• Proceedings of the Korean Operations and Management Science Society Conference
• /
• 2003.05a
• /
• pp.76-80
• /
• 2003

The procedure of finding operating conditions minimizing qualify loss is proposed with a real industry example. The procedure consists or major two parts - the selection or process variables critical to the response and He determination or operating conditions. The coefficients or ridge regression and the and stores or partial least squares are applied to select important process variables. Functional approach and Non-functional approach are used to find proper operating conditions of important process variables.

• Journal of the Korean Statistical Society
• /
• v.24 no.1
• /
• pp.31-44
• /
• 1995

In fitting a model, there always exists a discrepancy between the fitted model and the true functional relationship. In measuring this discrepancy, Box and Drapper (1959) used the criterion dividing the discrepancy into two parts which are the bias error part and the variance error one in single response case. In this paper, an optimum design which makes these two types of errors as small as possible is found by extending the Box and Drapper criterion to multiple response situation. Especially, a design is found to meat rotatability conditions when we fit a quadratic model to each response fearing cubic bias. Using the central composite design, an application of general results to a specific case is shown to help understanding the material.

• Communications for Statistical Applications and Methods
• /
• v.13 no.2
• /
• pp.273-283
• /
• 2006

In bioassay, the response curve is usually assumed monotone increasing, but its exact form is unknown, so it is very difficult to select the proper functional form for the parametric model. Therefore, we should probably use the nonparametric regression model rather than the parametric model unless we have at least the partial information about the true response curve. However, it is well known that the nonparametric regression estimate is not necessarily monotone. Therefore the monotonizing transformation technique is of course required. In this paper, we compare the finite sample properties of the monotone transformation methods which can be applied to the local linear quasi-likelihood response curve estimate.

• Molecules and Cells
• /
• v.44 no.3
• /
• pp.179-185
• /
• 2021

Vancomycin response regulator (VncR) is a pneumococcal response regulator of the VncRS two-component signal transduction system (TCS) of Streptococcus pneumoniae. VncRS regulates bacterial autolysis and vancomycin resistance. VncR contains two different functional domains, the N-terminal receiver domain and C-terminal effector domain. Here, we investigated VncR C-terminal DNA binding domain (VncRc) structure using a crystallization approach. Crystallization was performed using the micro-batch method. The crystals diffracted to a 1.964 Å resolution and belonged to space group P212121. The crystal unit-cell parameters were a = 25.71 Å, b = 52.97 Å, and c = 60.61 Å. The structure of VncRc had a helix-turn-helix motif highly similar to the response regulator PhoB of Escherichia coli. In isothermal titration calorimetry and size exclusion chromatography results, VncR formed a complex with VncS, a sensor histidine kinase of pneumococcal TCS. Determination of VncR structure will provide insight into the mechanism by how VncR binds to target genes.

• Steel and Composite Structures
• /
• v.48 no.3
• /
• pp.353-365
• /
• 2023

Shape memory alloys (SMAs) have emerged as a novel functional material that is being increasingly applied in diverse fields including medical, aeronautical and structural engineering to be used in the active, passive and semi-active structural control devices. This paper is mainly aimed at evaluating the ductility and response modification factor of the steel plate shear wall (SPSW) frames with and without the Ni-Ti shape memory alloys. To this end, different configurations were utilized, in which the walls were used in the first, third, middle, and all stories. The models were numerically analyzed using OpenSees Software. The obtained results indicate that improving the shape memory properties of alloys can greatly enhance the ductility and response modification factor. Furthermore, the model whose first and third stories are equipped with the SMA shear wall was found to be 290% more ductile, with a greater response modification factor compared to the unequipped frame.

• Clinical Psychopharmacology and Neuroscience
• /
• v.16 no.4
• /
• pp.449-460
• /
• 2018

Objective: Prior functional magnetic resonance imaging (fMRI) work has revealed that children/adolescents with disruptive behavior disorders (DBDs) show dysfunctional reward/non-reward processing of non-social reinforcements in the context of instrumental learning tasks. Neural responsiveness to social reinforcements during instrumental learning, despite the importance of this for socialization, has not yet been previously investigated. Methods: Twenty-nine healthy children/adolescents and 19 children/adolescents with DBDs performed the fMRI social/non-social reinforcement learning task. Participants responded to random fractal image stimuli and received social and non-social rewards/non-rewards according to their accuracy. Results: Children/adolescents with DBDs showed significantly reduced responses within the caudate and posterior cingulate cortex (PCC) to non-social (financial) rewards and social non-rewards (the distress of others). Connectivity analyses revealed that children/adolescents with DBDs have decreased positive functional connectivity between the ventral striatum (VST) and the ventromedial prefrontal cortex (vmPFC) seeds and the lateral frontal cortex in response to reward relative to non-reward, irrespective of its sociality. In addition, they showed decreased positive connectivity between the vmPFC seed and the amygdala in response to non-reward relative to reward. Conclusion: These data indicate compromised reinforcement processing of both non-social rewards and social non-rewards in children/adolescents with DBDs within core regions for instrumental learning and reinforcement-based decision-making (caudate and PCC). In addition, children/adolescents with DBDs show dysfunctional interactions between the VST, vmPFC, and lateral frontal cortex in response to rewarded instrumental actions potentially reflecting disruptions in attention to rewarded stimuli.

• Journal of The Korean Society of Integrative Medicine
• /
• v.9 no.3
• /
• pp.111-124
• /
• 2021

Purpose : The purpose of this study is to evaluate whether physical ability is improved by body stabilization, develop training methods to improve physical fitness factors suitable for body conditions, and provide future management and exercise materials to improve Taekwondo athletes' performance, after conducting the Body stabilization exercise (BSE) program on 22 elementary school Taekwondo athletes for 10 weeks to strengthen core muscles and evaluating Visual response speed test (VRST), Functional movement screen (FMS), Y-Balance test (YBT) and Vital capacity (VC). Methods : In order to examine the impact of the BSE program on Taekwondo athletes' VRST, FMS, YBT and VC this study conducted individual evaluations on all subjects, including VRST, FMS, YBT and VC before applying the programs, and compared exercise effects before and after the program, before and after exercise by a certain period. Results : After exercising, strength and quickness were improved significantly and reaction time was significantly shortened (p<.001). The total score of FMS was improved from 10.86±1.17 before to 11.68±0.99 after exercising, was statistically significant (p=.014). YBT was significantly improved from 91.11±4.84 before to 95.68±5.15 after exercising (p<.001). VC improved was statistically significant (p<.001). Conclusion : In conclusion, the BSE athletic program is expected to help Taekwondo athletes perform well by preventing and reducing injuries through the improvement of muscular strength, strength, speed, agility, step, kick, balance, flexibility, full body endurance and the combination of technical abilities.

• International Journal of High-Rise Buildings
• /
• v.12 no.3
• /
• pp.251-262
• /
• 2023

In response to China's "Regulations on the Management of Earthquake Resistance of Building Constructions" on the provision of eight types of important buildings to maintain functional after fortified earthquakes occur, "Guidelines for Seismic Design of post-quake functional buildings (Draft for Review)" distinguishes Class I and Class II buildings, and gives the performance objectives and seismic verification requirements for design earthquakes and severe earthquakes respectively. In this paper, a hospital and a school building are selected as examples to design according to the requirements of fortification of Intensity 8 and 7 respectively. Two design strategies, the seismic isolation scheme and energy dissipation scheme, are considered which are evaluated through elastic-plastic dynamic time-history analysis to meet the requirement of post-quake functional buildings. The results show that the seismic isolation design can meet the requirements in the above cases, and the energy dissipation scheme is difficult to meet the requirements of the "Guidelines" on floor acceleration in some cases, for which the scheme shall be made valid through the seismic resilience assessment. The research in this paper can provide a reference for designers to choose schemes for post-quake functional buildings.

• The Korean Journal of Nuclear Medicine
• /
• v.13 no.1_2
• /
• pp.31-36
• /
• 1979

The TRH stimulation test was known as a highly diagnostic method in hypothalamopituitary disorders. To evaluate the location and the extension of the lesion, we estimated TSH response to TRH test in 27 patients. Correlation between volume of sella and TSH response was also studied. The results obtained were as follows: 1. In Sheehan's syndrome, TSH response after TRH test were not observed in all of 12 patients. 2. All 2 acromegaly patients showed normal TSH response. 3. In 4 cases of chromophobe adenoma, 2 cases showed no TSH response. In 2 responded cases, one patient whose tumor mass extended to suprasella region was hypothyroid state. 4. In craniopharyingioma 3 cases, the tumor which extended to intrasella showed hypothyroid and no TSH response. 5. Correlation between volume of sella and TSH response were valuable in 2 cases, but no diagnostic significance. 6. In diabetes inspidus, TSH response were all absent. 7. In primary amenorrhea, TSH response observed in 1 case, which conformed with isolated FSH deficiency.

• Journal of the Korean Magnetic Resonance Society
• /
• v.22 no.4
• /
• pp.91-100
• /
• 2018

Benzisothiazolinone (BIT) is the preservative that is widely used in industrial and household products. In this study, zebrafish (Danio rerio) was exposed to BIT at different concentrations (control, 0.5 g/L, 1.0 g/L and 2.0 g/L) for 72 hours. The techniques of nuclear magnetic resonance (NMR) spectroscopy were applied to analyze the effects of BIT on zebrafish. The advantages of NMR are the minimal sample preparation and high reproducibility of experimental results. With the multivariate statistical analysis, dimethylamine, N-acetylaspartate, glycine and histidine were identified as an important metabolite in differentiating between the control and BIT-exposed group. This study will improve the understanding the metabolite changes in the zebrafish in response to BIT exposure.