• Journal of Korean Neurosurgical Society
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• 제41권6호
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• pp.387-390
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• 2007

Objective : To determine the presentation, incidence, and risk factors of seizures in patients treated for brain tumors. Methods : One hundred patients who consecutively underwent a craniotomy for the treatment of supratentorial brain tumors were assessed. The pathologies of the patients enrolled in the study included glioma [n=56], meningioma [n=31], metastatic brain tumor [n=7], primary central nervous system lymphoma [n=4], and central neurocytoma [n=2]. Anti-epileptic drugs [AEDs] were administered to all patients for up to six months after the surgery. Pre-defined variables for outcome analysis included tumor grade and location, extent of tumor resection, number of seizures, age at tumor diagnosis, adjuvant therapy, medication and radiological abnormalities. Results : Thirty patients [30%] presented at least a single episode of seizure at the time of admission. Five of these patients [16.7%] developed the seizure during the follow-up period. Newly developed seizure was noticed in six out of seventy patients [8.6%] without prior seizure. Histopathology was malignant gliomas in 10 and supratentorial meningioma in one. Early seizure developed only in two patients. Conclusion : Compared with patients without seizure, patients with seizure at the time of admission showed younger age [p=0.003], a higher portion of low-grade glioma [p=0.001], tumor location in the frontal and temporal lobes [p=0.003] and cortical involvement [p=0.017]. Our study suggestes that tumor progression is considered a significant risk factor for seizure development in glioma patients.

• The Korean Journal of Pain
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• 제34권4호
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• pp.437-446
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• 2021

Background: Non-invasive painless signaling therapy (NPST) is an electro-cutaneous treatment that converts endogenous pain information into synthetic non-pain information. This study explored whether pain improvement by NPST in failed back surgery syndrome (FBSS) patients is related to cerebral modulation. Methods: Electroencephalography (EEG) analysis was performed in 11 patients with FBSS. Subjects received daily NPST for 5 days. Before the first treatment, patients completed the Brief Pain Inventory (BPI) and Beck Depression Inventory and underwent baseline EEG. After the final treatment, they responded again to the BPI, reported the percent pain improvement (PPI), and then underwent post-treatment EEG. If the PPI grade was zero, they were assigned to the ineffective group, while all others were assigned to the effective group. We used standardized low-resolution brain electromagnetic tomography (sLORETA) to explore the EEG current-source distribution (CSD) associated with pain improvement by NPST. Results: The 11 participants had a median age of 67.0 years, and 63.6% were female. The sLORETA images revealed a beta-2 CSD increment in 12 voxels of the right anterior cingulate gyrus (ACG) and the right medial frontal area. The point of maximal CSD changes was in the right ACG. The alpha band CSD increased in 2 voxels of the left transverse gyrus. Conclusions: Pain improvement by NPST in FBSS patients was associated with increased cerebral activity, mainly in the right ACG. The change in afferent information induced by NPST seems to be associated with cerebral pain perception.

• Genes and Genomics
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• 제40권11호
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• pp.1149-1155
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• 2018

Epileptic encephalopathies are genetically heterogeneous disorders which leads to epilepsy and cause neurological disorders. Seizure threshold 2 (SZT2) gene located on chromosome 1p34.2 encodes protein mainly expressed predominantly in the parietal and frontal cortex and dorsal root ganglia in the brain. Previous studies in mice showed that mutation in this gene can confers low seizure threshold, enhance epileptogenesis and in human may leads to facial dysmorphism, intellectual disability, seizure and macrocephaly. Objective of this study was to find out novel gene or novel mutation related to the gene phenotype. We have identified a large consanguineous Saudi family segregating developmental delay, intellectual disability, epilepsy, high forehead and macrocephaly. Exome sequencing was performed in affected siblings of the family to study the novel mutation. Whole exome sequencing data analysis, confirmed by subsequent Sanger sequencing validation study. Our results showed a novel homozygous mutation (c.9368G>A) in a substitution of a conserved glycine residue into a glutamic acid in the exon 67 of SZT2 gene. The mutation was ruled out in 100 unrelated healthy controls. The missense variant has not yet been reported as pathogenic in literature or variant databases. In conclusion, the here detected homozygous SZT2 variant might be the causative mutation that further explain epilepsy and developmental delay in this Saudi family.

• 한국의류산업학회지
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• 제20권6호
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• pp.713-721
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• 2018

This study aimed to develop a draping manual for the basic bodice to be available in colleges and industries. For this, draping methods mentioned in six different textbooks were comparatively analyzed. As for the research method, draping methods were compared by using training textbook, and basic bodices designed with muslin were assessed using the 5-point Likert scale. First, the draping methods of basic bodices were comparatively analyzed. The main baselines were set as the center front line, the center back line, the bust line, and the shoulder blade line. The position of dart was suggested based on the princess line, in both the front and the back. The value of dart was classified as a fixed size with any associated excess. The length of dart was set based on the bust point and shoulder blade point or a fixed size. The amount of ease was randomly set based on the fixed size, bust circumference, waist circumference, interscye length, armholes and shoulder lines, or the worker's intuition. Second, according to the appearance evaluation of the patterns, the following patterns obtained the highest scores: A pattern 2.5cm away from the B.P point of the waist dart and shoulder dart in the frontal appearance, a pattern of 0.6~0.7cm ease for the front armhole, a pattern with an ease of 1.2cm in the bust and 0.6cm in the waist. As for back appearance, the pattern in which the point of waist dart is 2~3cm from the bust line received the highest score.

• 한국의류산업학회지
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• 제21권5호
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• pp.552-563
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• 2019

Jackets are regarded as an element used to judge ideas and fashion trends for the age in which they are presented. This article analyzed recent tailored jacket fashion trends by categorizing jackets according to design elements. For this, design elements of tailored jackets were categorized into silhouette, collar and lapel, shoulder and sleeve, and decorative elements. We collected and categorized the changes of 491 jackets that have appeared in collections over the past 5 years. The results showed shoulder and sleeve changes (36.25%), silhouette changes (33.4%), lapel and color changes (12.6%), decorative element changes (11.2%), and no changes (6.5%). Jacket forms with changed shoulders and sleeves appeared as styles that have laterally or vertically expanded the shoulder and arm hole with the production of various sleeve forms. Silhouette changes were expressed through forms such as exaggerated silhouettes of oversized-clothing, silhouettes made through cutting or layering, and the polarization of length. Forms with a changed collar and lapel appeared with polarization trends in which lapels dramatically grow larger or narrower, diverse frontal adjustments using no-collar designs, and the utilization of shawl-collars; in addition, forms with changed decorative elements were expressed with layered decorations such as pockets or collar add-ons, adjustment changes using buttons, ribbons or zippers, and various trimmings. The analysis results show that modern female tailored jackets are being made to realize an exaggerated physical beauty of shoulder, sleeve and torsos to maximize decorative effects through new attempts in design.

• 정보교육학회논문지
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• 제24권6호
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• pp.539-550
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• 2020

이 연구는 뇌과학과 교육을 접목하는 교육신경학의 관점에 기초한 연구이다. 이 관점에 기초하여 디지털 학습자료 활용의 뇌과학적 근거를 확인함과 아울러 교육적 시사점을 도출하는 것을 연구의 목적으로 하였다. 이 연구에서 얻어진 결과를 결론으로 제시하면, 다음과 같다. 첫째, 디지털 학습자료를 통한 다양한 감각 자극은 다중감각신경, 상구 심층부 등을 거치며 협동적 정보처리를 가능하게 한다. 둘째, 디지털 학습자료로 인한 간접경험은 거울신경계를 거쳐 학습 내용을 생생하게 이해하도록 도와준다. 셋째, 디지털 학습자료들이 일으킨 긍정적인 감정은 도파민, 망상활성체계, 전두 선조체, 대뇌 피질 등의 기능을 활성화시켜 준다. 이 연구의 결과를 통해 제시되는 교육적 시사점은 다음과 같다. 첫째, 교사는 디지털 학습자료를 선정할 때 표현 양식, 학습 내용, 수업의 흐름 및 역기능 측면까지 고려해야 한다. 둘째, 수업 장면에 따라 다양한 디지털 학습자료를 호기심과 즐거움의 유발, 흥미와 노력의 유지, 학습한 내용에 대한 복습의 목적으로 사용하는 것은 수업 효과를 위해 바람직하다.

• 동의생리병리학회지
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• 제35권6호
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• pp.267-273
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• 2021

Mibyeong (sub-health) is a concept that represents the sub-health in traditional East Asian medicine. Assuming that the nose sizes and shapes are related to respiratory function, in this study, we hypothesized that the nose size and shape features are related to the self-rated health (SRH) level and self-rated Mibyeong severity, and aimed to assess this relationship using a fully automated image analysis system. The nose size features were evaluated from the frontal and profile face images of 810 participants. The nose size features consisted of five length features, one area feature, and one volume feature. The level of SRH and the Mibyeong severity were determined using a questionnaire. The normalized nasal height was negatively associated with the self-rated health score (SRHS) (partial ρ = -0.125, p = 3.53E-04) and the Mibyeong score (MBS) (partial ρ = -.172, p = 9.38E-07), even after adjustment for sex, age, and body mass index. The normalized nasal volume (ρ = -.105, p = 0.003), the normalized nasal tip protrusion length (ρ = -.087, p = 0.014), and the normalized nares width (ρ = -.086, p = .015) showed significant correlation with the SRHS. The normalized nasal area (ρ = -.118, p = 0.001), the normalized nasal volume (ρ = -.107, p = .002) showed significant correlation with the MBS. The wider, longer, and larger the nose, the lower the SRHS and MBS, indicating that health status can be estimated based on the size and shape features of the nose.

• 대한토목학회논문집
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• 제30권2B호
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• pp.199-209
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• 2010

본 연구에서는 지표수 흐름 해석을 위한 2차원 유한요소모형을 개발하였다. 개발된 수치모형에서는 2차원 흐름 해석을 위한 천수방정식을 Galerkin법과 Newton-Raphson법에 의해 이산화하였으며 지형에 따라 삼각망과 사각망을 혼용하여 사용할 수 있도록 하였다. 구성된 대수방정식의 해는 유한요소법을 푸는데 매우 효율적인 프론탈 기법에 의해 구하였다. 개발된 모형을 두 개의 만곡부를 가지는 실험실 사행수로에 적용하여 만곡부에서의 횡방향 유속 및 수심 분포를 분석한 결과 만곡부에서 편수위 현상을 잘 재현함을 알 수 있었다. 또한 내측의 유속이 외측에 비해 빠르게 나타났고 유속분포는 두 만곡부의 중심을 기준으로 대칭적이었으며, 모의결과와 수리실험에 의한 실측값이 매우 잘 일치하였다. 본 모형을 완경사, 급경사, 역경사, 급격한 하상변화가 있는 수로와 위어를 포함한 수로에 적용하여 12개의 점변화류 수면곡선을 모의한 결과 수리학적으로 적합한 수면형상이 도출되었다.

• 치위생과학회지
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• 제23권3호
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• pp.193-198
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• 2023

Background: The nose is located at the center of the face, and it is possible to determine race, sex, and the like. Research using the nasal index (NI) classification method to classify the shape of the nose is currently in progress. However, domestic research is required as most research is being conducted abroad. In this study, we used a 3D program to confirm the ratio of the nose shape of Koreans. Methods: One hundred patients (50 males and 50 females) in their 20s were evaluated (IRB approval no. DKUDH IRB 2020-01-007). Cone beam computed tomography was performed using the Mimics ver.22 (Materialise Co., Leuven, Belgium) 3D program to model the patient's skull and soft tissues into three views: coronal, sagittal, and frontal. To confirm the ratio of measurement metrics, analysis was performed using the SPSS ver. 23.0 (IBM Co., Armonk, NY, USA) program. Results: Ten leptorrhine (long and narrow) type, 76 mesorrhine (moderate shape) type, and 14 platyrrhine (broad and short) type noses were observed. In addition, as a result of sex comparison, five males had the leptorrhine (long and narrow) type, 40 mesorrhine (moderate shape), and five platyrrhine (broad and short) types. For females, five patients had the leptorrhine (long and narrow) type, 36 patients had the mesorrhine (moderate shape) type, and nine patients had the platyrrhine (broad and short) type. Conclusion: This study will be helpful when performing nose-related surgeries and procedures in clinical practice and for similar studies in the future.

• Korean Journal of Radiology
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• 제22권8호
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• pp.1352-1368
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• 2021

Objective: For an accurate dynamic contrast-enhanced (DCE) MRI analysis, exact baseline T1 mapping is critical. The purpose of this study was to compare the pharmacokinetic parameters of DCE MRI using synthetic MRI with those using fixed baseline T1 values. Materials and Methods: This retrospective study included 102 patients who underwent both DCE and synthetic brain MRI. Two methods were set for the baseline T1: one using the fixed value and the other using the T1 map from synthetic MRI. The volume transfer constant (K^trans), volume of the vascular plasma space (v_p), and the volume of the extravascular extracellular space (v_e) were compared between the two methods. The interclass correlation coefficients and the Bland-Altman method were used to assess the reliability. Results: In normal-appearing frontal white matter (WM), the mean values of K^trans, v_e, and v_p were significantly higher in the fixed value method than in the T1 map method. In the normal-appearing occipital WM, the mean values of v_e and v_p were significantly higher in the fixed value method. In the putamen and head of the caudate nucleus, the mean values of K^trans, v_e, and v_p were significantly lower in the fixed value method. In addition, the T1 map method showed comparable interobserver agreements with the fixed baseline T1 value method. Conclusion: The T1 map method using synthetic MRI may be useful for reflecting individual differences and reliable measurements in clinical applications of DCE MRI.