• Korean Circulation Journal
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• 제54권7호
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• pp.363-381
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• 2024

With global aging, the number of patients with heart failure has increased markedly. Heart failure is a complex condition intricately associated with aging, organ damage, frailty, and cognitive decline, resulting in a poor prognosis. The relationship among frailty, sarcopenia, cachexia, malnutrition, and heart failure has recently received considerable attention. Although these conditions are distinct, they often exhibit a remarkably close relationship. Overlapping diagnostic criteria have been observed in the recently proposed guidelines and position statements, suggesting that several of these conditions may coexist in patients with heart failure. Therefore, a comprehensive understanding of these conditions is essential, and interventions must not only target these conditions individually, but also provide comprehensive management strategies. This review article provides an overview of the epidemiology, diagnostic methods, overlap, and prognosis of frailty, sarcopenia, cachexia, and malnutrition in patients with heart failure, incorporating insights from the FRAGILEHF study data. Additionally, based on existing literature, this article discusses the impact of these conditions on the effectiveness of guideline-directed medical therapy for patients with heart failure. While recognizing these conditions early and promptly implementing interventions may be advantageous, further data, particularly from well-powered, large-scale, randomized controlled trials, are necessary to refine personalized treatment strategies for patients with heart failure.

• Journal of the Optical Society of Korea
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• 제7권3호
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• pp.145-149
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• 2003

The anisotropy of electron energy distribution in oxygen plasmas produced by a high intensity laser was investigated by using polarization spectroscopy. An ultra-short pulsed laser with a pulse duration of 66.5 fs and a power density of $1 {\times} 10^17/ W/$\textrm{cm}^2$$ was used. At this power density and pulse duration, the plasma was generated predominantly by optical field ionization. The degree of polarization of OVI 1s$^2$2p$^2$p2- 1s$^2$4d$^2$D$^{0}$ (J = 1/2-3/2 and 3/2-5/2) transition line at 129.92 $\AA$ was measured. O VI 1s$^2$2p$^2$P$^2$ -1s$^2$4s$^2$S$^2$ (J = 1/2-1/2 and 3/2-1/2) transition line at 132.26 $\AA$ was used to calibrate the sensitivity of the optical system. The dependencies of the degree of polarization on the initial gas density and on the laser polarization were investigated. When the laser polarization was changed from a linear to a circular polarization, the degree of polarization was decreased. When the initial gas density was increased, the degree of polarization was decreased.

• Journal of Gastric Cancer
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• 제13권1호
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• pp.58-64
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• 2013

Alpha-fetoprotein-producing gastric cancer is associated with poor prognosis because of frequent liver and lymph node metastasis. We present a case with synchronous liver metastasis who survived for 5 years. A 69-year-old man with upper abdominal pain was referred to our hospital. Gastrointestinal endoscopy revealed a Borrmann II-like tumor in the lower part of the stomach. Computed tomography revealed a tumor in the left lobe of the liver. Serum alpha-fetoprotein levels were markedly increased. We performed distal gastrectomy after administering oral tegafur/gimeracil/oteracil potassium and administered hepatic intra-arterial cisplatin injection. Liver metastasis showed partial response on computed tomography. Despite left hepatic lobectomy, further metastases to the liver and mediastinal lymph nodes became difficult to control. After sorafenib tosylate administration, stabilization of the disease was observed for 4 months. We conclude that hepatic intra-arterial chemotherapy and oral administration of sorafenib tosylate may potentially improve the prognosis in such cases.

• 천문학회지
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• 제37권5호
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• pp.387-392
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• 2004

X-ray observations of galaxy clusters have played an important role in cosmology, especially in determining the cosmological density parameter and the fluctuation amplitude. While they represent the bright side of the universe together with the other probes including the cosmic microwave background and the Type Ia supernovae, the resulting information clearly indicates that the universe is dominated by dark components. Even most of cosmic baryons turns out to be dark. In order to elucidate the nature of dark baryons, we propose a dedicated soft-X-ray mission, DIOS (Diffuse Intergalactic Oxygen Surveyor). Recent numerical simulations suggest that approximately 30 to 50 percent of total baryons at z = 0 take the form of the warm-hot intergalactic medium (WHIM) with $10^5K < T < 10^7K $which has evaded the direct detection so far. The unprecedented energy resolution (${\~} 2eV$) of the XSA (X-ray Spectrometer Array) on-board DIGS enables us to identify WHIM with gas temperature $T = 10^6 {\~} 10^7K$ and overdensity $\delta$ = 10 ${\~}$ 100 located at z < 0.3 through emission lines of OVII and OVIII. In addition, WHIMs surrounding nearby clusters are detectable with a typical exposure time of a day, and thus constitute realistic and promising targets for DIOS.

• 대한기계학회논문집B
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• 제30권7호
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• pp.682-691
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• 2006

This study was conducted to assess the effect of mixed fuel composition and mass fraction on spray inner structure in evaporating transient spray under the various ambient conditions. Spray structure and spatial distribution of liquid phase concentration are investigated using a thin laser sheet illumination technique on the multi-component mixed fuels. A pulsed Ar+ laser was used as a light source. The experiments were conducted in a constant volume vessel with optical access. Fuel was injected into the vessel with electronically controlled common rail injector. Used fuel contain $i-octane(C_8H_{18}),\;n-dodecane(C_{12}H_{26})$ and $n-hexadecane(C_{16}H_{34})$ that are selected as low-, middle- and high-boiling point fuel, respectively. Experimental conditions are 25Mpa, 42MPa, 72MPa and 112MPa in injection pressure, $5kg/m^3,\;15kg/m^3\;and\;20kg/m^3$ in ambient gas density, 400K, 500K, 600K and 700K in ambient gas temperature, 300K and 368K in fuel temperature, and different fuel mass fraction. Experimental results indicate that the more high-boiling point component, the longer the liquid phase it were closely related to fuel physical properties, but injection pressure had no effect on. And there was a high correlation between the liquid phase length and boiling temperature at 75% distillation point.

• Journal of Mechanical Science and Technology
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• 제16권12호
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• pp.1702-1709
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• 2002

This paper analyzes heterogeneous distribution of branch-like structure at the downstream region of the spray. The liquid and vapor phase of the spray are obtained using a 35㎜ still camera and CCD camera in order to investigate spray structure of evaporating diesel spray. There have been many studies conducted on diesel spray structure but have yet only focused on the analyses of 2-D structure. There are a few information which is concerned with 3-D structure analysis of evaporating spray. The heterogeneous distribution of droplets in inner spray affects the mixture formation of diesel spray and the combustion characteristics of the diesel engines. In this study, the laser beam of 2-D plane was used in order to investigate 3-D structure of evaporating spray The incident laser beam was offset on the central axis of the spray. From the analysis of images taken by offset laser beam, we will examine the formation mechanism of heterogeneous distribution of the diesel spray by vortex flow at the downstream of the spray. The images of liquid and vapor phase of free spray are simultaneously taken through an exciplex fluorescence method. Through this, the branch-like structure consisting of heterogeneous distribution of the droplets forms high concentrated vapor phase at the periphery of droplets and at the spray tip.

• 대한두경부종양학회지
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• 제16권2호
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• pp.212-215
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• 2000

Background and Objective: Kikuchi's disease(KD) is an idiopathic, self-limited lymphadenopathy that was described as a distinctive type of necrotizing lymphadenitis affecting primarily cervical lymph nodes of young adults independently by Kikuchi and Fujimoto et al at first in 1972. The purpose of this study is a knowledge about clinicopathologic findings, many laboratory tests and differentiation of KD from other lymphadenitis due to lymphoma, systemic lupus erythematosus(SLE) and many viral disease. Materials and Methods: Thirty-four case of KD collected at Chonnam University Hospital in Kwang-Ju from 1992 through 2000 were evaluated with retrospective chart review. Results: The patients were consisted of 11 men and 23 women. All patients had tender or nontender cervical mass and fever was the most common associated symptom. The others was pain, weight loss, chills, cold sweating and headache et al. Multiple bilateral involvement of cervical lymphnodes was 25 cases(74%) and solitary involvement was 9 cases(26%). In laboratory tests, leukopenia was 12 cases(75%), elevated ESR 5 cases (34%) and elevated LDH 11 cases(69%). Conclusion: KD is necessary to differentiate from lymphoma and SLE, because of the different of therapeutic modality and prognosis. The diagnosis is established on the basis of histopathologic studies with excisional biopsy of lymph node.

• Current Research on Agriculture and Life Sciences
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• 제6권
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• pp.43-47
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• 1988

고추의 16개(個) 도입계통(導入系統)에 대(對)해서 내건성(耐乾性)을 알기 위(爲)하여 발식(鉢植)한 고추를 단수처리(斷水處理)하고 일정기간후(一定期間後)에 엽(葉)의 WSD치(値)를 측정(測定)해서 내건성(耐乾性)을 평가(評價)하였으며 성숙엽(成熟葉)의 기공밀도(氣孔密度)를 조사(調査)하여 WSD치(値)와의 상관(相關)을 구(求)하였다. WSD치(値)로부터 내건성(耐乾性)이 강한 계통(系統)의 순위(順位)는 No.3446, C. chaconce, Gogoshari, 팔방(八房)이였다. 성숙엽(成熟葉)의 기공밀도(氣孔密度)와 WSD치(値)와의 상관(相關)(r=0.581)이 인정(認定)되었다.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1987년도 Proceedings of Korea-Japan Panax Ginseng Symposium 1987 Seoul Korea
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• pp.20-28
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• 1987

To clarify central mechanisms of ginsenosides, changes in ingestive and ambulatory behaviors were investigated in rats after single or continuous infusion into the third cerebroventricle or various hypothalamic loci. Following single infusion into the third cerebroventricle, ginsenoside Rbl at doses of 0.05, 0.10 and 0.20 $\mu$mol dose-dependently decreased food intake. None of the doses tested affected ambulation. Drinking suppression was only observed at the maximum dose of 0.20 $\mu$mol. Equimolar injections into the peritoneum had no effects on ingestive behavior or ambulation. These findings indicated that ginsenoside Rbl specifically and centrally inhibited food intake. According to analyses of daily feeding patterns, this feeding suppression was the result of a decrease in meal size, not from changes in the postprandial intermeal interval or eating speed. The suppressed food intake was accompanied by hyperglycemia, leaving plasma insulin unaffected. Unilateral micro injection of 0.01 u mot ginsenoside Rb, into the ventromedial hypothalamus specifically decreased food intake, although equimolar injection into the lateral hypothalamic area did not affect food intake. Following continuous infusion of Rg, into the third cerebroventricle, the feeding inhibition due to surgical operation was attenuated. Rbs administered by the same procedure abolished the toxic effect of toxohormone-L on food intake. Taken together, these findings suggest that ginsenoside as a whole may have pharmacological potency to maintain feeding at a certain physiological level.

• 한국정밀공학회지
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• 제27권3호
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• pp.33-40
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• 2010

Multizeros(multiple order zeros) optical beams which belong to the Laguerre-Gaussian beams, have rotational phase and conically-shaped amplitude structures around multizeros points in their phase and amplitude profiles, respectively. Especially, they have their own characteristics that the multizero points do not vanish over free-space propagation. Therefore, they are expected to be adequate for the applications of long-range optical measurement by using their multizero points as optical markers for the deformation sensing. In this paper, fundamental properties of multizeros optical beams for long-range optical measurement applications are investigated and clarified. In particular, the mathematical investigations are described on the characteristics of multizeoros optical beams such as (1) separation of a multizero into isolated single order zeros, (2) topological charge of zeros distribution which are induced by superposing them. And also the outline of a fundamental experiment and its result are explained briefly.