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http://dx.doi.org/10.3746/jkfn.2012.41.2.192

The Aqueous Extract of Rubus coreanus Miquel Improves Scopolamine-Induced Memory Impairment in ICR Mice  

Choi, Mi-Ran (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University)
Lee, Min-Young (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University)
Hong, Ji-Eun (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University)
Lee, Jae-Yong (Dept. of Biochemistry, College of Medicine, Hallym University)
Chun, Jang-Woo (Research and Development Center, Hitejinro Co., Ltd.)
Kim, Tae-Hwan (Research and Development Center, Hitejinro Co., Ltd.)
Shin, Hyun-Kyung (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University)
Kim, Eun-Ji (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.41, no.2, 2012 , pp. 192-196 More about this Journal
Abstract
In the present study, we examined the effect of the aqueous extract of Rubus coreanus Miquel (RCM-Ex) on scopolamine-induced memory impairment in male ICR mice. Mice were fed the diet containing 100 mg/kg body weight/day of RCM-Ex for 4 weeks. To induce amnesia, scopolamine (an antagonist of muscarinic acetylcholine receptor, 1 mg/kg of body weight) was intraperitoneally injected into mice 30 min before starting the behavior tests. RCM-Ex reversed scopolamine-induced memory impairments in mice as evidence by the passive avoidance test and Morris water maze test. In addition, acetylcholineasterase activities were decreased in the brains of mice treated with RCM-Ex. These results suggest that RCM-Ex may be an effective agent for the prevention of the memory impairment induced by cholinergic dysfunction.
Keywords
Rubus coreanus Miquel; memory; scopolamine; passive avoidance test; Morris water maze test;
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Times Cited By KSCI : 11  (Citation Analysis)
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