• 영어어문교육
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• 제13권1호
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• pp.211-233
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• 2007

Caryl Churchill achieved spacial politics to resist dominant ideology in Cloud Nine. It is suggested that heterotopia is a counter-site to the places which are controlled by colonialism and sexuality. Churchill juxtaposes African colony of Victorian period in the first act and modern London in the second act. It implies that individuals are similarly oppressed by dominant ideology until now though several conditions for individuals are drastically improved. White heterosexual men in the play try to build their utopia to keep their privileges. If they find anything abnormal to their standard, they systematically classify people and organize them into the different ranks and levels to seclude them from their utopia. Actually, the ideal people in the ideal place are oppressed by patriarchal ideology, compulsory heterosexuality, and colonialism which are covertly associated with gender. Therefore, Churchill uses the cross-casting to challenge the artificiality of gender, sexuality, generation and race in the play. People realize that they need to find their own desires free from gender, compulsory heterosexuality, ethnic, and race and their subjectivity flowing in and out of space. It is the site that all the binary oppositions are deconstructed and creates new multiple nodes to expand the boundary of their communities to heterotopia in real places.

• Structural Engineering and Mechanics
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• 제64권1호
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• pp.121-133
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• 2017

This paper proposes an analytical solution method for free vibration of curved functionally graded (FG) nonlocal beam supposed to different thermal loadings, by considering porosity distribution via nonlocal elasticity theory for the first time. Material properties of curved FG beam are assumed to be temperature-dependent. Thermo-mechanical properties of porous FG curved beam are supposed to vary through the thickness direction of beam and are assumed to be temperature-dependent. Since variation of pores along the thickness direction influences the mechanical and physical properties, porosity play a key role in the mechanical response of curved FG structures. The rule of power-law is modified to consider influence of porosity according to even distribution. The governing equations of curved FG porous nanobeam under temperature field are derived via the energy method based on Timoshenko beam theory. An analytical Navier solution procedure is used to achieve the natural frequencies of porous FG curved nanobeam supposed to thermal loadings with simply supported boundary condition. The results for simpler states are confirmed with known data in the literature. The effects of various parameters such as nonlocality, porosity volume fractions, type of temperature rising, gradient index, opening angle and aspect ratio of curved FG porous nanobeam on the natural frequency are successfully discussed. It is concluded that these parameters play key roles on the dynamic behavior of porous FG curved nanobeam. Presented numerical results can serve as benchmarks for future analyses of curve FG nanobeam with porosity phases.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book II
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• pp.464-478
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• 2003

Free radicals and reactive oxygen species (ROS) caused by UV exposure or other environmental facts play critical roles in cellular damage and aging. The extract of tinged autumnal leaves of maple tree(Acer palmatum) has proven to be a powerful antioxidant. The Acer palmatum extract is very effective on the stabilization of biological membranes( containing unsaturated fatty acid). We studied photoprotective effect of the extract against UVB-induced cytotoxicity in human keratinocytes. The extract improved cell viability comparing to control after UVB irradiation. In the determination test of pro inflammatory cytokines the extract decreased expression of interleukin 1 a and 6, which play an important role in inflammation and skin erythema caused by UV. We also studied property of varying cosmetic formulations on the percutaneous absorption of the extract. After 24 hour in vitro penetration study, the content of the extract was more highly detected in skin residue part. This result showed the extract had relatively high compatibility of skin in our emulsion system. On human skin, after appling the product containing the extract we obtained a good result of antiwrinkle effect by skin visiometer. In conclusion, the Acer palmatum extract is a photoprotective and very effective in stressed and aged skin care. And we can predict the extract mainly affects on the skin cell and tissue in our emulsion system.

• Journal of Dairy Science and Biotechnology
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• 제37권2호
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• pp.83-93
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• 2019

Food spoilage by fungi is responsible for considerable food waste and economical losses. Among the food products, fermented dairy products are susceptible to deterioration due to the growth of fungi, which are resistant to low pH and can proliferate at low storage temperatures. For controlling fungal growth in dairy products, potassium sorbate and natamycin are the main preservatives used, and natamycin is approved by most countries for use in cheese surface treatment. However, a strong societal demand for less processed and preservative-free food has emerged. In the dairy products, lactic acid bacteria (LAB) are naturally present or used as cultures and play a key role in the fermentation process. Fermentation is a natural preservation technique that improves food safety, nutritional value, and specific organoleptic features. Production of organic acids is one of the main features of the LAB used for outcompeting organisms that cause spoilage, although other mechanisms such as antifungal peptides obtained from the cleavage of food proteins and competition for nutrients also play a role. More studies for better understanding these mechanisms are required to increase antifungal LAB available in the market.

• Toxicological Research
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• 제16권1호
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• pp.1-8
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• 2000

Astrocytes generate free radicals including nitric oxide (NO) and reactive oxygen intermediates(ROI) which in turn play roles in the pathogenesis of degenerative diseases and sclerotic changes of the brain. This study was designed to evaluate the mechanism that free radicals contribute to the cytotoxicty of rat neonatal primary astrocytes. Treatment with NO donors alone including soldium nitroprusside(SNP), S-nitrosoglucathinoe (GSNO), and S-nitroso-n-acetylpenicillamine (SNAP) showed a little effect on the death of rat neonatal primary astrocytes, whereas SNP markedly induced the death of RAW 264.7 cells. ROI inculding H2O2 and O2 donor also slightly induced the death of rat primary astrocytes. However, 3-morpholinosydnonimine(SIN-1), a donor of peroxynitrite (ONOO), which is a reactive compound of NO with superoxide, significantly decreased the viability of rat primary astrocytes in a dose-dependent manner. Cells were retarded in outgrowth of viability of cellular processes with cell shrinkage and detachment from culture dishes. Hoechst staining demonstrated that SIN-1-induced cell death might be due to an apoptosis which was characterized by nuclear condensation and fragmentation. SIN-1-induced apoptosis was prevented by the pretreatment with superoxide dismutase (SOD) and catalase in rat primary astorocytes. Furthermore, prevention of the generation of reduced glutathione (GSH) by DL-buthionine-[S, R]-sulfoximine (BSO) aggravated the cytotoxic effects of SNP, benzene triol, and SIN-1 in rat primary astrocytes. Taken together, it is suggested that peroxynitrite may be a major effector of apoptosis and cellular antioxidant system is important for cell survival in rat prima교 astrocytes.

• 한국환경농학회지
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• 제16권1호
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• pp.14-18
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• 1997

$SO_2$에 대한 양버즘나무의 내성을 증대시키고자 uniconazole, sodium benzoate 또는 ascorbic acid를 단용 또는 복합처리한 후 $SO_2$에 의한 가시피해정도, 엽록소함량 및 유리기 제거제로 활성산소의 독성을 중화시킬 수 있는 superoxide dismutase(SOD) 및 peroxidase(POD)의 활성변화를 조사하였다. Uniconazole처리에 의한 $SO_2$ 피해경감 효과는 SOD불활성제인 diethyldithiocarbamate(DDTC)를 다시 처리하므로써 가시피해가 증가하였고 SOD와 POD의 활성도 감소하였다. 유리기 제거제인 sodium benzoate와 ascorbic acid처리는 SOD나 POD 활성에 영향을 주지않으면서 $SO_2$의 피해를 경감시키고, DDTC의 $SO_2$피해증가 효과를 ascorbic acid 처리로 감소시킬 수 있었다. 이상의 결과로 미루어 uniconazole은 식물체내에서 산화방지물질의 역할을 하는 SOD의 활성을 증대시켜 $SO_2$가스의 피해를 경감시키는 효과가 인정되며, ascorbic acid와 sodium benzoate의 내성 증대 효과는 식물체내의 SOD나 POD 활성 증진과는 관계가 없는 것으로 판단된다.

• 한국축산식품학회지
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• 제36권4호
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• pp.558-565
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• 2016

The aim of this study was to investigate the influence of proteolytic pork hydrolysate (PPH) on yoghurt production by Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus. Fresh lean pork was cut into pieces and mixed with deionized water and dealt with protease, then the resulting PPH was added to milk to investigate the effects of PPH on yoghurt production. The fermentation time, the viable cell counts, the flavor, free amino acids compounds, and sensory evaluation of yoghurt were evaluated. These results showed that PPH significantly stimulated the growth and acidification of the both bacterial strains. When the content of PPH reached 5% (w/w), the increased acidifying rate occurred, which the fermentation time was one hour less than that of the control, a time saving of up to 20% compared with the control. The viable cell counts, the total free amino acids, and the scores of taste, flavor and overall acceptability in PPH-supplemented yoghurt were higher than the control. Furthermore, the contents of some characteristic flavor compounds including acids, alcohols, aldehydes, ketones and esters were richer than the control. We concluded that the constituents of PPH such as small peptide, vitamins, and minerals together to play the stimulatory roles and result in beneficial effect for the yoghurt starter cultures growth.

• Toxicological Research
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• 제13권4호
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• pp.359-365
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• 1997

Many factors are known to be responsible for cerebral ischemic injury, such as excitatory neurotransmitters, increased intraneuronal calcium, or disturbance of cellular energy metabolism. Recently, oxygen free radicals, formed during ischemia/reperfusion, have been proposed as one of the main causes of ischemia/reperfusion injury. Therefore, to investigate the role of oxygen free radical during ischemia/reperfusion, in the present study the effect of endogenous oxygen free radical scavenger, superoxide dismutase / catalase(SOD / catalase) on the release of [$^3$H]-5-hydroxytryptamine([$^3$H]-5-HT) during hypoxia/reoxygenation in rat hippocampal slices was measured. The hippocampus was obtained from the rat brain and sliced 400 gm thickness with manual chopper. After 30 min's preincubation in the normal buffer, the slices were incubated for 20 min in a buffer containing [$^3$H]-5-HT(0.1 $\mu$M, 74 $\mu$Ci) for uptake, and washed. To measure the release of [$^3$H]-5-HT into the buffer, the incubation medium was drained off and refilled every ten minutes through a sequence of 14 tubes. Induction of hypoxia for 20 min (gassing it with 95% N$_2$/5% CO$_2$) was done in the 6th and 7th tube, and oxygen free radical scavenger, SOD / catalase was added 10 minutes prior to induction of hypoxia. The radioactivity in each buffer and the tissue were counted using liquid scintillation counter and the results were expressed as a percentage of the total activity. When slices were exposed to hypoxia for 20 min, [$^3$H]-5-HT release was markedly decreased and a rebound release of [$^3$H]-5-HT was observed on the post-hypoxic reoxygenation period. SOD / catalase did not changed the release of [$^3$H]-5-HT in control group, but inhibited the decrease of [$^3$H]-5-HT release in hypoxic period and rebound increase of [$^3$H]-5-HT in reoxygenation period. This result suggest that superoxide anion may play a role in the hypoxic-, and reoxygenation-induced change of [$^3$H]-5-HT release in rat hippocampal slices.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제2권5호
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• pp.347-352
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• 2013

임펄스 잡음 제거 기법들에서 윈도우의 크기는 매우 중요한데, 보통 잡음의 밀도에 따라 적당한 크기의 윈도우를 사용한다. 이때 윈도우가 너무 작으면 잡음을 충분히 제거하지 못하며, 너무 크면 영상 내의 에지나 미세한 형태를 제대로 복원하지 못하고 흐릿하게 만들 수 있다. 또한 잡음이 있는 중앙 화소를 복원하기 위해 이러한 윈도우 내의 모든 화소들이 이용된다. 본 논문에서는 이러한 기존 방법과 달리 작은 크기의 윈도우를 사용하고 잡음이 없이 깨끗한 화소만을 사용하여 임펄스 잡음을 제거하는 새로운 반복적인 알고리즘을 제안한다. 제안된 방법은 모든 잡음 화소가 새로 계산된 추정치로 대체될 때까지 반복된다. 잡음 화소에 대해 최적의 값을 유추하기 위해 제안된 방법에서는 무잡음 화소를 이용한 유전자 프로그래밍 (GP) 기반의 추정자를 제안하는데, 이것은 윈도우 내의 무잡음 화소와, 산술 연산자 및 랜덤 상수들로 이루어진다. 실험을 통해 제안된 방법이 영상 내의 미세한 형태들을 잘 유지하면서 임펄스 잡음을 효과적으로 제거할 수 있음을 알 수 있었는데, 특히 심하게 잡음이 가해진 데이터의 복원에 매우 효과적임을 알 수 있었다.

• 컴퓨터교육학회논문지
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• 제22권3호
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• pp.123-133
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• 2019

본 연구는 스마트교육의 한 요소인 스마트 기기를 활용하여 축적된 데이터를 기초로 유아의 개별 맞춤학습을 위한 스마트교육환경을 구축하는데 목적을 두고 있다. 이를 위해 유치원 만5세 학급에서 자유선택활동 운영을 위한 개선 방안을 제안하고, 유아 스스로 놀이 계획을 세우고 평가하는 자유선택활동 운영시스템을 구현하였다. 본 연구 참여한 유아들은 놀이계획, 놀이수행 및 수행평가등 전체 활동시간을 스스로가 적극적이며 즐겁게 참여하였다. 그 결과 유아는 스마트기기를 통한 자신의 흥미영역에 대한 활동선택에 기존교육환경보다 적극적으로 참여하는 것을 확인할 수 있었다. 본 연구에서 제안된 자유선택활동 운영시스템을 이용한 교사는 분석된 자료를 활용하여 스마트기기를 이용한 개별유아의 흥미분야와 학습수준 및 교실의 각 영역별 이용형태를 혼자서 쉽게 파악할 수 있었다.