• Journal of the Korean Physical Society
• /
• 제73권11호
• /
• pp.1774-1786
• /
• 2018

Phenotypic variation among clones (individuals with identical genes, i.e. isogenic individuals) has been recognized both theoretically and experimentally. We investigate the effects of phenotypic variation on evolutionary dynamics of a population. In a population, the individuals are assumed to be haploid with two genotypes : one genotype shows phenotypic variation and the other does not. We use an individual-based Moran model in which the individuals reproduce according to their fitness values and die at random. The evolutionary dynamics of an individual-based model is formulated in terms of a master equation and is approximated as the Fokker-Planck equation (FPE) and the coupled non-linear stochastic differential equations (SDEs) with multiplicative noise. We first analyze the deterministic part of the SDEs to obtain the fixed points and determine the stability of each fixed point. We find that there is a discrete phase transition in the population distribution when the probability of reproducing the fitter individual is equal to the critical value determined by the stability of the fixed points. Next, we take demographic stochasticity into account and analyze the FPE by eliminating the fast variable to reduce the coupled two-variable FPE to the single-variable FPE. We derive a quasi-stationary distribution of the reduced FPE and predict the fixation probabilities and the mean fixation times to absorbing states. We also carry out numerical simulations in the form of the Gillespie algorithm and find that the results of simulations are consistent with the analytic predictions.

• 한국응급구조학회지
• /
• 제25권1호
• /
• pp.135-146
• /
• 2021

Purpose: This study aimed to evaluate the Citizen-Corps-Active-In-Disaster (CAIND) according to a new viewpoint based on changes in basic theoretical concepts and establish a development plan. Methods: A documentary survey was administered, and the study followed the technical approach method. Detailed information on CAIND was taken from scholarly monographs, specialty publications, and previous studies, including master and doctorate dissertations. Results: CAIND may be defined as legal auxiliary organizations composed of local residents who volunteer to prepare for "all kinds of disasters as well as prevention activities" and instill the ideology of "leading service organizations of safety as a form of community involvement," "resident-friendly organizational activities based on autonomous operation," and "performing activities which supplement their demands according to the realization of social welfare and regional conditions." Conclusion: The newly established basic theoretical concept included the concepts of "professionalism and possibilities," "social expandability," "voluntary participation," and "the realization and complementation of social welfare"

• 유통과학연구
• /
• 제20권10호
• /
• pp.67-77
• /
• 2022

Purpose: This study aims to determine the online shop service performance of fresh food products distribution, consumer motivation, and their relationship during the COVID-19 pandemic. Research design, data, and methodology: A survey was conducted online using Google Forms on 100 consumers of TaniHub application users. Data in the form of scale were analyzed descriptively to explain the service performance and consumer motivation. The service performance consists of technical services and marketing services. Technical service indicators consist of payment, delivery, and products. Meanwhile, the marketing service indicator consists of promotions and prices. The consumer motivation is characterized by reference, actualization, and lifestyle. The relationship between the two was analyzed using Spearman's rank correlation. Results: The most consumers are millennial generation who were active in social media. They are employees with Bachelor's and Master's qualifications and included in the middle economic groups. TaniHub online shop had good technical and fair marketing performance. The motivation of online shop consumers of fresh food products through the TaniHub application was high. Conclusions: The findings discovered a significant relationship between online shop service performance and consumer motivation. It indicates the need for improvement in marketing services, especially promotions, to improve the performance of this e-agribusiness company.

• Molecules and Cells
• /
• 제46권3호
• /
• pp.165-175
• /
• 2023

The transcription factor Nrf2 was originally identified as a master regulator of redox homeostasis, as it governs the expression of a battery of genes involved in mitigating oxidative and electrophilic stress. However, the central role of Nrf2 in dictating multiple facets of the cellular stress response has defined the Nrf2 pathway as a general mediator of cell survival. Recent studies have indicated that Nrf2 regulates the expression of genes controlling ferroptosis, an iron-and lipid peroxidation-dependent form of cell death. While Nrf2 was initially thought to have anti-ferroptotic function primarily through regulation of the antioxidant response, accumulating evidence has indicated that Nrf2 also exerts anti-ferroptotic effects via regulation of key aspects of iron and lipid metabolism. In this review, we will explore the emerging role of Nrf2 in mediating iron homeostasis and lipid peroxidation, where several Nrf2 target genes have been identified that encode critical proteins involved in these pathways. A better understanding of the mechanistic relationship between Nrf2 and ferroptosis, including how genetic and/or pharmacological manipulation of Nrf2 affect the ferroptotic response, should facilitate the development of new therapies that can be used to treat ferroptosis-associated diseases.

• 농촌계획
• /
• 제29권4호
• /
• pp.1-11
• /
• 2023

In this study, we present the necessary measurements of establishment and expansion in social welfare elements, understand the social welfare approach and the reality of social welfare services to solve the physical accessibility problem of the rural center revitalization in the recent trend of various attempts. The measurements were categorized according to the nature and form of the projects through content analysis method by using a master plans and casebooks of the rural center revitalization leading districts. The results show that the social welfare project of the rural center revitalization leading districts were categorized them into three sections of job creation vitalization, lifelong education, hobby and leisure supports, visiting services, it was classified into 11 sub-types. We arrive at a conclusion through analysis results, establishment of cooperative system between related organizations, active gathering of opinions from residents, training of local workforce, convergence with existing social welfare systems and projects, building private governance, for social welfare project operate stably in the rural center revitalization.

• Journal of the Korean Wood Science and Technology
• /
• 제52권4호
• /
• pp.363-374
• /
• 2024

Nyamplung (Calophyllum inophyllum L.) seeds, which account for 40% of the fruit, have been used as a raw material for biofuels, and the seed shells remaining after their extraction are wasted. In this study, we investigated the potential of waste Nyamplung seed shells in the form of pellets as a biomass energy resource. A completely randomized research design was implemented to evaluate the effects of torrefaction and heat treatment on the quality of produced pellets. Two observed treatments, namely, particle size (0.18-0.25, 0.25-0.43, and 0.43-0.84 mm) and torrefaction temperature (200℃, 225℃, and 250℃), were investigated. Our results showed that the calorific value of torrefied Nyamplung seed-shell pellets ranged from 4,245.60 to 4,528.00 cal/g, fulfilling the Indonesia Nasional Standard (≥ 4,000 cal/g). The quality of pellets were the best when produced from raw materials with a particle size of 0.18-0.25 mm and torrefaction temperature of 225℃. Thus, we concluded that waste Nyamplung seed shells are a good raw material for the production of pellets.

• 한국통신학회논문지
• /
• 제39C권8호
• /
• pp.615-625
• /
• 2014

국방부는 미래전에 대비하기 위한 국방 개혁안을 토대로 2010년 "군사시설 종합 발전계획(Mater Plan)"을 수립하였다. 이것은 합동성 및 3군 균형발전을 고려한 군사력 구조조정 및 군 자산관리를 위해 전국에 산재한 군사시설을 통폐합하기 위한 계획이었다. 그러나 현용 국방 군사 시설기준을 적용하여 "군사시설 종합 발전계획"을 추진하기 위해서는 시설 기준의 부재 및 비합리적인 시설규모 산정 사례 발생으로 제 개정의 필요성이 대두 되었다. 미래 전장 환경은 플랫폼(Plat form)기반에서 네트워크 중심전(Network Centric Warfare) 기반으로 변화하면서 C4I(Command, Control, Communication, Computer & Intelligence) 체계를 이용한 지휘 통제 능력이 더욱 요구되고 있다. 그러므로 국방 정보기술(IT)과 시설이 잘 융합되어야 성공적인 임무수행을 보장할 수 있을 것이다. 따라서 국방부도 시설 통폐합에 따른 지휘통제 시설의 정보통신기반과 설비의 구축을 네트워크 중심전 수행에 맞는 정책, 설계 기준 및 운용 지침을 시급히 갖추어야 할 것이다. 본 논문에서는 이러한 문제점을 해결하기 위해 국방 I3A Framework를 제안한다.

• Journal of Acupuncture Research
• /
• 제27권2호
• /
• pp.123-142
• /
• 2010

Objectives : The knee pain is the main reason of getting acupuncture treatment. In order to have confidence in the results of a study, it is necessary to establish that questionnaire is both valid and reliable in questionnaire related study. The aim of this study was to review the instruments that are currently in sue for assessing the knee joint. Methods : A literature study was performed to choose appropriate scales for assessment for pain and the function of the knee. Theoretically based scales were selected for review. Therefore, 18 scales for knee and 9 scale for pain were reviewed. the status of scales involved in knee treatment of acupuncture throughout several countries was evaluated. Results & Conclusion : Lysholm Knee Scoring Scale, Cincinnati knee rating system(CKRS) are adequate for ligament injury in knee. International Knee Documentation Committee scoring system(IKDC) may become a publication requirement for journals in view of the international standing of the committee. The available outcome measure for use in osteoarthritis are Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC), Lequesne Functional Severity Index(LFI) and Knee Injury and Osteoarthritis Outcome Score(KOOS), and in rheumatoid arthritis are McMaster-Toronto Arthritis patient function preference questionnaire(MACTAR), Quality of Life-Rheumatoid Arthritis Scale(QoL-RA Scale). Visual analog scale(VAS), verbal rating scale(VRS) are commonly used for the standard pain scale. For long term follow-up study The Medical Outcomes Study Short Form-36(SF-36), Arthritis Impact Measurement Scales(AIMS), Health Assessment Questionnaire(HAQ) should be included. Each measurement has its own composition and characteristics. Their validity, reliability, responsiveness and practical characteristics were already evaluated. We found 20 domestic and 28 overseas papers about knee treatment using acupuncture assessed with knee scales.

• 대한한의학원전학회지
• /
• 제7권
• /
• pp.161-197
• /
• 1994

I hereby have gained the following results by investigation and classification according to the contents of Masterial theses of 1015 volumes and Doctorial theses of 288 volumes, which have collected at their central libriaries, of theses which have published, until 1991, at Oriental Medical College of Kyunghee Univ., Kyungsan Univ., Dongguk Univ. and Taejon Univ. 1. The laboratory theses are more plentiful in number than those of literatural or clinical ones, especially more outstanding trends in the case of doctors. 2. In clinical theses, clinical obserbation was high frequnt in master and accupunture in doctor. 3. In laboratory theses, the usage of pharmacy was more frequnt than that of accupuntures or moxibutions. 4. In laboratory theses, it was more plentiful the case of being taken ill before experiment. 5. In experimental method, the drugs were more used complexed or complexed extract, in the case of accupunture, the methods were more adopted by general accup. and aqureaccupunture. 6. In laboritory theses, theses was abundant of no description of normal, control and laboratory groop. 7. It was the great number wi thin a day in the laboratory terms, the rats were most adopted as the objects of lab., in the number of lab method, doctor's was more plentiful than master's. 8. In literatural theses, there was expressed high frequnt trends of study of china, in era, Chosun dynasty in korea and Jin-Han in china. 9. The theory and books were mainly adopted as objects of theses study in the field of literature. 10. In another theses, there was many investigation of contents and drug and sign of illness were main object of study. 11. Laboratory theses had totally more reference and quotation than those of other theses. According to the above results, the number of laboratory theses are superior than clincal and literature theses, other study or statistical theses. But unfortunately they were not enough the transmission of meaning of theses and contribution of learning, beacuse how to do theses was not uni form and description was not evident. So afterward I think it is needed more careful attention and study in the method of theses works.

• 대한치과보철학회지
• /
• 제39권3호
• /
• pp.243-249
• /
• 2001

Statement of the problem. The interest in all-ceramic restorations has increased as more techniques have become available. With the introduction of machinable dental ceramics and CAD/CAM systems or Copy-milling systems there is a need for evaluating the quality levels of these new fabrication techniques. Purpose. This study was to evaluate the fitting accuracy of machined all-ceramic crowns made out of an industrially prefabricated feldspathic porcelain. Material and Methods. Three master models with different cutting depth (0.8mm/1.0mm/1.2mm)were produced using a palladium-silver alloy. A total of 36 working dies, 12 of each form, was used for the modellation of prototype resin copings and 36 additional crowns, 12 of each cutting depth, were produced by using the $CEREC^{(R)}2$ system for all crowns. The maginal fit of all 72 crowns was then evaluated on their respective master die at 54 circularly staggered points of measurement per crown under a fixation pressure of 30 N by using a computerized video image system. Results. The medians of the copy-milled $CELAY^{(R)}$ crowns ranged from 29 to $36{\mu}m$. The highest value for the marginal gap was found in group B (cutting depth 1.0mm) at $107{\mu}m$. The median for the $CEREC^{(R)}2$ crowns was found between 43.5 and $70{\mu}m$. The maximum values for all three groups ranged from $181{\mu}m$ to $286{\mu}m$. With $286{\mu}m$ the highest value for marginal gap was found in group C. the Kruskal-Wallis test and multiple comparisons analysis procedure revealed a significant influence of the production technique on the marginal fit in all three groups (p<0,02). Conclusion. 1. The $CELAY^{(R)}$ system is capable to produce all-ceramic crowns with a significantly better marginal fit than the $CEREC^{(R)}2$ system. 2. As far as premolar crowns produced with the $CEREC^{(R)}2$ system are concerned, the cutting depth has a significant influence on fitting accuracy. 3. The production of crowns with an acceptable marginal fit is possible with both systems. However, adhesive luting is recommended for milled feldspathic porcelain crowns.