• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.257-258
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• 1998

To reveal the interconnected brain regions involved in human working memory, their functional connectivity was analyzed using principal component analysis (PCA). rCBF PET scans were peformed on 5 normal volunteers during the verbal and visual working memory tasks and PCA was applied. PCA produced the first principal components related with the increase of the difficulty and the second one which demonstrate the dissociation of verbal and visual memory system.

• Communications for Statistical Applications and Methods
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• v.31 no.1
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• pp.87-104
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• 2024

Most functional magnetic resonance imaging (fMRI) studies in resting state have assumed that the functional connectivity (FC) between time series from distinct brain regions is constant. However, increased interest has recently been in quantifying possible dynamic changes in FC during fMRI experiments. FC study may provide insight into the fundamental workings of brain networks to brain activity. In this work, we focus on the specific problem of estimating the dynamic behavior of pairwise correlations between time courses extracted from two different brain regions. We compare the sliding-window techniques such as moving average (MA) and exponentially weighted moving average (EWMA), dynamic causality with vector autoregressive (VAR) model, dynamic conditional correlation (DCC) based on volatility, and the proposed alternative methods to use differencing and recursive residuals. We investigate the properties of those techniques in a series of simulation studies. We also provide an application with major depressive disorder (MDD) patient fMRI data to demonstrate studying dynamic correlations.

• Korean Journal of Biological Psychiatry
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• v.24 no.2
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• pp.68-74
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• 2017

Objectives It is well known that problem drinking is associated with alterations of brain structures and functions. Brain functions related to alcohol consumption can be determined by the resting state functional connectivity in various resting state networks (RSNs). This study aims to ascertain the alcohol effect on the structures forming predetermined RSNs by assessing their cortical thickness. Methods Twenty-six abstinent male patients with alcohol dependence and the same number of age-matched healthy control were recruited from an inpatient mental hospital and community. All participants underwent a 3T MRI scan. Averaged cortical thickness of areas constituting 7 RSNs were determined by using FreeSurfer with Yeo atlas derived from cortical parcellation estimated by intrinsic functional connectivity. Results There were significant group differences of mean cortical thicknesses (Cohen's d, corrected p) in ventral attention (1.01, < 0.01), dorsal attention (0.93, 0.01), somatomotor (0.90, 0.01), and visual (0.88, 0.02) networks. We could not find significant group differences in the default mode network. There were also significant group differences of gray matter volumes corrected by head size across the all networks. However, there were no group differences of surface area in each network. Conclusions There are differences in degree and pattern of structural recovery after abstinence across areas forming RSNs. Considering the previous observation that group differences of functional connectivity were significant only in networks related to task-positive networks such as dorsal attention and cognitive control networks, we can explain recovery pattern of cognition and emotion related to the default mode network and the mechanisms for craving and relapse associated with task-positive networks.

• Clinical Psychopharmacology and Neuroscience
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• v.16 no.4
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• pp.449-460
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• 2018

Objective: Prior functional magnetic resonance imaging (fMRI) work has revealed that children/adolescents with disruptive behavior disorders (DBDs) show dysfunctional reward/non-reward processing of non-social reinforcements in the context of instrumental learning tasks. Neural responsiveness to social reinforcements during instrumental learning, despite the importance of this for socialization, has not yet been previously investigated. Methods: Twenty-nine healthy children/adolescents and 19 children/adolescents with DBDs performed the fMRI social/non-social reinforcement learning task. Participants responded to random fractal image stimuli and received social and non-social rewards/non-rewards according to their accuracy. Results: Children/adolescents with DBDs showed significantly reduced responses within the caudate and posterior cingulate cortex (PCC) to non-social (financial) rewards and social non-rewards (the distress of others). Connectivity analyses revealed that children/adolescents with DBDs have decreased positive functional connectivity between the ventral striatum (VST) and the ventromedial prefrontal cortex (vmPFC) seeds and the lateral frontal cortex in response to reward relative to non-reward, irrespective of its sociality. In addition, they showed decreased positive connectivity between the vmPFC seed and the amygdala in response to non-reward relative to reward. Conclusion: These data indicate compromised reinforcement processing of both non-social rewards and social non-rewards in children/adolescents with DBDs within core regions for instrumental learning and reinforcement-based decision-making (caudate and PCC). In addition, children/adolescents with DBDs show dysfunctional interactions between the VST, vmPFC, and lateral frontal cortex in response to rewarded instrumental actions potentially reflecting disruptions in attention to rewarded stimuli.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.31 no.4B
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• pp.383-391
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• 2011

In this study, an evaluation method was proposed to determine the restoration section in the riverine ecobelt project. The target river for this study is the Hongcheon river in Kangwon-do. The Hongcheon river of 96 km was divided longitudinally into subsections of 2 km. The analysis through map and aerial photograph as well as field surveys were performed in 48-sub-sections. The fragmentation items were classified into connectivity and ecological functionality. The connectivity fragmentation was also divided into two items: the area discontinuity of the land use and the line discontinuity of river bank and road. Also, the ecological functional fragmentation was evaluated by using the items of river channel, river bed, vegetation, and the obstruction of river flow. These items was modified from those in the previous literature. From map analyses and field surveys, the fragmentation score was kept with each items in 48 sub-sections of Hongcheon river. The fragmentation rate was made from the total score in each section. The results showed that sections from F1 to G2 was evaluated to have high rates of all connectivity and functionality fragmentation of 1st or 2nd rate. Other sections have high connectivity fragmentation of 2nd rate, but low functional fragmentation. Thus, these sections are evaluated to be excludible in restoration site. This study seems to make a contribution to evaluate the fragmented sections for the riverine ecobelt project.

• Journal of the Korean Society of Clothing and Textiles
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• v.42 no.1
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• pp.183-194
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• 2018

This study investigated the characteristics of Omni Channel and examined the influence of them on consumers' perceived functional value and emotional value as well as the effect of perceived functional value and emotional value on user's intention of use through Omni Channel. To verify the research model, the questionnaire survey was conducted on 20's to 40's men and women residing in Seoul and the metropolitan area by convenience sampling. The number of copies used for data analysis was 696. To verify the research model, factor analysis, reliability analysis, and structural equation model analysis were performed using AMOS 20.0. First, Omni Channel characteristics consisted of four factors: instant connectivity, location-based provability, interactivity, and entertainment. Second, the instant connectivity, location-based provability and entertainment positively influenced functional value and emotional value; however, the interactivity was significant only to the emotional value. Third, consumers' perceived value of Omni Channel characteristics had a significant effect on attitude. Fourth, the more favorable the attitude toward Omni Channel is higher for the intention to use Omni Channel.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.9
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• pp.559-569
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• 2016

This study examined flow between regions based on the spatial structure of the territory and characterized the flow patterns by analyzing regional networks via transportation connectivity. To accomplish this, transportation connectivity of the entire nation was examined using 2010 national express bus OD data from the Korea Transport Database. After the initial analysis, 2010 car OD data describing networks in seven regions (125 cities and districts), Gangwon-do, Gyeongsangnam-do, Gyeongsangbuk-do, Jeollanam-do, Jeollabuk-do, Chungcheong-do and Seoul, were analyzed to identify transportation connectivity. The results revealed that Korea has strong triangular-belt-shaped transportation connectivity that connects among metropolitan areas in the Jeolla and Gyeongsang areas. Particular zones are set by regional characteristics and functional connectivity for each zone. The results of this study will be useful as a basic material to establish development strategies and customized regional policy development, as well as balanced development.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2012.05a
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• pp.11-12
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• 2012

• Korean Journal of Cognitive Science
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• v.29 no.3
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• pp.161-192
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• 2018

Retrieving temporal information of encoded events is one of the core control processes in episodic memory. Despite much prior neuroimaging research on episodic retrieval, little is known about how large-scale connectivity patterns are involved in the retrieval of sequentially organized episodes. Task-related functional connectivity multivariate pattern analysis was used to distinguish the different sequential retrieval. In this study, participants performed temporal episodic memory tasks in which they were required to retrieve the encoded items in either the forward or backward direction. While separately parsed local networks did not yield substantial efficiency in classification performance, the large-scale patterns of interactivity across the cortical and sub-cortical brain regions implicated in both the cognitive control of memory and goal-directed cognitive processes encompassing lateral and medial prefrontal regions, inferior parietal lobules, middle temporal gyrus, and caudate yielded high discriminative power in classification of temporal retrieval processes. These findings demonstrate that mnemonic control processes across cortical and subcortical regions are recruited to re-experience temporally-linked series of memoranda in episodic memory and are mirrored in the qualitatively distinct global network patterns of functional connectivity.

• Journal of Biomedical Engineering Research
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• v.26 no.4
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• pp.223-230
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• 2005

This paper presents a new approach to investigate spatial correlation between independent components of brain alpha activity in functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). To avoid potential problems of simultaneous fMRI and EEG acquisitions in imaging pure alpha activity, data from each modality were acquired separately under a 'three conditions' setup where one of the conditions involved closing eyes and relaxing, thus making it conducive to generation of alpha activity. The other two conditions -- eyes open in a lighted room or engaged in a mental arithmetic task, were designed to attenuate alpha activity. Using a Mixture Density Independent Component Analysis (MD-ICA) that incorporates flexible non-linearity functions into the conventional ICA framework, we could identify the spatiotemporal components of fMRI activations and EEG activities associated with the alpha rhythm. Then, the sources of the individual EEG alpha activity component were localized by a Maximum Entropy (ME) method that is specially designed to find the most probable dipole distribution minimizing the localization error in sense of LMSE. The resulting active dipoles were spatially transformed to 3D MRls of the subject and compared to fMRI alpha activity maps. A good spatial correlation was found in the spatial distribution of alpha sources derived independently from fMRI and EEG, suggesting the proposed method can localize the cortical areas responsible for generating alpha activity successfully in either fMRI or EEG. Finally a functional connectivity analysis was applied to show that alpha activity sources of both modalities were also functionally connected to each other, implying that they are involved in performing a common function: 'the generation of alpha rhythms'.