• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.30 no.1
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• pp.17-28
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• 2017

Objectives : The aim of this study is reviewing the literature to extracting the key parameter and finding the calibration parameter for the clinical study with economical assessment protocol on atopic dermatitis. Methods : Literature search is performed using PUBMED for literature published from Janurary 2000 to December 2016. We included randomized controlled trials(RCTs) with economic assessment in which human participants. Results : Among the articles published from January 2000 to December 2016, The 1464 articles were found. After reviewing the title, abstract and full text, the five articles were selected. Selected articles are classified 3 CEA(cost effective analysis)study, 1 CMA(cost minimizing analysis)study and 1 cost analysis study. Conclusions : We found highly reliable key parameters and calibration parameters, which might be necessary factors for developing research protocol of economic evaluation alongside clinical trial about atopic dermatitis patients.

• International Journal of Quality Innovation
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• v.3 no.2
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• pp.13-28
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• 2002

Higher efficiency and effectiveness of Research & Development phases can be attained using advanced statistical methodologies. In this work statistical methodologies are combined with a deterministic approach to engineering design. In order to show the potentiality of such integration, a simple but effective example is presented. It concerns the problem of optimising the performances of a paper helicopter. The design of this simple device is not new in quality engineering literature and has been mainly used for educational purposes. Taking full advantage of fundamental engineering knowledge, an aerodynamic model is originally formulated in order to describe the flight of the helicopter. Screening experiments were necessary to get first estimates of model parameters. Subsequently, deterministic evaluations based on this model were necessary to set up further experimental phases needed to search (or a better design. Thanks to this integration of statistical and deterministic phases, a significant performance improvement is obtained. Moreover, the engineering knowledge かms out to be developed since an explanation of the “why” of better performances, although approximate, is achieved. The final design solution is robust in a broader sense, being both validated by experimental evidence and closely examined by engineering knowledge.

• International Journal of Industrial Entomology and Biomaterials
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• v.21 no.1
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• pp.127-132
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• 2010

We have characterized full-length cDNA encoding Gall-6-tox protein, which was cloned from the fat body of the immunized Galleria mellonella larvae. The cloned cDNA of Gall-6-tox consists of 1301 nucleotides and contained an open reading frame of 891 nucleotides corresponding to a protein of 296 residues that includes a putative 16-residue signal sequence and a 280-residue mature peptide with a calculated mass of 30,707.73 Da. The deduced mature peptide contains conserved tandem repeats of six cysteine-stabilized alpha beta ($Cs{\alpha}{\beta}$) motifs, which was detected in scorpion toxins and insect defensins. In the sequence homology search, mature Gall-6-tox showed 34% and 28% amino acid sequence homology with Bomb-6-tox from Bombyx mori and Spod-11-tox from Spodoptera frugiperda, respectively. Gall-6-tox orthologs were only found in Lepidopteran species, indicating that this new immune-related gene family is specific to this insect order. RT-PCR analysis revealed that Gall-6-tox was expressed primarily in the larval fat bodies, hemocytes, and midgut against invading bacteria into hemocoel. Moreover, the expression time course of Gall-6-tox was examined up to 24 h in the fat bodies and midgut after injection of E. coli. Altogether, these results suggest that Gall-6-tox is derived from defensins and Gall-6-tox may play a critical role in Lepidoptera immune system.

• Annual Conference of KIPS
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• 2000.04a
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• pp.1112-1115
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• 2000

본 논문에서는 One-bit 변환을 기반으로 한 고속의 가변 블록 크기 움직임 예측 알고리즘을 제안한다. 제안된 방법은 블록 내의 평균값을 이용하여 8bit 화소값을 1bit로 변환한 후 움직임 예측을 수행한다. One-bit 변환을 통한 영상의 단순화는 움직임 추정의 계산적 부담을 감소시켜 빠른 탐색을 가능하게 한다. 그리고 블록 내의 움직임 정도를 미리 판별하여 이를 기반으로 한 적응적 탐색이 불필요한 탐색을 제거하고 움직임이 큰 블록에서는 정합과정을 심화시켜 보다 정확한 움직임 예측을 수행한다. 본 제안된 방식을 가지고 실험한 결과 한 프레임당 적은 수의 블록으로 고정된 크기의 블록을 가진 전역 탐색 블록 정합 알고리즘(full search block matching algorithm; FSBMA)보다 예측 에러를 적게 발생시켜 평균적으로 0.5dB 정도의 PSNR 개선을 가져왔다. 특히, 움직임이 많은 영상에서 뛰어난 효과를 나타냈다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.4
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• pp.1961-1974
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• 2019

In this letter, a harmonic-mean-based dual-antenna selection scheme at relay node is proposed in two-way relaying networks (TWRNs). With well-designed distributed orthogonal concatenated Alamouti space-time block code (STBC), a dual-antenna selection problem based on the instantaneous achievable sum-rate criterion is formulated. We propose a low-complexity selection algorithm based on the harmonic-mean criterion with linearly complexity $O(N_R)$ rather than the directly exhaustive search with complexity $O(N^2_R)$. From the analysis of network outage performance, we show that the asymptotic diversity gain function of the proposed scheme achieves as $1/{\rho}{^{N_R-1}}$, which demonstrates one degree loss of diversity order compared with the full diversity. This slight performance gap is mainly caused by sacrificing some dual-antenna selection freedom to reduce the algorithm complexity. In addition, our proposed scheme can obtain an extra coding gain because of the combination of the well-designed orthogonal concatenated Alamouti STBC and the corresponding dual-antenna selection algorithm. Compared with the common-used selection algorithms in the state of the art, the proposed scheme can achieve the best performance, which is validated by numerical simulations.

• Biodesign
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• v.6 no.4
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• pp.96-99
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• 2018

The gram-positive bacterium Staphylococcus aureus is a common cause of abscesses, sinusitis and food poisoning. The emergence of antibiotic-resistant strains has caused significant clinical issues worldwide. The HslU-HslV complex was first identified as a prokaryotic homolog of eukaryotic proteasomes. HslU is an unfoldase that mediates the unfolding of the substrate proteins, and it works with the protease HslV in the complex. To date, the protein complex has been mostly studied in gram-negative bacteria. In this study, we report the purification and crystallization of the full-length HslU from S. aureus. The crystal diffracted X-rays to a $3.5{\AA}$ resolution, revealing that the crystals belong to space group $P2_1$, with unit cell parameters of a = 166.5, b = 189.6, $c=226.6{\AA}$, and ${\beta}=108.1^{\circ}$. We solved the phage problem by molecular replacement using the structure of HslU from Haemophilus influenzae as a search model. The cell content analysis with this molecular replacement solution revealed that 24 molecules are contained in the asymmetric unit. This structure provides insight into the structural and mechanistic difference of the HslUV complex of gram-positive bacteria.

• East Asian Economic Review
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• v.23 no.1
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• pp.27-53
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• 2019

I employ search-and-matching to a multi-country and multi-sector Ricardian model with input-output linkages, trade in intermediate goods, and sectoral heterogeneity, in order to quantify the welfare effects from tariff changes. The paper shows that labor market frictions can be a source of comparative advantage in the sense that better labor market conditions contribute to lower cost in production. Labor market frictions play a critical role in determining the probability of exporting goods to trading partners, and interact with bilateral trade share, price, expenditures, etc. Unemployment and changes in unemployment rates due to tariff reductions contribute welfare changes across countries, implying that welfare effects based on quantitative trade models with full-employment are likely to be biased. I confirm the biased welfare effects by revisiting Caliendo and Parro (2015), who conduct an analysis of the welfare effects from the NAFTA from 1993 to 2005. I show that the welfare gap between theirs and mine has a positive correlation with changes in observed unemployment rates across countries. With the constructed model, I further conduct counterfactual exercises by asking what would happen if China's tariffs remain unchanged from 2006 to 2015. It turns out that there are mild welfare effects to trading partners in the world trading system.

• Ocean Systems Engineering
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• v.9 no.2
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• pp.111-133
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• 2019

Flow through a scaled horizontal axis marine current turbine was numerically simulated after validation and the turbine design was optimized. The computational fluid dynamics (CFD) code Ansys-CFX 16.1 for numerical modeling, an in-house blade element momentum (BEM) code for analytical modeling and an in-house surrogate-based optimization (SBO) code were used to find an optimal turbine design. The blade-pitch angle (${\theta}$) and the number of rotor blades (NR) were taken as design variables. A single objective optimization approach was utilized in the present work. The defined objective function was the turbine's power coefficient ($C_P$). A $3{\times}3$ full-factorial sampling technique was used to define the sample space. This sampling technique gave different turbine designs, which were further evaluated for the objective function by solving the Reynolds-Averaged Navier-Stokes equations (RANS). Finally, the SBO technique with search algorithm produced an optimal design. It is found that the optimal design has improved the objective function by 26.5%. This article presents the solution approach, analysis of the turbine flow field and the predictability of various surrogate based techniques.

• The Journal of the Convergence on Culture Technology
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• v.5 no.2
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• pp.381-388
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• 2019

In this paper, we propose a new wireless transport network, which is named as Mobile Xhaul Network(MXN), that is enable to bring cost efficiency of fronthaul, midhaul and backhaul and to make easy installation of 5G Radio Access Network(RAN). For this purpose, we design XDU discovery and xhaul link setup mechanism with MXN architecture and operational procedure. Especially, in this paper, we propose various types of beam discovery mechanisms for mmWave based radio access on XDU and evaluate proposed schemes. The Simulation result shows that threshold based scheme and information based scheme have less than about 50% beam discovery latency compared to full search scheme.

• Bulletin of the Korean Chemical Society
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• v.10 no.2
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• pp.177-184
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• 1989

The structure of cholesteryl isobutyrate, $(CH_3)_2CHCOOC_{27}H_{45}$, was determined by single crystal X-ray diffraction methods. Cholesteryl isobutyrate crystallized monoclinic space group $P2_1$, with a = 15.115 (8)${\AA}$, b = 9.636 (5)${\AA}$, c = 20.224 (9)${\AA}$, ${\beta}$ = 93.15 (5)$^{\circ}$, z = 4, $D_c = 1.03 g/cm^3 $and Dm= 1.04 g/$cm^3$. The intensity data were measured for the 3417 reflections, within $sin{\theta}/{\lambda} = 0.59{\AA}^{-1}$, using an automatic four-circle diffractometer and graphite monochromated Mo-$K_{\alpha}$ radiation. The structure was solved by fragment search Patterson methods and direct methods and refined by full-matrix least-squares methods. The final R factor was 0.129 for 2984 observed reflections. The two symmetry-independent molecules (A) and (B) are almost fully extended. The molecules are in antiparallel array forming monolayers with thickness $d_{100}$ = 15.2${\AA}$, and molecular long axes are nearly parallel to the [$\bar{1}$01] directions. The two distinct molecules form separate stacks with almost the same orientations, but with differing degrees of steroid overlap. Thers is a close packing of cholesteryl groups within the monolayers. The packing type is similar to those of cholesteryl hexanoate and cholesteryl oleate.