board(MLB). Experimental results demonstrate that FPD has great potential applied to broad industrial uses and that It Will be a powerful tool in the neat future.

• Genomics & Informatics
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• v.20 no.1
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• pp.5.1-5.10
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• 2022

Non-syndromic hearing loss (NSHL) is a common hereditary disorder. Both clinical and genetic heterogeneity has created many obstacles to understanding the causes of NSHL. The present study has attempted to ravel the genetic aetiology in NSHL progression and to screen out potential target genes using computational approaches. The reported NSHL target genes (2009-2020) have been studied by analyzing different biochemical and signaling pathways, interpretation of their functional association network, and discovery of important regulatory interactions with three previously established miRNAs in the human inner ear as well as in NSHL such as miR-183, miR-182, and miR-96. This study has identified SMAD4 and SNAI2 as the most putative target genes of NSHL. But pathogenic and deleterious non-synonymous single nucleotide polymorphisms discovered within SMAD4 is anticipated to have an impact on NSHL progression. Additionally, the identified deleterious variants in the functional domains of SMAD4 added a supportive clue for further study. Thus, the identified deleterious variant i.e., rs377767367 (G491V) in SMAD4 needs further clinical validation. The present outcomes would provide insights into the genetics of NSHL progression.

• Journal of the Korean Applied Science and Technology
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• v.39 no.1
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• pp.96-107
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• 2022

The purpose of this study was to demonstrate the effects of 8weeks Kettlebell training on the FMS and Balance in Middle school baseball player. Fourteen middle school baseball players were randomly assigned to a kettlebell group (n=8) and a control group (n=6), and kettlebell training was applied twice a week for 60 minutes. And the FMS, Y-balance test and static and dynamic balance test using smart shoes were tested before and after kettlebell training. Repeated two-way ANOVA measures was performed both before and after the exercise to verify the effect of kettlebell training. Also, if there was an interaction between time and group, a paired sample t-test was performed for each group. As a results of the study, FMS score showed a significant difference in IL (Inline Lunge) and TS(Total Score), and there was no significant difference in other variables of FMS. The YBT score showed a significant difference in all YBT variables except for the left AT. And the balance test using smart shoes, there was no significant interaction effect between group and period in all variables. In conclusion, it was found that the application of kettlebell training in middle school baseball players had an effects on the FMS and YBT scores related to functional movement and functional balance, but it did not affect the static/dynamic balance test using smart shoes evaluated by the foot pressure method. It seems that the results of this study can be provided as basic data necessary for planning a training program for middle school baseball players.

• Journal of Digital Convergence
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• v.20 no.1
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• pp.191-202
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• 2022

The purpose of this study is to examine the effect of a 10-week body stability exercise program, which was conducted on 24 male football players. The result of the Visual Response Speed Test using BlazePod, showed a significant increase of the upper arms, left foot and right foot for 15 second in number of reactions and reaction time (p<0.001). As a result of evaluating whether or not 7 functional movements were improved in order to evaluate the functional movement screen, Hurdle Step (p=0.001) and Active Straight Leg Rise (p=0.022) movements were significantly improved. significantly improved. As a result of measuring the y-balance Test in order to evaluate the balance ability, composite score(p<0.001) of both sides was significantly improved. The result of evaluating vital capacity, which was conducted to evaluate mobility and muscle endurance, showed a significant improvement in Forced vital capacity(p<0.001) and Forced expiratory volume in 1.0(p=0.003). In conclusion, a 10-week BSE program intervention in high school period, which can most improve the technical fitness necessary for the game in power, agility, leg strength, leg stability, mobility, and muscle endurance, will improve overall technical fitness, prevent football players from being injured and enhance their performance.

• Journal of the Korea Furniture Society
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• v.28 no.4
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• pp.259-267
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• 2017

Furniture should change according to space. Therefore, it is important that the flexibility of the furniture, the functional efficiency, the economical efficiency and the convenience of the furniture of today. These characteristics are also important for seminar tables that are used temporarily by a large number of people. The seminar furniture currently in use has no shielding plate, there are two forms of table and shielding plate folding table. Therefore, in this research, furniture design and product development that can complement the shortcomings of the seminar furniture currently in use were done. Analysis of problems through overseas investigation and domestic market research, design planning and design, and prototyping. We have sought to optimize the volume by applying the characteristics of RTA furniture to develop a lightweight, lightweight, lightweight, easy to install and easy to use shielding plate, and open and closed system. Basically developed two types of shielding board seminar table basic shape and Roll Screen type, we expanded the scope of application such as each color and pattern. In order to reduce the weight, we replaced the parts such as anchor bolts and hinges and the shielding plate with Roll Screen and pursued volume optimization. As a result of this research, it is expected that the system of mechanisms such as packaging standardization and damage prevention for weight reduction and volume optimization will contribute to building competitiveness by domestic office prefabricated furniture industry's original technology.

• Biomolecules & Therapeutics
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• v.31 no.1
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• pp.48-58
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• 2023

Interferon regulatory factor 3 (IRF3) integrates both immunological and non-immunological inputs to control cell survival and death. Small GTPases are versatile functional switches that lie on the very upstream in signal transduction pathways, of which duration of activation is very transient. The large number of homologous proteins and the requirement for site-directed mutagenesis have hindered attempts to investigate the link between small GTPases and IRF3. Here, we constructed a constitutively active mutant expression library for small GTPase expression using Gibson assembly cloning. Small-scale screening identified multiple GTPases capable of promoting IRF3 phosphorylation. Intriguingly, 27 of 152 GTPases, including ARF1, RHEB, RHEBL1, and RAN, were found to increase IRF3 phosphorylation. Unbiased screening enabled us to investigate the sequence-activity relationship between the GTPases and IRF3. We found that the regulation of IRF3 by small GTPases was dependent on TBK1. Our work reveals the significant contribution of GTPases in IRF3 signaling and the potential role of IRF3 in GTPase function, providing a novel therapeutic approach against diseases with GTPase overexpression or active mutations, such as cancer.

• Proceedings of the KSR Conference
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• 2008.06a
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• pp.292-298
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• 2008

Seoul Metro and Seoul Metropolitan Rapid Transit Corp. have started installing screen doors at subway platforms to improve the environment of subways and prevent passengers' accidents since 2006. They are still installing screen doors at subway platforms and Metropolitan Rapid Transit Corporations in other areas are also proceeding with installment of screen doors or making preparations for it. Grounding is necessary for installing PSD systems. In case that PSD grounding is connected with existing electrical equipment grounding system, it was decided to install separate grounding for safe operation of PSD system and passenger safety. However, it's very difficult to install new grounding at the subway station compound. A way to improve this condition is that we proceed with grounding by composing grounding station by carbon grounding rod. This paper will mainly deal with how to design and construct carbon ground rod, which has been applied to PSD system grounding since 2006, including its experimental examples. In this paper, ways to secure ground resistance below 5 ohms, which is resistance necessary for PSD grounding, and to compose grounding system were also discussed. Furthermore, a ground test to check the ability to fulfill a role of PSD grounding system was conducted. As a result of applying carbon grounding module, PSD system is being operated without any problem and the installment of PSD system will be continuously expanded in the future. It's also thought that a way to integrate grounding of each functional room which has been installed at the subway station compound and to arrange equipotential grounding should be reviewed and performed promptly.