• 대한의용생체공학회:의공학회지
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• 제20권4호
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• pp.503-513
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• 1999

본 논문에서는 일반적인 합성구경기법에 대한 통합 모형을 제시하고 수학적인 해석을 통하여 합성구경 기법들에 대한 초음파 빔패턴의 단일 표현식을 유도하였다. 이 결과를 이용하여 기존의 합성구경 기법들에 대한 성능을 분석하고 비교하였으며, 선형주사 영상에 적합한 새로운 합성구경 기법을 제안하였다. 제안된 방법은 모든 영상점에서 양방향 동적 집속이 가능하며, 이를 실제 영상에 적용하여 의료용 초음파 B-모드 영상의 해상도를 획기적으로 개선할 수 있다. 제안된 방법에 의하여 집속된 초음파 빔패턴은 기존의 방식과 비교하여 주엽의 폭이 절반으로 감소하고 측엽의 크기는 유사하다. 컴퓨터 모사실험을 통하여 본 논문의 해석결과와 제안된 합성구경 기법의 타당성을 검증하였다.

• 한국기계가공학회지
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• 제20권8호
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• pp.33-41
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• 2021

Recently, many studies have been conducted on substituting fossil fuels with bio-refineries in existing industrial systems using biomass. Among the various bio-refineries, microalgae have received wide attention because it uses inorganic compounds to produce useful substances, which are extracted by a cell disruption process. Although numerous cell disruption methods exist, cell disruption efficiency has been studied by ultrasonic treatment. Ultrasound is a high-frequency (20 kHz or higher) sound wave and causes cell disruption by cavitation when passing through a solvent. In this study, we used the microalgal species Chlorella sp., which was cultured in a plate-type photobioreactor. The experiment was conducted using a continuous low-frequency processing device. The reduction of cells with time due to cell disruption was fitted using a logistic model, and optimum conditions for highly efficient cell disruption were determined by conducting experiments under multiple conditions.

• Clinical Pain
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• 제18권2호
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• pp.138-141
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• 2019

Lateral epicondylopathy represents pain in the lateral (radial aspect) of the elbow caused by degeneration in the common extensor tendon. Calcium deposit frequently developes in lateral epicondylopathy, with the prevalence up to 46%. There are considerable debates on its treatment protocols for lateral epicondylopathy so far, likewise, the effective treatment method for calcific lateral epicondylopathy has not been established. We report here a case of chronic intractable calcific lateral epicondylopathy treated with ultrasound-guided barbotage and focused type extracorporeal shock wave therapy (ESWT). To our knowledge, this is the first report of calcific lateral epicondylopathy treated by ultrasound-guided barbotage combined with ESWT.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.1700-1703
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• 2008

The purpose of this study was to examine the effects of various mechanical stimuli for MC3T3-E1 cells. Among the several mechanical stimulations, we focused on compressive stain and ultrasound. In this study, we developed a bioreactor capable of applying controlled stimuli to scaffolds. PLLA/PCL scaffold was fabricated by using salt-leaching method. We performed dynamic cell culture using preosteoblasts MC3T3-E1 cells with 1MHz, 30mW/cm2 ultrasound and 10% of compressive strain. Result of CCK-8 analysis at 1, 4, 7, 10 days showed that mechanical stimuli had no significant effect for cell proliferation. However, those stimuli influenced ALP(Alkaline phopatase) activity, which is one of differentiation marker.

• 비파괴검사학회지
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• 제26권3호
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• pp.181-189
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• 2006

A 2D finite-element numerical simulation has been developed to investigate the generation of ultrasonic waves in a homogeneous isotropic elastic slab under a line-focused laser irradiation. Discussing the physical processes involved in the thermoelastic phenomena, we describe a model for the pulsed laser generation of ultrasound in a metal slab. Addressing an analytic method, on the basis of an integral transform technique, for obtaining the solutions of the elastodynamic equation, we outline a finite element method for a numerical simulation of an ultrasonic wave propagation. We present the numerical results for the displacements and the stresses generated by a line-focused laser pulse on the surface of a stainless steel slab.

• 비파괴검사학회지
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• 제25권6호
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• pp.446-450
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• 2005

We have built a spherically focused, not using acoustic mirrors, capacitive micromachined air-coupled ultrasonic transducer. A flexible backplate of a copper/polyimide backplate is used, permitting it to conform to a spherically shaped substrate. The backplate is patterned with $40-{\mu}m$ depressions having $80-{\mu}m$ center-to-center spacing. A $6-{\mu}m$ thick aluminized Mylar film completing the transducer is deformed to allow it to conform to the spherical backplate. The device's frequency spectrum is centered at 805kHz with -6dB points at 440 and 1210kHz.

• 대한의용생체공학회:의공학회지
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• 제30권5호
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• pp.418-427
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• 2009

As many people are westernizing their life style and food consumption habits, a number of patients who have malignant tumors which grow very rapidly and hazardously destroy the human body are increasing. Ultrasonic hyperthermia is not only one of the tumor treatment methods which employs the non-radioactive ultrasonic waves to increase the temperature at the tumor region up to $40\sim45^{\circ}C$ to destroy and suppress tumor cells but also has been proved by many studies. Due to the rapid development of High Intensity Focused Ultrasound(HIFU), the ultrasound hyperthemia extensively boosts its applications in clinical field. For those reasons, Computed simulation factor should be needed before inspection to patients. To prove efficiency of ultrasonic hyperthermia, precise acoustic field measurement considering tissue characteristics and a heating experiment with tissue mimicking material phantom were conducted for effectiveness of simulation program. Finally, in this study, the computer simulation program verified the anticipated temperature effects induced by ultrasound hyperthermia. In the near future, it is hoped that this simulation program could be utilized to improve the efficiency of ultrasound hyperthermia.

• 치위생과학회지
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• 제14권2호
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• pp.101-106
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• 2014

본 연구는 저 출력 초음파 장치를 이용하여 osteoblastlike MG-63 세포에 1 MHz, 3 Mz 강도의 초음파 처리 후 조골세포의 변화를 관찰하였다. 3 MHz 강도의 주파수를 osteoblast-like MG-63 세포에 처리한 결과 7일 후 성장률이 대조군보다 증가하였다. 저 출력 초음파가 골의 치유에 영향을 미치는 인자를 확인하였을 때 ALP, osteocalcin, VEGF, colla 1A1의 증가를 확인하였으며, 1 MHz 주파수 처리시 integrin alpha 2의 발현이 대조군과 유사하게 발현되는 것을 확인하였다. 반면에, osteonectin, osteopontin, fibronectin, MMP 2 등은 변화가 없음을 확인하였다. 그러므로 본 연구는 저 출력 초음파 장치는 뼈 치유 촉진 단백질들의 발현을 증가시켜 구강 내 외과적 수술 시 골 치유 촉진 효과에 대한 가능성을 제시하였으며 임상에서 골 치유 촉진을 위한 장비로서의 사용 가능성을 제시하였다고 생각된다.

• 한국음향학회지
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• 제31권6호
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• pp.399-409
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• 2012

본 논문에서는 초음파 연조직 팬텀에서 음향 복사력을 이용하여 횡탄성(shear modulus)을 측정하는 방법을 제안하였다. 이 방법은 집속 초음파 빔의 초점에서 음향 복사력에 의해 발생하는 변위의 상승시간에 기초하여 횡탄성을 정량적으로 산정한다. 제안한 방법의 타당성을 확인하기 위하여 횡파 전파법으로 측정한 횡파의 속도 및 횡탄성값 결과와 비교하였다. 횡파 전파법은 제한회절 송신음장에 의해 팬텀에서 발생하여 전파하는 횡파의 속도를 측정하여 횡탄성값을 계산하고, 이 값으로 교정된 데이터 획득 시스템에서 제안한 방법으로 측정한 횡탄성값을 횡파 전파법으로 측정한 값과 비교하여, 제안한 횡탄성 측정법의 유용성을 확인하였다. 두 방법 간의 상대오차는 횡파 속도는 4%로, 횡탄성값은 9% 이하로 계산되었다.

• 한국기계가공학회지
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• 제20권10호
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• pp.63-71
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• 2021

Using fossil fuels in existing industrial systems causes a variety of social problems. Recently, many studies have been conducted on bio-refineries, which aim to actively utilize biomass to reduce the use of fossil fuels and solve various social problems. Among them, research using microalgae as a third-generation biomass has attracted considerable attention. Microalgae use inorganic matter to produce organic matter, and cell destruction is necessary to extract useful organic materials from microalgae. The extracted organic materials are currently used in various industrial fields. Numerous cell-destruction methods exist. We have investigated cell disruption by sonication, especially its efficiency. Ultrasound is a sound wave with frequencies above 20 kHz, and destroys cells by sending high energy through a cavitation that occurs, according to the characteristics of the sound wave. The Dunaliella salina microalgae used in this study was cultured in a flat-type photobioreactor. Experiments were performed using a batch low-frequency processing device. Logistic model was applied to analyze the results of cell-destruction experiments using ultrasound. The proper conditions for the most efficient cell destruction were OD 1.4(microalgae concentration)), 54watt(output power) and 200mL(microalgae capacity).