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http://dx.doi.org/10.15230/SCSK.2017.43.1.1

Anti-aging and Anti-melanogenesis Effect of Cimicifuge dahurica, Coptis chinensis, Phellodendri amurense and Magnol obovata Extracts Mixture  

Shin, Seo Yeon (Department of Pharmaceutical Engineering, Dongshin University)
Kim, Gue Won (Department of Pharmaceutical Engineering, Dongshin University)
Kang, Se Won (WorldCostech Co, LTD)
Cho, Hong Suk (WorldCostech Co, LTD)
Kim, Eun Ji (WorldCostech Co, LTD)
Park, Kyung Mok (Department of Pharmaceutical Engineering, Dongshin University)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.43, no.1, 2017 , pp. 1-10 More about this Journal
Abstract
Cimicifuge dahurica (C. dahurica), Coptis chinensis (C. chinensis) and Phellodendri amurense (P. amurense) extracts has an detoxification effect and Magnol obovata bark (M. obovata) extracts has an antibacterial effect in oriental medicine. This study investigated the possibility of the extract mixture as a functional cosmetic ingredient by mixing C. dahurica, C. chinensis, P. amurense and M. obovata extracts. MTT assay was carried out for toxicity test and DPPH/ABTS experiments for antioxidant effects of the extract mixture. Results show that the extract mixture was safer and antioxidant effects in a dose-dependent manner than single extract of the mixture. The mixture effectively inhibited NO (nitric oxide) production, which indicate good efficacy for anti-inflammation. The mixture also protected UVB-induced cell damage and increased type 1 pro-collagen synthesis in fibroblast. In addition, it's treatment inhibited the melanin synthesis and tyrosinase activity by lowering expression of MITF, tyrosinase and TRPs in B16F10 melanoma cell. These results suggest that medicinal herbal extract mixture may be useful as a functional ingredient for anti-aging and skin whitening cosmetic formula.
Keywords
medicinal herbs; anti-oxidation; anti-aging; anti-melanogenesis; cosmetic ingredient;
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Times Cited By KSCI : 5  (Citation Analysis)
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