• Journal of Korean Medical classics
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• v.31 no.1
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• pp.79-93
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• 2018

Objectives : The climate changes in the natural realm displays pheonomena of excess and deficiency due to the principle of Yiyinyiyangzhiweidao. Here, overabundant qi arises due to the works of multiplication and insultation. When this overabundant qi is in force, the retaliating qi appears without fail to create a parallel. This is the Autonomous Equilibrium Mechanism found in the natural world. Studying this mechanism is deeply significant in understanding the mechanisms of diseases. Methods : The paper is written by reviewing the texts found in Huangdineijing's Chapters of Yunqi, which are $Q{\grave{i}}jiaobiandalun$, Wuchangzhengdalun, $Liuyuanzhengj{\grave{i}}dalun$, Zhizhenyaodalun, and Suwenliuqixuanzhumiyu. Results & Conclusions : The overabundance and retaliation in Five Circuits take the form of the restrained child of the Five Circuits takes revenge on the overabundant qi on behalf of his mother. The overabundance and retaliation in Six Qi take the form of rapid healing of Benqi which was in stagnation. Traditionally, overabundant qi is the only one in existence when the Five Circuits are in excess and the year of Hai yin wu wei you xu's regular transformation. During this time, retaliating qi does not exist. When Five Circuits are in deficiency and in the year of Si shen zi chou mao chen's pattern transformation, both the overabundant and deficiency qis exist. However, regardless of regular transformation or pattern transformation, overabundant qi and retaliating qi cannot exist at the same time. This seems to be the rational conclusion. There are some regulations that overabundance and retaliation follow. First, the strong and weak, and number of days coincide. Second, overabundance qi appear during the first half of the period when the qi of controling heaven is in place. During the later half of the period when the qi of terrestrial effect is in force, retaliation qi is the one that appears. Third, overabundance and retaliation does not end with one time. Rather, they will continue to repeat appearance and disappearance without any set pattern. Fourth, the overabundance and retaliation of the guest qi and dominant qi only has overabundance and no retaliation.

• Nutrition Research and Practice
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• v.13 no.2
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• pp.95-104
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• 2019

BACKGROUND/OBJECTIVES: Inflammatory Bowel Disease (IBD) has rapidly escalated in Asia (including Korea) due to increasing westernized diet patterns subsequent to industrialization. Factors associated with endoplasmic reticulum (ER) stress are demonstrated to be one of the major causes of IBD. This study was conducted to investigate the effect of Lycium barbarum (L. barbarum) on ER stress. MATERIALS/METHODS: Mouse embryonic fibroblast (MEF) cell line and polarized Caco-2 human intestinal epithelial cells were treated with crude extract of the L. chinense fruit (LF). Paracellular permeability was measured to examine the effect of tight junction (TJ) integrity. The regulatory pathways of ER stress were evaluated in MEF knockout (KO) cell lines by qPCR for interleukin (IL) 6, IL8 and XBP1 spliced form (XBP1s). Immunoglobulin binding protein (BiP), XBP1s and CCAAT/enhancer-binding homologous protein (CHOP) expressions were measured by RT-PCR. Scanning Ion Conductance Microscopy (SICM) at high resolution was applied to observe morphological changes after treatments. RESULTS: Exposure to LF extract strengthened the TJ, both in the presence and absence of inflammation. In polarized Caco-2 pretreated with LF, induction in the expression of proinflammatory marker IL8 was not significant, whereas ER stress marker XBP1s expression was significantly increased. In wild type (wt) MEF cells, IL6, CHOP and XBP1 spliced form were dose-dependently induced when exposed to $12.5-50{\mu}g/mL$ extract. However, absence of XBP1 or $IRE1{\alpha}$ in MEF cells abolished this effect. CONCLUSION: Results of this study show that LF treatment enhances the barrier function and reduces inflammation and ER stress in an $IRE1{\alpha}$-XBP1-dependent manner. These results suggest the preventive effect of LF on healthy intestine, and the possibility of reducing the degree of inflammatory symptoms in IBD patients.

• Journal of The Korean Association of Information Education
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• v.25 no.3
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• pp.571-578
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• 2021

This study compares Online SW-based maker education in terms of self-efficacy, learning motivation, and interest after applying differently according to blended learning strategies. First, a SW maker program for blended learning was developed and applied as a live seminar-type class including real-time interactive and a support-providing class consisting of online content and Q&A. As a result of comparing the differences between students according to the two strategies divided into pre- and post- survey, in the self-efficacy part, there was a significant difference in the positive efficacy and the overall part, and in the learning motivation part, the live seminar form was significantly higher in the confidence part. In the interest part, the support-providing form showed a significantly higher average in the instrumental interest and nervous part. In order to maintain the effect of maker activities like existing face-to-face situations in Online learning, it is necessary to increase sharing time between students, an integrated learning environment, and sufficient provision of exploration time and learning materials.

• Asia-Pacific Journal of Business
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• v.14 no.4
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• pp.233-254
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• 2023

Purpose - This study aims to verify whether the effect of tax avoidance on corporate value is non-linear in the Korean financial markets. Design/methodology/approach - This study believes that the cause of the inconsistent empirical analysis results of previous studies that verified the relationship between tax avoidance and firm value may be an error in assuming linearity, and verifies whether a nonlinear relationship exists. The sample company in this study is a December settlement corporation listed on the Korean stock market, and the analysis period is from 2000 to 2021. In the empirical analysis model, Tobin's Q is used as a proxy for corporate value, tax avoidance is used as the main independent variable, and a regression model is designed with corporate size, growth rate, and debt ratio set as control variables. Findings - As a result of the empirical analysis, it can be confirmed that there is an inverted U-shaped nonlinear relationship between tax avoidance and corporate value. In the additional analysis using Ohlson (1995) firm valuation model for the robustness of the results of the empirical analysis, the same nonlinear value relationship between tax avoidance can be confirmed. Research implications or Originality - This study is considered to be meaningful in that it verifies the non-linear relationship of tax avoidance, which has not been attempted in previous studies. The meaning of the inverted U-shaped nonlinear relationship presented in this study is that corporate tax avoidance acts as a factor that increases corporate value up to a certain level, but rather becomes a factor that decreases corporate value when it exceeds a critical point. These results are expected to provide new perspectives and perspectives on tax avoidance to companies belonging to the Korean capital market.

• Korean Journal of Environmental Biology
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• v.42 no.1
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• pp.80-94
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• 2024

This study aimed to examine the morphological characteristics and variation in main traits by comparing the growth of individuals of Ecklonia cava Kjellman(Laminariales, Phaeophyceae) under an aquaculture environment. This survey was conducted from April 2018 to November 2019 at the aquafarm in Jindo-gun, Jeollanam-do(South coast of Korea). To classify the morphology of individuals in the aquaculture farm of E. cava, we investigated fourteen morphological characteristics and calculated four ratios between the measured values. Juvenile individuals showed a simple or oblong lanceolate, and at 3-4 months, a short stipe and holdfast developed, along with a bladelet that developed into the secondary blade form. At 5-7 months, secondary blades were found to develop irregularly on the primary blade. At 8-10 months, the primary blade expanded and secondary blades elongated. At 11-12 months, the secondary blades became oblong. At 13-14 months, the thallus area expanded. At 15-16 months, tertiary blades were formed, the thallus became more complex, the stipe thickened, and the holdfast widened. At 17-18 months, secondary blades clearly developed along with lobes. At 19-20 months, tertiary blades developed and became similar to mature natural blades. In the principal component analysis (PCA), the monthly population of the first year(Q1) and that of the second year(Q2) of the cultured population were divided along PC1, which is related to secondary blade morphological characteristics and the holdfast width. Q2 and natural populations are distributed in descending order of volume in Jeju(J), East Coast(E), and South Coast(S) along PC2, which is related to primary blade and stipe morphological characteristics. The results of this study were judged to offer important criteria for the development of different varieties of E. cava.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.6
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• pp.677-682
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• 2018

The relationship-type research and development (R&D) portfolio is a method for selecting core technologies based on their unique purposes and characteristics when the criteria for selecting them are independent. This study presents a relationship-type R&D portfolio method as a way to derive core technologies, and describes the methodology by dividing it into three steps: 1) analyze the relationships between selection criteria and analytical indicators, 2) form a portfolio matrix that best matches each selection criteria, and 3) derive the core technologies. In this study, the relationships between four selection criteria for selecting core technologies and the analytical indicators for identifying the technology level, economics, and the technology itself, are written in a table with HoQ. Based on the relationship table, analytical indicators to be considered were derived to satisfy each selection criterion, and the derived analytical indicators and the selected technologies were constructed with two axes in the portfolio matrix. The satisfied portfolio, P0, that satisfies all four criteria, and the portfolio, P1~P4, that satisfies selection criteria based on the unique characteristics of the four criteria, were constructed, and core technologies derived. The selected core technologies can be utilized in selecting a core area against the future security environment through a process like key word analysis based on the specifications.

• Journal of Korea Water Resources Association
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• v.41 no.5
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• pp.491-501
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• 2008

In order to describe runoff characteristics of urban drainage area, outflow from subbasins divided by considering topography and flow path, is analyzed through stormwater system. In doing so, concentration time and time-area curve change significantly according to basin shape, and runoff characteristics are changed greatly by these attributes. Therefore, in this development study of FFC2Q model by MLTM, we aim to improve the accuracy in analyzing runoff by adding a module that considers basin shape, giving it an advantage over popular urban hydrology models, such as SWMM and ILLUDAS, that can not account for geometric shape of a basin due to their assumptions of unit subbasin as having a simple rectangular form. For subbasin shapes, symmetry types (rectangular, ellipse, lozenge), divergent types (triangle, trapezoid), and convergent types (inverted triangle, inverted trapezoid) have been analyzed in application of time-area curve for surface runoff analysis. As a result, we found that runoff characteristic can be quite different depending on basin shape. For example, when Gunja basin was represented by lozenge shape, the best results for peak flow discharge and overall shape of runoff hydrograph were achieved in comparison to observed data. Additionally, in case of considering subbasin shape, the number of division of drainage basin did not affect peak flow magnitude and gave stable results close to observed data. However, in case of representing the shape of subbasins by traditional rectangular approximation, the division number had sensitive effects on the analysis results.

• Journal of mucopolysaccharidosis and rare diseases
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• v.3 no.1
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• pp.28-32
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• 2017

Lipoid congenital adrenal hyperplasia (LCAH) is the severe form of congenital adrenal hyperplasia and is characterized by adrenal insufficiency with hyperpigmentation and female external genitalia irrespective of genetic sex. The steroidogenic acute regulatory protein (StAR) is required for the transport of cholesterol into the mitochondria for steroidogenesis, and defects in the StAR gene account for the majority of LCAH cases. In this report, we present a two-day-old hyperpigmented infant with phenotypical female genitalia. With consideration of the clinical and laboratory findings, the infant was suspected of having adrenal insufficiency due to LCAH and treated with glucocorticoid, mineralocorticoid, and sodium chloride. Karyotyping revealed 46, XY. Upon pelvis ultrasonography, adrenal hyperplasia with abdominal masses (thought to be the testicles) was reported. Molecular analysis with targeted exome sequencing revealed the homozygote mutation of c.772C>T ($p.Q258^*$) in exon 7 of the StAR gene. The early detection and treatment of adrenal insufficiency in infants with hyperpigmentation can prevent clinically apparent adrenal crises. During follow-up, the patient had a good clinical condition and maintained normal electrolyte and adrenocorticotropic hormone levels with medication.

• Journal of Korean Public Health Nursing
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• v.15 no.1
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• pp.1-12
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• 2001

This study. aimed to categorize attitude of smoking behaviors among female student smokers and to provide useful data for development of anti-smoking programs was conducted from Aug. 22 to Nov. 1. using the Q-method. After reviewing the literature the researcher proceeded to interview 10 female students, then developed a statement form consisting of 40 items, and then 30 female student smokers were sampled. The collected data were coded after having been scaled from 1 to 9 points, and analyzed using the PC QUANL program. Three types were identified; The first type focused on the right of the individual to smoke. the second type of students used smoking as a way to relieve their stress, and the third type of students wanted to use smoking as a tool to relate with their peer group. They smoked in closed areas, i.e. rest rooms. coffee shops - places that are not well ventilated and deep inhalation occurs. most subjects of the study started smocking at early ages(the average age was 17). Smoking at this age is especially harmful. It is suggested that the results of the study may be useful for designing anti-smoking health programs including health promotion.

• Bulletin of the Korean Mathematical Society
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• v.55 no.4
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• pp.1189-1208
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• 2018

The aim of this paper is to study the class of ${\Lambda}$-constacyclic codes of length $2p^s$ over the finite commutative chain ring ${\mathcal{R}}_a=\frac{{\mathbb{F}_{p^m}}[u]}{{\langle}u^a{\rangle}}={\mathbb{F}}_{p^m}+u{\mathbb{F}}_{p^m}+{\cdots}+u^{a-1}{\mathbb{F}}_{p^m}$, for all units ${\Lambda}$ of ${\mathcal{R}}_a$ that have the form ${\Lambda}={\Lambda}_0+u{\Lambda}_1+{\cdots}+u^{a-1}{\Lambda}_{a-1}$, where ${\Lambda}_0,{\Lambda}_1,{\cdots},{\Lambda}_{a-1}{\in}{\mathbb{F}}_{p^m}$, ${\Lambda}_0{\neq}0$, ${\Lambda}_1{\neq}0$. The algebraic structure of all ${\Lambda}$-constacyclic codes of length $2p^s$ over ${\mathcal{R}}_a$ and their duals are established. As an application, this structure is used to determine the Rosenbloom-Tsfasman (RT) distance and weight distributions of all such codes. Among such constacyclic codes, the unique MDS code with respect to the RT distance is obtained.