• 대한의용생체공학회:의공학회지
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• 제35권3호
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• pp.68-74
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• 2014

Recent research on mild cognitive impairment (MCI) has shown that cognitive and memory decline in this disease is accompanied by disruptive changes in the brain functional network. However, there have been no graph-theoretical studies using $^{11}C$-PIB PET data of the Alzheimer's Disease or mild cognitive impairment. In this study, we acquired $^{18}F$-FDG PET and $^{11}C$-PIB PET images of twenty-four normal aging control participants and thirty individuals with MCI from ADNI (Alzheimer's Disease Neuroimaging Initiative) database. Brain networks were constructed by thresholding binary correlation matrices using graph theoretical approaches. Both normal control and MCI group showed small-world property in $^{11}C$-PIB PET images as well as $^{18}F$-FDG PET images. $^{11}C$-PIB PET images showed significant difference between NC (normal control) and MCI over large range of sparsity values. This result will enable us to further analyze the brain using established graph-theoretical approaches for $^{11}C$-PIB PET images.

• The Korean Journal of Physiology and Pharmacology
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• 제26권6호
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• pp.415-425
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• 2022

Memory formation in the hippocampus is formed and maintained by circadian clock genes during sleep. Sleep deprivation (SD) can lead to memory impairment and neuroinflammation, and there remains no effective pharmacological treatment for these effects. Myricetin (MYR) is a common natural flavonoid that has various pharmacological activities. In this study, we investigated the effects of MYR on memory impairment, neuroinflammation, and neurotrophic factors in sleep-deprived rats. We analyzed SD-induced cognitive and spatial memory, as well as pro-inflammatory cytokine levels during SD. SD model rats were intraperitoneally injected with 10 and 20 mg/kg/day MYR for 14 days. MYR administration significantly ameliorated SD-induced cognitive and spatial memory deficits; it also attenuated the SD-induced inflammatory response associated with nuclear factor kappa B activation in the hippocampus. In addition, MYR enhanced the mRNA expression of brain-derived neurotropic factor (BDNF) in the hippocampus. Our results showed that MYR improved memory impairment by means of anti-inflammatory activity and appropriate regulation of BDNF expression. Our findings suggest that MYR is a potential functional ingredient that protects cognitive function from SD.

• Tuberculosis and Respiratory Diseases
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• 제43권3호
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• pp.377-387
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• 1996

연구배경 : 폐기능의 경한 저하는 운동능력이나 작업능력을 제한 시키지 않지만 심한 폐기능 저하는 중요한 제한 요인이 된다. 1980년 세계보건기구(WHO)에서는 폐기능의 감소를 impairment, 운동기능의 감소를 disability로 구분하였으며, 1986년 ATS에서 FVC가 50% 이하로 감소, FEV1이 40% 이하로 감소, FEV1/FVC가 40% 이하로 감소, 혹은 DLCO가 40% 이하로 감소된 경우, 또는 운동부하 검사에서 VO2max가 15 ml/Kg/min 이하이면 거의 모든 작업기능을 수행할 수 없는 심한 장애상태로 평가하였다. 이에 심한 기류폐쇄환자를 대상으로 impairment/disability를 평가하는데 있어 안정시 폐기능 검사와 운동부하검사의 역할 및 상관관계를 살펴보고자 하였다. 방법 : 성한 만성기류폐쇄(CAO; chronic airflow obstruction) 환자 19예를 대상으로 안정시 spirometry와 body plethysmograph를 시행하였으며, cycle ergometer를 이용하여 증상제한적 최대 운동검사(symptom limited maximal exercise test)를 분당 5 - 10 watt 씩 증가시키면서 시행하였다. 환자를 안정시 폐기능검사 결과에 따라 FEV1이 40% 이하인 경우 severe impairment군, 이상인 경우 non-severe impairment 군으로 구분하여 비교하였다. 결과 : 1. Severe impairment 군은 non-severe impairment 군에 비하여 기도폐쇄 및 저산소증이 유의하게 심하였고, VO2max가 유의하게 감소되어 운동수행상태가 현저하게 감소되어 있었다. 2. Severe impairment 군은 운동부하검사에서 환기제한장애(ventilatory limitation)를 보였으며, 운동제한 증상은 10예중 9예가 호흡곤란이었다. 3. 만성기류폐쇄 환자중에서 결핵 파괴성 폐질환 환자의 장애가 가장 심하였다. 4. 안정시 폐기능검사 결과 중에서 FEV1이 심한 장애를 결정하는 가장 유용한 지표였으며, VO2max와의 상관관계도 가장 컷다(r = 0.81, p < 0.001). 5. 안정시 폐기능검사에 의한 심한 폐기능장애(impairment by WHO)는 sensitivity 80%, specificity 89%로 심한 운동장애(disability by WHO)를 예측할 수 있었다. 결론 : 심한 기류폐쇄환자에서는 안정시 폐기능검사 특히 FEV1으로 운동수행상태를 잘 예측할 수 있어, 운동부하검사를 시행하지 않고서도 안정시 폐기능검사인 폐기능 장애(impairment by WHO)에 따라 운동기능 장애(disability by WHO)를 충분히 판단할 수 있을 것으로 생각된다.

• 한국식품영양과학회지
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• 제41권2호
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• pp.192-196
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• 2012

현재까지 복분자가 인지능력 및 기억력에 미치는 영향에 대해 연구된 바가 없다. 본 연구에서는 복분자 물추출물이 기억력에 미치는 영향을 조사하기 위해 복분자 물추출물을 100 mg/kg body weight/day로 4주간 투여한 후 스코폴라민(1 mg/kg body weight)을 복강 주사하여 기억력 감퇴를 유발한 후 수동회피시험과 수중미로시험을 실시하여 복분자물추출물의 기억력 개선 효과를 평가하였다. 수동회피실험에서 스코폴라민으로 기억력 감퇴를 유도한 경우 밝은 방에서의 체류시간이 현저히 짧아졌고 복분자 물추출물을 섭취한 군에서는 밝은 방에서의 체류 시간이 스코폴라민 투여군에 비해 현저히 증가하였다. 또한 수중미로시험에서도 스코폴라민 투여군의 도피대를 찾아가는 탈출잠복기가 정상대조군에 비해 현저히 증가하였고 복분자 물추출물 투여군에서는 스코폴라민 군에 비해 탈출잠복기가 유의적으로 감소하였다. 대뇌피질에서 기억력에서 중요한 역할을 하는 acetylcholinesterase활성은 스코폴라민에 의해 증가하고, 복분자 물추출물에 의해 감소하였다. 이상의 결과는 복분자 물추출물이 항콜린제인 스코폴라민에 의해 유도된 기억력 감퇴를 효과적으로 개선함을 보여주며, 이는 acetylcholinesterase의 활성을 저해함으로써 이루어짐을 나타낸다. 향후 더 많은 연구가 필요하나 본 연구는 복분자 물추출물을 기억력 개선 또는 증강제로 개발할 수 있는 가능성을 제시한다.

• 대한간호학회지
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• 제31권5호
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• pp.749-758
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• 2001

The purpose of the study was to analyze the functional status of low income elderly living at home according to their socio-economic factors, sensory function, health status, medical service utilization, commodity and types of chronic disease. Method: Functional status was defined by the level of mobility, ADL and IADL categorized as independently functional, mildly impaired, moderately disabled, and severely disabled. The data was collected by home-visit interviews with 567 community dwelling adults who were 65 years of age or more with low a income status subsidized by government in ChonAn. Results: 9.9% of community dwelling older adults were severely disabled, and 44.4% were moderately disabled in their functional status. There were significant differences in the functional status by age, education, religion, and types of family structure. The older adults with hearing impairment or dental problems had a significantly higher rate of severe disability. Self-rated health status and medical service utilization were also significant factors to the differences in functional status. The functional status of older adults was also significantly related to the presence of chronic health problems such as chronic back pain, stroke, and Alzheimer-dementia. Conclusion: The results confirmed that community dwelling older adults with low income status were more functionally disabled in comparison to general older adults at national level, while the relating factors to their functional status seemed similar to other studies on older adults. Further studies were suggested to look into functional status longitudinally and focus on the changes of functional status by managing modifiable influencing factors.

• BMB Reports
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• 제45권11호
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• pp.671-676
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• 2012

Caloric restriction (CR) has been associated with health benefits and these effects have been attributed, in part, to modulation of oxidative status by CR; however, data are still controversial. Here, we investigate the effects of seventeen weeks of chronic CR on parameters of oxidative damage/modification of proteins and on antioxidant enzyme activities in cardiac and kidney tissues. Our results demonstrate that CR induced an increase in protein carbonylation in the heart without changing the content of sulfhydryl groups or the activities of superoxide dismutase and catalase (CAT). Moreover, CR caused an increase in CAT activity in kidney, without changing other parameters. Protein carbonylation has been associated with oxidative damage and functional impairment; however, we cannot exclude the possibility that, under our conditions, this alteration indicates a different functional meaning in the heart tissue. In addition, we reinforce the idea that CR can increase CAT activity in the kidney. Moreover, CR caused an increase in CAT activity in kidney, without changing other parameters. Protein carbonylation has been associated with oxidative damage and functional impairment; however, we cannot exclude the possibility that, under our conditions, this alteration indicates a different functional meaning in the heart tissue. In addition, we reinforce the idea that CR can increase CAT activity in the kidney.

• 대한두개안면성형외과학회지
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• 제21권3호
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• pp.161-165
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• 2020

Background: Microstomia is defined as a condition with a small sized-mouth that results in functional impairment such as difficulty with food intake, pronunciation, and poor oral hygiene and cosmetic problems. Several treatment methods for microstomia have been proposed. None of them are universally applicable. This study aims at analyzing the cases treated at our institution critically reviewing the pertinent literature. Methods: The medical records of all microstomia patients treated in our hospital from November 2015 to April 2018 were reviewed retrospectively. Of these, all patients who received surgical treatment for microstomia were included in the study and analyzed for etiology, chief complaint, surgical method, and outcomes. The functional outcomes of mouth opening and intercommissure distance before and after the surgery were evaluated. The cosmetic results were assessed according to the patients' satisfaction. Results: Five patients with microstomia were corrected. Two cases were due to scar contracture after chemical burn, two cases derived from repeated excision of skin cancer, and one patient suffered sequela of Stevens-Johnson syndrome. The following surgical methods were applied: one full-thickness skin graft on the buccal mucosa, three buccal mucosal advancement flaps after triangular excision of the mouth corner, and one local buccal mucosal flap. Mouth opening was increased by 6.0 mm, and the intercommissure distance improved by 7.2 mm on average. Follow-up was 9.6 months (range, 5-14 months). Cosmetic assessment was as follows: two patients found the results excellent, three judged it as good. Conclusion: Microstomia has several causes. In order to achieve optimal functional recovery and aesthetic improvement it is important to precisely evaluate the etiologic factors and the severity of the impairment and to carefully choose the appropriate surgical method.

• 대한간호학회지
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• 제45권1호
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• pp.118-128
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• 2015

Purpose: Evidence suggests that some patients with breast cancer experience cognitive difficulties following chemotherapy. This longitudinal study was done to examine the prevalence of cognitive impairment and trajectory of cognitive function over time in women with breast cancer, who received adjuvant chemotherapy. Methods: Participants were 137 patients with breast cancer. They completed neuropsychological tests and the Functional Assessment of Cancer Therapy-Cognitive Function before adjuvant therapy (pretest), toward the end of adjuvant therapy (posttest), and 6 months after the completion of adjuvant therapy (follow-up test). Of the patients, 91 were treated with adjuvant chemotherapy and 46 patients who did not receive chemotherapy made up the comparison group. A reliable-change index and repeated-measure ANOVA were used for statistical analyses. Results: At the posttest point, over 30% of patients showed complex cognitive impairment and reported greater difficulty in subjective cognitive function. At the follow-up test point, 22.0% of patients exhibited complex cognitive impairment and 30.8% of patients complained of subjective cognitive impairment. Repeated-measure ANOVA showed significant decreases after receiving chemotherapy followed by small improvements 6 months after the completion of chemotherapy in cognitive domains of change for attention and concentration, memory, executive function, and subjective cognitive function. Conclusion: These results suggest that chemotherapy in patients with breast cancer may be associated with objective and subjective cognitive impairments. Further studies are needed to explore the potential risk factors and predictor of chemotherapy-related cognitive changes. Also nursing interventions for prevention and intervention of cognitive impairments should be developed and tested.

• The Journal of Korean Physical Therapy
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• 제15권4호
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• pp.412-430
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• 2003

Functional stability is dependent on integrated local and global muscle function. Movement dysfunction can present as a local and global problem, though both frequently occur together. To good understand how movement induces pain syndrome, the optimal actions and interaction of the multiple anatomic and functional systems involved in motion must be considered. Minor alterations in the precision of movement cause microtrauma and, if allowed to continue, will cause macrotrauma and pain. These alteration of the movement result in the development of compensatory movement and movement impairment. Muscle that become tight tend to pull the body segment to which they are attached, creating postural deviation. The antagonistic muscles may become weak and allow postural deviations due to lack of balanced support. Both hypertonic and inhibited muscles will cause an alteration of the distribution of pressure over the joint(s) that they cross and, thus, may not only result from muscle dysfunction, but produce joint dysfunction as well. Alteration of the shoulder posture and movement dysfunction may sometimes result in compression of neurovascular structures in the shoulder and arm. There is a clear link between reduced proprioceptive input, altered motor unit recruitment and the neurovascular compression. This report start with understanding of the impaired alignment, movement patterns and neuromuscular compression of the shoulder girdle by movement impairment to approach method of the movement dysfunction.

• 한국산업보건학회지
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• 제19권2호
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• pp.156-169
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• 2009

In this study, the authors introduced DASH (Disabilities of the arm, shoulder, and hand), which had been developed for evaluating the functional impairment in the movement of upper extremities in regular daily activities, work ability and sports/performing arts ability. It is an ergonomic risk assessment tool used for industrial workers and also a disability measurement tool for upper extremity disorders arising from musculoskeletal disorders and symptom. This study intended to examine the applicability of DASH in occupational health field. Firstly, DASH development process and composition were reviewed through The DASH outcome measure user's manual and early articles. Secondly, reliability, validity, and responsiveness of the DASH in various languages at the application stage as well as its reliability and validity at the early stage of development were investigated. Thirdly, focusing on the application of DASH to clinical cases, workers with musculoskeletal symptoms, healthy workers, workers with other diseases, and general population were discussed besides workers with major musculoskeletal disorders. Lastly, DASH questionnaire was examined for its potential as a reference for assessing the functional impairment in the movement of upper extremities of workers with musculoskeletal symptoms in industrial workers in Korea.