• International Journal of Quality Innovation
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• 제3권2호
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• pp.174-182
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• 2002

System identification and controller formulation are essential in dynamic process control. In system identification, data for system identification are obtained, and then they are analyzed so that the system model of the process is built, identified, and diagnosed. In controller formulation, the control equation is derived based on the result of the system identification. There has been much theoretical research on system identification and controller formulation. These theories are very useful when they are appropriately applied. To our regret, however, these theories are not always effectively applied in practice because the engineers and the operators who manage the process often do not have the necessary understanding of required time series analysis methods. On the other hand, because of widespread use of statistical packages, system identification such as estimating ARMA models can be done with little understanding of time series analysis methods. Therefore, it might be said that the most theoretically difficult part in practice is the controller formulation. In this paper, lists of control equations are proposed as a useful tool for practitioners to use. The tool supports bridging the gap between theory and practice in dynamic process control. Also, for some models, the generalized control equations are obtained.

• 한국임상수의학회지
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• 제24권3호
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• pp.312-314
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• 2007

애완토끼에서 털응애증은 가려움증과 비듬을 동반한 피부염을 유발하는 가장 흔한 외부 기생충이다. 본 연구에서 털응애에 감염된 총 32두의 애완 토끼에 imidacloprid 10% (w/v)와 moxidectin 10% (w/v) 합제 0.4ml를 적용하였다. 적용한 합제의 치료율은 4, 8 및 12주에 각각 100%이었으며, 부작용은 관찰되지 않았다. 본 연구에서 imidacloprid와 moxidectin 합제는 토끼의 털응애 치료에 효과적이었다.

• 대한기계학회논문집B
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• 제30권3호
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• pp.262-269
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• 2006

Segregation algorithms of the incompressible Wavier-Stokes equations using P1P1/P2P1 finite element formulation are newly proposed. P1P1 formulation allocates velocity and pressure at the same nodes, while P2P1 formulation allocates pressure only at the vertex nodes and velocity at both the vertex and the midpoint nodes. For a comparison of both the elapsed time and the accuracy between the two methods, they have been applied to the well-known benchmark problems. The three cases chosen are the two-dimensional steady and unsteady flows around a fixed cylinder, decaying vortex, and impinging slot jet. It is shown that the proposed P2P1 semi-segregation algorithm performs better than the conventional P1P1 segregation algorithm in terms of both accuracy and computation time.

• 한국식품과학회지
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• 제18권3호
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• pp.221-225
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• 1986

소시지 배합시에 부산물의 사웅가능성을 Linear Programming에 의해 조사하였다. 원료육 중류만을 고려하여 8가지의 제한조건 조합((1)수분 및 고기함량, (1)+염통, (1)+내장육, (1)+머리고기, (1)+염통+등지방, (1)+염통, 十 내 장육,(1)+ 염통 + 머리고기 . (1) + 염통+머리고기+등지방)에 의해 최소가격 배합을 시도하여 본 결과. 현실적으로 가장 경제적인 배합은 수분 및 고기함량과 염통 및 내장육 사용을 고려한 것으로 나타났다. 등지방의 사용을 고려하였을 경우가 가장 비싼 배합비를 초래하였다. 그러나 이러한 결과는 국내 규정에 제한이 없는 식물성 단백질 등 결착제 및 증량제를 첨가할 경우에 달라질 수 있다.

• 대한한방부인과학회지
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• 제27권3호
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• pp.104-115
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• 2014

Objectives: As treating acne is difficult and demands of cosmetic are increasing, the development of new Korea traditional herbal formulation and functional cosmetics of acne is required. The aim of this study is the discovery and composition for the development of new Korea traditional herbal formulation and functional cosmetics of acne. Methods: Searched patent informations related to herbal cosmetics published in 1996~2014, we extracted the patent information and analysis component about effecting of anti-inflammatory and anti-acne. Results: Out of 759 patent informations we searched, 72 those about effecting anti-inflammatory and anti-acne were selected. Also, 159 components of 72 patent informations were reclassified by frequency and characteristic. Conclusions: We expect the effect and safety of new traditional herbal formulation which is composed of high frequency herb in patent informations related to herbal cosmetics.

• Archives of Pharmacal Research
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• 제25권4호
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• pp.534-540
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• 2002

To develop novel transdermal formulation for aceclofenac, microemulsion was prepared for increasing its skin permeability. Based on solubiity and phase studies, oil and surfactant was selected and composition was determined. Microemulsion was spontaneously prepared by mixing ingredients and the physicochemical properties such was investigated. The mean diameters of microemulsion were approximately 90 nm and the system was physically stable at room temperature at least for 3 months. In addition, the in vitro and in vivo performance of microemulsion formulation was evaluated. Aceclofenac was released from microemulsion in acidic aqueous medium, and dissolved amounts of aceclofenac was approximately 30% after 240 min. Skin permeation of aceclofenac from microemulsion formulation was higher than that of cream. Following transdermal application of aceclofenac preparation to delayed onset muscle soreness, serum creatine phosphokinase and lactate dehydrogenase activity was significantly reduced by aceclofenac. Aceclofenac in microemulsion was more potent than cream in the alleviation of muscle pain. Therefore, the microemulsion formulation of aceclofenac appear to be a reasonable transdermal delivery system of the drug with enhanced skin permeability and efficacy for the treatment of muscle damage.

• 대한약침학회지
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• 제24권3호
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• pp.142-151
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• 2021

Objectives: Although Korean Medicine (KM) subsidized by the National Health Insurance (NHI) has been used for a long time, there has been no active analysis using claims data. Therefore, the purpose of this study was to examine the NHI KM utilization trend using NHI statistics and to measure the level of market concentration by year. Methods: By restructuring the contents of NHI Statistics for Pharmaceuticals for 2010-2019, the claim cases, costs, and annual growth rates of KM were demonstrated by year, sex, age group, region, therapeutic group, and KM treatment. The proportion of highly used k treatments in cost was calculated as the concentration ratio (CR) k and its trend by year was investigated. Results: In 2019, the NHI cost on KM amounted to ₩38.2 billion KRW, increasing by 11.6% per year on average in 2010-2019. Notably, KM was used more frequently among women and patients aged ≥ 65 years, and the mixed formulation accounted for 95% of the total cost of KM. The CR of the simple formulation increased rapidly, whereas that of the mixed formulation remained constant. In 2019, three simple formulation treatments- peony, licorice, and ginseng- accounted for 93.8% of the total cost for KM (CR3 = 93.8%). Conclusion: NHI KM is rapidly increasing. Investigating the CR of KM confirmed that KM prescriptions have been concentrated in small numbers over the past 10 years.

• Structural Engineering and Mechanics
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• 제69권6호
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• pp.615-626
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• 2019

The 3-noded metric Timoshenko beam element with an offset of the internal node from the element centre is used here to demonstrate the best-fit paradigm using function space formulation under locking and mesh distortion. The best-fit paradigm follows from the projection theorem describing finite element analysis which shows that the stresses computed by the displacement finite element procedure are the best approximation of the true stresses at an element level as well as global level. In this paper, closed form best-fit solutions are arrived for the 3-noded Timoshenko beam element through function space formulation by combining field consistency requirements and distortion effects for the element modelled in metric Cartesian coordinates. It is demonstrated through projection theorems how lock-free best-fit solutions are arrived even under mesh distortion by using a consistent definition for the shear strain field. It is shown how the field consistency enforced finite element solution differ from the best-fit solution by an extraneous response resulting from an additional spurious force vector. However, it can be observed that when the extraneous forces vanish fortuitously, the field consistent solution coincides with the best-fit strain solution.

• Smart Structures and Systems
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• 제29권2호
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• pp.279-286
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• 2022

In this article, a novel propagation formulation of Rayleigh waves in a compressible isotropic half-space with impedance boundary condition is proposed by embedding the normal stress. In a two-dimensional case, it is assumed that a design boundary is free of normal traction and a shear traction depends on linearly a normal component of displacements multiplied by frequencies. Therefore, impedance boundary conditions affect the normal stress, where the impedance parameters correspond to dimensions of stresses over velocity. On the other hand, vanished impedance values are traction-free boundary conditions. The main purpose of this article is to present theoretically the existence and uniqueness of a Rayleigh wave formulation relying on secular equation's mathematical analyses. Its velocity varies along with the impedance parameters. Moreover, numerical experiments with different values for the velocity of Rayleigh waves are carried out. The present Rayleigh waves study is a fundamental step in analyzing the cause and effect of physical states such as building or structure damages resulting from natural dynamics. The results of the study generate a basic design formulation theory to test the effects of Rayleigh waves affecting structures when an earthquake occurs. The presence and uniqueness of the proposed formulation is verified by mutual comparisons of several numerical examples.

• 대한한의학회지
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• 제35권3호
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• pp.49-59
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• 2014

Background: Eight positions for new formulations in Jingyuequanshu is a unique classifying system and each position can be presented as a network. Network analysis is an effective method of visualizing the relationship of textual information. Purpose: This study aimed to analyze the structure of the eight positions for new formulations in Jingyuequanshu, and to acquire information about composing materia medica. Methods: We constructed an initial database and binary matrix of eight positions for new formulation in Jingyuequanshu, including its herbs and formulations. With this data, we carried out frequency and network analysis. Results: We analyzed each of the eight positions for new formulation, entire positions, and five positions after removing 'causal/cold/hot' positions. We found that the formulas of the causal position are distributed throughout the new formulation, and those of the cold and hot positions are also distributed similarly but the two groups are exclusive to each other. The other 5 positions are distributed exclusively to one another. Conclusions: Eight positions for new formulation of Jingyuequanshu were classified into three axes by exploratory network analysis. One is an axis of causal position, another is an axis of cold/hot positions, and the last is an axis of the other five positions.