• The Korea Journal of Herbology
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• v.30 no.4
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• pp.95-100
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• 2015

Objectives : The purpose of this study was to research the whitening effects and developing by cosmetics of the extract fromDioscoreae Rhizoma, which is one of the most popular health-promoting herb in herbal medications.Methods : We performed tyrosinase inhibition assay, reverse transcription-polymerase chain reaction (RT-PCR) and western blot for whitening effects. Also we measured MTT assay for cell viability.Results : The results were obtained as follows : For whitening effect, tyrosinase inhibition rate of extract fromDioscoreae Rhizomashowed more than 42.28% at 1,000 ㎍/㎖ concentration. Cell toxicity effect on melanoma cells (B16F10) of extract fromDioscoreae Rhizomashowed 81.97% with toxicity at 50 ㎍/㎖ concentration. So we were measured at a concentrations of 5, 10 and 50 ㎍/㎖ in all experiments involving cell. In addition, whitening related mRNAs including microphthalmia associated transcription factor (MITF), tyrosinase related protein-1 (TRP-1), tyrosinase related protein-2 (TRP-2), tyrosinase were reduced byDioscoreae Rhizoma. We also foundDioscoreae Rhizomatransiently decreased protein kinase A (PKA) which is known to be upstream to the down regulation of MITF and tyrosinase. But phosphorylation of extracellular signal related kinase (pERK) were increased byDioscoreae Rhizoma. These results imply thatDioscoreae Rhizomadecrease melanogenesis via ERK activation and subsequent down regulation of MITF and tyrosinase.Conclusions : Therefore, all these findings suggested the potent usage ofDioscoreae Rhizomaas materials of functional cosmetics by confirming whitening activity related with melanin content.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.3 s.47
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• pp.329-343
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• 2004

Recently, our society has prominently raised the desire to well-being life since not only our economical situations are better than before, but environmental pollution become serious. In well-being trends, the natural or nature-related products are also issued on their usages as bio-/raw materials for our living industries, such as cosmetics, household goods, and so on. Especially, various materials which comes from medicinal plants has been discovered their physiological properties and validated their functions. Thus, they have been subjected to several processes, including extraction, isolation and concentration, and popularly introduced to cosmetic industry. In these reasons, a variety of cosmetic Products using natural materials has been developed, which are focused on whitening, wrinkle improvement, and anti-aging. In this report, we present a brief review of the function and classification of natural products interested in until now, and introduce the natural materials for cosmetics having physiological activities on skin, including Fructan, Acrea extract, Portulaca extract, Licorce extract, Dandelion extract, Ulmus extract, SC-glucan, Arbutin, and Sophora extract.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.1
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• pp.81-86
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• 2021

The cosmetic industry is technology-intensive in the field of fine chemistry and continues to grow globally. The functional aspects have been mainly emphasized in the past to increase the market share in these cosmetics industries. Recently, however, efforts have been made to attract the attention of consumers to the visual effects as well as the excellent performance of cosmetics at home and abroad. Accordingly, cosmetic manufacturers are trying various technologies that encapsulate the cosmetic emulsion and modify the shape, color, and texture of the emulsion capsule. The basic and easiest method of encapsulating emulsion is dropping the emulsion through the nozzle from emulsion storage. On the other hand, the existing method of encapsulating emulsion has a limit in reducing the size of the capsule. In this study, the limit was shown by theory and numerical analysis method, and the emulsion encapsulation phenomena occurring in the micro-channel were studied to apply microfluidics as an alternative.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.48 no.4
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• pp.385-392
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• 2022

In this study, keratin peptides were produced through high-temperature anaerobic fermentation of keratin, a protein contained in deer antler, with Fervidobacterium islandicum AW-1, and factors related to human hair, confirming the possibility of keratin peptides as cosmetic ingredients. As a result of the cytotoxicity and proliferation of deer antler fermented keratin peptide according to the concentration in the dermal papilla cell line, cytotoxicity was not observed and the cell proliferation effect was shown. For human dermal papilla cells, statistically significant increasing in growth factors according to the deer antler fermented keratin peptide was determined possiblity of effects on hair growth. Cosmetic products containing deer antler fermented keratin peptides were manufactured and skin safety and anti hair loss efficacy clinical tests were conducted. As a result, after 12 weeks of use, the total number of hairs statistically significant increased compared to before using the product and the difference in total number of hairs compared to the control group was found. In conclusion, we suggest that the possibility of fermented deer antler keratin peptide as a cosmeceutical ingredient as well as a health functional food material was confirmed.

• The Journal of the Convergence on Culture Technology
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• v.9 no.1
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• pp.565-570
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• 2023

There are people who are sensitive to cosmetic ingredients, such as pregnant women and skin disease patients. There are also people who experience side effects from cosmetics. To avoid this, it is cumbersome to search for harmful ingredients in cosmetics one by one when shopping. In addition, knowing and remembering functional ingredients that suit you is helpful when purchasing new cosmetics. There is a need for a system that allows you to immediately know the cosmetics ingredients in the field through photography. In this paper, we introduce an application for smartphones, <Hwa Ahn>, which allows you to immediately know the cosmetics ingredients by photographing the ingredients displayed in the cosmetics. This system is more effective and convenient than the existing system in that it automatically recognizes and automatically classifies the ingredients of the cosmetic when the camera is illuminated on the cosmetic ingredients or retrieves the photos of the cosmetic ingredients from the album. If the system is widely used, it is expected that it will prevent skin diseases caused by cosmetics in daily life and reduce purchases of cosmetics that are not suitable for you.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.43 no.1
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• pp.1-10
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• 2017

Cimicifuge dahurica (C. dahurica), Coptis chinensis (C. chinensis) and Phellodendri amurense (P. amurense) extracts has an detoxification effect and Magnol obovata bark (M. obovata) extracts has an antibacterial effect in oriental medicine. This study investigated the possibility of the extract mixture as a functional cosmetic ingredient by mixing C. dahurica, C. chinensis, P. amurense and M. obovata extracts. MTT assay was carried out for toxicity test and DPPH/ABTS experiments for antioxidant effects of the extract mixture. Results show that the extract mixture was safer and antioxidant effects in a dose-dependent manner than single extract of the mixture. The mixture effectively inhibited NO (nitric oxide) production, which indicate good efficacy for anti-inflammation. The mixture also protected UVB-induced cell damage and increased type 1 pro-collagen synthesis in fibroblast. In addition, it's treatment inhibited the melanin synthesis and tyrosinase activity by lowering expression of MITF, tyrosinase and TRPs in B16F10 melanoma cell. These results suggest that medicinal herbal extract mixture may be useful as a functional ingredient for anti-aging and skin whitening cosmetic formula.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.33 no.4
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• pp.227-230
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• 2007

The multi-lamellar and liquid crystal structures have drawn great public attention in the functional cosmetic and skin-related medicinal areas recently. The structure of an emulsion containing aqueous phase as a binding water and fixed oil phase components forming an association compound of the multi-lamellar structure can reconstruct the intercellular lipid lamellar structure in the stratum corneum and restore barrier function of the skin. In this study, we investigated the beneficial effect of bio-mimic liquid crystal emulsions (BLCE) containing higher fatty alcohol, lecithin, and cholesterol on the skin barrier function, and evaluated its cytotoxicity.

• KSBB Journal
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• v.27 no.5
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• pp.319-323
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• 2012

Vitamin C or L-ascorbic acid, an essential nutrient for humans with antioxidative property, was coated with natural wax to be used as functional additives for cosmetics. Coating of vitamin C was performed using carnauba wax and olive wax in self-designed reaction chamber for 60 min. The yield of coated vitamin C with carnawuba wax and olive wax were up to $94.6{\pm}1.2%$ and $82.5{\pm}1.4%$, respectively. The stability of the carnauba wax-coated vitamin C in the lotion was improved 17.8% than that of uncoated vitamin C during 30 day storage at $25^{\circ}C$. Color and the layer separation of the lotion added with the coated vitamin C showed better property than with the uncoated vitamin C. The coated vitamin C can be applied to cosmetic ingredients as a stable additive.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.47 no.3
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• pp.265-271
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• 2021

Nanoparticles are substances that are smaller in size and smaller than cells that make up the skin. Therefore, they are very suitable as mediators for transmitting drugs or genes across cell membranes, and also deliver specific ingredients into the skin.In this study, nanoparticles were extracted from mugwort and particles of around 100 nm were obtained through dynamic light scattering (DLS), and the results of concentration-dependent enhancement of cell viability in fibroblasts were obtained through MTT assay. In addition, it was confirmed that the COL1A1 mRNA expression level was increased and the IL-6 mRNA expression level was decreased through the quantitative real-time PCR analysis method. Moreover, as these nanoparticles were confirmed to be stable, they can be applied not only to cell experiments but also to cosmetic formulations. While the demand for plant-derived ingredients continues to increase, excluding chemical ingredients from the recent cosmetics industry trend, there is a limitation in that there are few research results suggesting the application field of plant-derived nanoparticles. Therefore, in order to overcome the limitations of the cosmetic industry at the present time, the results obtained in this study present nanoparticles derived from Artemisia princeps (NDAP) as a highly functional cosmetic material.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.45 no.3
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• pp.225-235
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• 2019

Cymbopogon citratus (CC) and Perilla frutescens (PF) are known to exert various biological effects. However, their skin hydration and skin barrier effects remain unclear. This study investigated effects of their extracts on skin hydration and skin barrier and analysed the phenolic compounds. effects of these extracts on skin hydration in HaCaT cells showed that Hyaluronic acid production in cells treated with ethanol extracts was higher than that treated with water extracts for both CC and PF. HPLC was used to analyse 19 phenolic compounds in CC and PF ethanol extracts (CCE and PFE). Results revealed chlorogenic acid and p-coumaric acid in CCE and rosmarinic acid and caffeic acid in PFE. Expression levels of hyaluronan synthase 1 (HAS1), HAS2, HAS3, and aquaporin 3 (AQP3), which are related to skin moisturization, and filaggrin and loricrin, which are related to skin barrier were higher in cells treated with CCE than with PFE. CCE and PFE also increased expression of PPAR-a protein involved in skin moisturization and epidermal differentiation in a concentration-dependent manner. As major components of CCE, chlorogenic acid and p-coumaric acid increased PPAR-a protein expression. Thus, CCE and PFE could be used as functional cosmetic materials for skin hydration and skin barrier effects.