• 보건교육건강증진학회지
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• 제22권4호
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• pp.179-202
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• 2005

Purpose: The purpose of this study was to develop the health promotion program for rural elderly through PRECEDE process. Method: The health promotion program was developed based on the preliminary diagnosis. The data collection was performed from March 10th to April 9th, 2003. The subjects were selected at Mari Myun, Geochang Gun, in Korea. The preliminary diagnosis was examined with the 115 elders. Data was analyzed by descriptive statistics and Cronbach's n test with SPSS/Win 10.0 program. Results: The health promotion program was developed based on diagnostic result using PRECEDE model. The developed program was corrected and revised with the advices from 6 experts. The final program included health responsibility(cancer prevention and early detection, hygienic, false teeth management no smoking and moderation in drink, and chronic disease prevention and management), physical activity(6 kinds of exercise), nutrition(low sodium diet calcium intake, and right eating habit), spiritual growth(spiritual demand and death preparation teaching), interpersonal relations(relationship with couple, children, grandchildren, neighborhood), and stress management(sports dance, foot massage, positive thought, and song class). Conclusion: I propose that it is necessary to identity the effect of health promotion program for rural elderly. And strategy development that can spread the health promotion program elderly is needed.

• 한국환경농학회지
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• 제23권3호
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• pp.123-127
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• 2004

In many organisms, trehalose has been Down as an energy source and a protectant against various environmental stresses such as desiccation, freezing, heat and osmotic pressure. Previously, we have isolated and characterized the genes encoding trehalose-6-phosphate synthase (ZrTPS1) and trehalose-6-phosphate phosphatase (ZrTPS2) from one of the most osmotolerant yeasts, Zygosaccharomyces rouxii. We have also generated transgenic plants by co-introduction of ZrTPS2 and ZrTPS2 into potato plant (ZrTPS2-2A-ZrTPS1 plant) in an attempt to metabolically engineer trehalose in the transgenic plant using the foot-and-mouth disease virus(FMDV) 2A system and to generate drought resistant crop plants. In this research, we assayed previously generated the ZrTPS2-2A-ZrTPS1 plant biofunctionally by drought treatment, and measured the amount of trehalose in the ZrTPS2-2A-ZrTPS1 transgenic plants. The ZrTPS2-2A-ZrTPS1 transgenic plant showed strong drought resistance in spite of little or no accumulation of transgenic in he transgenic plant compared with control plant.

• 생약학회지
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• 제47권2호
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• pp.137-142
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• 2016

Enterovirus is a common cause of several severe diseases such as myocarditis, hand-foot-mouth disease, and meningitis in children and adult. There are many try to develop new antiviral drug for direct treatment in virus infection. However, synthetic chemical antiviral drug is not working. To overcome this limitation, we examined plant extracts. The antiviral effect of plant extracts was screened by HeLa cell survival assay in coxsackievirus B3 (CVB3) infection. We observed a strong antiviral effect of Poria cocos extract in a dose-dependent manner (1 mg/ml~0.01 mg/ml). P. cocos extract (1 mg/ml) treatment was dramatically decreased virus protease 2A induced eIF4G-I cleavage and virus capsid protein VP1 production. CVB3 positive and negative strand RNA amplification were significantly reduced in P. cocos extract treatment. P. cocos extract completely blocked early time activation of ERK and AKT activity in CVB3 infection. Taken together these data indicate that the treatment of P. cocos extract strongly inhibit CVB3 replication. Poria cocos extract may possible to developed as a therapeutic agent for enterovirus.

• 성인간호학회지
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• 제14권2호
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• pp.306-314
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• 2002

Purpose: This study was intended to examine the effects of a telephone consulting program on self-efficacy and self-care in NIDDM patients. Method: Sixty-eight NIDDM patients participated. Thirty-six were assigned to the experimental group and received the telephone consulting program from one to two times per week for 4 weeks. This program was undertaken by base on small booklet relating to diabetic disease summary, diet, drug, exercise, foot management, prevention and treatment of complications, and insulin injection methods. Result: 1. Hypothesis 1 that "the experimental group who receives the telephone consulting program will have higher self-efficacy score than the control group who does not have the telephone consulting" was supported (t=5.12, p= .000). 2. Hypothesis 2 that "the experimental group who receives the telephone consulting program will have higher self-care score than the control group who does not have the telephone consulting" was supported(t=5.29, p= .000). Conclusion: The telephone consulting program improved self-efficacy and self-care in NIDDM patients. Accordingly, this program can be adopted as an effective nursing intervention in the care of the diabetic patients.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.691-694
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• 2013

Purpose: By carrying out a meta-analysis of randomized controlled trials that compared sorafenib or combined chemotherapy with placebo or combined chemotherapy, the effectiveness of sorafenib in hepatocellular carcinoma was evaluated in the present study, which also provided clinical practice guidelines of evidence-based-medicine. Methods: We reviewed PubMed citations concerning sorafenib treating hepatocellular carcinoma in randomized controlled trials from Jan 2000 to July 2012. All the literature was extracted by Cochrane systematic reviews and underwent meta-analysis with RewMan 5.0 software. Results: Finally, four papers documenting randomized controlled studies were included. Compared with controls, sorafenib was shown to significantly increase overall survival (OS), time to progression (TTP), and disease control rates (DCR), but not the time to symptom progression (TTSP) in hepatocellular carcinoma patients. The incidence of grade-III/IV adverse reactions, including hand-foot-skin reactions, diarrhea, hypertension and skin rash or desquamation, in sorafenib treatment group was higher than that in controls. However, there was no significant difference in the incidence of hypodynamia between the two groups. Conclusions: Sorafenib exerts significant curative effects in hepatocellular carcinoma.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2016년도 추계학술발표대회
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• pp.330-333
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• 2016

최근 구제역의 발생으로 인해 농 축산업계 및 관련 산업분야에 막대한 피해를 야기함에 따라, 구제역의 발병에 따른 다양한 사회적 파급효과의 분석이 필요하다. 본 논문에서는 온라인 뉴스를 대상으로 텍스트 마이닝 방법들을 사용하여 구제역으로 인한 경제적, 환경적, 그리고 정책적 파급효과를 분석하는 공학적 방법론을 제안한다. 제안하는 시스템은 먼저, 구제역 관련 온라인 뉴스를 수집한 후, 토픽 모델링의 대표적인 방법 중 하나인 LDA(Latent Dirichlet Allocation)를 활용하여 뉴스 기사로부터 키워드들을 추출한다. 둘째, 추출된 키워드들로부터 구제역으로 인한 파급효과의 분석을 위해 동시출현 키워드 네트워크를 구성한다. 셋째, 키워드 네트워크 타임라인을 통해 각 파급효과들의 변화를 분석한다. 마지막으로, 사례분석을 통해 2010년 7월부터 2011년 12월까지 한국에서 발생한 구제역으로 인한 사회적 파급효과의 분석을 수행하였다.

• Clinical and Experimental Pediatrics
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• 제59권10호
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• pp.395-401
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• 2016

Since the outbreak of the enterovirus 71 (EV71) infection in Malaysia in 1997, large epidemics of EV71 have occurred in the Asia-Pacific region. Many children and infants have died from serious neurological complications during these epidemics, and EV71 infection has become a serious public health problem in these areas. EV71 infection causes hand, foot and mouth disease (HFMD) in children, and usually resolves spontaneously. However, EV71 occasionally involves the central nervous system (CNS), and induces diverse neurological complications such as brainstem encephalitis, aseptic meningitis, and acute flaccid paralysis. Among those complications, brainstem encephalitis is the most critical neurological manifestation because it can cause neurogenic pulmonary hemorrhage/edema leading to death. The characteristic clinical symptoms such as myoclonus and ataxia, cerebrospinal fluid (CSF) pleocytosis, and brainstem lesions on magnetic resonance imaging, in conjunction with the skin rash of HFMD and the isolation of EV71 from a stool, throat-swab, or CSF sample are typical findings indicating CNS involvement of EV71 infection. Treatment with intravenous immunoglobulin and milrinone are recommended in cases with severe neurological complications from EV71 infection, such as brainstem encephalitis. Despite the recent discovery of receptors for EV71 in human cells, such as the scavenger receptor B2 and P-selection glycoprotein ligand 1, it is not known why EV71 infection predominantly involves the brainstem. Recently, 3 companies in China have completed phase III clinical trials of EV71 vaccines. However, the promotion and approval of these vaccines in various countries are problems yet to be resolved.

• 대한환경공학회지
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• 제36권10호
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• pp.679-684
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• 2014

가축전염병 확산을 방지하기 위하여 조성된 긴급매몰지의 경우 침출수 누출이 확인되면 원형저장조로 이설된 경우가 있는데, 저장조 내 낮은 함수율과 혼합문제로 인해 분해가 거의 이루어지지 않고 있는 실정이다. 본 연구에서는 사체의 안정화를 촉진할 수 있도록 원형저장조를 생물반응조(Bioreactor)로 구조를 변경하였다. 침출수를 재순환하고 미생물을 공급하여 안정화에 필요한 미생물활동을 증가시켰다. 원형저장조 내부 유기물의 변형을 고려한 침하량 모형을 사용하여 예측한 침하량 최종치는 생물저장조 구조 변경 후 5년간 약 30%이었다.

• Journal of Acupuncture Research
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• 제19권1호
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• pp.203-209
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• 2002

Objective : The chonguinyoung pulse diagnosis method is convenient than twelve meridian pulse diagnosis method The $\ll$Maek-bup(脉法)$\gg$ are founded at Mawangtweo(馬王堆) of the han dynasty tomb in 1973, but it could diagnosis the exsitance of illness of twelve meridian also . Methods : In accordance to $\ll$Naekuoung(內經)$\gg$ inyoungmaek(人迎脈) in could be taken at the which is the pulse point of carotid artery on the line of foot yangmyoung stomach meridian (足陽明胃經) and chongumaek (寸口脈) at the taeyoun acu-point (太淵穴) pulse point on the line of hand taeyeun lung meridian (手太陰肺經). Results : Chonguinyoung pulse diagnosis method could be emphased on the point of diagnosing sick person and healthy person by the balance of yin (陰) yan (陽) composition in the body. Conclusion : Chonguinyoung pulse diagnosis method could be the indication of improvement and progress of disease also it could be adapt to diagnosis of twelve meridian and it is impossible to making choice of acupuncture, medication, moxibustion, vene-section and strengthing-eleminating treatment method (補瀉方法).

• Korean Journal of Acupuncture
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• 제25권4호
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• pp.59-71
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• 2008

Objectives : The aim of this study was to show the rationale of point-selection for acupuncture and moxibustion in the Uterine section(in the Naegyeong Chapter) of the Dong-Ui-BO-Gam. Methods : We reviewed the causes of each disease in the Uterine section of the Dong-Ui-BO-Gam, and then explained the rationale of acupoint-selection for the treatment of those diseases referring to etiology and physiology of Oriental medicine, other applications of each acupoints in the Dong-Ui-BO-Gam, characteristic of each acupoints, flow of Gi (Qi) through meridian pathways and specific acupoints etc. Results : There are comments on acupuncture and moxibustion for abnormal menstruation, amenorrhea, metrorrhagia, leukorrhea, bleeding from uterus after menopause in the Uterine section of the Dong-Ui-BO-Gam. Conclusions : Acupoints of conception vessel, and three foot Yin meridians are preferably used for acupuncture and moxibustion in the Uterine section of the Dong-Ui-BO-Gam. Out of them, CV3 is most frequently used and SP6, CV6, BL23, LR2 are also used often.