• 대한조선학회논문집
• /
• 제47권5호
• /
• pp.671-679
• /
• 2010

This paper introduces a new hull form design method for the bow of a full ship, by actively applying the relation between the fore-body hull form and its wave resistance characteristics. For the hull form design, the Series 60($C_B=0.8$) hull is chosen as the parent ship, and Kracht's charts are used to determine the parameters of the bulbous bow in the early stages of hull form design. Several hull forms have been tested in order to obtain enough hull form variations with various bow shapes and design parameters in the search of the best design. In order to investigate the resistance characteristics of the designed hull forms, numerical simulations with corresponding model tests have been rigorously performed. For the numerical simulations, the Marker-density method is employed to track the nonlinear phenomena of the free surface(program IUBW). Model tests have also been performed to achieve an improved research performance using the designed hulls. Both numerical and experimental results show that the wave resistance of the hull forms can be effectively diminished if the bows are designed using the method introduced in this research. It is also expected that this research can facilitate better productivity in hull form design, especially at the preliminary design stage of a full ship type vessel.

• Journal of Applied Biological Chemistry
• /
• 제64권3호
• /
• pp.225-236
• /
• 2021

The epipyrone (EPN) biosynthetic gene cluster of Epicoccum nigrum is composed of epnC, epnB, and epnA, which encode cytochrome P450 oxidase, glycosyltransferase, and highly reducing polyketide synthase, respectively. Gene inactivation mutants for epnA, epnB, and epnC were previously generated, and it was found that all of them were incapable of producing EPN and any of its related compounds. It was also reported that epnB inactivation abolished epnA transcription, generating ΔepnAB. This study shows that the introduction of native epnC readily restored EPN production in ΔepnC, suggesting that epnC is essential for polyketide release from EpnA and implies that EpnC works during the polyketide chain assembly of EpnA. Introduction of epnC promoter-epnA restored EPN production in ΔepnA. The ΔepnB genotype was prepared by introducing the epnA expression vector into ΔepnAB, and it was found that the resulting recombinant strain did not produce any EPN-related compounds. A canonical epnB inactivation strain was also generated by deleting its 5'-end. At the deletion point, an Aspergllus nidulans gpdA promoter was inserted to ensure the transcription of epnA, which is located downstream of epnB. Examination of the metabolite profile of the resulting ΔepnB mutant via LC-mass spectrometry verified that no EPN-related compound was produced in this strain. This substantiates that C-glycosylation by EpnB is a prerequisite for the release of EpnA-tethered product. In conclusion, it is proposed that cytochrome P450 oxidase and glycosyltransferase work in concert with polyketide synthase to generate EPN without the occurrence of any free intermediates.

• Biomolecules & Therapeutics
• /
• 제27권3호
• /
• pp.290-301
• /
• 2019

Paeonol has neuroprotective function, which could be useful for improving central nervous system disorder. The purpose of this study was to characterize the functional mechanism involved in brain transport of paeonol through blood-brain barrier (BBB). Brain transport of paeonol was characterized by internal carotid artery perfusion (ICAP), carotid artery single injection technique (brain uptake index, BUI) and intravenous (IV) injection technique in vivo. The transport mechanism of paeonol was examined using conditionally immortalized rat brain capillary endothelial cell line (TR-BBB) as an in vitro model of BBB. Brain volume of distribution (VD) of [$^3H$]paeonol in rat brain was about 6-fold higher than that of [$^{14}C$]sucrose, the vascular space marker of BBB. The uptake of [$^3H$]paeonol was concentration-dependent. Brain volume of distribution of paeonol and BUI as in vivo and inhibition of analog as in vitro studies presented significant reduction effect in the presence of unlabeled lipophilic compounds such as paeonol, imperatorin, diphenhydramine, pyrilamine, tramadol and ALC during the uptake of [$^3H$]paeonol. In addition, the uptake significantly decreased and increased at the acidic and alkaline pH in both extracellular and intracellular study, respectively. In the presence of metabolic inhibitor, the uptake reduced significantly but not affected by sodium free or membrane potential disruption. Similarly, paeonol uptake was not affected on OCTN2 or rPMAT siRNA transfection BBB cells. Interestingly. Paeonol is actively transported from the blood to brain across the BBB by a carrier mediated transporter system.

• Nuclear Engineering and Technology
• /
• 제53권1호
• /
• pp.282-293
• /
• 2021

This paper examines gamma-ray shielding properties of SBC-Bx glass system with the chemical composition of 40SiO₂-10B₂O₃-xBaO-(45-x)CaO- yZnO- zMgO (where x = 0, 10, 20, 30, and 35 mol% and y = z = 6 mol%). Mass attenuation coefficient (µ/ρ) which is an essential parameter to study gamma-ray shielding properties was obtained in the photon energy range of 0.015-15 MeV using PHITS Monte Carlo code for the proposed glasses. The obtained results were compared with those calculated by WinXCOM program. Both the values of PHITS code and WinXCOM program were observed in very good agreement. The (µ/ρ values were then used to derive mean free path (MFP), electron density (N_eff), effective atomic number (Z_eff), and half value layer (HVL) for all the glasses involved. Additionally, G-P method was employed to estimate exposure buildup factor (EBF) for each glass in the energy range of 0.015-15 MeV up to penetration depths of 40 mfp. The results reveal that gamma-ray shielding effectiveness of the SBC-Bx glasses evolves with increasing BaO content in the glass sample. Such that SBC-B35 glass has superior shielding capacity against gamma-rays among the studied glasses. Gamma-ray shielding properties of SBC-B35 glass were compared with different conventional shielding materials, commercial glasses, and newly developed HMO glasse. Therefore, the investigated glasses have potential uses in gamma shielding applications.

• 화훼연구
• /
• 제26권4호
• /
• pp.166-178
• /
• 2018

In this study, the principal objective was to investigate the effect of light quality and vessel ventilation on the growth and development, physiology, activities of antioxidant enzymes, and contents of mineral nutrients of carnation (Dianthus caryophyllus L.) 'Marble Beauty'. Single node cuttings stuck into the plant growth regulator (PGR)-free MS medium in containers covered with caps with or without a ventilation filter were cultured first four weeks under white and then additional four weeks under either white (control), blue, red, or red + blue light emitting diodes (LEDs) for 56 days. Interestingly, a ventilated culture condition not only reduced the percentage of the hyperhydricity, but also increased the total chlorophyll content (Chl a + Chl b) of the plantlets as compared to the non-ventilated condition. In addition, blue LEDs produced plantlets with the greatest number of shoots and red LEDs produced plantlets with the greatest shoot length. The quality of plantlets was improved under a ventilation condition. Besides, under a ventilated condition, red + blue LEDs raised APX activity, and blue LEDs not only raised the activity of the CAT, but also increased tissue contents of such elements as K, Ca, Mg, Zn, Mn and Fe. The red LEDs increased contents of B and Si under a ventilated condition, and Na accumulation under a non-ventilated condition. Thus, including blue or red LEDs as the light source in a ventilated culture condition will produce plantlets of carnation 'Marble Beauty' in vitro with improved quality.

• 한국수자원학회논문집
• /
• 제54권3호
• /
• pp.203-215
• /
• 2021

본 연구에서는 유역내 댐 건설과 하천내 식생성장으로 육역화 현상이 진행되는 내성천 환경 변화의 원인을 파악하기 위해 내성천 유역에 위치한 3개 관측소를 대상으로 2010년부터 2019년까지 관측된 수문자료와 항공사진 및 지형자료를 수집하여 수문특성에 따른 수위-유량관계 변화 및 횡단면의 침식·퇴적 변화율을 분석하였다. 또한 상류 지류인 월호교 관측소에서 인위적인 유량 조절 유무에 따른 영향을 비교하였다. 분석결과, 내청천에서는 2013년부터 2015년까지 지속적인 가뭄에 의해 홍수터에서는 식생활착 및 식생사주 면적 증가로 육역화가 진행되었고, 저수위에서는 흐름부 축소, 유속 및 하상소류력 증가로 지속적인 하상침식이 발생한 것으로 판단되었다.

• 자원리싸이클링
• /
• 제31권1호
• /
• pp.21-28
• /
• 2022

폐리튬이온배터리를 고온에서 용융환원시키면 코발트, 니켈 및 구리 금속합금상을 얻을 수 있다. 이러한 금속합금상으로부터 금속을 분리회수하기 위한 공정을 개발하기 위해 코발트, 니켈 및 구리 금속을 혼합한 금속혼합물을 3% 과산화수소를 함유한 2 M 황산용액으로 침출하면 9.6%의 구리와 함께 코발트와 니켈이 모두 침출된다. 침출용액에서 Cyanex 301로 구리(II)가 선택적으로 추출되었으며, 30% 왕수로 구리(II)를 탈거했다. 구리가 분리된 여액에서 이온성액체인 ALi-SCN으로 Co(II)를 선택적으로 추출했으며, 15%의 암모니아용액으로 3단의 교차식 탈거를 통해 모두 탈거했다. 본 연구를 통해 코발트, 니켈 및 구리 금속혼합물의 황산침출액에서 용매추출로 세 금속을 분리할 수 있는 공정을 제안했다.

• The Journal of Advanced Prosthodontics
• /
• 제14권4호
• /
• pp.212-222
• /
• 2022

PURPOSE. To evaluate and compare the effect of impression type (conventional vs digital) and the number of implants on the time from the impressions to the generation of working casts of mandibular implant-supported fixed completearch frameworks, as well as on patient satisfaction. MATERIALS AND METHODS. 17 participants, 3 or 4 implants, received 2 types of digital impression methods (DI) and conventional (CI). In DI, two techniques were performed: scanning with the scan bodies (SC) and scanning with a device attached to the scan bodies (SD) (BR 10 2019 026265 6). In CI, the making of a solid index (SI) and open-tray impression (OT) were used. The outcomes were used to evaluate the time and the participant satisfaction with conventional and digital impressions. The time was evaluated through the timing of the time obtained in the workflow in the conventional and digital impression. The effect of the number of implants on time was also assessed. Satisfaction was assessed through a questionnaire based on seven. The Wilcoxon test used to identify the statistical difference between the groups in terms of time. The Mann-Whitney test was used to analyze the relationship between the time and the number of implants. Fisher's test was used to assess the patient satisfaction (P<.05). RESULTS. The time with DI was shorter than with CI (DI, $\tilde{x}=02:58$; CI, $\tilde{x}=31:48$) (P<.0001). The arches rehabilitated with 3 implants required shorter digital impression time (3: $\tilde{x}=05:36$; 4: $\tilde{x}=09:16$) (P<.0001). Regarding satisfaction, the DI was more comfortable and pain-free than the CI (P<.005). CONCLUSION. Digital impressions required shorter chair time and had higher patient acceptance than conventional impressions.

• 한국표면공학회:학술대회논문집
• /
• 한국표면공학회 2001년도 춘계학술발표회 초록집
• /
• pp.72-72
• /
• 2001

Plasma polymerized thin films have been deposited on Si(lOO) substrates at $25-400^{\circ}C$ using thiophene ($C_4H_4S$) precursor by plasma assisted chemical vapor deposition (PACVD) method for low-dielectric device application. In order to compare physical properties of the as-grown thin films, the effects of the plasma power, gas flow ratio and deposition temperature on the dielectric constant and thermal stability were mainly studied. XRD and TED studies revealed that the as-grown thin films have highly oriented amorphous polymer structure. XPS data showed that the polymerized thin films that grown under different RF power and deposition temperature as well as different gas ratio of $Ar:H_2$ have different stoichiometric ratio of C and S compared with that of monomer, indicating a formation of mixture polymers. Moreover, we also realized that oxygen free and thermally stable polymer thin films could be grown at even $400^{\circ}C$. The results of SEM, AFM and TEM showed that the polymer films with smooth surface and sharp interface could be grown under various deposition conditions. From the electrical property measurements such as I-V and C-V characteristics, the minimum dielectric constant and the best leakage current were obtained to be about 3.22 and $10-11{\;}A/\textrm{cm}^2$, respectively.

• 농촌계획
• /
• 제29권3호
• /
• pp.1-14
• /
• 2023

Due to the 3 years and 4 months of corona, many things have changed throughout society, such as social activities, free movement, and lifestyle. One of them is the increasing public interest and demand for walking tours. Public awareness of health and leisure activities has increased due to lifestyle changes, aging, and urbanization following the spread of infectious diseases such as COVID-19, and demand for walking tour services is also increasing. As of 2019, nationwide About 560 'Walking Trails' of 1,849 courses were created, with a total length of 18,000 km. In this study, in a situation where social interest and necessity for walking tours are increasing, studies related to walking tours are reviewed, and sustainable management plans for walking tours are proposed. To this end, the concept and research trends of walking tours were examined through literature related to walking tours, and in-depth interviews were conducted with a total of 17 people, 8 visitors and 9 officials, with Ansan Daebudo Haesol-gil as the target. Visitors In-depth interviews with 180 contents were coded, and 147 effective contents were divided into 20 subcategories and organized into 7 upper categories. In-depth interviews with 101 stakeholders were individually coded, 96 effective contents were divided into 14 subcategories, and organized into 5 upper categories. After that, it was reviewed based on the contents organized through qualitative content analysis, and the Five implications were derived. The significance of this study is that the study was conducted on specific Haesol-gil in the suburbs of the metropolitan area. The limitation of this study was that more detailed investigations and considerations were not conducted on the positive and negative effects of walking tours on the Daebudo area. As a follow-up study, academic arrangements and case studies on regional regeneration through walking tours are required.