• Journal of Korean Biological Nursing Science
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• 제16권4호
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• pp.292-299
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• 2014

Purpose: This is a study on the structural model that aims to build a path model of multivariates affecting the quality of health-related living for liver cirrhosis patients and specify causal relations affecting the quality of health-related living for liver cirrhosis patients. Methods: The research was conducted on 244 patients diagnosed with liver cirrhosis and the data were collected from July 2013 to January 2014. The collected data were analyzed using IBM SPSS 19.0 and AMOS 21.0 statistical programs. Results: All the fit indexes of the path model properly met the assessment criteria. Anxiety, depression, functional status, and perceived health directly affected the quality of health-related living for liver cirrhosis patients and anxiety, depression, and functional status directly affected perceived health. Social support, anxiety, and depression directly affected the functional status. Conclusion: It is necessary to segment the severity of liver cirrhosis in testing its direct and indirect effects on the quality of health-related living for patients with the condition.

• 대한간호학회지
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• 제42권3호
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• pp.311-321
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• 2012

Purpose: This study was designed to construct and test a structural equation modeling on specific domain health status and the Selection Optimization Compensation (SOC) strategy affecting successful aging in elderly people. Methods: The model construction was based on the SOC model by Baltes and Baltes. Interviews were done with 201 elderly people aged 65 or older. Interview contents included demographics, functional health status, emotional health status, social health status, SOC strategies, and successful aging. Data were analyzed using SPSS 15.0 and AMOS 7.0. Results: Model fit indices for the modified model were GFI=.93, CFI=.94, and RMSEA=.07. Three out of 7 paths were found to have a significant effect on successful aging in this final model. Functional health status had a direct and positive effect on successful aging. Emotional health status influenced successful aging through SOC strategies. Conclusion: This study suggests that interventions for improving functional health status and for strengthening SOC strategies are critical for successful aging. Continuous development of a variety of successful aging programs using SOC strategy is suggested.

• 한국미생물·생명공학회지
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• 제50권4호
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• pp.465-476
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• 2022

The importance of beneficial microorganisms, particularly probiotics, that coexist in the human body, is being increasingly recognized. Probiotics are representative health functional foods that provide health benefits to humans through the production of various metabolites, including short-chain fatty acids. However, the health benefits are strain-specific, and the use of each probiotic strain should follow guidelines that assure its safety. Accurate identification of the strain should be managed through genetic and phenotypic analyses of the strain. Besides, the functionality of probiotics should be disclosed in vitro and in vivo so that they can be used as legal functional ingredients (i.e., individual standards). In this review, we deal with the guidelines, including the technical factors related to probiotic strains. The common health effects of probiotic strains include proliferation of beneficial bacteria, control of harmful bacteria, and facilitation of bowel activities. Probiotics with various functionalities (e.g., body fat and cholesterol reduction, vaginal health, and improvement of skin's immune system) have been investigated as "individual standards of raw materials for health functional foods" provided by MFDS. In the future, various biotechnologies including synthetic biology can be applied to produce customized probiotics to improve human health.

• 한국식품영양과학회지
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• 제43권7호
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• pp.1112-1121
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• 2014

본 연구는 대도시 폐경기 중년 여성의 건강기능성식품에 대한 인지도 및 섭취 실태를 파악하여 향후 폐경기 전후 여성들을 위해 필요한 정보 제공 및 교육에 기초 자료를 제공하고자 실시되었으며 중요한 연구 결과는 다음과 같다. 폐경기 전후 중년 여성들은 자신의 건강 상태를 비교적 양호한 것으로 지각하고 있으며, 폐경 및 건강기능성식품에 대한 인식문항에서는 임신가능성 여부 및 폐경기 증상에 대해서는 높은 지식수준을 보였지만 폐경의 정의 및 건강 관련 사항에 대해서는 대부분 잘 모르는 것으로 나타났다. 또한 건강기능성식품에 대한 지식의 정답률은 48.7%로 지식수준이 높지 않은 것으로 나타났다. 그러나 건강기능성식품을 구매 또는 섭취한 경험이 있는 사람은 83.7%로 나타났고 구입처는 타인의 소개(35.0%)와 약국 병원(27.8%)이 가장 많았으며 건강기능성식품의 주요 섭취 이유는 질병 예방(29.6%), 영양소 보충(20.3%), 피로 회복(16.0%) 순으로 나타났다. 본 연구의 조사대상자인 폐경기 전후의 중년 여성들은 건강기능성식품을 구매할 때 효과를 가장 중요하게 생각하고 있으며, 일반 건강기능성식품의 경우 구매 또는 섭취한 경험이 있는 사람이 83.7%로 높게 나타났지만 폐경기 증상 완화를 위한 건강기능성식품의 경우 구입한 경험이 없는 대상자가 65.9%로 더 많았다. 또한 섭취한 건강기능성식품의 성분을 조금 알고 있는 대상자(56.4%)가 가장 많았고 모르는 대상자(25.5%)가 그 뒤를 이어 건강기능의 성분에 대한 지식이 매우 부족한 것으로 나타났다. 그러나 건강관심도에 따라서 건강기능식품의 구매빈도 및 섭취빈도, 폐경기 증상 완화를 위한 건강기능성식품 구매 및 섭취 여부에 유의한 차이를 보였다. 또한 폐경 증상 완화를 위해 콩 제품에 대한 인지도가 가장 높았으며 실제 섭취도 가장 많이 하는 것으로 나타났다. 폐경기 전후의 중년 여성들을 대상으로 실시한 본 연구 결과를 종합해 보면 이제는 사회에서 폐경을 맞는 여성들을 대상으로 교육을 실시하여 폐경에 대한 정확한 정보를 전달하고 폐경 후의 생활을 건강하게 보낼 수 있도록 정보제공 및 교육적 지원이 필요한 것으로 사료된다.

• 근관절건강학회지
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• 제24권2호
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• pp.130-139
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• 2017

Purpose: This study was conducted to explore the mediating effect of nutritional status in the relationship between symptom experience and functional status among in patients with lung cancer undergoing chemotherapy. Methods: Subject (N=139) were lung cancer patients visiting the D hospital in B city. Data collection was conducted from May 2016 to February 2017. Seven nutritional status measurement tools, 22 symptom experience tools, and 15 EORTC QLQ-C30 functional scales were used to measure nutritional, symptom, and functional levels. The collected data were analyzed by SPSS / WIN 21.0 using descriptive analysis, Pearson correlation, 3-step regression analysis of Baron and Kenny, and Sobel test. Results: There was a significant positive correlation between symptom experience and nutritional status, a significant negative correlation between symptom experience and functional status, and significant negative correlation between nutritional status and functional status. Symptom experience had direct effect and indirect effects on functional status through nutritional status. Conclusion: For enhancing functional status in lung cancer patients, it is necessary to develop nursing intervention programs to palliate symptoms and improve nutritional status.

• 근관절건강학회지
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• 제25권2호
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• pp.112-121
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• 2018

Purpose: This study was conducted to explore the mediating effect of nutritional status on the relationship between symptom experience and functional status of patients with Chronic Obstructive Pulmonary Disease (COPD). Methods: A total of 141 COPD patients visiting D hospital and I hospital in B city were enrolled in this study. Data were collected from January 2017 to July 2017. Outcome variables were measured by Mini Nutritional Assessment Short-Form (MNA-SF) for nutritional status, The Memorial Symptom Assessment Scale (MSAS) for symptom experience, and The Functional Performance Inventory Short Form (FPI-SF) for functional status. The data were analyzed with descriptive statistics, Pearson's correlation, and path analysis using SPSS/WIN 21.0 and AMOS 25. Results: There was a significant negative correlation between symptom experience and nutritional status (r=-.61, p<.001), a significant negative correlation between symptom experience and functional status (r=-.40, p<.001), and significant positive correlation between nutritional status and functional status (r=.47, p<.001). Symptom experience had indirect effects on functional status through nutritional status. Conclusion: For enhancing functional status in COPD patients, it is necessary to develop nursing intervention programs to enhance symptom management as well as nutritional status.

• 근관절건강학회지
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• 제18권1호
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• pp.83-92
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• 2011

Purpose: The purpose of this study was to identify the changes of physical function, perceptual and cognitive function, emotional function, and functional independence in the institutionalized aged according to functional group activity program (self help Tai Chi exercise plus functional task). Methods: Study subjects were 20 institutionalized aged from June to October in 2010. The subjects received functional group activity program two times a week for 15 weeks. Physical function (grip strength, coordination, lower extremity strength, balance, gait, trunk flexibility), perceptual and cognitive function, emotional function(depression, social skill), and functional independence were measured before and after the program. Results: The subjects showed significantly increased physical function (coordination, lower extremity strength, gait, trunk flexibility), perceptual and cognitive function, emotional function (depression, social skill), and functional independence. The functional group activity program may be an effective strategy for institutionalized elders to enhance their functions. Conclusion: The functional group activity program may be effective on elderly institutions which have limitation in human, material, environmental resources.

• Genomics & Informatics
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• 제10권2호
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• pp.106-109
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• 2012

Pulse rate is known to be related to diverse phenotypes, such as cardiovascular diseases, lifespan, arrhythmia, hypertension, lipids, diabetes, and menopause. We have reported two genomewide significant genetic loci responsible for the variation in pulse rate as a part of the Korea Association Resource (KARE) project, the genomewide association study (GWAS) that was conducted with 352,228 single nucleoride polymorphisms typed in 8,842 subjects in the Korean population. GJA1 was implied as a functionally causal gene for pulse rate from the KARE study, but lacked evidence of replication. To re-evaluate the association of a locus near GJA1 with pulse rate, we looked up this signal in another GWAS conducted in a Health Examinee-shared cohort of 3,703 samples. Not only we were able to confirm two pulse rate loci (1q32.2a near CD46 and 6q22.13c near LOCL644502) identified in the KARE GWAS, we also replicated a locus (6q22.31c) near GJA1 by the lookup in the Health Examinee GWAS. Considering that the GJA1-encoded protein is a major component of cardiac gap junctions, a functional study might be necessary to validate its genuine molecular biological role in the synchronized contraction of the heart.

• 보건의료산업학회지
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• 제12권2호
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• pp.125-134
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• 2018

Objectives : The purpose of this study was to analyze factors related to the functional state of stroke patients after discharge from hospital. Methods : The data was provided from a hospital in Wonju, Gangwon-do. The subjects of the analysis were those who were admitted to the emergency room due to stroke from July to December 2016. The dependent variable was the patient's functional status as measured by the modified Rankin Scale(mRS). Independent variables were demographic factors (age, sex, and marriage status), transportation and distance factors (transportation, travel distance), inpatient factors (lengths of stay, Charlson Comorbidity Index (CCI), Tissue plasminogen activator, National Institute of Health Stroke Scale (NIHSS). Hierarchial regression analysis was applied for the analysis. Results : In the hierarchical regression analysis, Model 3, including socio-demographic factors, transportation, distance factors, and inpatient factors, was the best fitted model. It showed that functional status of stroke patients was positively associated with age, length of stay, CCI, NIHSS, and negatively associated with unmarried status. Conclusions : Results indicated that management of stroke requires care from the pre-disease stage, and a customized education program policy is needed for high-risk stroke patients who are older and have comorbid illness.

• 한국식품위생안전성학회지
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• 제32권5호
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• pp.343-347
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• 2017

건강기능식품에서 이산화규소 분석 방법을 확립하기 위하여 산(불산과 붕산)분해를 이용한 ICP-OES 방법을 수행하였다. 이 방법의 검출한계와 정량한계는 각각 0.07 mg/L, 0.20 mg/L 이었다. 검량선은 0.2~20.0 mg/L의 농도범위에서 우수한 직선성($r^2$ 0.99)을 보였다. 글루코사민 제품에 이산화규소 0.4, 1.0, 2.0% (w/w)를 첨가하여 시험한 결과 90.22~94.14%의 회수율과 0.72~1.67%의 정밀성을 나타내었다. 확립된 방법으로 시중에 유통되는 건강기능식품 11품목의 이산화규소 함량을 분석한 결과 0.02~1.80% (w/w)로 나타났다. 이 결과는 건강기능식품에 이산화규소의 사용기준 2% (w/w) 이하를 만족하는 결과로 시험한 제품들은 규격에 적합하였다. 따라서 본 연구에서 확립된 이 방법은 건강기능식품 중 이산화규소를 쉽고, 빠르게 분석할 수 있으며, 건강기능식품 중 이산화규소 함량 분석에 효율적으로 사용될 수 있다.