• Nonlinear Functional Analysis and Applications
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• v.28 no.3
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• pp.671-684
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• 2023

In this paper, we prove the generalized Hyers-Ulam stability of a general quintic functional equation, $\sum\limits_{k=0}^{6}(-1)^k{_6}C_kf(x+(3-k)y)=0$, by using the fixed point method.

• BMB Reports
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• v.43 no.2
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• pp.79-90
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• 2010

Mouse models are crucial for the functional annotation of human genome. Gene modification techniques including gene targeting and gene trap in mouse have provided powerful tools in the form of genetically engineered mice (GEM) for understanding the molecular pathogenesis of human diseases. Several international consortium and programs are under way to deliver mutations in every gene in mouse genome. The information from studying these GEM can be shared through international collaboration. However, there are many limitations in utility because not all human genes are knocked out in mouse and they are not yet phenotypically characterized by standardized ways which is required for sharing and evaluating data from GEM. The recent improvement in mouse genetics has now moved the bottleneck in mouse functional genomics from the production of GEM to the systematic mouse phenotype analysis of GEM. Enhanced, reproducible and comprehensive mouse phenotype analysis has thus emerged as a prerequisite for effectively engaging the phenotyping bottleneck. In this review, current information on systematic mouse phenotype analysis and an issue-oriented perspective will be provided.

• Journal of the Korean Society for Precision Engineering
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• v.22 no.3 s.168
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• pp.162-169
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• 2005

The functional external fixator system fur bone deformity near joints in legs using the worm gear was developed for curing the difference angles in fracture bone and the lengthening bar for curing the difference length in fracture bone. Both experiments and FE analysis were performed to compare the elastic stiffness in several loading modes and to improve the functional external fixator system for the bone deformity. The FE model using the compressive and bending FE analysis was applied to the FE analysis due to the angle differences. The results show that the compressive stiffness value in experiment was 175.43N/mm; the bending stiffness value in experiment was 259.74N/mm; compressive stiffness value in FEM was 188.67N/mm; bending stiffness value in FEA was 285.71N/mm. The errors between experiments and FEA were less than 10%. The maximum stress (157MPa) to the angle of clamp was lower than the yield stress (176.4MPa) of SUS316L. The stiffnesses in both axial compressive and bending of the new fixator are about 2 times higher than other products except EBI (2003).

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2004.10a
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• pp.1248-1251
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• 2004

The functional external fixator system for bone deformity near joints in legs using the worm gear was developed for curing the difference angles in fracture bone and the lengthening bar for curing the difference length in fracture bone. Both experiments and FE analysis were performed to compare the elastic stiffness in several loading modes and to improve the functional external fixator system for bone deformity near joints in legs. The FE model using the compressive and bending FE analysis was applied the FE analysis due to the angle differences. The results show that the compressive stiffness value in experiment was 175.43N/mm, the bending stiffness value in experiment was 259.74N/mm, compressive stiffness value in FEM was 188.67N/mm, bending stiffness value in FEA was 285.71N/mm. The errors between experiments and FEA were less than 10％. The maximum stress (157MPa) to the angle of clamp was lower than the yield stress (176.4MPa) of SUS316L. The stiffnesses in both axial compressive and bending of the new fixator are about 2 times higher than other products except EBI (2003).

• KOREAN JOURNAL OF CROP SCIENCE
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• v.54 no.3
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• pp.332-338
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• 2009

Rapid extension of genomic database leads to the remarkable advance of functional genomics. This study proposes a novel methodology of functional analysis using 5-methyltrytophan (5 MT) mutant together with their 2-DE analysis and public microarray database. A total of 24 proteins was changed in 5 MT mutant and four remarkably different expressed proteins were identified. Among them, three spots were converted to Affymetrix probe. A total of 155 microarray samples from Gene Expression Omnibus (GEO) in NCBI was retrieved and followed by constructing gene co-expression networks over a broad range of biological issues through Self-Organising Tree Algorithm. Three co-expressing gene clusters were retrieved and each functional categorization with differential expression pattern was exhibited from 5 MT resistance mutant rice. It was indicated new co-expression networks in the mutant. This study suggests that on investigating possibility which correspond 2-DE to microarray database with their full potential.

• The Journal of the Acoustical Society of Korea
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• v.20 no.5
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• pp.54-60
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• 2001

This paper investigates the equivalent circuit analysis method for the multi-functional device in mobile telephones, which works both as a buzzer and a vibrator in a single unit form. With a representative multi-functional device, we construct the corresponding equivalent circuits for the buzzer mode and the vibrator mode of the device, respectively, and analyze the performance of each of the modes. For proper construction of the circuit, we analyze the structure and operation mechanism of the device, and develop a computer simulation tool to simulate the behavior of the device. Validity of the analysis method is verified through comparison of the analysis results with experimental measurement results, which shows good agreement between the two sets of data.

• Annals of Clinical Neurophysiology
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• v.22 no.2
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• pp.82-91
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• 2020

Electroencephalography (EEG) produces time-series data of neural oscillations in the brain, and is one of the most commonly used methods for investigating both normal brain functions and brain disorders. Quantitative EEG analysis enables identification of frequencies and brain activity that are activated or impaired. With studies on the structural and functional networks of the brain, the concept of the brain as a complex network has been fundamental to understand normal brain functions and the pathophysiology of various neurological disorders. Functional connectivity is a measure of neural synchrony in the brain network that refers to the statistical interdependency between neural oscillations over time. In this review, we first discuss the basic methods of EEG analysis, including preprocessing, spectral analysis, and functional-connectivity and graph-theory measures. We then review previous EEG studies of brain network characterization in several neurological disorders, including epilepsy, Alzheimer's disease, dementia with Lewy bodies, and idiopathic rapid eye movement sleep behavior disorder. Identifying the EEG-based network characteristics might improve the understanding of disease processes and aid the development of novel therapeutic approaches for various neurological disorders.

• The Korea Journal of Herbology
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• v.38 no.1
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• pp.45-53
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• 2023

Objectives : Network pharmacology-based research is one of useful tool to predict the possible efficacy and molecular mechanisms of natural materials with multi compounds-multi targeting effects. In this study, we investigated the functional underlying mechanisms of Astragalus membranaceus Bunge (AM) on its anti-obesity effects using a network pharmacology analysis. Methods : The constituents of AM were collected from public databases and its target genes were gathered from PubChem database. The target genes of AM were compared with the gene set of obesity to find the correlation. Then, the network was constructed by Cytoscape 3.9.1. and functional enrichment analysis was conducted to predict the most relevant pathway of AM. Results : The result showed that AM network contained the 707 nodes and 6867 edges, and 525 intersecting genes were exhibited between AM and obesity gene set, indicating that high correlation with the effects of AM on obesity. Based on GO biological process and KEGG Pathway, 'Response to lipid', 'Cellular response to lipid', 'Lipid metabolic process', 'Regulation of chemokine production', 'Regulation of lipase activity', 'Chemokine signaling pathway', 'Regulation of lipolysis in adipocytes' and 'PPAR signaling pathway' were predicted as functional pathways of AM on obesity. Conclusions : AM showed high relevance with the lipid metabolism related with the chemokine production and lipolysis pathways. This study could be a basis that AM has promising effects on obesity via network pharmacology analysis.

• Proceedings of the Korean Society of Crop Science Conference
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• 2022.10a
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• pp.216-216
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• 2022

The starch-branching enzymes (BEs) are responsible for synthesizing the amylopectin, which plays an important role in determining the structural and physical properties of starch granules. BE has two differently functioning isoforms (BEI and BEIIa/b) based on their difference in the chain-length pattern by the degree of polymerization (DP), which mainly contributes to the amylopectin chain length distribution in starch biosynthesis. In this study, we investigated functional haplotypes and evolutionary analyses of SBE1 in 374 rice accessions (320 Korean bred and 54 wild). The analyses were performed based on the classified subpopulations. Haplotype analysis generates a total of 8 haplotypes, of which only four haplotypes were functional carrying four functional SNPs in four different exons of SBE1 on chromosome 6. Nucleotide diversity analysis showed a highest pi-value in aromatic group (0.0029), while the lowest diversity value was in temperate japonica (0.0002), indicating the signal of this gene evolution origin. Different directional selections could be estimated by negative Tajima's D value of temperate japonica (-1.1285) and positive Tajima's D value of tropical japonica (0.9456), where the selective sweeps were undergone by both positive purifying and balancing selections. Phylogenetic analysis indicates a closer relationship of the wild with most of the cultivated subgroups indicating a common ancestor for SBE1 gene. FST-values indicate distant genetic relationships of temperate japonica from all other classified groups. PCA and population structure analysis show an admixed structure of wild and cultivated subpopulations in some proportions.

• Journal of the Korean Society of Systems Engineering
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• v.9 no.2
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• pp.69-82
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• 2013

US DoD operated JCIDS(Joint Capability Integration and Development System) for top down requirement generation. Although the JCIDS can be a good practice for the countries which are trying to shift from bottom up to top down requirement generation, it contains many processes related with review and approval. In this study we structured a joint capability integration and development process from the JCIDS eliminating the organization dependent review or approval process so that it can be applied to any organization with some modification. Furthermore we implemented the process in the computer aided systems engineering tool, Cradle, for convenient use of the process. The result of this study can provide a basic process for top down capability development, and an efficient why of doing each element of the process using CASE tool.