• 제목/요약/키워드: Fractional

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A FRACTIONAL-ORDER TUMOR GROWTH INHIBITION MODEL IN PKPD

  • Byun, Jong Hyuk;Jung, Il Hyo
    • East Asian mathematical journal
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    • 제36권1호
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    • pp.81-90
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    • 2020
  • Many compartment models assume a kinetically homogeneous amount of materials that have well-stirred compartments. However, based on observations from such processes, they have been heuristically fitted by exponential or gamma distributions even though biological media are inhomogeneous in real environments. Fractional differential equations using a specific kernel in Pharmacokinetic/Pharmacodynamic (PKPD) model are recently introduced to account for abnormal drug disposition. We discuss a tumor growth inhibition (TGI) model using fractional-order derivative from it. This represents a tumor growth delay by cytotoxic agents and additionally show variations in the equilibrium points by the change of fractional order. The result indicates that the equilibrium depends on the tumor size as well as a change of the fractional order. We find that the smaller the fractional order, the smaller the equilibrium value. However, a difference of them is the number of concavities and this indicates that TGI over time profile for fitting or prediction should be determined properly either fractional order or tumor sizes according to the number of concavities shown in experimental data.

FRACTIONAL PARTIAL DIFFERENTIAL EQUATIONS AND MODIFIED RIEMANN-LIOUVILLE DERIVATIVE NEW METHODS FOR SOLUTION

  • Jumarie, Guy
    • Journal of applied mathematics & informatics
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    • 제24권1_2호
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    • pp.31-48
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    • 2007
  • The paper deals with the solution of some fractional partial differential equations obtained by substituting modified Riemann-Liouville derivatives for the customary derivatives. This derivative is introduced to avoid using the so-called Caputo fractional derivative which, at the extreme, says that, if you want to get the first derivative of a function you must before have at hand its second derivative. Firstly, one gives a brief background on the fractional Taylor series of nondifferentiable functions and its consequence on the derivative chain rule. Then one considers linear fractional partial differential equations with constant coefficients, and one shows how, in some instances, one can obtain their solutions on bypassing the use of Fourier transform and/or Laplace transform. Later one develops a Lagrange method via characteristics for some linear fractional differential equations with nonconstant coefficients, and involving fractional derivatives of only one order. The key is the fractional Taylor series of non differentiable function $f(x+h)=E_{\alpha}(h^{\alpha}{D_x^{\alpha})f(x)$.

Fractional Duffing 방정식에서의 카오스 거동 해석 (Analysis of Chaotic Behavior in Fractional Duffing Equation)

  • 배영철
    • 한국전자통신학회논문지
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    • 제10권12호
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    • pp.1389-1394
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    • 2015
  • 최근에 fractional calculus의 개념을 적용하여 fractional 미분 방정식으로 표현되는 기법이 제어공학, 수학, 물리학 등에 적용하고자 하는 노력이 나타나고 있다. 본 논문에서는 Duffing 방정식으로 표현되는 동적 방정식을 정수 차수가 아닌 fractional 차수로 표현하고 이 fractional 실수 차수에서 차수의 크기에 따라 카오스 거동이 존재함을 실수 차수의 값을 변화시켜가면서 시계열 데이터와 위상공간으로 확인하고자 한다.

CERTAIN FRACTIONAL INTEGRAL INEQUALITIES INVOLVING HYPERGEOMETRIC OPERATORS

  • Choi, Junesang;Agarwal, Praveen
    • East Asian mathematical journal
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    • 제30권3호
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    • pp.283-291
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    • 2014
  • A remarkably large number of inequalities involving the fractional integral operators have been investigated in the literature by many authors. Very recently, Baleanu et al. [2] gave certain interesting fractional integral inequalities involving the Gauss hypergeometric functions. Using the same fractional integral operator, in this paper, we present some (presumably) new fractional integral inequalities whose special cases are shown to yield corresponding inequalities associated with Saigo, Erd$\acute{e}$lyi-Kober and Riemann-Liouville type fractional integral operators. Relevant connections of the results presented here with those earlier ones are also pointed out.

A STUDY OF THE RIGHT LOCAL GENERAL TRUNCATED M-FRACTIONAL DERIVATIVE

  • Chauhan, Rajendrakumar B.;Chudasama, Meera H.
    • 대한수학회논문집
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    • 제37권2호
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    • pp.503-520
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    • 2022
  • We introduce a new type of fractional derivative, which we call as the right local general truncated M-fractional derivative for α-differentiable functions that generalizes the fractional derivative type introduced by Anastassiou. This newly defined operator generalizes the standard properties and results of the integer order calculus viz. the Rolle's theorem, the mean value theorem and its extension, inverse property, the fundamental theorem of calculus and the theorem of integration by parts. Then we represent a relation of the newly defined fractional derivative with known fractional derivative and in context with this derivative a physical problem, Kirchoff's voltage law, is generalized. Also, the importance of this newly defined operator with respect to the flexibility in the parametric values is described via the comparison of the solutions in the graphs using MATLAB software.

A FORMULA RELATED TO FRACTIONAL CLACULUS

  • Choi, June-Sang
    • 대한수학회논문집
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    • 제12권2호
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    • pp.457-466
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    • 1997
  • We give a formula related to fractional calculus which may be useful in solving some fractional linear differential equations. We also give a brief survey of the history of the fractional calculus.

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THE (k, s)-FRACTIONAL CALCULUS OF CLASS OF A FUNCTION

  • Rahman, G.;Ghaffar, A.;Nisar, K.S.;Azeema, Azeema
    • 호남수학학술지
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    • 제40권1호
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    • pp.125-138
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    • 2018
  • In this present paper, we deal with the generalized (k, s)-fractional integral and differential operators recently defined by Nisar et al. and obtain some generalized (k, s)-fractional integral and differential formulas involving the class of a function as its kernels. Also, we investigate a certain number of their consequences containing the said function in their kernels.

A NONRANDOM VARIATIONAL APPROACH TO STOCHASTIC LINEAR QUADRATIC GAUSSIAN OPTIMIZATION INVOLVING FRACTIONAL NOISES (FLQG)

  • JUMARIE GUY
    • Journal of applied mathematics & informatics
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    • 제19권1_2호
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    • pp.19-32
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    • 2005
  • It is shown that the problem of minimizing (maximizing) a quadratic cost functional (quadratic gain functional) given the dynamics dx = (fx + gu)dt + hdb(t, a) where b(t, a) is a fractional Brownian motion of order a, 0 < 2a < 1, can be solved completely (and meaningfully!) by using the dynamical equations of the moments of x(t). The key is to use fractional Taylor's series to obtain a relation between differential and differential of fractional order.